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1.发明授权Metallic object with a thin polyphase oxide coating and process for the manufacture thereof 失效具有薄多环氧化物涂层的金属物体及其制造方法公开(公告)号：US06524718B1
公开(公告)日：2003-02-25
申请号：US09297220
申请日：1999-06-21
IPC分类号： B32B1504
CPC分类号： C25D11/02 , A61F2310/00796 , A61L27/32 , B05D7/14 , C23C30/00 , Y10T428/12556
摘要： A metallic object, having a metallic substrate of a valve metal or a valve metal alloy inclusive of intermetallic phases, and a thin polyphase oxide coating, is disclosed. The polyphase oxide coating has a metal oxide phase and at least one other organic and/or inorganic phase. The polyphase oxide coating is produced by bringing the metallic substrate into contact with an organic and/or inorganic component to be integrated into the polyphase oxide coating such that the inorganic and/or organic phases are present at or in the direct vicinity of the substrate surface and by simultaneously or subsequently anodically polarizing the substrate material in an electrolytic solution.
摘要翻译： 公开了一种金属物体，其具有阀金属的金属基底或包括金属间相的阀金属合金和薄的多相氧化物涂层。 多相氧化物涂层具有金属氧化物相和至少一种其它有机和/或无机相。 多相氧化物涂层是通过使金属基材与有机和/或无机组分接触而制成的，以将其整合到多相氧化物涂层中，使得无机和/或有机相存在于基材表面的直接附近 并且通过同时或随后在电解液中阳极极化基板材料。
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2.发明申请OSTEOGENIC COMPOSITE MATRIX, METHOD FOR THE PRODUCTION THEREOF AND IMPLANT AND SCAFFOLD FOR TISSUE ENGINEERING PROVIDED WITH A COATING FORMED BY SAID OSTEOGENIC COMPOSITE MATRIX 有权软骨组合物基质，其生产方法，用于组织工程的植入物和SCAFFOLD，用由酸性复合基质形成的涂层公开(公告)号：US20100119575A1
公开(公告)日：2010-05-13
申请号：US12572884
申请日：2009-10-02
CPC分类号： A61L27/48 , A61L2430/02 , C08L89/06
摘要： The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibres produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibres.
摘要翻译： 本发明涉及由细胞外基质（ECM-组分）的胶原和非胶原组分组成的成骨复合基质，制备所述基质的方法，提供用于组织工程的植入物或支架的制备方法 具有由所述成骨复合基质形成的涂层，并且用于刺激和加速例如硬组织形成。 骨骼中的植入物骨整合。 本发明的成骨复合基质包括胶原蛋白和至少一种非胶原ECM组分或其衍生物，其中胶原组分由通过纤维发生产生的非交联胶原纤维组成，非胶原ECM组分或其衍生物被整合到 说胶原纤维。
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公开(公告)号：US20060035229A1
公开(公告)日：2006-02-16
申请号：US10519988
申请日：2003-07-04
申请人： Dieter Scharnweber , Rene Beutner , Sophie Roessler , Thomas Hanke , Hartmut Worch , Bernd Schwenzer , Jan Michael
发明人： Dieter Scharnweber , Rene Beutner , Sophie Roessler , Thomas Hanke , Hartmut Worch , Bernd Schwenzer , Jan Michael
CPC分类号： A61K9/0024 , A61K9/1611 , A61K9/167 , A61L27/306 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00641 , B01J2219/00722 , C25D11/02 , C40B40/06
摘要： A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5′-terminal or 3′-terminal molecule areas that are incorporated stably into the metal oxide layer. The unincorporated areas of the nucleic acid compounds that are not incorporated into the metal oxide layer are freely accessible for subsequent interactions with other molecules such as complementary nucleic acids having active ingredients attached thereto.
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4.发明授权Osteogenic composite matrix, method for the production thereof and implant and scaffold for tissue engineering provided with a coating formed by said osteogenic composite matrix 有权成骨复合基质，其生产方法和用于组织工程的植入物和支架，其具有由所述成骨复合基质形成的涂层公开(公告)号：US08043627B2
公开(公告)日：2011-10-25
申请号：US12572884
申请日：2009-10-02
CPC分类号： A61L27/48 , A61L2430/02 , C08L89/06
摘要： The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibers produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibers.
