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    ENHANCED SENSITIVITY CARBON NANOTUBES AS TARGETED PHOTOACOUSTIC MOLECULAR IMAGING AGENTS
    3.
    发明申请
    ENHANCED SENSITIVITY CARBON NANOTUBES AS TARGETED PHOTOACOUSTIC MOLECULAR IMAGING AGENTS 审中-公开
    增强型敏感性碳纳米管作为靶向光电分子成像剂

    公开(公告)号：US20100074845A1

    公开(公告)日：2010-03-25

    申请号：US12552313

    申请日：2009-09-02

    申请人： Sanjiv S. Gambhir ,  Hongjie Dai ,  Zhuang Liu ,  Adam de la Zerda

    发明人： Sanjiv S. Gambhir ,  Hongjie Dai ,  Zhuang Liu ,  Adam de la Zerda

    IPC分类号： A61K49/00 ,  C07D209/56 ,  C07K5/08 ,  C07K16/46 ,  C07H21/00 ,  C07H1/00 ,  C07J1/00 ,  C07D239/00 ,  C07D473/00 ,  C07C53/00

    CPC分类号： A61K49/225 ,  B82Y5/00

    摘要： The present disclosure provides contrast photoacoustic probes, and compositions comprising such probes, designed to non-invasively detect and monitor various disease states, or targets within a subject human or animal. The probes are designed to be optically excited in tissue, ultimately generating thermal energy, which is transformed into acoustic energy by the response of the aqueous environment in the subject to the thermal emissions. The acoustic energy (sound) can then be detected by suitably applied transducers and digitally transformed into images indicating the location of the probe in the subject. One aspect of the disclosure encompasses photoacoustic probes that comprise: a carbon nanotube and a plurality of dye molecules bound to the carbon nanotube. The probes may further comprise a targeting moiety for localizing the probe at the site of a specific target. Another aspect of the present disclosure encompasses methods of detecting a target in animal or human subject, comprising: delivering a photoacoustic probe to a subject, allowing the photoacoustic probe to selectively bind to a target of the subject; and illuminating the system with an optical energy absorbable by the photoacoustic probe to generate an acoustic signal; and detecting the acoustic signal, thereby detecting the target in the subject.

    摘要翻译： 本公开提供了对比度光声探针和包含这样的探针的组合物，其被设计成非侵入性地检测和监测各种疾病状态或受试者人或动物内的靶标。 探针被设计为在组织中被光学激发，最终产生热能，其通过受试者中的水性环境对热发射的响应而转化为声能。 然后可以通过适当地应用的换能器来检测声能（声音），并且数字地转换成指示被检体中探针位置的图像。 本公开的一个方面包括光声探测器，其包含：碳纳米管和结合到碳纳米管的多个染料分子。 探针还可以包含用于在特定靶位点定位探针的靶向部分。 本公开的另一方面包括检测动物或人类受试者中的靶的方法，包括：将光声探测器递送至受试者，允许光声探测器选择性地结合受试者的靶标; 并用光声探测器吸收的光能照射该系统以产生声信号; 并检测声信号，从而检测被摄体中的目标。

    Molecular imaging of living subjects using Raman spectroscopy and labeled Raman nanoparticles
    5.
    发明授权
    Molecular imaging of living subjects using Raman spectroscopy and labeled Raman nanoparticles 有权
    使用拉曼光谱和标记拉曼纳米粒子的活体受体的分子成像

    公开(公告)号：US08795628B2

    公开(公告)日：2014-08-05

    申请号：US12598780

    申请日：2008-05-05

    申请人： Sanjiv S. Gambhir ,  Shay Keren ,  Ian Walton ,  David Guagliardo

    发明人： Sanjiv S. Gambhir ,  Shay Keren ,  Ian Walton ,  David Guagliardo

    IPC分类号： A61K51/00 ,  A61K49/00

    CPC分类号： G01N21/658 ,  B82Y30/00

    摘要： Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a living host using a plurality of Raman nanoparticles; methods of generating multimodality images by combining Raman images with other functional/anatomical images; labeled Raman nanoparticles; and the like, are provided.

