-
1.发明授权Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion 有权用两亲性硫醚涂覆疏水表面以减少蛋白质吸附和细胞粘附公开(公告)号：US07427410B2
公开(公告)日：2008-09-23
申请号：US10246362
申请日：2002-09-18
摘要： The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This reduction may be achieved, for example, by controlling the spacing or length of pendant chains or hydrophilic blocks in an amphiphilic thioether. Techniques for determining spacing include adsorbing the thioether from a solution or a colloidal suspension, or controlling the degree of polymerization of the thioether. Techniques for controlling the length of the pendant chains include controlling the degree of polymerization of the pendant chains. Multiblock copolymers of poly(propylene sulfide) and poly(ethylene glycol) (“PPS-PEG”) represent an exemplary family of amphiphilic thioethers. Methods for coating surfaces with amphiphilic thioethers are also provided.
摘要翻译： 本发明提供了用特别设计的硫醚和两亲性硫醚涂覆表面的方法和设备，其减少蛋白质吸附和/或细胞粘附。 该还原可以通过例如通过控制两亲性硫醚中的侧链或亲水嵌段的间隔或长度来实现。 用于确定间隔的技术包括从溶液或胶体悬浮液中吸附硫醚，或控制硫醚的聚合度。 用于控制侧链长度的技术包括控制侧链的聚合度。 聚（丙烯硫醚）和聚（乙二醇）（“PPS-PEG”）的多嵌段共聚物代表两亲性硫醚的典型族。 还提供了用两亲硫醚涂覆表面的方法。
-
公开(公告)号：US07091127B2
公开(公告)日：2006-08-15
申请号：US10246500
申请日：2002-09-18
IPC分类号： H01L21/302
CPC分类号： B29C43/003 , B29C2043/025 , B41M3/006 , C23F1/02 , G01Q80/00 , G03F7/0002 , H01L51/0015 , H01L51/0021
摘要： The present invention provides methods and apparatus for locally patterning surfaces. In one such method, an oxidizable thioether is adsorbed onto a conductive surface. The surface is then contacted with a fluid medium. A conducting stamp is then brought into contact with the fluid medium above the thioether-coated surface. Next, a potential is applied between the stamp and the surface. It is expected that the charge will be transferred through the medium to the coated surface along a shortest distance path, thereby locally oxidizing the thioether and effectively creating a negative patterned image of the conducting stamp on the surface. Remaining adsorbed thioether may then be used as a mask for standard etching or material addition procedures.
-
3.发明授权公开(公告)号：US08119335B2
公开(公告)日：2012-02-21
申请号：US11333090
申请日：2006-01-17
CPC分类号： B82Y10/00 , B82Y40/00 , G03F7/0002 , G03F7/2014 , G03F7/2043 , Y10S430/143 , Y10T428/24802
摘要： The present invention provides methods and apparatus for selectively patterning surfaces using radical species generated with a photocatalyst. The photocatalyst may comprise a photocatalytic semiconductor or a photosensitizer. The radical species are brought into contact with an oxidizable coating disposed on the surface, thereby locally oxidizing and selectively patterning the surface. The photocatalyst is preferably disposed on a delivery device, such as a stamp, mask, or scanning probe, that is brought into close proximity or contact with the coated surface. The photocatalyst is then excited in a manner capable of generating radical species, for example, oxygen-containing radical species, in appropriate media. It is expected that these radical species will be transferred to the coated surface along a substantially shortest distance path, thereby locally oxidizing and patterning the surface.
摘要翻译： 本发明提供了使用由光催化剂生成的自由基物质来选择性地图案化表面的方法和装置。 光催化剂可以包含光催化半导体或光敏剂。 使自由基物质与设置在表面上的可氧化涂层接触，从而局部氧化并选择性地图案化该表面。 光催化剂优选地设置在与涂覆表面紧密接触或接触的输送装置，例如印模，掩模或扫描探针上。 然后在适当的介质中以能够产生自由基物质，例如含氧自由基物质的方式激发光催化剂。 预期这些自由基物质将沿着基本上最短的距离路径转移到涂覆的表面，从而局部氧化和图案化表面。
-
4.发明申请METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION 有权点保护核酸放大和检测的方法和装置公开(公告)号：US20140356874A1
公开(公告)日：2014-12-04
申请号：US14262683
申请日：2014-04-25
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L7/00 , B01L2300/0861 , B01L2300/18 , B01L2400/06 , C12Q1/6825 , C12Q1/6846 , C12Q2547/101 , C12Q2563/173 , C12Q2565/607 , C12Q2527/101 , C12Q2563/107 , C12Q2565/629
摘要： Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging.
