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公开(公告)号：US09790621B2
公开(公告)日：2017-10-17
申请号：US10900455
申请日：2004-07-27
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
CPC classification number: C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
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公开(公告)号：US09434984B2
公开(公告)日：2016-09-06
申请号：US10902597
申请日：2004-07-29
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
CPC classification number: C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
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公开(公告)号：US09428797B2
公开(公告)日：2016-08-30
申请号：US10902682
申请日：2004-07-29
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
CPC classification number: C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
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4.发明授权Analyte detection utilizing polynucleotide sequences, composition, process and kit 失效使用多核苷酸序列，组成，过程和试剂盒的分析物检测公开(公告)号：US09134302B2
公开(公告)日：2015-09-15
申请号：US08479995
申请日：1995-06-07
Applicant: Robert G. Pergolizzi , Jannis G. Stavrianopoulos , Elazar Rabbani , Dean L. Engelhardt , Stan Kline , Paula J. Olsiewski
Inventor： Robert G. Pergolizzi , Jannis G. Stavrianopoulos , Elazar Rabbani , Dean L. Engelhardt , Stan Kline , Paula J. Olsiewski
CPC classification number: G01N33/53 , C12Q1/6813 , C12Q1/6876 , Y10T436/143333
Abstract: A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.
Abstract translation: 在样品中检测其上具有分子可识别部分的分析物（A）的方法，其包括：提供（B）其上具有其上的分子桥接实体：（i）能够识别分析物上的分子识别部分的部分; 和（ii）包含多核苷酸序列的部分; 和（C）其上具有的信令实体：（i）能够退火到所述桥接实体的多核苷酸部分从而形成稳定的多核苷酸杂交体的多核苷酸部分，和（ii）信号产生部分; 形成复合物，其包括：（1）通过其分子可识别部分复合的分析物（A）至（2）实体（B）的识别部分; 实体（B）通过其上的多核苷酸部分复合到（3）信令实体的多核苷酸部分; 以及通过存在于复合体中的信号产生部分来检测信号。
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5.发明授权公开(公告)号：US08735145B2
公开(公告)日：2014-05-27
申请号：US11929897
申请日：2007-10-30
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Keller , Dean L. Engelhardt
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Keller , Dean L. Engelhardt
IPC: C12N15/00
CPC classification number: C12N15/1132 , C07K14/005 , C07K14/62 , C12N9/1247 , C12N15/87 , C12N2740/16322 , C12Q1/6897 , C12Q1/703 , C12Q2525/301 , C12Q2525/307
Abstract: The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.
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Patent Agency Ranking
6.发明授权公开(公告)号：US08557522B2
公开(公告)日：2013-10-15
申请号：US10900451
申请日：2004-07-27
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
CPC classification number: C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
Abstract translation: 本发明提供了用于分析物检测，定量和扩增的新型组合物和方法。 分析物的核酸阵列和文库可有效地并入到这样的组合物和方法中。 使用通用检测元件，信号实体等来检测并且如果需要或期望量化分析物。 靶分析物的扩增也由本发明的组合物和方法提供。
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公开(公告)号：US08288092B2
公开(公告)日：2012-10-16
申请号：US11925556
申请日：2007-10-26
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman , Marleen Walner
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman , Marleen Walner
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C12P19/34 , C12Q1/6844 , C12Q1/6853 , C12Q2531/119 , C12Q2525/301 , C12Q2525/161
Abstract: The invention is directed to nucleic acid sequences having decreased thermodynamic stability to complementary sequence as well as a method for producing these sequences.
Abstract translation: 本发明涉及对互补序列具有降低的热力学稳定性的核酸序列以及用于产生这些序列的方法。
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8.发明授权公开(公告)号：US08247179B2
公开(公告)日：2012-08-21
申请号：US12580053
申请日：2009-10-15
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman , Dakai Liu
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman , Dakai Liu
CPC classification number: C12Q1/6818 , C12Q1/6834 , C12Q1/6844 , C12Q1/6853 , C12Q1/686 , G01N21/64 , G01N21/6486 , C12Q2565/101 , C12Q2533/101 , C12Q2561/113
Abstract: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.