    摘要翻译： 使用拉曼纳米颗粒成像活体的方法; 产生已经施用拉曼纳米粒子的活体的真实图像的方法; 使用多个拉曼纳米粒子对活体进行多重成像的方法; 通过将拉曼图像与其他功能/解剖图像组合来产生多模态图像的方法; 标记的拉曼纳米颗粒; 等等。

    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME
    6.
    发明申请
    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME 有权
    润滑剂及其制备和使用方法

    公开(公告)号：US20120295326A1

    公开(公告)日：2012-11-22

    申请号：US13562881

    申请日：2012-07-31

    申请人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    发明人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC分类号： C12N9/02 ,  C12N1/21 ,  C12N1/19 ,  C12N15/63 ,  C12N5/10

    CPC分类号： C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

    Luciferases and methods for making and using the same
    8.
    发明授权
    Luciferases and methods for making and using the same 有权
    萤光素酶及其制备和使用方法

    公开(公告)号：US08173791B2

    公开(公告)日：2012-05-08

    申请号：US13070665

    申请日：2011-03-24

    申请人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    发明人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N9/02

    CPC分类号： C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

    MAGNETOTACTIC BACTERIA MRI POSITIVE CONTRAST ENHANCEMENT AGENT AND METHODS OF USE
    9.
    发明申请
    MAGNETOTACTIC BACTERIA MRI POSITIVE CONTRAST ENHANCEMENT AGENT AND METHODS OF USE 审中-公开
    MAGNETOTACTIC BACTERIA MRI正向对比增强剂及其使用方法

    公开(公告)号：US20100135912A1

    公开(公告)日：2010-06-03

    申请号：US12627299

    申请日：2009-11-30

    申请人： Sanjiv S. Gambhir ,  Michael Benoit ,  A. C. Matin ,  Yoram Barak ,  Shay Keren ,  Dirk Mayer

    发明人： Sanjiv S. Gambhir ,  Michael Benoit ,  A. C. Matin ,  Yoram Barak ,  Shay Keren ,  Dirk Mayer

    IPC分类号： A61K49/08 ,  C12N1/20

    CPC分类号： A61K49/1896 ,  C12N1/20 ,  C12P3/00 ,  C12R1/01

    摘要： Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. Magnetospirillum magneticum AMB-1 produces positive MRI contrast when generating ultrasmall magnetite particles (10-40 nm diameter). Positive MRI contrast permits clearer distinction from image voids compared to negative contrast. T1-weighted MRI showed that such bacteria increased positive contrast 2.2-fold (p

    摘要翻译： 磁共振成像（MRI）通过造影剂增强，如超顺磁性氧化铁（SPIO）颗粒，类似于由磁能细菌产生的磁铁矿颗粒。 当产生超小磁铁矿颗粒（直径为10-40nm）时，Magnetospirillum magneticum AMB-1产生正的MRI对比度。 与负面对比相比，正面MRI对比可以更清晰地区分图像空洞。 T1加权MRI显示，在小鼠肿瘤异种移植物中肿瘤内注射后，这种细菌体外增加了2.2倍（p <0.02）和2.0倍（p <0.02）。 静脉输送后，Magnetospirillum磁性AMB-1靶向肿瘤并产生增加的阳性MRI对比（1.4倍; p <0.01）。 通过活细胞计数，放射性标记的AMB-1的microPET成像和肿瘤切片的普鲁士蓝染色显示AMB-1肿瘤靶向。 因此，磁性细菌提供了通过MRI改善癌症诊断和监测治疗反应的工具。

    BIOLUMINESCENCE RESONANCE ENERGY TRANSFER (BRET) SYSTEMS AND METHODS OF USE THEREOF
    10.
    发明申请
    BIOLUMINESCENCE RESONANCE ENERGY TRANSFER (BRET) SYSTEMS AND METHODS OF USE THEREOF 有权
    生物共振能量转移（BRET）系统及其使用方法

    公开(公告)号：US20100047813A1

    公开(公告)日：2010-02-25

    申请号：US12365984

    申请日：2009-02-05

    申请人： Sanjiv S. Gambhir ,  Abhijit De

    发明人： Sanjiv S. Gambhir ,  Abhijit De

    IPC分类号： G01N33/53

    CPC分类号： G01N33/542 ,  C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include bioluminescence resonance energy transfer (BRET) systems, methods of detecting a protein-protein interaction, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, methods to determine the efficacy of a test compound administered to modulate the interaction of a first protein with a second protein in a living animal, BRET vectors, kits relating to each of the above, transgenic cell or progeny thereof and/or animals relating to each of the above, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括生物发光共振能量转移（BRET）系统，检测蛋白质 - 蛋白质相互作用的方法，用于检测活体动物中第一种蛋白质与第二种蛋白质的相互作用的非侵入性方法，确定功效的方法 施用以调节活体动物中第一蛋白质与第二蛋白质的相互作用的测试化合物，BRET载体，与上述每种相关的试剂盒，转基因细胞或其后代和/或与上述每种相关的动物，和/或 类似。