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公开(公告)号:US10203297B2
公开(公告)日:2019-02-12
申请号:US14879948
申请日:2015-10-09
Applicant: INTEL CORPORATION
Inventor: Jonathan S. Daniels , Oguz H. Elibol , Grace M. Credo , Xing Su
IPC: G01N27/327 , C12Q1/68 , G01R27/26 , G01N27/22 , G01K7/34 , G06K7/08 , G01D5/24 , G01L1/14 , B82Y30/00
Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.
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公开(公告)号:US20180372601A1
公开(公告)日:2018-12-27
申请号:US15865914
申请日:2018-01-09
Applicant: Intel Corporation
Inventor: Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
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公开(公告)号:US11630863B2
公开(公告)日:2023-04-18
申请号:US17403791
申请日:2021-08-16
Applicant: Intel Corporation
Inventor: Xing Su , Kai Wu , Noureddine Tayebi , Grace Credo
IPC: G06F16/901 , H03M7/30 , G06F16/11 , G06F16/178 , G16B30/00 , G16B50/50
Abstract: Devices, methods, and systems for encoding data as DNA are provided. An encoder device can include circuitry to encode a data file having a bit sequence encoding data and to generate a virtual DNA (VDNA) sequence of virtual nucleotide bases (Vnb) that reversibly encodes the bit sequence of the data file, divide the VDNA sequence into a plurality of VDNA fragments, associate each VDNA fragment with an archive library sequence (Arc_SEQ), and generate a read instruction (READ) sequence of differences between each VDNA fragment and each associated Arc_SEQ including sufficient instruction to facilitate regeneration of each VDNA fragment from each associated Arc_SEQ. A codeword sequence (Code_SEQ) is additionally generated for each VDNA fragment that includes a codename identifying the associated Arc_SEQ, the READ sequence associated with the VDNA fragment, and an index sequence (Idx_SEQ) including an index mapping of the VDNA fragment in the VDNA sequence.
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公开(公告)号:US10655166B2
公开(公告)日:2020-05-19
申请号:US15727296
申请日:2017-10-06
Applicant: Intel Corporation
Inventor: Xing Su , Lei B. Sun , Jacque H. Georger, Jr.
IPC: C12Q1/6837 , B01J19/00 , B01L3/00 , B82Y15/00 , B82Y30/00 , G01N33/543 , C40B60/04
Abstract: Apparatus and methods are disclosed for electrically active combinatorial-chemical (EACC) chips for biochemical analyte detection. An apparatus includes a substrate that has an array of regions defining multiple cells, wherein each of the cells includes a reaction cavity that contains multiple functional binding groups. A method of detecting an analyte providing the reaction cavity between a source and a drain or a pair of electrodes, applying a voltage and monitoring a parameter indicative of an analyte characteristic. A process of fabricating an EACC include bonding an analyte to the multiple functional binding groups of each reaction cavity, and forming an analyte sensing structure including the substrate.
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公开(公告)号:US20170363578A1
公开(公告)日:2017-12-21
申请号:US15633150
申请日:2017-06-26
Applicant: Intel Corporation
Inventor: Xing Su , Kai Wu , David J. Liu
CPC classification number: G01N27/74 , B01J2219/00576 , B01J2219/00648 , B01J2219/00655 , B01J2219/00725 , B01J2219/0074 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/0439 , B03C1/032 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01R33/1269
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises multiple zones such as a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
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公开(公告)号:US10513734B2
公开(公告)日:2019-12-24
申请号:US15457244
申请日:2017-03-13
Applicant: Intel Corporation
Inventor: Xing Su , Mark Oldham
IPC: C12Q1/68 , C12Q1/6874 , C12Q1/6869 , G01N27/00 , G01N27/414
Abstract: Devices and methods for detecting, identifying, and sequencing, compounds, complexes, and molecules are described. Electronic detection is combined with optical excitation to determine the presence or identity of an analyte of interest. Embodiments of the invention additionally provide devices and methods that allow highly parallel nucleic acid sequence determination.
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公开(公告)号:US20190050495A1
公开(公告)日:2019-02-14
申请号:US15929022
申请日:2018-06-19
Applicant: Intel Corporation
Inventor: Xing Su , Kai Wu , Noureddine Tayebi
Abstract: Devices, methods, and systems for encoding data as DNA are provided. An encoder device can include an encoder engine configured to encode a data file having a bit sequence encoding data and further configured to generate a virtual DNA (VDNA) sequence of virtual nucleotide bases (Vnb) that reversibly encodes the bit sequence of the data file, divide the VDNA sequence into a plurality of VDNA fragments, associate each VDNA fragment with an archive library sequence (Arc_SEQ), and generate a read instruction (READ) sequence of differences between each VDNA fragment and each associated Arc_SEQ including sufficient instruction to facilitate regeneration of each VDNA fragment from each associated Arc_SEQ. A codeword sequence (Code_SEQ) is additionally generated for each VDNA fragment comprising a codename identifying the associated Arc_SEQ, the READ sequence associated with the VDNA fragment, and an index sequence (Idx_SEQ) including an index mapping of the VDNA fragment in the VDNA sequence.
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公开(公告)号:US09863857B2
公开(公告)日:2018-01-09
申请号:US14448141
申请日:2014-07-31
Applicant: INTEL CORPORATION
Inventor: Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
CPC classification number: G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
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公开(公告)号:US20170183727A1
公开(公告)日:2017-06-29
申请号:US15457244
申请日:2017-03-13
Applicant: Intel Corporation
Inventor: Xing Su , Mark Oldham
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6869 , G01N27/00 , G01N27/4145 , C12Q2521/101 , C12Q2521/543 , C12Q2537/157 , C12Q2563/116 , C12Q2565/607
Abstract: Devices and methods for detecting, identifying, and sequencing, compounds, complexes, and molecules are described. Electronic detection is combined with optical excitation to determine the presence or identity of an analyte of interest. Embodiments of the invention additionally provide devices and methods that allow highly parallel nucleic acid sequence determination.
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公开(公告)号:US09689842B2
公开(公告)日:2017-06-27
申请号:US14072336
申请日:2013-11-05
Applicant: INTEL CORPORATION
Inventor: Xing Su , Kai Wu , David J Liu
CPC classification number: G01N27/74 , B01J2219/00576 , B01J2219/00648 , B01J2219/00655 , B01J2219/00725 , B01J2219/0074 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/0439 , B03C1/032 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01R33/1269
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises multiple zones such as a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
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