公开(公告)号：US06387373B1

公开(公告)日：2002-05-14

申请号：US08840034

申请日：1997-04-24

Applicant: D. Craig Wright ,  Donald F. H. Wallach

Inventor： D. Craig Wright ,  Donald F. H. Wallach

IPC: A61K3900

CPC classification number: A61K39/39 ,  A61K9/1272 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  C12N2760/16134 ,  C12N2760/16234

Abstract: The present invention features an adjuvanted vaccine, and methods for preparing an adjuvanted vaccine, preferably for immunizing against influenza, where the adjuvant is a lipid vesicle, and preferably is a nonphospholipid, paucilamellar lipid vesicle. The antigen may be encapsulated in the central cavity of the adjuvant, or mixed in solution with the adjuvant. Moreover, the adjuvant may carry a secondary adjuvant to further improve the immune response.

Abstract translation: 本发明的特征在于佐剂疫苗，以及用于制备佐剂化疫苗的方法，优选用于免疫流感，其中佐剂是脂质囊泡，并且优选是非磷脂，薄膜脂质囊泡。 抗原可以封装在佐剂的中心腔中，或者与佐剂在溶液中混合。 此外，佐剂可以携带辅助佐剂以进一步改善免疫应答。

公开(公告)号：US5549901A

公开(公告)日：1996-08-27

申请号：US322827

申请日：1994-10-13

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K9/127 ,  A61K31/14 ,  A61K31/23 ,  A61K45/06 ,  A61K7/40

CPC classification number: A61K9/1272 ,  A61K31/14 ,  A61K31/23 ,  A61K45/06

Abstract: An antimicrobial lipid-containing oil-in-water emulsion comprising an agent selected from the group consisting of glycerol monooleate, glycerol trioleate, glycerol monolaurate, and glycerol dilaurate as the primary lipid and a cationic halogen-containing compound having a C.sub.12 -C.sub.16 chain as a positive charge producing agent is disclosed. The antimicrobial emulsion can be used in the form of a pharmaceutical preparation to inhibit the growth of a wide variety of infectious pathogens.

Abstract translation: 一种含抗菌脂质的水包油乳液，其包含选自甘油单油酸酯，甘油三油酸酯，甘油单月桂酸酯和甘油二月桂酸酯作为主要脂质的试剂和具有C12-C16链的阳离子含卤素化合物 公开了一种正电荷产生剂。 抗微生物乳剂可以以药物制剂的形式使用，以抑制多种感染性病原体的生长。

公开(公告)号：US4824666A

公开(公告)日：1989-04-25

申请号：US120041

申请日：1987-11-13

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K39/002 ,  C12N1/10 ,  G01N33/569 ,  G01N33/54

CPC classification number: A61K39/002 ,  C12N1/10 ,  G01N33/56905

Abstract: A method of producing large scale growth of parasites of the genus Toxoplasma is disclosed which comprises inoculating the microorganisms into a non-adherent human cell line, such as a monocytoid lymphoma cell line, and maintaining the cell line in tissue culture media capable of supporting the growth of the microorgranism while the cell line is being maintained. This large scale production allows for the development of vaccines for Toxoplasma microorganisms which previously have been hard to grow in the numbers needed to readily prepare vaccines, and allows for more rapid antibody detection procedures with regard to these microorganisms. There are also disclosed methods for preparing such vaccines, and methods for carrying out antibody detection assays.

Abstract translation: 公开了一种产生弓形虫属寄生虫大规模生长的方法，其包括将微生物接种到非贴壁人细胞系如单核细胞淋巴瘤细胞系中，并将细胞系保持在能够支持 在保持细胞系的同时微生物的生长。 这种大规模生产允许开发以前难以在容易制备疫苗所需的数量生长的弓形虫微生物的疫苗，并且允许针对这些微生物的更快速的抗体检测程序。 还公开了制备这种疫苗的方法和用于进行抗体检测测定的方法。

公开(公告)号：US6034073A

公开(公告)日：2000-03-07

申请号：US593651

申请日：1996-01-29

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K9/107 ,  A01N25/04 ,  A01N57/12 ,  A61K31/66 ,  A61K47/44 ,  A61L2/00 ,  G11B20/10 ,  A01N57/26 ,  A01N43/08 ,  A01N43/16

CPC classification number: G11B20/10009 ,  A01N25/04 ,  A01N57/12 ,  A61L2/0088

Abstract: Methods and pharmaceutical compositions for inactivating an envelope virus using an oil-in-water emulsion including an oil, a surfactant, and an organic phosphate-based solvent are disclosed. These methods can be used to inactivate a wide variety of envelope viruses, such as HIV.

