公开(公告)号：US08673238B2

公开(公告)日：2014-03-18

申请号：US13854297

申请日：2013-04-01

Applicant: Cepheid

Inventor： Douglas Dority ,  Ronald Chang

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/06 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2400/0421 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0644 ,  G01N1/18 ,  G01N1/28 ,  G01N1/405 ,  Y10T436/255 ,  Y10T436/2575

Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.

Abstract translation: 用于控制多个室之间的流体流动的流体控制和处理系统包括主体，其包括与流体位移区域流体连续耦合的流体处理区域。 流体位移区域是可减压的，以将流体吸入流体移动区域并且可加压以从流体位移区域排出流体。 身体至少包括一个外部端口。 流体处理区域与至少一个外部端口流体耦合。 流体位移区域与主体的至少一个外部端口流体耦合。 主体相对于多个室可调节以将至少一个外部端口选择性地与多个室流体连通。

公开(公告)号：US20210147933A1

公开(公告)日：2021-05-20

申请号：US17103688

申请日：2020-11-24

Applicant: Cepheid

Inventor： Yuh-Min Chiang ,  Douglas Dority ,  Dustin Dickens ,  Jennifer Glass ,  Reuel Van Atta

IPC: C12Q1/6876 ,  B01L3/00

Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.

公开(公告)号：US09212980B2

公开(公告)日：2015-12-15

申请号：US14169402

申请日：2014-01-31

Applicant: Cepheid

Inventor： Douglas Dority ,  Ronald Chang

IPC: B01L3/00 ,  G01N1/40 ,  G01N1/28 ,  G01N1/18

CPC classification number: B01L3/502715 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/06 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0848 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2400/0421 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0644 ,  G01N1/18 ,  G01N1/28 ,  G01N1/405 ,  Y10T436/255 ,  Y10T436/2575

Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.

公开(公告)号：US12203135B2

公开(公告)日：2025-01-21

申请号：US18481156

申请日：2023-10-04

Applicant: Cepheid

Inventor： Yuh-Min Chiang ,  Douglas Dority ,  Dustin Dickens ,  Jennifer Glass ,  Reuel Van Atta

IPC: C12Q1/6876 ,  B01L3/00 ,  B01L7/00

Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having a well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.

公开(公告)号：US20240068030A1

公开(公告)日：2024-02-29

申请号：US18481156

申请日：2023-10-04

Applicant: Cepheid

Inventor： Yuh-Min Chiang ,  Douglas Dority ,  Dustin Dickens ,  Jennifer Glass ,  Reuel Van Atta

IPC: C12Q1/6876 ,  B01L3/00

CPC classification number: C12Q1/6876 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/50851 ,  B01L7/52

Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having a well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.

公开(公告)号：US20140093430A1

公开(公告)日：2014-04-03

申请号：US13632945

申请日：2012-10-01

Applicant: Cepheid

Inventor： Ronald Chang ,  Douglas Dority

IPC: G01N21/75

CPC classification number: G01N21/75 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00833 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/505 ,  B01L3/508 ,  B01L7/52 ,  B01L2300/042 ,  B01L2300/0809 ,  B01L2300/0858 ,  B01L2300/168 ,  B01L2300/1805 ,  F28D2021/0077 ,  F28F3/12 ,  F28F21/04 ,  F28F2280/10 ,  G01N21/0303 ,  G01N21/0332 ,  G01N2035/00326

Abstract: A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.

Abstract translation: 具有用于保持样品的反应室的反应容器通过制造具有限定室的小壁的刚性框架的壳体来制造。 壳体还限定了用于将流体引入腔室的端口。 至少一个片或薄膜连接到刚性框架以形成腔室的至少一个主壁。 在优选实施例中，两个片或膜连接到刚性框架的相对侧面以形成腔室的两个相对的主壁，主壁通过次壁彼此连接。

公开(公告)号：US11795506B2

公开(公告)日：2023-10-24

申请号：US17103688

申请日：2020-11-24

Applicant: Cepheid

Inventor： Yuh-Min Chiang ,  Douglas Dority ,  Dustin Dickens ,  Jennifer Glass ,  Reuel Van Atta

IPC: B01L3/00 ,  C12Q1/6879 ,  C12Q1/6876 ,  B01L7/00

CPC classification number: C12Q1/6876 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/50851 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2400/0406 ,  B01L2400/0487

Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.

公开(公告)号：US09316590B2

公开(公告)日：2016-04-19

申请号：US13632945

申请日：2012-10-01

Applicant: Cepheid

Inventor： Ronald Chang ,  Douglas Dority

IPC: G01N21/62 ,  G01N21/75 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  F28F3/12 ,  F28F21/04 ,  G01N21/03 ,  F28D21/00 ,  G01N35/00

CPC classification number: G01N21/75 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00833 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/505 ,  B01L3/508 ,  B01L7/52 ,  B01L2300/042 ,  B01L2300/0809 ,  B01L2300/0858 ,  B01L2300/168 ,  B01L2300/1805 ,  F28D2021/0077 ,  F28F3/12 ,  F28F21/04 ,  F28F2280/10 ,  G01N21/0303 ,  G01N21/0332 ,  G01N2035/00326

Abstract: The present invention provides a reaction vessel and apparatus for performing heat-exchanging reactions. The vessel has a chamber for holding a sample, the chamber being defined by a plurality of walls, at least two of the walls being light transmissive to provide optical windows to the chamber. The apparatus comprises at least one heating surface for contacting at least one of the plurality of walls, at least one heat source for heating the surface, and optics positioned to optically interrogate the chamber while the heating surface is in contact with at least one of the plurality of walls.

Abstract translation: 本发明提供一种用于进行热交换反应的反应容器和装置。 容器具有用于保持样品的室，所述室由多个壁限定，至少两个壁是透光的，以向室提供光学窗口。 该装置包括用于接触多个壁中的至少一个的至少一个加热表面，用于加热该表面的至少一个热源以及定位成光学询问该室的光学器件，同时该加热表面与该至少一个 多个墙壁。