公开(公告)号：US10758631B2

公开(公告)日：2020-09-01

申请号：US15951911

申请日：2018-04-12

Applicant: LI-COR, Inc.

Inventor： Vassil Elitzin ,  William M. Volcheck ,  Katie Schaepe ,  Rahul Patil

IPC: A61K49/00 ,  C09B23/01 ,  A61M5/00 ,  C09B23/08 ,  A61B5/20 ,  A61B5/00

Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.

公开(公告)号：US20180296704A1

公开(公告)日：2018-10-18

申请号：US15951911

申请日：2018-04-12

Applicant: LI-COR, Inc.

Inventor： Vassil Elitzin ,  William M. Volcheck ,  Katie Schaepe ,  Rahul Patil

IPC: A61K49/00 ,  C09B23/01 ,  A61B5/00 ,  A61B5/20 ,  A61M5/00

CPC classification number: A61K49/0032 ,  A61B5/0071 ,  A61B5/201 ,  A61B2505/05 ,  A61K49/0063 ,  A61M5/007 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/086

Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.

公开(公告)号：US20200085976A1

公开(公告)日：2020-03-19

申请号：US16687450

申请日：2019-11-18

Applicant: LI-COR, INC.

Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin ,  Joy Kovar

IPC: A61K49/00 ,  A61B5/20 ,  A61B5/00 ,  C09B23/10 ,  C09B23/08 ,  C09B23/01

Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

公开(公告)号：US10548991B2

公开(公告)日：2020-02-04

申请号：US14949654

申请日：2015-11-23

Applicant: LI-COR, Inc.

Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin

IPC: A61K49/00 ,  C09B23/10 ,  A61B5/00 ,  A61B5/20

Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

公开(公告)号：US20200078474A1

公开(公告)日：2020-03-12

申请号：US16687479

申请日：2019-11-18

Applicant: LI-COR, INC.

Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin

IPC: A61K49/00 ,  A61B5/20 ,  A61B5/00 ,  C09B23/10 ,  C09B23/08 ,  C09B23/01

Abstract: A composition comprising: a polymorphic form of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-ulfonatobutyl)-3H-indol- 1- ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and an acceptable excipient.

公开(公告)号：US20130280172A1

公开(公告)日：2013-10-24

申请号：US13836202

申请日：2013-03-15

Applicant: LI-COR, INC.

Inventor： Xinshe Xu ,  Daniel R. Draney ,  Mark Cradduck ,  Lael Cheung ,  Kousik Kundu ,  William M. Volcheck

IPC: A61K49/00

CPC classification number: A61K49/0058 ,  A61K49/0032 ,  A61K49/0052 ,  C07D471/04 ,  C07F9/6561 ,  C07K19/00 ,  C08B37/0072 ,  C09B23/0008 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/083 ,  C09B23/086 ,  C09B69/00 ,  G01N33/574 ,  G01N33/58 ,  G01N33/582

Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.

公开(公告)号：US11167046B2

公开(公告)日：2021-11-09

申请号：US16687450

申请日：2019-11-18

Applicant: LI-COR, INC.

Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin ,  Joy Kovar

IPC: A61K49/00 ,  C09B23/10 ,  A61B5/00 ,  A61B5/20 ,  C09B23/01 ,  C09B23/08

Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

公开(公告)号：US09089603B2

公开(公告)日：2015-07-28

申请号：US13836202

申请日：2013-03-15

Applicant: LI-COR, INC.

Inventor： Xinshe Xu ,  Daniel R. Draney ,  Mark Cradduck ,  Lael Cheung ,  Kousik Kundu ,  William M. Volcheck

IPC: C07D471/04 ,  A61K49/00 ,  C09B23/01 ,  C09B23/08 ,  C09B69/00 ,  G01N33/574 ,  G01N33/58 ,  C07F9/6561 ,  C07K19/00 ,  C08B37/08

CPC classification number: A61K49/0058 ,  A61K49/0032 ,  A61K49/0052 ,  C07D471/04 ,  C07F9/6561 ,  C07K19/00 ,  C08B37/0072 ,  C09B23/0008 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/083 ,  C09B23/086 ,  C09B69/00 ,  G01N33/574 ,  G01N33/58 ,  G01N33/582

Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.

Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。