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公开(公告)号：US10526287B2
公开(公告)日：2020-01-07
申请号：US15567978
申请日：2016-04-22
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC: C07D211/22 , C07D211/26 , C07D309/20 , C07D215/44 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D239/30 , C07C215/44 , C07D417/06 , C07D263/32 , C07D205/12 , C07D207/32 , C07D211/36 , C07D213/64 , C07D305/06 , C07C255/58 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C215/42 , C07C255/30 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/69 , C07D213/73 , C07D295/195 , A61P35/00
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US20180290976A1
公开(公告)日：2018-10-11
申请号：US15567978
申请日：2016-04-22
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC: C07D211/26 , C07D211/58 , C07C211/40 , C07D213/38 , C07C229/10 , C07D213/73 , C07C255/58 , C07D211/76 , C07D401/06 , C07C215/42 , C07C233/41 , C07C217/08 , C07C237/06 , C07D295/195 , C07C229/38 , C07C255/30 , C07D213/69 , C07D305/06
CPC classification number: C07D211/26 , A61P35/00 , C07B2200/07 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C215/42 , C07C215/44 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C255/30 , C07C255/58 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/44 , C07D205/12 , C07D207/32 , C07D211/22 , C07D211/36 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/64 , C07D213/69 , C07D213/73 , C07D215/44 , C07D239/30 , C07D263/32 , C07D295/195 , C07D305/06 , C07D309/20 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D417/06
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US09980952B2
公开(公告)日：2018-05-29
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D471/04 , A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20140315949A1
公开(公告)日：2014-10-23
申请号：US14358455
申请日：2012-11-19
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC: C07D213/64 , C07D401/12 , C07D405/12
CPC classification number: C07D213/64 , C07D213/81 , C07D401/12 , C07D405/12
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US20140288123A1
公开(公告)日：2014-09-25
申请号：US14358558
申请日：2012-11-19
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC: C07D213/64
CPC classification number: C07D213/64 , C07D221/18 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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Patent Agency Ranking
公开(公告)号：US20170312252A1
公开(公告)日：2017-11-02
申请号：US15482584
申请日：2017-04-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Kwong Wah Lai , Jun Liang , Birong Zhang , Sharada Labadie , Daniel Ortwine , Peter Dragovich , James Kiefer , Victor S. Gehling , Jean-Christophe Harmange
IPC: A61K31/41 , A61K31/4025 , C07D207/04 , C07D237/04
CPC classification number: A61K31/41 , A61K31/4025 , C07D207/04 , C07D237/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09469646B2
公开(公告)日：2016-10-18
申请号：US14839273
申请日：2015-08-28
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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8.发明申请公开(公告)号：US20150376190A1
公开(公告)日：2015-12-31
申请号：US14766632
申请日：2014-02-11
Applicant: CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.
Abstract translation: 具有用于调节组蛋白甲基修饰酶的结构式（II）的试剂，其组合物和用途，例如作为抗癌剂。
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公开(公告)号：US20140275092A1
公开(公告)日：2014-09-18
申请号：US14209449
申请日：2014-03-13
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Steven F. Bellon , Victor S. Gehling , Jean-Christophe Harmange
IPC: C07D487/04 , C07D498/04
CPC classification number: C07D487/04 , A61K31/337 , A61K31/437 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/14 , C07D498/04 , C12N9/99
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作一种或多种组蛋白脱甲基酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20180009735A1
公开(公告)日：2018-01-11
申请号：US15658219
申请日：2017-07-24
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Cote , Martin Duplessis , Victor S. Gehling , Andrew Charles Good , Jean-Christophe Harmange , Yves LeBlanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC: C07C211/42 , C07D401/12 , A61K31/135 , A61K31/166 , C07D309/04 , C07D305/08 , C07D295/185 , C07D231/12 , C07D215/08 , C07D213/38 , C07D211/46 , C07D211/26 , C07D207/06 , C07D205/12 , C07D205/04 , C07C317/36 , C07C255/58 , C07C237/48 , C07C229/50 , C07C217/74 , A61K45/06 , A61K31/517 , A61K31/495 , A61K31/4747 , A61K31/4545 , A61K31/445 , A61K31/4406 , A61K31/437 , A61K31/4155 , A61K31/415 , A61K31/40 , A61K31/397 , A61K31/351 , A61K31/337 , A61K31/277 , A61K31/196 , C07D405/12
CPC classification number: C07C211/42 , A61K31/135 , A61K31/166 , A61K31/196 , A61K31/277 , A61K31/337 , A61K31/351 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/4406 , A61K31/445 , A61K31/4545 , A61K31/4747 , A61K31/495 , A61K31/517 , A61K45/06 , C07C217/74 , C07C229/50 , C07C237/48 , C07C255/58 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2603/94 , C07D205/04 , C07D205/12 , C07D207/06 , C07D211/26 , C07D211/46 , C07D211/78 , C07D213/38 , C07D215/08 , C07D231/12 , C07D295/185 , C07D305/08 , C07D309/04 , C07D401/12 , C07D405/12
Abstract: Provided herein are compounds of formula I: and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.
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