公开(公告)号：US09164037B2

公开(公告)日：2015-10-20

申请号：US11698338

申请日：2007-01-26

申请人： Michael Bassler ,  Peter Kiesel ,  Oliver Schmidt

发明人： Michael Bassler ,  Peter Kiesel ,  Oliver Schmidt

IPC分类号： G01N33/48 ,  G01N21/64 ,  G06F19/00 ,  G06F19/12 ,  G01N31/00 ,  G06G7/58 ,  G01N15/10 ,  G01N15/14

CPC分类号： G01N21/6408 ,  G01N21/6458 ,  G01N2015/1075 ,  G01N2015/1486 ,  G06F19/12 ,  G06F2217/16 ,  G16H50/20

摘要： A method is provided for extracting the position of a particle, e.g., a moving or stationary particle that is excited or is emitting light. The method includes, among other steps, detecting and recording a signal based on, for example, the movement of the particle, a correlation step to eliminate noise and to create a transformed signal, a matching or fitting step to match the transformed signal to a fit function and an extracting or determining step to determine the position of the particle from the fit function. In one form, at least two particle positions are detected so that the distance between the subject particles can be determined.

摘要翻译： 提供了用于提取颗粒的位置的方法，例如被激发或正在发光的移动或静止的颗粒。 除了其他步骤之外，该方法包括基于例如粒子的移动来检测和记录信号，消除噪声并产生变换信号的相关步骤，匹配或拟合步骤，以将变换后的信号与 拟合函数和提取或确定步骤以从拟合函数确定粒子的位置。 在一种形式中，检测至少两个颗粒位置，使得可以确定主体颗粒之间的距离。

公开(公告)号：US08120782B2

公开(公告)日：2012-02-21

申请号：US12603627

申请日：2009-10-22

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Uma Srinivasan

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Uma Srinivasan

IPC分类号： G01B9/02

CPC分类号： G01J3/26 ,  G01N21/45 ,  G01N2021/451 ,  G02B26/001

摘要： A tunable optical cavity can be tuned by relative movement between two reflection surfaces, such as by deforming elastomer spacers connected between mirrors or other light-reflective components that include the reflection surfaces. The optical cavity structure includes an analyte region in its light-transmissive region, and presence of analyte in the analyte region affects output light when the optical cavity is tuned to a set of positions. Electrodes that cause deformation of the spacers can also be used to capacitively sense the distance between them. Control circuitry that provides tuning signals can cause continuous movement across a range of positions, allowing continuous photosensing of analyte-affected output light by a detector.

摘要翻译： 可调光学腔可以通过两个反射表面之间的相对运动进行调节，例如通过变形连接在反射镜之间的弹性体隔离物或包括反射表面的其它光反射部件。 光腔结构包括其透光区域中的分析物区域，并且当光学腔被调谐到一组位置时，分析物区域中的分析物的存在影响输出光。 导致间隔物变形的电极也可用于电容地感测它们之间的距离。 提供调谐信号的控制电路可以在一定范围的位置上引起连续的运动，从而允许由检测器对被分析物影响的输出光进行持续的光敏。

公开(公告)号：US07936463B2

公开(公告)日：2011-05-03

申请号：US11702325

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

IPC分类号： G01B9/02

CPC分类号： G01N21/0303 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

摘要： A device can include both a photosensing component and an optical cavity structure, with the optical cavity structure including a part that can operate as an optical cavity in response to input light, providing laterally varying output light. For example, the optical cavity can be a graded linearly varying filter (LVF) or other inhomogeneous optical cavity, and the photosensing component can have a photosensitive surface that receives its output light without it passing through another optical component, thus avoiding loss of information. The optical cavity part can include a region that can contain analyte. Presence of the analyte affects the optical cavity part's output light, and the photosensing component can respond to the output light, providing sensing results indicating the analyte's optical characteristics.