摘要翻译： 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测加入到扩增反应中的染料中的色移或荧光来实现。 这种检测可以由操作者视觉执行，或者可以使用成像技术（例如分光光度成像）来实现。
-
公开(公告)号：US20110039967A1
公开(公告)日：2011-02-17
申请号：US12905949
申请日：2010-10-15
IPC分类号： C08L75/04 , C08G18/00 , C08K5/3417 , C08J9/00
CPC分类号： C08G18/3203 , A61B17/3498 , A61B2017/00867 , A61B2017/00871 , A61B2017/2932 , B82Y30/00 , C08G18/08 , C08G18/3221 , C08G18/3271 , C08G18/3281 , C08G18/3284 , C08G18/3287 , C08G18/3851 , C08G18/73 , C08G2280/00 , C08J9/0085 , C08L75/04 , C08L75/12 , C08L75/14
摘要： New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxyl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.
摘要翻译： 新形状记忆聚合物组合物，用于合成新形状记忆聚合物的方法，以及包括致动器和形状记忆聚合物的装置，其中形状记忆聚合物包括致动器的至少一部分。 一种形状记忆聚合物，其包含物理形成网状结构的聚合物组合物，其中所述聚合物组合物具有形状记忆行为并且可以形成为永久性初级形状，重新形成稳定的二次形状，并且可控地致动以恢复永久性初级 形状。 聚合物具有最佳的脂肪族网络结构，因为通过使用对称的单体使悬挂链最小化，并且具有匹配的胺和羟基，提供具有透明度，紧密（窄温度范围）单一过渡的聚合物和聚合物泡沫以及高形状恢复和恢复力 这对植入人体尤其有用。
-
公开(公告)号：US5863650A
公开(公告)日：1999-01-26
申请号：US851197
申请日：1997-05-05
申请人： Kevin E. Healy , Jane P. Bearinger
发明人： Kevin E. Healy , Jane P. Bearinger
IPC分类号： A61L31/10 , C08F265/10 , C08F290/06 , C09D4/00 , C09D171/02 , B32B27/30
CPC分类号： C09D4/00 , A61L31/10 , C08F265/10 , C08F290/062 , C09D171/02 , Y10T428/24975 , Y10T428/265 , Y10T428/31667 , Y10T428/31928 , Y10T428/31935
摘要： An biologically compatible coating, enables an apparatus to which it is applied to resist to cell adhesion and/or protein adsorption. The coating comprises a polyacrylamide network grafted to a surface of the apparatus at polymerization sites on that surface and a poly(ethylene glycol) network interpenetrating the polyacrylamide network, and is prepared by sequentially polymerizing the polyacrylamide and poly(ethylene glycol) layers.
摘要翻译： 生物相容的涂层使得其应用的装置能抵抗细胞粘附和/或蛋白质吸附。 该涂层包括在该表面的聚合位点处接枝到设备表面的聚丙烯酰胺网络和互穿聚丙烯酰胺网络的聚（乙二醇）网络，并且通过依次聚合聚丙烯酰胺和聚（乙二醇）层来制备。
-
公开(公告)号：US09315858B2
公开(公告)日：2016-04-19
申请号：US13115877
申请日：2011-05-25
CPC分类号： C12Q1/6844 , B01L3/502776 , B01L3/5029 , B01L7/52 , B01L2300/0609 , B01L2300/0851 , B01L2300/1877 , C12Q1/689 , C12Q1/701 , C12Q2537/101
摘要： Provided herein are methods and apparatus for detecting a target nucleic acid in a sample and related methods and apparatus for diagnosing a condition in an individual. The condition is associated with presence of nucleic acid produced by certain pathogens in the individual.