Abstract translation: 公开了使用包含油，表面活性剂和有机磷酸酯基溶剂的水包油乳液灭活包膜病毒的方法和药物组合物。 这些方法可用于灭活多种包膜病毒，如HIV。

公开(公告)号：US6015832A

公开(公告)日：2000-01-18

申请号：US2228

申请日：1997-12-31

Applicant: James R. Baker, Jr. ,  D. Craig Wright ,  Michael M. Hayes ,  Tarek Hamouda ,  Joan Brisker

Inventor： James R. Baker, Jr. ,  D. Craig Wright ,  Michael M. Hayes ,  Tarek Hamouda ,  Joan Brisker

IPC: A01N25/04 ,  A01N25/30 ,  A01N59/12 ,  A61K9/107 ,  A61K31/075 ,  A61K31/10 ,  A61K31/185 ,  A61K31/198 ,  A61K31/22 ,  A61K31/23 ,  A61K31/341 ,  A61K47/06 ,  A61K47/44 ,  A61P31/04 ,  A61K31/225

CPC classification number: A61K31/661 ,  A01N25/04 ,  A01N59/12 ,  A61K31/075 ,  A61K31/10 ,  A61K31/185 ,  A61K31/198 ,  A61K31/341 ,  A61K9/107 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/943

Abstract: Methods for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of bacteria such as Bacillus.

Abstract translation: 提供了使用水包油乳液灭活细菌（包括细菌孢子）的方法。 水包油乳液包含油，表面活性剂和有机磷酸盐基溶剂。 这些方法可用于灭活多种细菌如芽孢杆菌。

公开(公告)号：US5626844A

公开(公告)日：1997-05-06

申请号：US363204

申请日：1994-12-27

Applicant: Paul V. Lemley ,  D. Craig Wright

Inventor： Paul V. Lemley ,  D. Craig Wright

IPC: A61K38/00 ,  C07K16/16 ,  A61K39/395 ,  A61M5/20

CPC classification number: C07K16/16 ,  A61K38/00

Abstract: Monoclonal antibodies against the A chain of ricin have been found to be ective in protecting mammals from morbidity arising from exposure to ricin toxin. The neutralizing action of the antibodies does not appear to be mediated by complement or by immunoprecipitation. The antibodies of the invention are characterized as of isotype IgG1 having the binding characteristics which include: a) binding specifically to the neutralizing epitope of the ricin A chain and b) providing in vitro protection of at least 95% of EL-4 cells from 100 .eta.g/mL ricin challenge when said antibody is present in the tissue culture at a level of at least 1000 .eta.g/mL.

Abstract translation: 已经发现针对A蓖麻毒素链的单克隆抗体在保护哺乳动物免受暴露于蓖麻毒素的发病率方面是有效的。 抗体的中和作用似乎不被补体或免疫沉淀介导。 本发明的抗体的特征在于具有结合特征的同种型IgG1，其包括：a）特异性结合蓖麻毒素A链的中和表位，和b）提供体外保护至少95％的EL-4细胞从100 当所述抗体以至少1000等于/ mL的水平存在于组织培养物中时，其质量/ mL蓖麻毒蛋白攻击。

公开(公告)号：US5618840A

公开(公告)日：1997-04-08

申请号：US443937

申请日：1995-05-18

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K9/107 ,  A01N25/04 ,  A01N33/12 ,  A61K9/127 ,  A61K31/14 ,  A61K31/23 ,  A61K31/231 ,  A61K31/57 ,  A61K31/575 ,  A61K45/06 ,  A61K47/44 ,  A61P17/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61K7/40

CPC classification number: A61K45/06 ,  A61K31/14 ,  A61K31/23 ,  A61K31/231 ,  A61K9/1272 ,  Y10S514/943

Abstract: An antibacterial oil-in-water emulsion for inhibiting the growth of Helicobacter pylori is disclosed. The oil-in-water emulsion of the invention comprises droplets of an oily discontinuous phase dispersed in a continuous phase. The oily discontinuous phase contains an oil carrier and a glycerol ester selected from the group consisting of glycerol monooleate and glycerol monostearate. The emulsion can be positively charged, negatively charged or chargeless. In one embodiment, the emulsion is positively charged and further comprises a cationic halogen-containing compound having a C.sub.12 -C.sub.16 chain as a positive charge producing agent. In another embodiment, the emulsion is negatively charged and further comprises an negative charge producing agent having a C.sub.12 -C.sub.22 chain. The disclosed emulsions can be administered to individuals, for example, orally, to treat or prevent Helicobacter pylori infections.

