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1.发明授权Method for specifically detecting analyte using photocurrent, and electrode, measuring cell and measuring device for use therein 有权使用光电流专门检测分析物的方法，以及用于其中的电极，测量元件和测量装置公开(公告)号：US08092670B2
公开(公告)日：2012-01-10
申请号：US11992858
申请日：2006-09-28
申请人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
发明人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
IPC分类号： G01N27/26 , G01N33/48 , G01N33/487 , G01N33/49 , G01N33/493 , G01N33/50 , G01N33/53 , G01N33/533
CPC分类号： G01N33/5438
摘要： A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.
摘要翻译： 公开了一种方法，电极，测量单元和测量装置，其可以使用光电流以高灵敏度，简单和准确的方式检测和定量地确定具有特定粘合特性的分析物。 该方法包括使工作电极和对电极与电解质介质接触，其中工作电极通过探针物质固定在其上的分析物，并且其中分析物与致敏染料结合; 用光照射工作电极对光敏染料进行光刺激; 并且检测在工作电极和对电极之间流动的光电流，其中通过将电子从光激发敏化染料转移到工作电极而产生光电流。 工作电极包括电子接受层，其包含能够响应于光激发而接受从感光染料释放的电子的电子接受物质，其中探针物质被负载在电子接受层的表面上。 电子接受物质是具有比敏化染料的最低未占据分子轨道（LUMO）的能级更低的氧化物半导体。 电解质介质包括电解质和至少一种选自非质子溶剂和质子溶剂的溶剂，其中电解质包含能够提供氧化的致敏染料与电子的盐。
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2.发明申请Method for Specifically Detecting Analyte Using Photocurrent, and Electrode, Measuring Cell and Measuring Device for Use Therein 有权使用光电流特异性检测分析物的方法，电极，测量单元及其使用的测量装置公开(公告)号：US20090294305A1
公开(公告)日：2009-12-03
申请号：US11992858
申请日：2006-09-28
申请人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
发明人： Makoto Bekki , Hitoshi Ohara , Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Hiroshi Ishikawa , Yumi Osaki , Hiromasa Tokudome , Yoko Yamada , Masahiro Miyauchi
CPC分类号： G01N33/5438
摘要： A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.
摘要翻译： 公开了一种方法，电极，测量单元和测量装置，其可以使用光电流以高灵敏度，简单和准确的方式检测和定量地确定具有特定粘合特性的分析物。 该方法包括使工作电极和对电极与电解质介质接触，其中工作电极通过探针物质固定在其上的分析物，并且其中分析物与致敏染料结合; 用光照射工作电极对光敏染料进行光刺激; 并且检测在工作电极和对电极之间流动的光电流，其中通过将电子从光激发敏化染料转移到工作电极而产生光电流。 工作电极包括电子接受层，其包含能够响应于光激发而从感光染料中释放的电子的受电子物质，其中探针物质被负载在电子接受层的表面上。 电子接受物质是具有比敏化染料的最低未占据分子轨道（LUMO）的能级更低的氧化物半导体。 电解质介质包括电解质和至少一种选自非质子溶剂和质子溶剂的溶剂，其中电解质包含能够提供氧化的致敏染料与电子的盐。
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3.发明授权公开(公告)号：US09514513B2
公开(公告)日：2016-12-06
申请号：US13056510
申请日：2009-08-06
申请人： Jong S. Kim , Hiroshi Ishikawa , Joel S. Schuman , Gadi Wollstein
发明人： Jong S. Kim , Hiroshi Ishikawa , Joel S. Schuman , Gadi Wollstein
CPC分类号： G06T3/0075 , A61B3/102
摘要： Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional technology offers little toward the goal of inter-device compatibility between extant 2D OCT images and newer 3D OCT images for the same or comparable subjects, as in the context of ongoing monitoring the quantitative status of a patient's eyes. The inventive methodology is particularly useful to identify the scan location of tissue in a 2D OCT image within the 3D OCT volumetric data, thereby allowing clinicians to image a patient via 3D OCT, based on available 2D OCT images, with minimal inter-device variation.