Abstract translation: 本发明提供用于实时核酸检测过程的组合物。 这种实时核酸检测方法是用连接于核酸引物，核苷酸，核酸探针或核酸结合剂的能量转移元件进行的。 实时核酸检测允许定性或定量检测或测定样品中感兴趣的单链或双链核酸。 本发明提供了其它方法，包括从被分析物或分析物库中除去一部分均聚物序列，例如聚A序列或尾部的方法。 还描述和提供了用于进行这种去除方法的组合物。
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9.发明授权Nucleic acid sequencing processes using non-radioactive detectable modified or labeled nucleotides or nucleotide analogs, and other processes for nucleic acid detection and chromosomal characterization using such non-radioactive detectable modified or labeled nucleotides or nucleotide analogs 失效使用非放射性可检测的修饰或标记核苷酸或核苷酸类似物的核酸测序方法，以及使用这种非放射性可检测修饰或标记核苷酸或核苷酸类似物的核酸检测和染色体表征的其他过程公开(公告)号：US08097405B1
公开(公告)日：2012-01-17
申请号：US08486069
申请日：1995-06-07
Applicant: Dean Engelhardt , Elazar Rabbani , Stanley Kline , Jannis G. Stavrianopoulos , Dollie Kirtikar
Inventor： Dean Engelhardt , Elazar Rabbani , Stanley Kline , Jannis G. Stavrianopoulos , Dollie Kirtikar
CPC classification number: C12Q1/6816 , A61K47/62 , C07B59/008 , C07H19/04 , C07H19/10 , C07K17/06 , C12Q1/6804 , C12Q2525/117
Abstract: A process for determining the sequence of nucleic acids of interest employs nucleotides or nucleotide analogs that have been made detectable by non-radioactive modifying or labeling. Such nucleotides or nucleotide analogs are modified on the sugar moieties, the phosphate moieties or the base moieties, including base analogs. Modified nucleotide analogs can be attached to or coupled to or incorporated into DNA or RNA. The modified or labeled nucleotides or nucleotide analogs are also useful in processes for detecting the presence of nucleic acids of interest and for characterizing chromosomal sequences. Detection processes using the modified or labeled nucleotides or nucleotide analogs extend to the use of a gel for separating or resolving hybrids formed between non-radioactively labeled oligonucleotides or polynucleotides and such nucleic acids of interest.
Abstract translation: 用于确定感兴趣的核酸序列的方法使用已经通过非放射性修饰或标记可检测的核苷酸或核苷酸类似物。 这些核苷酸或核苷酸类似物在糖部分，磷酸酯部分或碱基部分（包括碱基类似物）上被修饰。 修饰的核苷酸类似物可以连接到DNA偶联或并入DNA或RNA中。 修饰或标记的核苷酸或核苷酸类似物也可用于检测感兴趣的核酸的存在和表征染色体序列的方法。 使用经修饰或标记的核苷酸或核苷酸类似物的检测方法延伸到使用凝胶来分离或拆分在非放射性标记的寡核苷酸或多核苷酸与所关注的核酸之间形成的杂交体。
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公开(公告)号：US20090286285A1
公开(公告)日：2009-11-19
申请号：US11925556
申请日：2007-10-26
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman , Marleen Walner
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman , Marleen Walner
CPC classification number: C12Q1/6869 , C12P19/34 , C12Q1/6844 , C12Q1/6853 , C12Q2531/119 , C12Q2525/301 , C12Q2525/161
Abstract: The invention is directed to nucleic acid sequences having decreased thermodynamic stability to complementary sequence as well as a method for producing these sequences.
Abstract translation: 本发明涉及对互补序列具有降低的热力学稳定性的核酸序列以及用于产生这些序列的方法。
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