公开(公告)号：US5559282A

公开(公告)日：1996-09-24

申请号：US437072

申请日：1995-05-05

Applicant: Kevin D. Knight ,  Graham A. Knight ,  Colin D. Knight

Inventor： Kevin D. Knight ,  Graham A. Knight ,  Colin D. Knight

IPC: G01M3/12 ,  G01M3/04 ,  G01M3/26

CPC classification number: G01M3/12

Abstract: A method and apparatus for testing the effectiveness of a building air barrier, or part thereof, whereby an identification of any air leakage therethrough is provided. A soap solution (or other solution having a similar bubbling characteristic) is applied to a selected air barrier test area. An open-ended flask is positioned over the test area and a centrifugal (or standard) fan is activated at the head of the flask to create an air pressure differential across the air barrier. In the presence of the air pressure differential the soap solution will bubble if there is an air leakage in the air barrier within the test area and, therefore, the existence or non-existence of bubbles in this area identifies whether or not there is an air leakage (i.e. break) in the air barrier in that area.

Abstract translation: 一种用于测试建筑物空气屏障或其一部分的有效性的方法和装置，由此提供了通过其识别任何空气泄漏。 将肥皂溶液（或具有类似起泡特性的其它溶液）施加到所选择的空气阻挡试验区域。 将开口的烧瓶放置在测试区域的上方，并且在烧瓶的头部处启动离心（或标准）风扇，以在空气屏障上产生气压差。 在存在空气压差的情况下，如果在测试区域内的空气屏障中存在空气泄漏，则肥皂溶液将会起泡，因此在该区域中存在或不存在气泡来识别是否存在空气 在该地区的空气屏障中泄漏（即断裂）。

公开(公告)号：USD1026445S1

公开(公告)日：2024-05-14

申请号：US29756392

申请日：2020-10-28

Applicant: Kendall Gholston ,  Willie C. Knight, Sr. ,  Christine Gholston ,  Dianne D. Knight

Designer： Kendall Gholston ,  Willie C. Knight, Sr. ,  Christine Gholston ,  Dianne D. Knight

Abstract: FIG. 1 is a perspective top front right view of a hook attachment for footwear, showing our new design;
FIG. 2 is a perspective top rear left view thereof;
FIG. 3 is a front elevation view thereof;
FIG. 4 is a rear elevation view thereof;
FIG. 5 is a right elevation view thereof;
FIG. 6 is a left elevation view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.

公开(公告)号：US11608099B1

公开(公告)日：2023-03-21

申请号：US17082257

申请日：2020-10-28

Applicant: Kendall Gholston ,  Willie C. Knight ,  Christine Gholston ,  Dianne D. Knight

Inventor： Kendall Gholston ,  Willie C. Knight ,  Christine Gholston ,  Dianne D. Knight

IPC: A43C19/00 ,  B62B5/00 ,  A43B3/16

Abstract: The hand truck foot hook may comprise a retaining strap and a hook. The hand truck foot hook may be adapted to pull the bottom of a hand truck out from under a load using a foot of a user. The retaining strap may detachably couple to a shoe worn on the foot of the user. The hook may be coupled to the retaining strap such that the hook is accessible on the top of the foot. The hook may removably engage the bottom of the hand truck such that the bottom of the hand truck is pulled back when the shoe is pulled back. As a non-limiting example, the hook may engage an axle of the hand truck.

公开(公告)号：US20120225050A1

公开(公告)日：2012-09-06

申请号：US13079541

申请日：2011-04-04

Applicant: Chris D. Knight ,  Julia J. Dibner ,  Fenglan Yan

Inventor： Chris D. Knight ,  Julia J. Dibner ,  Fenglan Yan

IPC: A61K38/48 ,  A61P31/04 ,  A61P1/12 ,  A61P1/00 ,  A61P37/00

CPC classification number: A61K38/48 ,  A23K10/12 ,  A23K20/147 ,  A23K20/189 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A61K38/482 ,  A61K38/4873 ,  A61K38/488 ,  A61K38/4886 ,  C12Y304/00 ,  C12Y304/21 ,  C12Y304/22 ,  C12Y304/23 ,  C12Y304/24

Abstract: The present invention provides methods for improving gut health. In particular, the invention provides methods for improving gut health by improving the digestibility of dietary proteins, decreasing the flow of protein to the lower gastrointestinal tract, and/or decreasing the levels of Clostridium bacteria the upper intestinal tract of a subject. The methods comprise administering to the subject a supplement consisting essentially of at least one protease.

