-
公开(公告)号：US20030116707A1
公开(公告)日：2003-06-26
申请号：US10223401
申请日：2002-08-19
申请人： Micromass Limited
发明人： Jeff Brown , Dominic Gostick , Edouard S. P. Bouvier , John Charles Gebler , Peter Jeng Jong Lee , James Ian Langridge , Emmanuelle Claude , Weibin Chen
IPC分类号： H01J049/04
CPC分类号： H01J49/0418 , B01L3/5088
摘要： A MALDI sample plate 1 is disclosed which comprises a metallic substrate 2 having a circular groove or moat 3. A hydrophobic polytetrafluoroethylene layer 4 is applied to the substrate 2 and a central portion 5 of the substrate 2 is laser etched which roughens the surface of the substrate 2. A thin polystyrene layer is then applied to the polytetrafluoroethylene layer 4 and the central portion 5.
摘要翻译： 公开了一种MALDI样品板1，其包括具有圆形槽或护城河3的金属基板2.将疏水性聚四氟乙烯层4施加到基板2上，并且激光蚀刻基板2的中心部分5，其粗糙化表面 然后将薄聚苯乙烯层施加到聚四氟乙烯层4和中心部分5。
-
公开(公告)号：US20010010354A1
公开(公告)日：2001-08-02
申请号：US09805062
申请日：2001-03-14
申请人： MICROMASS LIMITED
发明人： James Speakman , Raymond Clive Haines , Patrick James Turner , Thomas Oliver Merren , Stuart Alan Jarvis
IPC分类号： H01J049/00
CPC分类号： H01J49/063 , H01J49/0481 , H01J49/105
摘要： A plasma mass spectrometer comprises a plasma torch (1) for generating ions from a sample introduced into a plasma (2), a nozzle-skimmer interface (3, 5) for transmitting said ions into a first evacuated chamber (11), ion guiding means (12), an apertured diaphragm (18) dividing said first evacuated chamber (11) from a second evacuated chamber, and an ion mass-to-charge ratio analyzer in the second chamber for producing a mass spectrum. The ion guiding means comprises a multipole rod-set (13, 14, 15), means for applying an AC voltage between rods in the set, and means (22) for introducing into said ion guiding means an inert gas selected from the group comprising helium, neon, argon, krypton, xenon and nitrogen so that the partial pressure of said inert gas inside said rod-set is at least 10null3 torr. Interfering peaks in the spectrum, such as ARnull, are thereby reduced
摘要翻译： 等离子体质谱仪包括用于从引入等离子体（2）中的样品产生离子的等离子体焰炬（1），用于将所述离子传输到第一真空室（11）中的喷嘴 - 撇渣器界面（3,5），离子导向 装置（12），在第二室中将所述第一抽真空室（11）与第二抽空室分开的有孔隔膜（18）和离子质荷比分析器产生质谱。 离子引导装置包括多极杆组（13,14,15），用于在组中的杆之间施加AC电压的装置，以及用于将所述离子引导装置引入惰性气体的装置（22），所述惰性气体选自包括 氦气，氖气，氩气，氪气，氙气和氮气，使得所述棒组件内的所述惰性气体的分压至少为10 -3乇。 从而降低光谱中的干扰峰，如AR +
-
公开(公告)号：US6107623A
公开(公告)日：2000-08-22
申请号：US138152
申请日：1998-08-21
CPC分类号： H01J49/004 , H01J49/4215
摘要： The invention provides methods and apparatus for tandem mass spectrometry (MS/MS) in which parent ions generated from a sample are passed through a mass filter (2) and are fragmented into daughter ions in fragmentation means (3), the daughter ions being passed through a discontinuous output mass analyser, such as a time-of-flight analyzer (16) or an ion storage device (29). The range of possible parent mass-to-charge ratios is split into a plurality of smaller ranges, and the mass filter (2) is set to pass ions of each smaller range in turn. A flag is set for each smaller range which produces daughter ions of interest, and the mass filter (2) is set to pass each mass-to-charge ratio of the flagged ranges so that the mass-to-charge ratios of the fragmented ions produced for each of the mass-to-charge ratios passed may be determined using the discontinuous analyser (16, 29). The flagged ranges may be themselves split into a plurality of still smaller ranges, which are correspondingly flagged.