Abstract translation: 公开了一种用于抑制幽门螺杆菌生长的抗菌水包油乳剂。 本发明的水包油乳液包含分散在连续相中的油性不连续相的液滴。 油相不连续相含有选自甘油单油酸酯和甘油单硬脂酸酯的油载体和甘油酯。 乳液可以带正电，带负电荷或无电荷。 在一个实施方案中，乳液是带正电荷的，并且还包含具有C12-C16链作为正电荷产生剂的阳离子含卤素化合物。 在另一个实施方案中，乳液是带负电荷的，并且还包含具有C12-C22链的负电荷产生剂。 所公开的乳剂可以例如口服给予个体，以治疗或预防幽门螺杆菌感染。

公开(公告)号：US5961975A

公开(公告)日：1999-10-05

申请号：US472211

申请日：1995-06-07

Applicant: Ali Ibrahim Fattom ,  Walter W. Karakawa ,  D. Craig Wright

Inventor： Ali Ibrahim Fattom ,  Walter W. Karakawa ,  D. Craig Wright

IPC: A61K39/395 ,  A61K39/00 ,  A61K39/002 ,  A61K39/085 ,  A61K39/09 ,  A61P31/04 ,  A61P37/04 ,  C07K14/195 ,  C07K14/41 ,  C07K14/705 ,  C07K16/00 ,  C07K16/12 ,  C12P19/04 ,  C12Q1/14 ,  G01N33/569 ,  A61K39/40

CPC classification number: A61K39/085 ,  C07K16/1271 ,  C12P19/04 ,  A61K39/00

Abstract: A process is disclosed for culturing clinical Staphylococcus epidermidis cells that reproducibly enables identification of a limited number of predominant serotypes. Two predominant serotypes common to most clinical cases of S. epidermidis have been identified and are denoted Type I and Type II. A particular polysaccharide surface antigen is associated with each of the Type I and Type II serotypes. The surface antigens can be used to provide active and passive immunization against S. epidermidis infection and to produce a hyperimmune immunoglobulin or antibodies for treatment of S. epidermidis infection.

Abstract translation: 公开了用于培养临床表皮葡萄球菌细胞的方法，其可再现地使得能够鉴定有限数量的主要血清型。 已经鉴定了大多数表皮葡萄球菌临床病例常见的两种主要血清型，并且表示为I型和II型。 特定的多糖表面抗原与I型和II型血清型各自相关。 表面抗原可用于提供针对表皮葡萄球菌感染的主动和被动免疫，并产生用于治疗表皮葡萄球菌感染的超免疫免疫球蛋白或抗体。

公开(公告)号：US5730989A

公开(公告)日：1998-03-24

申请号：US482552

申请日：1995-06-07

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K9/00 ,  A61K9/127 ,  A61K39/02 ,  A61K39/39 ,  A61K39/08 ,  A61K39/112

CPC classification number: A61K39/0275 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/39 ,  A61K9/1272 ,  A61K2039/521 ,  A61K2039/55555

Abstract: The present invention concerns an oral preparation useful as an immunizing agent or vaccine against gram negative bacterial infection. This oral preparation can also be used as a treatment for those infected with gam negative bacteria. The preparations can be used against any gram negative bacterial infection, including Escherichia coli, Shigella flexneri 2a, and Salmonella enteriditis.

Abstract translation: 本发明涉及可用作抗革兰氏阴性细菌感染的免疫剂或疫苗的口服制剂。 这种口服制剂也可以用作感染gam阴性细菌的人的治疗。 制剂可用于抗革兰氏阴性细菌感染，包括大肠杆菌，志贺氏菌志贺氏菌2a和沙门氏菌肠炎。

公开(公告)号：US5700679A

公开(公告)日：1997-12-23

申请号：US661051

申请日：1996-06-07

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K9/00 ,  A61K9/127 ,  C12N7/06 ,  A61L15/48

CPC classification number: C12N7/00 ,  A61K9/0034 ,  A61K9/1272 ,  C12N2740/16063 ,  Y10S424/14

Abstract: A novel formulation having anti-viral and spermicidal properties has been developed. The formulation contains lipid vesicles having an outer bilayer formed of a non-ionic amphiphile, a surfactant such as having spermicidal and/or anti-viral activity, an oil and a sterol. The selection of the components making the vesicle is such that the formulation provides rapid spermicidal or anti-viral activity. The formulation and methods of the invention are particularly useful in the mucous membranes such as the vaginal tract and has been tested against viruses such as HIV and Vaccinia.

Abstract translation: 已经开发了具有抗病毒和杀精性的新型制剂。 该制剂含有具有由非离子两亲物形成的外层双层脂质囊泡，具有杀精和/或抗病毒活性的表面活性剂，油和甾醇。 制备囊泡的组分的选择使得该制剂提供快速的杀精或抗病毒活性。 本发明的制剂和方法特别适用于诸如阴道粘膜的粘膜，并已针对HIV和牛痘等病毒进行了测试。