Abstract translation: 本发明提供了改善肠道健康的方法。 特别地，本发明提供了通过改善膳食蛋白质的消化率，降低蛋白质向下胃肠道的流动和/或降低受试者上肠道的梭菌细菌的水平来改善肠道健康的方法。 所述方法包括向受试者施用基本上由至少一种蛋白酶组成的补充物。

公开(公告)号：US20110072693A1

公开(公告)日：2011-03-31

申请号：US12923491

申请日：2010-09-23

Applicant: Garrett D. Knight

Inventor： Garrett D. Knight

IPC: E02F9/28

CPC classification number: E02F9/2833 ,  E02F9/2825

Abstract: A tooth retention device for attachment to an excavator bucket, which has a tooth mounting portion, a fork shaped body fitting over the edge of the bucket, a clamp passing through the body and the bucket, and a wedge holding the clamp in position, in which the wedge has a threaded rod and a threaded block on the rod. The rod is rotatable to move the block between locked and released positions.

Abstract translation: 一种用于附接到挖掘机铲斗的齿保持装置，其具有齿安装部分，配合在铲斗边缘上的叉形体，穿过主体和铲斗的夹具以及将夹具保持在适当位置的楔形物 楔形件具有螺纹杆和杆上的螺纹块。 杆可旋转以在锁定位置和释放位置之间移动块。

公开(公告)号：US07582668B2

公开(公告)日：2009-09-01

申请号：US11598250

申请日：2006-11-08

Applicant: Xiangping Qian ,  Luke W. Ashcraft ,  Jianchao Wang ,  Bing Yao ,  Hong Jiang ,  Gustave Bergnes ,  Bradley P. Morgan ,  David J. Morgans, Jr. ,  Dashyant Dhanak ,  Steven D. Knight ,  Nicholas D. Adams ,  Cynthia A. Parrish ,  Kevin J. Duffy ,  Duke Fitch ,  Rosanna Tedesco

Inventor： Xiangping Qian ,  Luke W. Ashcraft ,  Jianchao Wang ,  Bing Yao ,  Hong Jiang ,  Gustave Bergnes ,  Bradley P. Morgan ,  David J. Morgans, Jr. ,  Dashyant Dhanak ,  Steven D. Knight ,  Nicholas D. Adams ,  Cynthia A. Parrish ,  Kevin J. Duffy ,  Duke Fitch ,  Rosanna Tedesco

IPC: A61K31/4178 ,  C07D403/10

CPC classification number: C07D233/64 ,  C07C235/48 ,  C07C235/50 ,  C07C235/52 ,  C07C237/22 ,  C07C255/57 ,  C07C255/59 ,  C07C255/60 ,  C07C257/08 ,  C07C257/18 ,  C07C259/18 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07C275/26 ,  C07C275/40 ,  C07C275/42 ,  C07C281/06 ,  C07C307/10 ,  C07C311/37 ,  C07C311/46 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/273 ,  C07D211/34 ,  C07D211/76 ,  C07D213/30 ,  C07D231/12 ,  C07D231/14 ,  C07D233/61 ,  C07D233/70 ,  C07D235/06 ,  C07D235/16 ,  C07D235/18 ,  C07D235/26 ,  C07D239/36 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08 ,  C07D263/10 ,  C07D263/12 ,  C07D263/32 ,  C07D271/06 ,  C07D271/07 ,  C07D271/10 ,  C07D271/113 ,  C07D277/30 ,  C07D277/42 ,  C07D277/56 ,  C07D285/02 ,  C07D285/125 ,  C07D295/145 ,  C07D295/155 ,  C07D333/38 ,  C07D403/10 ,  C07D403/12 ,  C07D413/06 ,  C07D471/04 ,  C07D498/04 ,  C07F9/6506 ,  C07F9/6561

Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

Abstract translation: 提供了可用于治疗癌症或其它增殖性疾病的式I化合物及其药学上可接受的盐。

公开(公告)号：US20080255182A1

公开(公告)日：2008-10-16

申请号：US12007143

申请日：2008-01-07

Applicant: Xiangping Qian ,  Andrew I. McDonald ,  Han-Jie Zhou ,  Luke W. Ashcraft ,  Bing Yao ,  Hong Jiang ,  Jennifer Kuo Chen Huang ,  Jianchao Wang ,  David J. Morgans ,  Bradley P. Morgan ,  Gustave Bergnes ,  Dashyant Dhanak ,  Steven D. Knight ,  Nicholas D. Adams ,  Cynthia A. Parrish ,  Kevin Duffy ,  Duke Fitch ,  Rosanna Tedesco

Inventor： Xiangping Qian ,  Andrew I. McDonald ,  Han-Jie Zhou ,  Luke W. Ashcraft ,  Bing Yao ,  Hong Jiang ,  Jennifer Kuo Chen Huang ,  Jianchao Wang ,  David J. Morgans ,  Bradley P. Morgan ,  Gustave Bergnes ,  Dashyant Dhanak ,  Steven D. Knight ,  Nicholas D. Adams ,  Cynthia A. Parrish ,  Kevin Duffy ,  Duke Fitch ,  Rosanna Tedesco

IPC: A61K31/437 ,  A61P35/00

CPC classification number: C07D233/64 ,  C07C235/48 ,  C07C235/50 ,  C07C235/52 ,  C07C237/22 ,  C07C255/57 ,  C07C255/59 ,  C07C255/60 ,  C07C257/08 ,  C07C257/18 ,  C07C259/18 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07C275/26 ,  C07C275/40 ,  C07C275/42 ,  C07C281/06 ,  C07C307/10 ,  C07C311/37 ,  C07C311/46 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/273 ,  C07D211/34 ,  C07D211/76 ,  C07D213/30 ,  C07D231/12 ,  C07D231/14 ,  C07D233/61 ,  C07D233/70 ,  C07D235/06 ,  C07D235/16 ,  C07D235/18 ,  C07D235/26 ,  C07D239/36 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08 ,  C07D263/10 ,  C07D263/12 ,  C07D263/32 ,  C07D271/06 ,  C07D271/07 ,  C07D271/10 ,  C07D271/113 ,  C07D277/30 ,  C07D277/42 ,  C07D277/56 ,  C07D285/02 ,  C07D285/125 ,  C07D295/145 ,  C07D295/155 ,  C07D333/38 ,  C07D403/10 ,  C07D403/12 ,  C07D413/06 ,  C07D471/04 ,  C07D498/04 ,  C07F9/6506 ,  C07F9/6561

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract translation: 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

公开(公告)号：US07041465B1

公开(公告)日：2006-05-09

申请号：US09637216

申请日：2000-08-11

Applicant: Scott J. Hultgren ,  Frederic G. Sauer ,  Gabriel Waksman ,  Klaus Fuetterer ,  Devapriya Choudhury ,  Stefan D. Knight ,  Michelle Barnhart

Inventor： Scott J. Hultgren ,  Frederic G. Sauer ,  Gabriel Waksman ,  Klaus Fuetterer ,  Devapriya Choudhury ,  Stefan D. Knight ,  Michelle Barnhart

IPC: C12Q1/68 ,  C12N1/20 ,  G01N33/554 ,  A61K38/00 ,  C07K1/00

CPC classification number: C12Q1/18 ,  A61K38/00 ,  C07K14/47 ,  Y02A50/406 ,  Y02A50/473

Abstract: Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit. The present invention also relates to the complex formed from the binding of such mimic compounds to the hydrophobic groove of a pilus subunit. Competitively interacting with the binding site of pili subunits will negatively affect the chaperone/usher pathway, which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures, and thus prevent or inhibit pilus assembly.