摘要翻译： 本发明提供串联质谱法（MS / MS）的方法和装置，其中从样品产生的亲本离子通过质量过滤器（2），并在碎片装置（3）中碎裂成子离子，子离子通过 通过不连续输出质量分析器，例如飞行时间分析器（16）或离子存储装置（29）。 可能的母体质荷比的范围被分成多个较小的范围，并且质量过滤器（2）被设置为依次通过每个较小范围的离子。 对于产生感兴趣的子离子的每个较小的范围设置标志，并且质量过滤器（2）被设置为通过标记范围的每个质荷比，使得碎裂离子的质荷比 可以使用不连续分析仪（16,29）来确定通过的每个质荷比。 标记的范围本身可以分成多个相应标记的较小范围。
-
公开(公告)号：US5661298A
公开(公告)日：1997-08-26
申请号：US649795
申请日：1996-05-17
申请人： Robert H. Bateman
发明人： Robert H. Bateman
CPC分类号： H01J49/30 , H01J49/282
摘要： A mass spectrometer is provided having a plurality of analyzers and including at least one magnetic sector analyzer and, typically, an orthogonal-acceleration time-of-flight mass analyzer. Bypass means are provided so that by switching of the direction of the ion beam, the magnetic sector analyzer may be bypassed and the time-of-flight analyzer used either to analyse the beam of ions from the source or daughter ions produced by fragmentation of that beam.
摘要翻译： 提供了具有多个分析器并且包括至少一个磁性扇区分析仪和通常是正交加速度飞行时间质量分析器的质谱仪。 提供了旁路装置，使得通过切换离子束的方向，可以绕过磁性扇区分析仪，并且飞行时间分析仪用于分析来自源或子离子的离子束 光束。
-
公开(公告)号：US5766954A
公开(公告)日：1998-06-16
申请号：US635938
申请日：1996-04-26
IPC分类号： G01N31/00 , B01D59/44 , G01N27/62 , G01N30/02 , G01N30/72 , G01N30/84 , G01N30/88 , G01N31/12 , G01N33/28 , G01N33/00
CPC分类号： G01N30/84 , B01D59/44 , G01N31/12 , G01N33/2835 , G01N2030/025 , G01N2030/8405 , G01N30/7206 , Y10T436/22 , Y10T436/24 , Y10T436/25875
摘要： A continuous flow method of determining the quantitative isotopic composition of hydrogen comprised in a compound is disclosed, together with apparatus for carrying out the method. The method involves introducing the sample to be analysed into a flow of carrier gas which does not contain hydrogen, the carrier gas then being arranged to flow through a heated catalytic reactor which contain a chromium-based catalyst. The sample is pyrolysed in the catalytic reactor so as to form molecular hydrogen which is then analysed mass-spectrometrically. Preferably a gas chromatrograph is disposed before the catalytic reactor so that one or more components or a mixture may be separately analysed.
摘要翻译： PCT No.PCT / GB95 / 02192 Sec。 371日期：1996年4月26日 102（e）日期1996年4月26日PCT提交1995年9月15日PCT公布。 第WO96 / 08719号公报 日期：1996年3月21日公开了一种确定化合物中所含的氢的定量同位素组成的连续流动方法以及用于实施该方法的装置。 该方法包括将要分析的样品引入不含氢气的载气流中，然后将载气流经包含铬基催化剂的加热催化反应器。 样品在催化反应器中热解，形成分子氢，然后进行质谱分析。 优选地，气相色谱仪设置在催化反应器之前，使得可以单独分析一种或多种组分或混合物。
-
公开(公告)号：US07038197B2
公开(公告)日：2006-05-02
申请号：US10274989
申请日：2002-10-22
CPC分类号： H01J49/067 , H01J49/0027
摘要： A mass spectrometer is disclosed wherein a z-lens upstream of an orthogonal acceleration Time of Flight mass analyser is repeatedly switched between a first mode wherein ions are transmitted to the mass analyser for subsequent mass analysis with a relatively high transmission and a second mode wherein ions are transmitted with a relatively low transmission. If it is determined that mass spectral data obtained when the mass analyser is in the first mode is suffering from saturation, then suitably scaled mass spectral data obtained when the mass analyser is in the second mode is used instead. If the saturation is severe then the mass spectral data obtained in the first mode may be replaced in its entirety with mass spectral data obtained in the second mode.