摘要翻译： 本发明涉及由细胞外基质（ECM-组分）的胶原和非胶原组分组成的成骨复合基质，制备所述基质的方法，提供用于组织工程的植入物或支架的制备方法 具有由所述成骨复合基质形成的涂层，并且用于刺激和加速例如硬组织形成。 骨骼中的植入物骨整合。 本发明的成骨复合基质包括胶原蛋白和至少一种非胶原ECM组分或其衍生物，其中胶原组分由通过纤维发生产生的非交联胶原纤维组成，非胶原ECM组分或其衍生物被整合到 说胶原纤维。
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5.发明申请公开(公告)号：US20050079198A1
公开(公告)日：2005-04-14
申请号：US10918743
申请日：2004-08-16
CPC分类号： C25D9/02 , A61L27/34 , A61L27/54 , A61L2300/232 , A61L2300/236 , A61L2300/252 , A61L2300/406 , A61L2300/426 , A61L2300/606 , C08L5/08
摘要： The invention describes an article made from chitosan-coated metal, where an impermeable chitosan layer having a barrier action is present on the metal through electrochemical polarisation in a chitosan-containing solution. The incorporation of biologically active components into the chitosan coating enables the coating to be matched to various applications and the bio-compatibility of correspondingly modified surfaces to be increased. Metallic articles or surfaces coated in this way are used, for example, as material for medical implants.
摘要翻译： 本发明描述了由壳聚糖涂覆的金属制成的制品，其中通过在含壳聚糖的溶液中的电化学极化，在金属上存在具有屏障作用的不可渗透的壳聚糖层。 将生物活性成分并入壳聚糖涂层中使得涂层能够匹配各种应用，并且相应改性表面的生物相容性增加。 以这种方式涂覆的金属制品或表面例如用作医疗植入物的材料。
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6.发明授权Process for producing a gradient coating made of calcium phosphate phases and metal oxide phase on metallic implants 失效在金属植入物上生产由磷酸钙相和金属氧化物相制成的梯度涂层的方法
公开(公告)号：US5723038A
公开(公告)日：1998-03-03
申请号：US718445
申请日：1996-12-02
申请人： Dieter Scharnweber , Henrike Bersch , Hartmut Worch , Jurgen Hofinger , Curt Kranz , Wolfgang Pompe
发明人： Dieter Scharnweber , Henrike Bersch , Hartmut Worch , Jurgen Hofinger , Curt Kranz , Wolfgang Pompe
CPC分类号： C25D9/04 , A61L27/32 , A61F2310/00796 , Y10S623/901
摘要： The invention concerns a process for producing a gradient coating of calcium phosphat phases and metal oxide phases on metallic implants, in particular made of titanium or titanium alloys, for use as dental, jaw or joint implants. A solution containing calcium ions and phosphate ions is used as electrolyte of which the pH is slightly acidic to approximately neutral. The substrate electrodes are alternately polarized cathodically and anodically. The layer deposited in a gratuated manner is adherent, has a fine structure and is distinguished by a high degree of biocompatibility.
摘要翻译： PCT No.PCT / DE96 / 00197 Sec。 371日期1996年12月2日第 102（e）日期1996年12月2日PCT PCT 1996年2月6日PCT公布。 公开号WO96 / 24391 日期1996年8月15日本发明涉及在用作牙科，颌骨或关节植入物的金属植入物，特别是由钛或钛合金制成的钙磷脂相和金属氧化物相的梯度涂层的方法。 使用含有钙离子和磷酸根离子的溶液作为电解质，其pH值略微为中性至酸性。 基板电极在阴极和阳极交替极化。 以令人满意的方式沉积的层是粘附的，具有精细的结构并且被高度的生物相容性区分开来。
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7.发明授权Metallic object with a nucleic acid coating and derivatives thereof and method for producing said object 有权具有核酸涂层的金属物体及其衍生物及其制造方法公开(公告)号：US07585965B2
公开(公告)日：2009-09-08
申请号：US10519988
申请日：2003-07-04
申请人： Dieter Scharnweber , René Beutner , Sophie Roessler , Thomas Hanke , Hartmut Worch , Bernd Schwenzer , Jan Michael
发明人： Dieter Scharnweber , René Beutner , Sophie Roessler , Thomas Hanke , Hartmut Worch , Bernd Schwenzer , Jan Michael
CPC分类号： A61K9/0024 , A61K9/1611 , A61K9/167 , A61L27/306 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00641 , B01J2219/00722 , C25D11/02 , C40B40/06
摘要： A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5′-terminal or 3′-terminal molecule areas that are incorporated stably into the metal oxide layer. The unincorporated areas of the nucleic acid compounds that are not incorporated into the metal oxide layer are freely accessible for subsequent interactions with other molecules such as complementary nucleic acids having active ingredients attached thereto.
