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    Il-8 production promoters and use thereof
    9.
    发明申请
    Il-8 production promoters and use thereof 审中-公开
    Il-8生产促进剂及其用途

    公开(公告)号：US20070082068A1

    公开(公告)日：2007-04-12

    申请号：US10579323

    申请日：2004-11-17

    申请人： Hideo Satsu ,  Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Shinichi Yokota ,  Makoto Shimizu

    发明人： Hideo Satsu ,  Tatsumasa Mae ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Shinichi Yokota ,  Makoto Shimizu

    IPC分类号： A61K36/185 ,  A61K36/534 ,  A61K31/045 ,  A61K31/015 ,  A61K36/48

    CPC分类号： A61K31/045 ,  A23L33/105 ,  A61K31/015 ,  A61K36/185 ,  A61K36/484 ,  A61K36/534

    摘要： An object of the present invention is to provide IL-8 production promoters derived from safe food materials and to provide immunostimulants or preventive or treating agents of infectious disease comprising the IL-8 production promoter. The present inventors have found that a composition comprising, as an active ingredient, at least one plant extract from peppermint, dokudami (houttuynia herb), or licorice promotes IL-8 production, and that a composition comprising, as an active ingredient, at least one compound selected from the group consisting of α-humulene, α-pinene, β-pinene, and L-menthol promotes IL-8 production. These IL-8 production promoters can be used in foods and drinks supplemented with immunostimulants or preventive or treating agents of infectious disease.

    摘要翻译： 本发明的目的是提供衍生自安全食品材料的IL-8生产促进剂，并提供包含IL-8生产启动子的感染性疾病的免疫刺激剂或预防或治疗剂。 本发明人已经发现，包含作为活性成分的至少一种来自薄荷，dokudami（香草）或甘草的植物提取物的组合物促进IL-8产生，并且包含至少包含作为活性成分的组合物 选自α-葎草酮，α-蒎烯，β-蒎烯和L-薄荷醇的一种化合物促进IL-8的产生。 这些IL-8生产促进剂可用于补充有免疫刺激剂或感染性疾病预防或治疗剂的食品和饮料中。

    Methods of treating cancer using a heat shock factor activity inhibitor
    10.
    发明授权
    Methods of treating cancer using a heat shock factor activity inhibitor 失效
    使用热休克因子活性抑制剂治疗癌症的方法

    公开(公告)号：US06903116B2

    公开(公告)日：2005-06-07

    申请号：US10339063

    申请日：2003-01-09

    申请人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

    发明人： Shin-ichi Yokota ,  Kozo Yamamoto ,  Souichi Morikawa ,  Yoshihide Fuse ,  Mikio Kitahara

    IPC分类号： C07D405/06 ,  A61K31/445 ,  A61K31/40

    CPC分类号： C07D405/06

    摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor.The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

    摘要翻译： 通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。 新型化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质产生的抑制剂，其抑制热休克因子（转录调节因子）的活性，从而进而抑制转录 在基因区域中具有用于转录调节RNA的热休克元件的结构基因的结构基因，从而抑制基因翻译成蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。 它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。