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公开(公告)号：US20110158906A1
公开(公告)日：2011-06-30
申请号：US12673472
申请日：2008-08-13
IPC分类号： A61K51/06 , C07H21/00 , C07K14/79 , C07K16/32 , C07K14/465 , C12N9/96 , C07K14/705 , C07K16/00 , A61K49/00 , A61K39/395 , A61K31/704 , A61K33/24 , A61K31/337 , A61K31/519 , A61K31/53 , A61K31/192 , C12N5/09 , A61P35/00 , A61P25/00 , A61P1/00 , A61P9/00 , A61P11/00
CPC分类号： A61K47/6921 , A61K47/549 , A61K47/551 , A61K47/60 , A61K47/6907
摘要： The present invention provides a micelle comprising an amphiphilic block copolymer, said amphiphilic block copolymer consisting of (a) a hydrophobic polymer attached to the 5′ end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 5′ end of said second nucleic acid molecule; and/or (b) a hydrophobic polymer attached to the 3′ end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 3′ end of said second nucleic acid molecule.
摘要翻译： 本发明提供一种包含两亲性嵌段共聚物的胶束，所述两亲性嵌段共聚物由（a）连接于第一核酸分子的5'端的疏水性聚合物组成，其中所述第一核酸分子与第二核酸 分子，其中能够选择性结合特定细胞类型和/或组织的靶向单元连接到所述第二核酸分子的5'末端; 和/或（b）连接到第一核酸分子的3'末端的疏水性聚合物，其中所述第一核酸分子与第二核酸分子杂交，其中能够选择性结合特定细胞类型的靶向单元 和/或组织连接到所述第二核酸分子的3'末端。
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公开(公告)号：US20120283432A1
公开(公告)日：2012-11-08
申请号：US13406016
申请日：2012-02-27
申请人： Neil Gregory PSCHIRER , Felix Eickemeyer , Jan Schöneboom , Jianqiang Qu , Martin Könemann , Klaus Müllen , Chen Li , Andreas Herrmann , Peter Erk , Gero Nordmann , Alfred Kuhn , Anders Hagfeldt , Tomas Edvinsson
发明人： Neil Gregory PSCHIRER , Felix Eickemeyer , Jan Schöneboom , Jianqiang Qu , Martin Könemann , Klaus Müllen , Chen Li , Andreas Herrmann , Peter Erk , Gero Nordmann , Alfred Kuhn , Anders Hagfeldt , Tomas Edvinsson
IPC分类号： C07D311/78 , C07D491/16 , C07D417/10 , C07D405/10 , C07D417/14 , C07D491/06 , C07D471/16
CPC分类号： H01G9/2031 , C07D221/18 , C07D311/78 , C07D311/92 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/06 , C07D491/06 , C09B5/62 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1044 , C09K2211/1048 , C09K2211/1059 , C09K2211/1088 , H01G9/2059 , H01L51/0053 , H01L51/006 , H01L51/0067 , H01L51/0068 , H01L51/0069 , H01L51/0071 , H01L51/4226 , Y02E10/542 , Y02E10/549
摘要： Use of rylene derivatives I with the following definition of the variables: X together both —COOM; Y a radical -L-NR1R2 (y1) -L-Z—R3 (y2) the other radical hydrogen; together both hydrogen; R is optionally substituted (het)aryloxy, (het)arylthio; P is —NR1R2; B is alkylene; optionally substituted phenylene; combinations thereof; A is —COOM; —SO3M; —PO3M2; D is optionally substituted phenylene, naphthylene, pyridylene; M is hydrogen; alkali metal cation; [NR5]4+; L is a chemical bond; optionally indirectly bonded, optionally substituted (het)arylene radical; R1, R2 are optionally substituted (cyclo)alkyl, (het)aryl; together optionally substituted ring comprising the nitrogen atom; Z is —O—; —S—; R3 is optionally substituted alkyl, (het)aryl; R′ is hydrogen; optionally substituted (cyclo)alkyl, (het)aryl; R5 is hydrogen; optionally substituted alkyl (het)aryl; m is 0, 1, 2; n, p m=0: 0, 2, 4 where: n+p=2, 4, if appropriate 0; m=1: 0, 2, 4 where: n+p=0, 2, 4; m=2: 0, 4, 6 where: n+p=0, 4, 6, or of mixtures thereof as photosensitizers in solar cells.
