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![Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide](/abs-image/US/2022/02/22/US11254679B2/abs.jpg.150x150.jpg)
公开(公告)号：US11254679B2
公开(公告)日：2022-02-22
申请号：US16631915
申请日：2018-07-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C. D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2022/06/09/US20220177482A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220177482A1
公开(公告)日：2022-06-09
申请号：US17677312
申请日：2022-02-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2020/07/16/US20200223852A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200223852A1
公开(公告)日：2020-07-16
申请号：US16631915
申请日：2018-07-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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Patent Agency Ranking
公开(公告)号：US20230271946A1
公开(公告)日：2023-08-31
申请号：US18134564
申请日：2023-04-13
Applicant: Bristol-Myers Squibb Company
Inventor： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Maxime C.D. Soumeillant , Daniel S. Treitler , Jianji Wang , Bin Zheng , Michael J. Smith , Neil A. Strotman , Steven Tymonko , Tamas Benkovics
IPC: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08
CPC classification number: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08 , C07B2200/13
Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula:
Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.-
![PROCESS FOR THE PREPARATION OF 4-(8-(2-CHLOROPHENOXY)-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)BICYCLO[2.2.1]HEPTAN-1-OL AND NOVEL INTERMEDIATES THEREFOR](/abs-image/US/2016/02/11/US20160039813A1/abs.jpg.150x150.jpg)
5.发明申请PROCESS FOR THE PREPARATION OF 4-(8-(2-CHLOROPHENOXY)-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)BICYCLO[2.2.1]HEPTAN-1-OL AND NOVEL INTERMEDIATES THEREFOR 有权制备4-（8-（2-氯苯氧基） - [1,2,4]三唑并[4,3-A]吡啶-3-基）双氰胺[2.2.1]庚烷-1-醇和新的方法 其中间性公开(公告)号：US20160039813A1
公开(公告)日：2016-02-11
申请号：US14817352
申请日：2015-08-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Xinhua Qian , Keming Zhu , Joerg Deerberg , Wendy Wangying Yang , Kana Yamamoto , Matthew R. Hickey
IPC: C07D471/04 , C07C51/29 , C07D213/77 , C07C29/00 , C07C35/29 , C07C61/13
CPC classification number: C07D471/04 , C07C29/00 , C07C35/29 , C07C51/29 , C07C61/13 , C07C2602/42 , C07D213/77
Abstract: A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.
Abstract translation: 提供了制备4-（8-（2-氯苯氧基） - [1,2,4]三唑并[4,3-a]吡啶-3-基）双环[2.2.1]庚-1-醇和 在此过程中使用的新型中间体。 该化合物是在治疗各种代谢疾病中表现出活性的11-β羟基类固醇脱氢酶I型抑制剂。
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公开(公告)号：US20210107897A1
公开(公告)日：2021-04-15
申请号：US17131718
申请日：2020-12-22
Applicant: Bristol-Myers Squibb Company
Inventor： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Maxime C.D. Soumeillant , Daniel S. Treitler , Jianji Wang , Bin Zheng , Michael J. Smith , Neil A. Strotman , Steven Tymonko , Tamas Benkovics
IPC: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08
Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
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公开(公告)号：US10899745B2
公开(公告)日：2021-01-26
申请号：US16498442
申请日：2018-03-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ke Chen , Joerg Deerberg , Dong Lin , Michael Dummeldinger , Bahar Inankur , Sergei Kolotuchin , Jun Li , Amanda J. Rogers , Victor W. Rosso , Eric M. Simmons , Daniel S. Treitler , Jianji Wang , Michael J. Smith , Tamas Benkovics
IPC: C07D403/12 , C07C211/09 , C07D237/24 , C07D249/08
Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
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![Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates therefor](/abs-image/US/2017/02/28/US09580420B2/abs.jpg.150x150.jpg)
8.发明授权Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates therefor 有权制备4-（8-（2-氯苯氧基） - [1,2,4]三唑并[4,3-a]吡啶-3-基）双环[2.2.1]庚-1-醇的方法和新颖的 中间体公开(公告)号：US09580420B2
公开(公告)日：2017-02-28
申请号：US14817352
申请日：2015-08-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Xinhua Qian , Keming Zhu , Joerg Deerberg , Wendy Wangying Yang , Kana Yamamoto , Matthew R. Hickey
IPC: C07D213/77 , C07C35/29 , C07D471/04 , C07C29/00 , C07C51/29 , C07C61/13
CPC classification number: C07D471/04 , C07C29/00 , C07C35/29 , C07C51/29 , C07C61/13 , C07C2602/42 , C07D213/77
Abstract: A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.
Abstract translation: 提供了制备4-（8-（2-氯苯氧基） - [1,2,4]三唑并[4,3-a]吡啶-3-基）双环[2.2.1]庚-1-醇和 在此过程中使用的新型中间体。 该化合物是在治疗各种代谢疾病中表现出活性的11-β羟基类固醇脱氢酶I型抑制剂。
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