摘要翻译： 光学相干断层扫描（OCT）的进展促使从具有3D成像能力的光谱域OCT向时域OCT提供2D OCT图像的转变。 然而，传统技术对于相同或可比较的对象的现有2D OCT图像和较新的3D OCT图像之间的设备间兼容性的目标几乎没有提供，如在持续监测患者眼睛的定量状态的情况下。 本发明的方法对于在3D OCT体积数据内识别2D OCT图像中的组织的扫描位置特别有用，从而允许临床医生基于可用的2D OCT图像以最小的装置间变化通过3D OCT对患者进行成像。
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公开(公告)号：US09002146B2
公开(公告)日：2015-04-07
申请号：US13985699
申请日：2012-02-15
CPC分类号： G02F1/01708 , B82Y20/00 , G02F1/2257 , G02F2001/01733 , G02F2001/01775 , G02F2001/212 , G02F2001/215 , G02F2203/48
摘要： An object of the present invention is to realize an optical gate switch of a monolithic integration type which can avoid problems of losses caused by light coupling of a phase modulation unit to a interferometer optical circuit unit, and can be minimized by integration. The optical gate switch according to the present invention includes an optical waveguide wafer in which a quantum well having a phase modulation effect which is generated by an intersubband transition is set as a core layer; a Michelson interferometer formed on the optical waveguide wafer; and a variable light intensity attenuation unit adjusting a light balance of an interferometer in one of reflection side arms of the Michelson interferometer reflection.
摘要翻译： 本发明的目的是实现一种单片集成型的光栅开关，其可以避免相位调制单元与干涉仪光电路单元的光耦合引起的损耗问题，并且可以通过集成最小化。 根据本发明的光栅开关包括光波导晶片，其中具有通过跨带过渡产生的相位调制效应的量子阱被设置为核心层; 形成在光波导晶片上的迈克尔逊干涉仪; 以及可变光强度衰减单元，其调节迈克尔逊干涉仪反射的反射侧臂之一中的干涉仪的光平衡。
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公开(公告)号：US08607604B2
公开(公告)日：2013-12-17
申请号：US13178928
申请日：2011-07-08
申请人： Norikazu Tezuka , Kazuharu Hirokawa , Keisuke Ihara , Kei Osawa , Hiroshi Ishikawa , Taiji Torigoe , Ryuichi Yamamoto , Yukihiro Hashimoto , Nobuyuki Izutsu , Koji Takahashi
发明人： Norikazu Tezuka , Kazuharu Hirokawa , Keisuke Ihara , Kei Osawa , Hiroshi Ishikawa , Taiji Torigoe , Ryuichi Yamamoto , Yukihiro Hashimoto , Nobuyuki Izutsu , Koji Takahashi
IPC分类号： C21D7/06
CPC分类号： B24C1/10 , B23G9/001 , B23P9/04 , B23P15/00 , C21D9/0093 , F01D5/066 , F05D2230/311 , F05D2230/90 , F05D2260/941 , F05D2300/211 , F05D2300/2112 , F05D2300/2261 , F16B33/06 , Y10T29/479
摘要： A bolt has a male screw with a surface hardening portion that has an increased surface hardness and that is applied with a compressive residual stress. The male screw is formed by cutting the bolt, and performing a process to provide at least on the surface of the male screw of the bolt the surface hardening portion that has increased hardness and that is applied with a compressive residual stress. As a result, the fatigue resistance of the male screw is improved and the bolt is effective for use in a portion where the male screw is subject to a repetitive stress.