摘要翻译： 使用二烯衍生物I与以下变量的定义：X一起-COOM; Y是自由基-L-NR1R2（y1）-L-Z-R3（y2）另一个基团氢; 一起氢; R是任选取代的（het）芳氧基，（het）芳硫基; P是-NR1R2; B是亚烷基; 任选取代的亚苯基; 其组合; A是-COOM; -SO3M; -PO3M2; D是任选取代的亚苯基，亚萘基，亚吡啶基; M是氢; 碱金属阳离子; [NR5] 4+; L是化学键; 任选间接结合的，任选取代的（亚乙基）亚芳基; R1，R2是任选取代的（环）烷基，（het）芳基; 一起任选取代的包含氮原子的环; Z为-O- -S-; R3是任选取代的烷基，（het）芳基; R'是氢; 任选取代的（环）烷基，（het）芳基; R5是氢; 任选取代的烷基（het）芳基; m为0,1,2; n，p m = 0：0,2,4其中：n + p = 2,4，如果合适0; m = 1：0,2,4其中：n + p = 0,2,4; m = 2：0,4,6其中：n + p = 0,4,6或其混合物作为太阳能电池中的光敏剂。
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3.发明授权公开(公告)号：US09133485B2
公开(公告)日：2015-09-15
申请号：US12933426
申请日：2009-03-27
申请人： Andreas Herrmann , Harry Abts , Benedikt Greulich
发明人： Andreas Herrmann , Harry Abts , Benedikt Greulich
CPC分类号： C12N15/907 , C12N9/22 , C12N2800/30 , C12N2800/80 , C12N2830/42
摘要： The invention lies in the field of production of recombinant gene products in eukaryotic cells. The invention refers to methods and materials for the fast and reproducible generation of production cells lines suitable for large scale production of recombinant gene products. The invention encompasses specific vector systems, genetic engineered host-cells and methods of use.
摘要翻译： 本发明在真核细胞中重组基因产物的生产领域。 本发明涉及适用于大规模生产重组基因产物的生产细胞系快速和可重复生成的方法和材料。 本发明包括特异性载体系统，遗传工程宿主细胞和使用方法。
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公开(公告)号：US09039947B2
公开(公告)日：2015-05-26
申请号：US13497359
申请日：2010-09-23
申请人： Michael Jahns , Gallus Schechner , Martin Goetzinger , Holger Hauptmann , Andreas Herrmann , Marco Sartory
发明人： Michael Jahns , Gallus Schechner , Martin Goetzinger , Holger Hauptmann , Andreas Herrmann , Marco Sartory
CPC分类号： A61C13/081 , A61C13/0003 , A61C13/083 , A61C13/09 , B29C43/146 , B29C43/203 , B29C2043/147 , B29C2043/148
摘要： A system and method for making a layered dental appliance. The system can include a first portion comprising a negative of a first layer of a layered dental appliance, and a second portion comprising a positive shape of a second layer of the layered dental appliance. The method can include providing a mold comprising a negative of an outer shape of a layered dental appliance, and positioning a slurry in the mold, forming a first layer of the layered dental appliance. The method can further include providing a solid structure comprising a positive shape of a second layer of the layered dental appliance, and pressing the solid structure into the slurry in the mold.
摘要翻译： 一种用于制造分层牙科器具的系统和方法。 该系统可以包括第一部分，其包括层状牙科器具的第一层的阴极，以及包括层状牙科器具的第二层的正形状的第二部分。 该方法可以包括提供包括层状牙科器具的外形的负极的模具，以及将浆料定位在模具中，形成层状牙科器具的第一层。 该方法可以进一步包括提供包括层状牙科器具的第二层的正形状的固体结构，并将固体结构压入模具中的浆料中。
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公开(公告)号：US08746904B2
公开(公告)日：2014-06-10
申请号：US13181667
申请日：2011-07-13
申请人： Andreas Herrmann , Reinhard Koenig
发明人： Andreas Herrmann , Reinhard Koenig
CPC分类号： B60R1/06 , B60J5/0404 , B60J10/78
摘要： A seal of an exterior rear view mirror assembly relative to a body part of a motor vehicle is described, which is formed as one piece, and comprises a sealing pad and a sealing grommet integrally molded on the sealing pad. The sealing pad covers at least one section of the surface of a minor base of the exterior rear view minor assembly lying on the bodywork side. The sealing grommet serves for sealing at least one feed-through opening, which is provided on the bodywork side for feed-through of the cable harness of the exterior rear view minor assembly. The sealing grommet is formed as an open hollow body on the free end, which is turned away from the sealing pad. A passage opening is provided for the cable harness at the intersection of the symmetry axis of the hollow body with the sealing pad.
摘要翻译： 描述了相对于机动车辆的主体部分的外部后视镜组件的密封件，其形成为一体，并且包括密封垫和一体地模制在密封垫上的密封垫圈。 所述密封垫覆盖位于所述车身侧的所述外部后视小配件的副底座的表面的至少一个部分。 密封垫圈用于密封至少一个馈通开口，该开口设置在车体侧以用于外部后视镜小组件的电缆线束的馈通。 密封垫圈在自由端上形成为敞开的空心体，其远离密封垫。 在中空体的对称轴与密封垫的交叉处，为电缆束提供通道开口。
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公开(公告)号：US08602570B2
公开(公告)日：2013-12-10
申请号：US13164872
申请日：2011-06-21
CPC分类号： B60R1/06
摘要： An exterior rear view mirror for a motor vehicle, which exterior rear view mirror consists of at least two components which are connected to each other. At least one connection between the components includes at least one connecting arrangement, which is suitable for transfer of both transverse forces and compression forces and tractive forces, as well as transfer of moments from a first component to a second component. The connecting arrangement comprises a spring arranged on the first component, with inclined flanks, diverging at least in sections, seen from the first component, and a receiving groove, which is assigned to the spring, provided on the second component. The spring engages in the receiving groove. The spring and the receiving groove comprise a complementary, positive interlocking cross-section, at least in sections, so that the inclined flanks and the receiving groove form a rearward engagement normal to the receiving groove.