摘要翻译： 公开了一种质谱仪，其中在正交加速时间飞行质量分析仪上游的z轴透镜在第一模式之间重复切换，其中离子被传输到质量分析器以进行相对较高透射率的后续质量分析，其中离子 以较低的传输速率传输。 如果确定当质量分析器处于第一模式时获得的质谱数据饱和，则使用质量分析器处于第二模式时获得的适当缩放的质谱数据。 如果饱和度严重，则在第一模式中获得的质谱数据可以用第二模式获得的质谱数据全部替代。
-
公开(公告)号：US5757012A
公开(公告)日：1998-05-26
申请号：US709089
申请日：1996-09-06
CPC分类号： H01J49/025
摘要： A Faraday Cup charged-particle detector for use in an isotopic ratio mass spectrometer is provided with a charged-particle collector substrate being at least partially composed of carbon produced by burning wood or other grained or cellular organic material so that the substrate surface has an open cellular structure and wherein the cells are of elongated tubular form. The detector is economic to manufacture, reliable and has an increased lifetime.
摘要翻译： 具有用于同位素比质谱仪的法拉第杯带电粒子检测器具有带电粒子收集器基底，其至少部分地由通过燃烧木材或其它粒状或细胞有机材料产生的碳构成，使得基底表面具有开口 细胞结构，其中细胞是细长的管状形式。 检测仪经济，制造可靠，寿命更长。
-
公开(公告)号：US5903002A
公开(公告)日：1999-05-11
申请号：US958608
申请日：1997-10-27
CPC分类号： H01J49/025
摘要： A Faraday Cup charged-particle detector for use in an isotopic ratio mass spectrometer is provided with a charged-particle collector substrate being at least partially composed of carbon produced by burning wood or other grained or cellular organic material so that the substrate surface has an open cellular structure and wherein the cells are of elongated tubular form. The detector is economic to manufacture, reliable and has an increased lifetime.
摘要翻译： 具有用于同位素比质谱仪的法拉第杯带电粒子检测器具有带电粒子收集器基底，其至少部分地由通过燃烧木材或其它粒状或细胞有机材料产生的碳构成，使得基底表面具有开口 细胞结构，其中细胞是细长的管状形式。 检测仪经济实用，可靠，寿命长。
-
9.发明授权
公开(公告)号：US5756994A
公开(公告)日：1998-05-26
申请号：US766299
申请日：1996-12-13
申请人： Stevan Bajic
发明人： Stevan Bajic
CPC分类号： H01J49/165 , H01J49/0445 , H01J49/067
摘要： Atmospheric Pressure Chemical Ionization (APCI) and electrospray ionization sources for the mass spectrometric analysis of solutions, and associated methods. The apparatus and methods are characterised in that ions generated by APCI or electrospray are directed such that their directions of travel immediately on formation can be resolved into two perpendicular components, one of which is aligned with a linear first trajectory which passes through an entrance orifice, an extraction chamber and into an evacuation port through which the extraction chamber is evacuated. The direction of travel is such that the component of velocity so aligned is smaller than the component perpendicular to it. Ions leave the chamber along a second trajectory which is inclined at an angle between 30.degree. and 150.degree. to the linear first trajectory and may pass into a mass analyzer. The apparatus and method provide improved sensitivity and a lower noise level in comparison with prior apparatus and methods using APCI and electrospray ionization sources.
摘要翻译： 大气压化学电离（APCI）和电喷雾离子源用于溶液的质谱分析及相关方法。 该装置和方法的特征在于，由APCI或电喷雾产生的离子被定向成使得其立即形成的行进方向可以分解成两个垂直分量，其中一个垂直分量与通过入口孔的线性第一轨迹对齐， 提取室并进入抽空口，抽空室通过该抽空口排出。 行进方向是这样排列的速度分量小于垂直于它的分量。 离子室沿着与线性第一轨迹倾斜30°至150°之间的角度的第二轨迹离开，并且可以进入质量分析器。 与使用APCI和电喷雾电离源的现有装置和方法相比，该装置和方法提供了改进的灵敏度和较低的噪声水平。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.022 秒)