摘要翻译： 螺栓具有具有表面硬化部分的外螺纹，其具有增加的表面硬度并且施加有压缩残余应力。 通过切割螺栓形成外螺纹，并且执行至少在螺栓的外螺纹的表面上提供具有增加的硬度并施加有压缩残余应力的表面硬化部的工艺。 结果，提高了外螺纹的耐疲劳性，并且螺栓对于使用阳螺纹受到重复应力的部分是有效的。
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6.发明授权Method and apparatus for segmenting an image in order to locate a part thereof 有权用于分割图像以便定位其一部分的方法和装置公开(公告)号：US08441481B2
公开(公告)日：2013-05-14
申请号：US13007449
申请日：2011-01-14
申请人： Davi Geiger , Hiroshi Ishikawa
发明人： Davi Geiger , Hiroshi Ishikawa
IPC分类号： G06T17/00
CPC分类号： G06T7/162 , G06K9/342 , G06K9/346 , G06K9/6224 , G06T7/11 , G06T17/00 , G06T2200/04 , G06T2207/10072 , G06T2207/20072 , G06T2207/30004
摘要： A method is disclosed to automatically segment 3D and higher-dimensional images into two subsets without user intervention, with no topological restriction on the solution, and in such a way that the solution is an optimal in a precisely defined optimization criterion, including an exactly defined degree of smoothness. A minimum-cut algorithm is used on a graph devised so that the optimization criterion translates into the minimization of the graph cut. The minimum cut thus found is interpreted as the segmentation with desired property.
摘要翻译： 公开了一种自动将3D和更高维度图像分割成两个子集的方法，无需用户干预，对解决方案没有拓扑限制，并且以这样的方式使解决方案在精确定义的优化标准中是最佳的，包括精确定义 光滑程度。 在设计的图上使用最小切割算法，使得优化标准转化为图形切割的最小化。 因此找到的最小切割被解释为具有期望属性的分割。
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7.发明申请NORMALIZATION OF RETINAL NERVE FIBER LAYER THICKNESS MEASUREMENTS MADE BY TIME DOMAIN-OPTICAL COHERENCE TOMOGRAPHY 有权通过时域光学相干测量法，对神经纤维层厚度测量进行正规化公开(公告)号：US20130077046A1
公开(公告)日：2013-03-28
申请号：US13510732
申请日：2010-11-19
申请人： Jong S. Kim , Hiroshi Ishikawa , Joel S. Schuman , Gadi Wollstein
发明人： Jong S. Kim , Hiroshi Ishikawa , Joel S. Schuman , Gadi Wollstein
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , G01B9/02027 , G01B9/02087 , G01B9/02091 , G01B11/06 , G01B2290/65
摘要： A scan location matching (SLM) method identifies conventional time domain optical coherence tomography (TD-OCT) circle scan locations within three-dimensional spectral domain OCT scan volumes. A technique uses both the SLM algorithm and a mathematical retinal nerve fiber bundle distribution (RNFBD) model, which is a simplified version of the anatomical retinal axon bundle distribution pattern, to normalize TD-OCT thickness measurements for the retinal nerve fiber layer (RNFL) of an off-centered TD-OCT circle scan to a virtual location, centered on the optic nerve head. The RNFBD model eliminates scan-to-scan RNFL thickness measurement variation caused by manual placement of TD-OCT circle scan.
摘要翻译： 扫描位置匹配（SLM）方法识别三维频域OCT扫描体积内的常规时域光学相干断层扫描（TD-OCT）圆扫描位置。 一种技术使用SLM算法和数字视网膜神经纤维束分布（RNFBD）模型，其是解剖视网膜轴突束分布模式的简化版本，以对视网膜神经纤维层（RNFL）的TD-OCT厚度测量进行归一化， 的偏心的TD-OCT圆周扫描到以视神经头为中心的虚拟位置。 RNFBD模型消除了由手动放置TD-OCT圆形扫描引起的扫描到扫描RNFL厚度测量变化。
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8.发明授权Aqueous solution of olanexidine, method of preparing the aqueous solution, and disinfectant 有权奥兰西汀的水溶液，水溶液的制备方法和消毒剂公开(公告)号：US08334248B2
公开(公告)日：2012-12-18
申请号：US12879467
申请日：2010-09-10
申请人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
发明人： Kazuyoshi Miyata , Yasuhide Inoue , Akifumi Hagi , Motoya Kikuchi , Hitoshi Ohno , Kinji Hashimoto , Kinue Ohguro , Tetsuya Sato , Hidetsugu Tsubouchi , Hiroshi Ishikawa , Takashi Okamura , Koushi Iwata
CPC分类号： A61K9/0014 , A01N47/44 , A61K31/155 , A61K31/191 , A61K31/522 , A61K45/06 , A61K47/12 , A61L2/18 , A01N37/36 , A01N25/32 , A01N2300/00 , A61K2300/00
摘要： The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.
