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公开(公告)号：US20090250630A1
公开(公告)日：2009-10-08
申请号：US12374000
申请日：2007-07-05
IPC分类号： G01N21/64 , G01J1/58 , H01L31/105
CPC分类号： H01L31/1055 , G01N21/6428 , H01L31/103
摘要： A photodiode (200), for instance a PN or a PIN photodiode, is disclosed. The photodiode receives incident radiation having first and second spectral distributions, where the first spectral distribution is spectrally shifted from the second spectral distribution. The photodiode has a first semiconductor layer (211) capable of absorbing incident radiation (231) having a first spectral distribution without generating a photocurrent, while simultaneously transmitting incident radiation having a second spectral distribution to the intrinsic layer (212) for generating a photocurrent (213). The photodiode may be used in connection with detecting the presence of target molecules that has been labeled with labeling agents, such as fluorophores or quantum dots. The labeling agents are characterized by the Stokes shift and, therefore, they emit fluorescent radiation having the second spectral distribution that is spectrally shifted from the illumination radiation having the first spectral distribution.
摘要翻译： 公开了一种光电二极管（200），例如PN或PIN光电二极管。 光电二极管接收具有第一和第二光谱分布的入射辐射，其中第一光谱分布从第二光谱分布光谱偏移。 光电二极管具有能够吸收具有第一光谱分布而不产生光电流的入射辐射（231）的第一半导体层（211），同时将具有第二光谱分布的入射辐射传输到本征层（212）以产生光电流 213）。 光电二极管可用于检测已经用标记试剂如荧光团或量子点标记的靶分子的存在。 标记试剂的特征在于斯托克斯位移，因此，它们发射具有与具有第一光谱分布的照射辐射光谱偏移的第二光谱分布的荧光辐射。
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公开(公告)号：US08399855B2
公开(公告)日：2013-03-19
申请号：US12374000
申请日：2007-07-05
IPC分类号： G01N21/64
CPC分类号： H01L31/1055 , G01N21/6428 , H01L31/103
摘要： A photodiode (200), for instance a PN or a PIN photodiode, is disclosed. The photodiode receives incident radiation having first and second spectral distributions, where the first spectral distribution is spectrally shifted from the second spectral distribution. The photodiode has a first semiconductor layer (211) capable of absorbing incident radiation (231) having a first spectral distribution without generating a photocurrent, while simultaneously transmitting incident radiation having a second spectral distribution to the intrinsic layer (212) for generating a photocurrent (213). The photodiode may be used in connection with detecting the presence of target molecules that has been labeled with labeling agents, such as fluorophores or quantum dots. The labeling agents are characterized by the Stokes shift and, therefore, they emit fluorescent radiation having the second spectral distribution that is spectrally shifted from the illumination radiation having the first spectral distribution.
摘要翻译： 公开了一种光电二极管（200），例如PN或PIN光电二极管。 光电二极管接收具有第一和第二光谱分布的入射辐射，其中第一光谱分布从第二光谱分布光谱偏移。 光电二极管具有能够吸收具有第一光谱分布而不产生光电流的入射辐射（231）的第一半导体层（211），同时将具有第二光谱分布的入射辐射传输到本征层（212）以产生光电流 213）。 光电二极管可用于检测已经用标记试剂如荧光团或量子点标记的靶分子的存在。 标记试剂的特征在于斯托克斯位移，因此，它们发射具有与具有第一光谱分布的照射辐射光谱偏移的第二光谱分布的荧光辐射。
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3.发明申请INTEGRATED DEVICE HAVING AN ARRAY OF PHOTODETECTORS AND AN ARRAY OF SAMPLE SITES 审中-公开具有照相机阵列和样品库阵列的集成设备公开(公告)号：US20100230610A1
公开(公告)日：2010-09-16
申请号：US12294469
申请日：2007-03-20
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/76 , Y10T29/49826
摘要： An integrated device for detecting emissions from a sample (70) involves forming an array of photo detectors (20) for detecting the emissions and forming an array of sites for receiving the sample such that edges of the sites are defined by edges of the photo detectors. A side wall of a site using a diode can provide a side wall suitable for ink-jet printing samples such as biomolecules with no extra mask steps. This helps enable the sample and the photo detector to be mutually aligned more easily or more cost effectively than conventional devices where the site for receiving the sample is formed separately from the photo detector. The detection can be in any direction, such as lateral or vertical detection. Lateral optical detection with a shielded photodiode means only light emanating from one pixel/spot is detected. A light source (200) to stimulate emissions can be integrated.