摘要翻译： 一种用于机动车辆的外部后视镜，该外部后视镜由彼此连接的至少两个部件组成。 组件之间的至少一个连接件包括至少一个连接装置，其适于传递横向力和压缩力和牵引力，以及从第一部件到第二部件传递力矩。 连接装置包括布置在第一部件上的弹簧，其具有从第一部件至少部分地发散的倾斜侧面，以及设置在第二部件上的分配给弹簧的接收槽。 弹簧接合在接收槽中。 弹簧和接收槽至少部分地包括互补的正互锁横截面，使得倾斜的侧面和接收槽形成与接收槽垂直的向后接合。
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公开(公告)号：US08517547B2
公开(公告)日：2013-08-27
申请号：US13150771
申请日：2011-06-01
IPC分类号： G02B5/08
CPC分类号： B60R1/072
摘要： The subject is an exterior rear view mirror with at least one base support and a carrier plate holding the mirror glass, adjustably arranged in relation to the base support. At least one friction bearing is provided between the carrier plate and the base support, which includes at least one friction spring arranged on the carrier plate, projecting in the direction of the base support, with at least one first guide support and at least one second guide support assigned to the base support. The first and second guide surfaces come into contact with each other. A slot, arranged on the base support, assigned to the friction spring, comprises a receiving opening, into which the friction spring is inserted. The receiving opening is bordered by at least one wall, which forms at least a second guide surface of the friction bearing.
摘要翻译： 被摄对象是具有至少一个基座支撑件的外部后视镜，以及保持相对于基座支撑件可调节地布置的镜玻璃的托板。 至少一个摩擦轴承设置在承载板和基座支撑件之间，该支承板包括布置在承载板上的至少一个摩擦弹簧，其在基座支撑件的方向上以至少一个第一引导支撑件和至少一个第二引导支撑件 指导支持分配给基础支持。 第一和第二引导表面彼此接触。 分配给摩擦弹簧的位于基座支架上的槽包括容纳开口，摩擦弹簧插入其中。 所述接收开口由至少一个壁形成边界，所述至少一个壁形成所述摩擦轴承的至少第二引导表面。
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公开(公告)号：US08430545B2
公开(公告)日：2013-04-30
申请号：US13243303
申请日：2011-09-23
IPC分类号： F21V8/00
CPC分类号： B60Q1/2665 , B60R1/1207 , F21Y2107/90
摘要： A lighting module for a vehicle is suggested, consisting of a housing and at least two light conductors or light conductor sections, which are arranged in the housing and extend along the external contour of the lighting module, with at least two LEDs, which are arranged on at least one circuit board in the housing. The light of at least two LEDs is coupled into the at least two light conductors, and a connection lens, which is adapted to the external contour of the light conductor, is installed between the light conductor sections.
摘要翻译： 建议一种用于车辆的照明模块，其包括壳体和至少两个光导体或光导体部分，其布置在壳体中并沿着照明模块的外部轮廓延伸，具有至少两个LED，其布置 在壳体中的至少一个电路板上。 至少两个LED的光耦合到至少两个光导体中，并且适配于光导体的外部轮廓的连接透镜安装在光导体部分之间。
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公开(公告)号：US08393743B2
公开(公告)日：2013-03-12
申请号：US12763247
申请日：2010-04-20
申请人： Andreas Herrmann
发明人： Andreas Herrmann
IPC分类号： G02B7/18
CPC分类号： B60R1/06 , B60R13/04 , B60R13/06 , B60R13/0892
摘要： A rear-view mirror with foam-backed door seal is presented that fills the space between mirror base and vehicle with a foam in a simple way upon its being mounted to a vehicle.
摘要翻译： 提供了具有泡沫背盖的门密封件的后视镜，其在安装到车辆上时以简单的方式用泡沫填充镜底座和车辆之间的空间。
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10.发明授权Imine based liquid crystals for the controlled release of bioactive materials 有权用于控制释放生物活性物质的基于亚胺的液晶公开(公告)号：US08158135B2
公开(公告)日：2012-04-17
申请号：US12294398
申请日：2007-03-19
IPC分类号： A61K9/00
CPC分类号： A61L9/12 , A01M1/2077 , A61L9/044 , A61L9/16
摘要： The present invention relates to a delivery system based on a film of an imine forming liquid crystalline phase, mixed with at least with one biologically active substance, to which a constant or variable electric field can be applied. The delivery system can be used as a delivery system for biologically active substances such as flavors, fragrances, bactericides, fungicides, insecticides, insect attractants or repellents, agrochemicals or pharmaceuticals.
摘要翻译： 本发明涉及一种基于形成液晶相的亚胺膜与至少一种生物活性物质混合的递送系统，可以施加恒定或可变电场。 输送系统可用作生物活性物质如香料，香料，杀菌剂，杀真菌剂，杀虫剂，昆虫引诱剂或驱虫剂，农用化学品或药物的递送系统。
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