Abstract translation: 许多革兰氏阴性病原体在其表面上组装粘性纤毛结构，使其能够定居宿主组织并引起疾病。 本发明涉及模拟伴侣蛋白G1β链或者一个真菌亚单位的氨基末端基序的新化合物。 本发明还涉及由这种模拟化合物与真菌亚单位的疏水性凹槽的结合形成的复合物。 与pili亚基的结合位点的竞争性相互作用将对分子伴侣/启动子通路产​​生负面影响，这是革兰氏阴性细菌组装粘性纤毛结构的一种分子机制，从而防止或抑制肠组织。

公开(公告)号：US07019008B2

公开(公告)日：2006-03-28

申请号：US11119026

申请日：2005-04-29

Applicant: Dashyant Dhanak ,  Steven D. Knight ,  Jian Jin ,  Ralph A. Rivero ,  Anthony Sapienza

Inventor： Dashyant Dhanak ,  Steven D. Knight ,  Jian Jin ,  Ralph A. Rivero ,  Anthony Sapienza

IPC: A61K31/496 ,  C07D409/14

CPC classification number: C07D409/12

Abstract: A compound of Formula (I): wherein: R1 is C1-6 alkyl, benzyl, or (CH2)n—C(O)NH2; wherein the benzyl may be unsubstituted or substituted by one or two C1-6 alkyl, halogen, C1-6 alkoxy, or methylenedioxy groups; R2 is benzimidazolyl, quinolinyl, benzofuranyl, napthyl, indolyl, benzothiophenyl, phenyl, furanyl, thienyl, or pyridyl substituted or unsubstituted by one, two or three halogen, C1-3 alkyl, C1-3 alkoxy, or methylenedioxy groups; X1 and X2 are independently hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, nitro, CF3, or CN; n is 1, 2, or 3; m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.

Abstract translation: 式（I）的化合物：其中：R 1是C 1-6烷基，苄基或（CH 2 CH 2） -C（O）NH 2; 其中苄基可以是未取代的或被一个或两个C 1-6烷基，卤素，C 1-6烷氧基或亚甲二氧基取代; R 2是苯并咪唑基，喹啉基，苯并呋喃基，萘基，吲哚基，苯并噻吩基，苯基，呋喃基，噻吩基或被1,2或3个卤素取代或未取代的吡啶基， 亚烷基，C 1-3烷氧基或亚甲二氧基; X 1和X 2独立地是氢，卤素，C 1-3烷基，C 1-3烷氧基 ，硝基，CF 3或CN; n为1,2或3; m为1,2或3; 或其药学上可接受的盐。

公开(公告)号：US06733759B2

公开(公告)日：2004-05-11

申请号：US09792998

申请日：2001-02-26

Applicant: Francis J. Ivey ,  Julia J. Dibner ,  Christopher D. Knight

Inventor： Francis J. Ivey ,  Julia J. Dibner ,  Christopher D. Knight

IPC: A61K3905

CPC classification number: A61K39/39 ,  A23K10/18 ,  A23K20/10 ,  A23K40/00 ,  A23K40/20 ,  A23K40/25 ,  A23K50/75 ,  A61K2039/521 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/5555 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/55583 ,  A61K2039/55594 ,  Y10S426/807

Abstract: A nutrient formulation including moisture, a coloring agent, a palatability modifier, and/or an adjuvant which is designed for use in poultry and other animals, and a method of feeding it which improves subsequent livability, cumulative feed efficiency, weight gain, and resistance to disease challenge or other stresses is disclosed.

Abstract translation: 包括水分，着色剂，适口性调节剂和/或设计用于家禽和其他动物的佐剂的营养配方及其喂养方法，其提高随后的活力，累积饲料效率，体重增加和抗性 公开了疾病挑战或其它应力。