摘要翻译： 用于检测来自样品（70）的发射的集成装置涉及形成用于检测发射的光电检测器（20）的阵列，并形成用于接收样品的位置阵列，使得位置的边缘由光电检测器的边缘限定 。 使用二极管的位点的侧壁可以提供适合于喷墨打印样品的侧壁，例如没有额外掩模步骤的生物分子。 这有助于样品和光电检测器与传统的接收样品的部位与光电检测器分开形成的装置更容易或更经济地相互对准。 检测可以在任何方向，例如横向或垂直检测。 使用屏蔽光电二极管的横向光学检测意味着仅检测到从一个像素/点发出的光。 可以集成用于刺激排放物的光源（200）。
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4.发明申请METHOD FOR PERFORMING MOLECULAR REACTIONS BY USING IMMISCIBLE INTERMEDIATE FLUIDS 审中-公开通过使用可疑中间流体进行分子反应的方法公开(公告)号：US20140017687A1
公开(公告)日：2014-01-16
申请号：US14004439
申请日：2012-03-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/16 , B01L2300/0636 , B01L2300/088 , B01L2400/0487 , G01N35/08
摘要： The present invention relates to a method for performing molecular reactions in a device comprising the steps of (a) introducing one or more reagent solution(s) and an immiscible intermediate fluid into the device, wherein the device comprises a substrate, on which chemically or biochemically recognizable entities are immobilized; (b) performing molecular reactions between the immobilized chemically or biochemically recognizable entities and the reagent solution(s); or on the immobilized chemically or biochemically recognizable entities in the presence of the reagent solution(s); (c) displacing the reagent solution(s) present on the substrate by the immiscible intermediate fluid; (d) separating the immiscible intermediate fluid and the reagent solution(s); and reusing the reagent solution(s) and/or immiscible intermediate fluid for one or more repetitions of steps (a) to (e). The invention further relates to a device for performing a molecular reaction, comprising a reaction zone, reservoirs and liquid connections and a col lection and regeneration zone wherein the immiscible intermediate fluid and the reagent solution(s) are separable by gravitational separation; or a redirection and distribution module, wherein the immiscible intermediate fluid and reagent solution(s) are separated. The invention also relates to the use of an immiscible intermediate fluid for displacing a reagent solution present in a reaction zone in a microfluidic device, as well as the use of a corresponding device for performing a sequencing reaction or a nucleic acid synthesis reaction.
摘要翻译： 本发明涉及一种在器件中进行分子反应的方法，包括以下步骤：（a）将一种或多种试剂溶液和不混溶的中间体流体引入该装置，其中该装置包括基底，化学或 生化鉴定实体被固定化; （b）在固定的化学或生化学可识别的实体和试剂溶液之间进行分子反应; 或在试剂溶液存在下在固定的化学或生物化学可识别的实体上; （c）通过不混溶的中间流体置换存在于基板上的试剂溶液; （d）分离不混溶的中间体液体和试剂溶液; 并重复使用试剂溶液和/或不混溶的中间体液体进行一个或多个重复的步骤（a）至（e）。 本发明还涉及一种用于进行分子反应的装置，包括反应区，储存器和液体连接以及收集和再生区，其中不混溶的中间流体和试剂溶液可通过重力分离而分离; 或重定向和分配模块，其中不混溶的中间流体和试剂溶液被分离。 本发明还涉及不混溶中间体液体用于置换微流体装置中反应区中存在的试剂溶液的用途，以及使用相应的装置进行测序反应或核酸合成反应。
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公开(公告)号：US20110171086A1
公开(公告)日：2011-07-14
申请号：US13120456
申请日：2009-10-01
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/086
摘要： A microfluidic device is provided, the microfluidic device comprising: a plurality of chambers (3, 4, 5, 6) adapted for performing chemical, biochemical, or physical processes and a flow path (9) connecting the plurality of chambers (3, 4, 5, 6) adapted for accommodating at least one magnetic particle (7) subsequently moving through the plurality of chambers The plurality of chambers (3, 4, 5, 6) are separated by at least one valve-like structure (10) adapted to enable passing-through of the at least one magnetic particle (7) from one of the plurality of chambers to another one of the plurality of chambers. At least one delaying structure (11, 111) adapted to delay movement of the at least one magnetic particle (7) along the flow path is provided.