摘要翻译： 设备可以包括光敏元件和光学腔结构，其中光学腔结构包括响应于输入光可以作为光腔工作的部件，提供横向变化的输出光。 例如，光学腔可以是渐变的线性变化的滤光器（LVF）或其他不均匀的光学腔，并且光敏元件可以具有接收其输出光而不通过另一个光学部件的感光表面，从而避免信息的丢失。 光腔部分可以包括可以含有分析物的区域。 分析物的存在影响光腔部分的输出光，并且光敏元件可以对输出光进行响应，提供指示分析物的光学特性的感测结果。

公开(公告)号：US07817281B2

公开(公告)日：2010-10-19

申请号：US11702320

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Uma Srinivasan

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Uma Srinivasan

IPC分类号： G01B9/02

CPC分类号： H01S3/08081 ,  G01J3/26 ,  H01S3/105

摘要： An inhomogeneous optical cavity is tuned by changing its shape, such as by changing reflection surface positions to change tilt angle, thickness, or both. Deformable components such as elastomer spacers can be connected so that, when deformed, they change relative positions of structures with light-reflective components such as mirrors, changing cavity shape. Electrodes can cause deformation, such as electrostatically, electromagnetically, or piezoelectrically, and can also be used to measure thicknesses of the cavity. The cavity can be tuned, for example, across a continuous spectrum, to a specific wavelength band, to a shape that increases or decreases the number of modes it has, to a series of transmission ranges each suitable for a respective light source, with a modulation that allows lock-in with photosensing for greater sensitivity, and so forth. The optical cavity can be a linear variable filter fabricated on the photosensitive surface of a photosensing component such as a photosensor array or a position-sensitive detector.

摘要翻译： 通过改变其形状来调整不均匀的光学腔，例如通过改变反射面位置来改变倾斜角，厚度或两者。 变形部件如弹性体间隔件可以连接，使得当变形时，它们改变结构与诸如反射镜的光反射部件的相对位置，改变腔体形状。 电极可能导致变形，例如静电，电磁或压电，也可用于测量腔的厚度。 空腔可以例如通过连续光谱被调谐到特定波长带，以使其具有的模式数量增加或减少的形状调整到各自适用于相应光源的一系列传输范围，其中 允许通过光敏锁定来实现更高灵敏度的调制，等等。 光腔可以是制造在诸如光电传感器阵列或位置敏感检测器的感光部件的感光表面上的线性可变滤波器。

公开(公告)号：US07718948B2

公开(公告)日：2010-05-18

申请号：US11633323

申请日：2006-12-04

申请人： Peter Kiesel ,  Oliver Schmidt

发明人： Peter Kiesel ,  Oliver Schmidt

IPC分类号： H01J40/14

CPC分类号： H01L31/02165 ,  G01J3/02 ,  G01J3/0259 ,  G01J3/26 ,  G01J9/0246 ,  H01S3/0014 ,  H01S3/1305

摘要： To monitor light pulses from a light source, such as a laser, sense signals are provided to a photosensing component or array, causing photosensing during a series of one or more sense periods for the light pulse. Each light pulse can be provided through a transmission structure, such as a layered structure, that provides output light with an energy-dependent position on the photosensing component. A pulse's sensing results can be used to obtain a set of one or more differential quantities; for example, with a photosensing array, two cells of the array can be read out and compared. For a narrow band light pulse, a transmission structure can provide a spot on the photosensing component, and the light spot position can be sensed.

摘要翻译： 为了监测来自光源（例如激光器）的光脉冲，感测信号被提供给光敏元件或阵列，在光脉冲的一个或多个感测周期的系列期间引起光敏。 每个光脉冲可以通过诸如分层结构的传输结构提供，其提供光敏部件上的能量相关位置的输出光。 可以使用脉冲的感测结果来获得一个或多个差分量的集合; 例如，使用光敏阵列，可以读出并比较阵列的两个单元。 对于窄带光脉冲，透射结构可以在光敏元件上提供光点，并且可以感测光点位置。

公开(公告)号：US07554673B2

公开(公告)日：2009-06-30

申请号：US11702470

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

IPC分类号： G01B9/02

CPC分类号： G01N21/031 ,  B01L3/5085 ,  B01L2200/10 ,  B01L2300/168 ,  G01J3/26 ,  G01N2021/391

摘要： While two or more analytes within an optical cavity move relative to an array of photosensing elements, the cavity provides output light that has a position/time varying intensity function that depends on optical characteristics of the analytes and on the relative movement. The output light is photosensed to obtain sensing results that depend on the position/time varying intensity function. The sensing results are used to obtain information about at least one of the analytes. The relative movement can, for example, be caused by moving analytes within channels within the cavity, such as by causing flow of a medium that carries the analytes through the channels. Or the analytes can be in wells of a biochip, with the cavity defined by reflective slides on opposite surfaces of the biochip, and the slides and biochip can be caused to move together relative to the array.