摘要翻译： 本发明提供一种消毒剂，其含有浓度足以显示出有效杀菌作用的奥拉西丁，并且几乎没有任何副作用，例如皮肤刺激。 具体而言，本发明提供一种含有含有奥拉西丁和至少等摩尔量葡萄糖酸的水溶液的消毒剂，除了葡萄糖酸以外，基本上既不含葡萄糖酸以外的酸也不含有酸。
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公开(公告)号：US08284424B2
公开(公告)日：2012-10-09
申请号：US11492000
申请日：2006-07-25
申请人： Tomoyuki Shoya , Minoru Koshimizu , Yoshitsugu Hirose , Toshiroh Shimada , Shigehiko Sasaki , Kiwame Tokai , Hiroyuki Hattori , Hiroshi Ishikawa , Sho Hasegawa
发明人： Tomoyuki Shoya , Minoru Koshimizu , Yoshitsugu Hirose , Toshiroh Shimada , Shigehiko Sasaki , Kiwame Tokai , Hiroyuki Hattori , Hiroshi Ishikawa , Sho Hasegawa
摘要： A work information generation system includes: a plurality of terminals that display a document; and a server that conducts communications with the plurality of terminals, wherein each of the plurality of terminals includes a notification section that sends notification of identification information given to each of the plurality of terminals and identification information of a document in association with each other to the server in response to display of the document, and wherein the server includes: a determination section; a work information generation section; and a work information retention section as described in the specification.
摘要翻译： 工作信息生成系统包括：显示文档的多个终端; 以及与所述多个终端进行通信的服务器，其中，所述多个终端中的每一个包括通知部，其将给予所述多个终端中的每一个的识别信息的通知和彼此关联的文档的识别信息发送给 服务器响应于所述文档的显示，并且其中所述服务器包括：确定部分; 工作信息生成部; 以及说明书中描述的工作信息保持部分。
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10.发明申请BLOOD VESSEL SEGMENTATION WITH THREE DIMENSIONAL SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY 有权具有三维光谱域光学相干光谱的血管血管分期公开(公告)号：US20120213423A1
公开(公告)日：2012-08-23
申请号：US13321301
申请日：2010-05-27
CPC分类号： G06T19/00 , A61B5/0066 , A61B5/0073 , A61B5/02007 , G01B9/02044 , G01B9/02083 , G01B9/02091 , G01N21/4795 , G06K9/0061 , G06K9/4609 , G06K2009/00932 , G06T7/11 , G06T7/143 , G06T2207/10101 , G06T2207/30101 , G06T2210/41
摘要： In the context of the early detection and monitoring of eye diseases, such as glaucoma and diabetic retinopathy, the use of optical coherence tomography presents the difficulty, with respect to blood vessel segmentation, of weak visibility of vessel pattern in the OCT fundus image. To address this problem, a boosting learning approach uses three-dimensional (3D) information to effect automated segmentation of retinal blood vessels. The automated blood vessel segmentation technique described herein is based on 3D spectral domain OCT and provides accurate vessel pattern for clinical analysis, for retinal image registration, and for early diagnosis and monitoring of the progression of glaucoma and other retinal diseases. The technique employs a machine learning algorithm to identify blood vessel automatically in 3D OCT image, in a manner that does not rely on retinal layer segmentation.
摘要翻译： 在眼部疾病如青光眼和糖尿病性视网膜病变的早期检测和监测的背景下，使用光学相干断层摄影技术在OCT眼底图像中难以识别血管图案。 为了解决这个问题，增强学习方法使用三维（3D）信息来实现视网膜血管的自动分割。 本文描述的自动血管分割技术基于3D光谱域OCT，并提供用于临床分析，视网膜图像配准以及早期诊断和监测青光眼和其他视网膜疾病进展的精确血管模式。 该技术采用机器学习算法，以不依赖于视网膜层分割的方式在3D OCT图像中自动识别血管。
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