摘要翻译： 本文提供了用于检测样品中靶核酸的方法和装置以及用于诊断个体状况的相关方法和装置。 该条件与个体中某些病原体产生的核酸的存在相关。
-
公开(公告)号：US08883871B2
公开(公告)日：2014-11-11
申请号：US13099146
申请日：2011-05-02
IPC分类号： C08J9/00 , B29C67/20 , C08G18/73 , C08G18/72 , C08G18/75 , B29C71/04 , B29C71/02 , C08G18/83 , C08G18/67 , C08G18/32 , C08G63/52 , B29C51/00 , B29C47/00 , C08G101/00
CPC分类号： C08G18/3206 , B29C45/0001 , B29C47/00 , B29C47/0009 , B29C51/00 , B29C51/002 , B29C61/06 , B29C67/20 , B29C71/02 , B29C71/04 , B29K2075/00 , B29K2105/04 , C08G18/673 , C08G18/675 , C08G18/722 , C08G18/73 , C08G18/758 , C08G18/83 , C08G63/52 , C08G2101/00 , C08G2280/00
摘要： This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape.
摘要翻译： 本发明涉及化学聚合物组合物，合成方法，以及关于能够显示形状记忆行为（SMP）的聚合物的装置的制造方法，该聚合物首先能聚合成具有热塑性质的直链或支链聚合物结构，随后加工成 装置通过聚合物熔体，溶液和分散体的典型工艺，然后与保持加工形状的形状记忆热固性聚合物交联。
-
公开(公告)号：US08882786B2
公开(公告)日：2014-11-11
申请号：US10781582
申请日：2004-02-17
CPC分类号： A61B17/0057 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2017/00867 , A61B2017/00871
摘要： Systems for closure of a physical anomaly. Closure is accomplished by a closure body with an exterior surface. The exterior surface contacts the opening of the anomaly and closes the anomaly. The closure body has a primary shape for closing the anomaly and a secondary shape for being positioned in the physical anomaly. The closure body preferably comprises a shape memory polymer.
摘要翻译： 关闭物理异常的系统。 封闭通过具有外表面的封闭体实现。 外表面接触异常开口并关闭异常。 闭合体具有用于闭合异常的主要形状和用于定位在物理异常中的次级形状。 封闭体优选地包括形状记忆聚合物。
-
公开(公告)号：US20120124719A1
公开(公告)日：2012-05-24
申请号：US13168618
申请日：2011-06-24
IPC分类号： A41D13/05
摘要： Methods and apparatus are provided for protecting the external ear from the elements, heat, cold, wind, rain and/or snow. In some embodiments, an ear protector comprises a conforming anchor with an opening through which the external ear may be passed. The ear protector further comprises an insulating outer covering that, in combination with the anchor, forms the ear protector with a chamber positioned between the outer covering and the anchor. During use, the chamber is configured to receive the external ear, with the anchor's opening conformably positioned in proximity to at least a portion of the ear's root. The perimeter of the conforming anchor's opening resiliently deforms during passage of the external ear through the opening and into the chamber, and then conforms to the geometry of at least a portion of the ear root in order to securely and comfortably maintain the ear protector in position over the external ear without additional external support. The conforming anchor preferably is fabricated from a closed cell foamed elastomer.
摘要翻译： 提供了用于保护外耳免受元件，热，冷，风，雨和/或雪的方法和装置。 在一些实施例中，耳朵保护器包括具有外耳道可穿过的开口的一致的锚。 耳朵保护器还包括绝缘外覆盖物，其与锚固件组合形成具有定位在外覆盖物和锚固件之间的腔室的护耳器。 在使用期间，腔室被构造成接收外耳，其中锚的开口顺应地定位在耳朵根部的至少一部分附近。 在外耳道通过开口并进入腔室时，适形锚的开口的周边弹性变形，然后符合耳根的至少一部分的几何形状，以便牢固和舒适地将耳朵保护器保持在适当位置 无需外部支持。 优选地，适形锚固件由闭孔发泡弹性体制成。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.025 秒)