摘要翻译： 虽然光学腔内的两个或更多个分析物相对于光敏元件阵列移动，但腔提供具有取决于分析物的光学特性和相对运动的位置/时间变化强度函数的输出光。 输出光被光照以获得取决于位置/时变强度函数的感测结果。 感测结果用于获得关于至少一种分析物的信息。 例如，相对运动可以通过在腔内的通道内移动分析物，例如通过使携带分析物的介质流过通道而引起。 或者分析物可以在生物芯片的孔中，其中空腔由生物芯片的相对表面上的反射片限定，并且可以使载片和生物芯片相对于阵列一起移动。

公开(公告)号：US07547904B2

公开(公告)日：2009-06-16

申请号：US11315386

申请日：2005-12-22

申请人： Oliver Schmidt ,  Peter Kiesel ,  Noble M. Johnson

发明人： Oliver Schmidt ,  Peter Kiesel ,  Noble M. Johnson

IPC分类号： G01N15/06 ,  G01N21/49 ,  G01N21/85

CPC分类号： G01N33/54373 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01J3/02 ,  G01J3/0259 ,  G01J3/26 ,  G01N21/05 ,  G01N21/31 ,  G01N21/6402 ,  G01N21/6454 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/052 ,  G01N2021/3137 ,  G01N2021/317 ,  G01N2021/6417 ,  G01N2021/6463 ,  G01N2021/6467 ,  G01N2021/6482 ,  G01N2021/651

摘要： Photons emanating from a channel in a fluidic structure or from moving objects are sensed using a photosensor array in an integrated circuit. The array includes subrange cells that photosense within respective subranges of a photon energy range. For example, the subrange cells can receive photons in their respective subranges from a transmission structure that has laterally varying properties. The photons can be emitted in response to excitation or can be scattered in response to illumination.

摘要翻译： 使用集成电路中的光电传感器阵列感测从流体结构的通道或移动物体发出的光子。 该阵列包括在光子能量范围的相应子范围内的光密度的子范围单元格。 例如，子范围单元可以从具有横向变化的特性的传输结构接收其各自子范围内的光子。 可以响应于激发而发射光子，或者可以响应于照明而散射光子。

公开(公告)号：US07522786B2

公开(公告)日：2009-04-21

申请号：US11316241

申请日：2005-12-22

申请人： Peter Kiesel ,  Oliver Schmidt

发明人： Peter Kiesel ,  Oliver Schmidt

IPC分类号： G02B6/00 ,  G01J3/45 ,  G02F1/35

CPC分类号： G02B6/4215 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/26 ,  G01J3/2803 ,  G02B6/29358 ,  G02B6/4298

摘要： In detection and sensing, light is transmitted through layers or structures that vary laterally, such as with a constant gradient or a step-like gradient. After transmission, a position of a transmitted portion of the light or of output photons can be used to determine wavelength change or to obtain other photon energy information. The light can be received, for example, from a stimulus-wavelength converter such as an optical fiber sensor or another optical sensor. A component that propagates the light from the converter to a transmission structure can spread the light across the transmission structure's entry surface. At the exit surface of the transmission structure, photosensor components can sense or detect transmitted light or output photons, such as with a photosensor array or a position sensor. A photosensed quantity can be compared, such as with another photosensed quantity or with a calibration quantity. A differential quantity can be obtained using photosensed quantities.

