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公开(公告)号：US11920191B2
公开(公告)日：2024-03-05
申请号：US17151657
申请日：2021-01-18
Applicant: Life TECHNOLOGIES CORPORATION
Inventor： Mingsong Chen , Kuan Moon Boo , Tiong Han Toh , Mauro Aguanno , Soo Yong Lau , Huei Yeo , Wei Fuh Teo
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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公开(公告)号：US10239059B2
公开(公告)日：2019-03-26
申请号：US14778106
申请日：2014-02-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Tiong Han Toh , Wuh Ken Loh , Kuan Moon Boo , Sandro Klein , Daniel Welsh
IPC: B01L7/00
Abstract: In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen, and a link bar. The device lid portion is attached to the proximal side of the handle portion with a first pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is pivotably connected to the device housing at a first terminal end portion and a second pin at an opposite second terminal end portion, wherein the handle portion is elevated away from the device lid portion before the cover is moved to an open position.
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Patent Agency Ranking
公开(公告)号：US10471431B2
公开(公告)日：2019-11-12
申请号：US14613496
申请日：2015-02-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Chee Kiong Lim , Way Xuang Lee , Wuh Ken Loh , Chee Wee Ching , Chin Yong Koo , Siew Ying Koh , Tiong Han Toh , Kuan Moon Boo , Soo Yong Lau
IPC: B01L7/00 , C12Q1/6806
Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.
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公开(公告)号：US20160228876A1
公开(公告)日：2016-08-11
申请号：US15017393
申请日：2016-02-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Yong Chu , Jeffrey Marks , Jacob Freudenthal , Mingsong Chen , Tiong Han Toh , Mauro Aguanno , Lik Seng Lau , Lian Seng Loh , Kok Siong Teo , Zeng Wei Chu , Xin Mathers , Michael Uy , Huei Yeo , Kuan Moon Boo , Way Xuang Lee , Chin Yong Koo , Wei Fuh Teo , Soo Yong Lau , Hon Siu Shin , Zeqi Tan , Thomas Wessel , Woo David
CPC classification number: B01L7/52 , B01L2200/145 , B01L2300/18 , B01L2300/1822 , C12Q1/6806 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/026 , G01N2021/6439 , G01N2035/00316 , G01N2035/00366 , G01N2201/061 , G01N2201/12
Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
Abstract translation: 提供生物分析系统。 该系统包括样品块组件。 样品块组件包括被配置为容纳样品架的样品块，样品保持器被配置为接收多个样品。 该系统还包括配置成使多个样品循环通过一系列温度的控制系统。 所述系统还包括自动盘，其包括滑动组件，所述托盘被配置为可将所述样品块组件从关闭位置可逆地滑动至打开位置，以允许使用者接近所述多个样品保持器。
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公开(公告)号：US20240309441A1
公开(公告)日：2024-09-19
申请号：US18583747
申请日：2024-02-21
Applicant: Life Technologies Corporation
Inventor： Mingsong Chen , Soo Yong Lau , Kuan Moon Boo , Mauro Aguanno , Huei Yeo , Tiong Han Toh , Wei Fuh Teo
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The instrument may further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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公开(公告)号：USD865218S1
公开(公告)日：2019-10-29
申请号：US29625653
申请日：2017-11-10
Designer： Xin Mathers , Sandro Klein , Tiong Han Toh , Huei Steven Yeo
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公开(公告)号：US20160228875A1
公开(公告)日：2016-08-11
申请号：US14778106
申请日：2014-02-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Tiong Han Toh , Wuh Ken LOH , Kuan Moon BOO , Sandro David KLEIN , Daniel WELSH
IPC: B01L7/00
CPC classification number: B01L7/52 , B01L2300/043 , B01L2300/1822
Abstract: In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen and a link bar. The device lid portion is attached to the proximal side of the handle portion with a pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is operably connected to the device housing and the pin such that a distal side of the handle portion is elevated away from the device lid portion when the cover is moved to an open position.
Abstract translation: 一方面，公开了一种热循环仪系统。 热循环仪可以由装置壳体和可操作地连接到装置壳体的盖组成。 盖可以包括手柄部分，装置盖部分，样品块压板和连杆。 装置盖部分用销钉安装在把手部分的近侧。 样品块压板可操作地连接到手柄部分，使得当手柄部分与装置盖部分齐平并且盖处于关闭位置时，样品块压板位于样品块上。 连杆可操作地连接到装置壳体和销上，使得当盖移动到打开位置时把手部分的远端从装置盖部分升高。
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