摘要翻译： 金属物体具有由薄金属氧化物层和与其结合的核酸或核酸衍生物制成的涂层。 核酸化合物具有稳定结合到金属氧化物层中的5'末端或3'末端分子区域。 未掺入金属氧化物层的核酸化合物的未掺入的区域可以自由地接近以便随后与其它分子例如与其连接的活性成分的互补核酸相互作用。
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8.发明申请Osteogenic Composite Matrix, Method for the Production Thereof and Implant and Scaffold for Tissue Engineering Provided with a Coating Formed by Said Osteogenic Composite matrix 审中-公开成骨复合基质，其生产方法和用于组织工程的植入物和支架提供由所述成骨复合基质形成的涂层公开(公告)号：US20070237799A1
公开(公告)日：2007-10-11
申请号：US11578607
申请日：2005-04-15
CPC分类号： A61L27/48 , A61L2430/02 , C08L89/06
摘要： The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example the implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibres produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibres.
摘要翻译： 本发明涉及由细胞外基质（ECM-组分）的胶原和非胶原组分组成的成骨复合基质，制备所述基质的方法，提供用于组织工程的植入物或支架的制备方法 具有由所述成骨复合基质形成的涂层，并且用于刺激和加速硬组织形成，例如骨骼中的植入物骨整合。 本发明的成骨复合基质包括胶原蛋白和至少一种非胶原ECM组分或其衍生物，其中胶原组分由通过纤维发生产生的非交联胶原纤维组成，非胶原ECM组分或其衍生物被整合到 说胶原纤维。
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公开(公告)号：US07229545B2
公开(公告)日：2007-06-12
申请号：US10414284
申请日：2003-04-16
CPC分类号： A61L27/34 , A61L2430/02 , A61L27/46 , A61L27/54 , C08L89/06
摘要： A biomimetically produced bone-analogous coating, comprising organic and inorganic main constituents, is suitable for coating metallic implant materials of any desired surfaces. The coating comprises a collagen matrix mineralized with calcium phosphate.
摘要翻译： 包含有机和无机主要成分的生物测量生产的骨 - 类似涂层适用于涂覆任何所需表面的金属植入材料。 该涂层包括用磷酸钙矿化的胶原基质。
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10.发明授权Support material for tissue engineering, for producing implants or implant materials, and an implant produced with the support material 有权用于组织工程，用于生产植入物或植入物材料的支撑材料以及由支撑材料生产的植入物公开(公告)号：US07763272B2
公开(公告)日：2010-07-27
申请号：US10799329
申请日：2004-03-12
申请人： Peter Offermann , Hartmut Worch , Wolfgang Pompe , Michael Gelinsky , Gerhilt Schmack , Gerald Hoffmann , Uwe Köckritz
发明人： Peter Offermann , Hartmut Worch , Wolfgang Pompe , Michael Gelinsky , Gerhilt Schmack , Gerald Hoffmann , Uwe Köckritz
IPC分类号： A61F2/02
CPC分类号： C12N5/0068 , A61F2/105 , A61F2/30756 , A61F2002/30062 , A61F2002/30225 , A61F2002/30448 , A61F2002/30602 , A61F2002/30762 , A61F2002/30766 , A61F2002/30892 , A61F2002/30971 , A61F2002/4648 , A61F2210/0004 , A61F2220/005 , A61F2230/0069 , A61F2310/00365 , A61F2310/00383 , A61L27/18 , A61L27/3633 , A61L27/38 , A61L27/3847 , A61L27/3852 , B33Y80/00 , C12N2533/40 , C12N2533/50 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C08L67/04
摘要： A scaffold for tissue culture and cell culture and for producing implant materials, in particular bone, cartilage or skin replacements or extra-corporal organ replacements or for other applications in medicine or biotechnology is made of biocompatible materials. It has at least one base material which is electrostatically flocked with fibers on at least one side. Through the electrostatic flocking the fibers are arranged almost perpendicularly on the surface of the base material and exhibits a high fiber pull-out resistance. The scaffold provides an elastic growth lattice, which is stable against compression, for cell colonization in vitro or the ingrowth of cells in vivo. Implants or implant materials can be produced with the scaffold.
摘要翻译： 用于组织培养和细胞培养和用于生产植入材料，特别是骨，软骨或皮肤替代物或体外器官替代物或用于医学或生物技术中的其它应用的支架由生物相容性材料制成。 它至少有一种基材在至少一面被静电地植绒在纤维上。 通过静电植绒，纤维几乎垂直地布置在基材的表面上并表现出高的纤维拉出阻力。 支架提供弹性生长格子，其对于压缩是稳定的，用于体外细胞定植或体内细胞向内生长。 植入物或种植体材料可以用支架生产。
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