摘要翻译： 在检测和感测中，光通过横向变化的层或结构透射，例如以恒定的梯度或阶梯状梯度。 在传输之后，可以使用光或输出光子的透射部分的位置来确定波长变化或获得其它光子能量信息。 光可以例如从诸如光纤传感器或另一光学传感器的刺激 - 波长转换器接收。 将来自转换器的光传播到透射结构的部件可以将光传播穿过透射结构的入射表面。 在透射结构的出射表面处，光电传感器部件可以感测或检测透射光或输出光子，例如用光电传感器阵列或位置传感器。 可以比较光照数量，例如与另一张照片数量或校准数量。 使用光照量可以获得差分量。

公开(公告)号：US07433552B2

公开(公告)日：2008-10-07

申请号：US11316303

申请日：2005-12-22

申请人： Peter Kiesel ,  Oliver Schmidt

发明人： Peter Kiesel ,  Oliver Schmidt

IPC分类号： G02B6/00

CPC分类号： G01N21/78 ,  G01J1/42 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/26 ,  G01J3/2803 ,  G01N21/4788

摘要： Light, such as from an analyte-wavelength converter or other optical sensor, is propagated to a detector or transmission structure with an entry surface and with output positions such as in an exit surface. For example, the position of light output by such a detector can be used to detect presence of an analyte such as a biomolecule or chemical. Or relative quantities of photons provided at positions of the exit surface can indicate analyte information such as presence, absence, quantity, or concentration. The detector or transmission structure can have a laterally varying energy transmission function, such as with a constant gradient or a step-like gradient. At the exit surface of the transmission structure, a photosensor array or position sensor can sense transmitted light or output photons, and, in response, circuitry can provide signals indicating the analyte information.

摘要翻译： 诸如来自分析物 - 波长转换器或其他光学传感器的光被传播到具有进入表面和诸如出口表面的输出位置的检测器或传输结构。 例如，这种检测器输出的光的位置可用于检测分析物如生物分子或化学物质的存在。 或者在出射表面的位置处提供的光子的相对量可以指示分析物信息，例如存在，不存在，数量或浓度。 检测器或传输结构可以具有横向变化的能量传输功能，例如具有恒定梯度或阶梯状梯度。 在透射结构的出射表面处，光电传感器阵列或位置传感器可以感测透射光或输出光子，并且作为响应，电路可以提供指示分析物信息的信号。

公开(公告)号：US20080186500A1

公开(公告)日：2008-08-07

申请号：US11702249

申请日：2007-02-05

申请人： Oliver Schmidt ,  Peter Kiesel ,  Michael Bassler

发明人： Oliver Schmidt ,  Peter Kiesel ,  Michael Bassler

IPC分类号： G01B9/02

CPC分类号： G01N21/39 ,  G01N21/0303 ,  G01N21/253

摘要： Output light from an optical cavity includes, for each of a set of modes, an intensity function, and a mode's intensity function includes information, such as about an optical characteristic of an analyte or of a region. For example, the intensity function can include a peak, and its central energy, maximum intensity, contrast, or intermediate intensity width (e.g. FWHM) can indicate the optical characteristic. The output light can be photosensed, providing electrical signals that depend on the optical characteristic. Information about the analyte or region can then be obtained using the electrical signals. For example, the information can be about both refractive index and absorption of an analyte. Cavity-only absorption values, independent, for example, of absorption outside the cavity and of inhomogeneous illumination, can be obtained based on contrast or intermediate intensity width. For detection of glucose in bodily fluid, derivatives of absorption can be obtained.

摘要翻译： 来自光学腔的输出光对于一组模式中的每一个包括强度函数，并且模式的强度函数包括诸如关于分析物或区域的光学特性的信息。 例如，强度函数可以包括峰值，并且其中心能量，最大强度，对比度或中间强度宽度（例如，FWHM）可以指示光学特性。 输出光可以被光照，提供取决于光学特性的电信号。 然后可以使用电信号获得关于分析物或区域的信息。 例如，该信息可以关于分析物的折射率和吸收。 基于对比度或中等强度宽度，可以获得独立于例如空腔外的吸收和不均匀照射的仅腔吸收值。 为了检测体液中的葡萄糖，可以得到吸收的衍生物。