摘要翻译： 提供了一种微流体装置，所述微流体装置包括：适于进行化学，生物化学或物理过程的多个腔室（3,4,5,6）和连接所述多个腔室（3,4）的流路（9） ，5,6），其适于容纳随后移动通过所述多个室的至少一个磁性颗粒（7）。所述多个室（3,4,5,6）由至少一个阀状结构（10）分隔，所述阀状结构（10）适于 以使所述至少一个磁性颗粒（7）从所述多个室中的一个到达所述多个室中的另一个。 提供了适于延迟至少一个磁性颗粒（7）沿流动路径移动的至少一个延迟结构（11,111）。
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6.发明授权Semiconductor device with an operating frequency larger than 50 MHz comprising a body composed of a soft ferrite material 失效工作频率大于50MHz的半导体器件包括由软铁氧体材料构成的主体公开(公告)号：US06323533B1
公开(公告)日：2001-11-27
申请号：US09556547
申请日：2000-04-24
IPC分类号： H01L2900
CPC分类号： H01F17/0006 , H01L27/08
摘要： A semiconductor device (1) with an operating frequency above 50 MHz comprises a body (2) composed of a soft ferrite material, which body (2) has a surface (3) to which a semiconductor element (4), a pattern of conductors (5,6) and a passive element in the form of a planar inductor (7) are fastened by means of a layer (8) of adhesive. In order to reduce the manufacturing costs of the semiconductor device without adversely affecting the performance of the semiconductor device performance, a soft ferrite material is applied having a ferromagnetic resonance frequency smaller than the operating frequency of the semiconductor device.
摘要翻译： 工作频率高于50MHz的半导体器件（1）包括由软铁氧体材料构成的主体（2），所述主体（2）具有与半导体元件（4）一起的表面（3），导体图案 （5,6）和平面电感器（7）形式的无源元件通过粘合剂层（8）固定。 为了降低半导体器件的制造成本而不会不利地影响半导体器件性能的性能，施加具有小于半导体器件的工作频率的铁磁共振频率的软铁氧体材料。
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公开(公告)号：US09108220B2
公开(公告)日：2015-08-18
申请号：US14117378
申请日：2012-06-05
申请人： Cristian Bogdan Craus , Jacob Marinus Jan Den Toonder , Roel Penterman , Pieter Jan Van Der Zaag
发明人： Cristian Bogdan Craus , Jacob Marinus Jan Den Toonder , Roel Penterman , Pieter Jan Van Der Zaag
CPC分类号： B06B3/00 , B02C19/18 , C12M47/06 , G01N1/286 , Y10T29/49826
摘要： According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.
摘要翻译： 根据本发明的一个方面，提供了一种通过超声将碎片分子分解的装置。 该装置包括具有容器状形状的平面形状的盒和碎片装置。 通过在破碎仪器中施加低压力，将药筒拉向碎裂仪器，因此空间上封闭由碎裂仪器组成的流体隔室。 之后，可以处理包含在药筒的样品室中的样品的超声处理。 密封层设置在药筒和碎裂仪器之间，以便牢固地保持药筒的固定，以便防止流体隔室泄漏。
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公开(公告)号：US08784623B2
公开(公告)日：2014-07-22
申请号：US13003308
申请日：2009-02-17
IPC分类号： G01N27/327
CPC分类号： G01N33/48721
摘要： A nanopore device is described wherein is provided a sample input (110), an input chamber (120), and first and second sample chambers (130, 140) connected to the input chambers (120) via first and second nanopores (135, 145).
摘要翻译： 描述了纳米孔装置，其中提供了样品输入（110），输入室（120）以及通过第一和第二纳米孔（135,145）连接到输入室（120）的第一和第二样品室（130,140） ）。
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9.发明申请IN VITRO DIAGNOSTIC TESTING INCLUDING AUTOMATED BROKERING OF ROYALTY PAYMENTS FOR PROPRIETARY TESTS 审中-公开在体外诊断测试中，包括自动检测专有费用的专有费用公开(公告)号：US20130226621A1
公开(公告)日：2013-08-29
申请号：US13881512
申请日：2011-10-24
摘要： A method comprises: recording an electronic record of diagnostic events including the performing of in-vitro diagnostic tests; during the recording, identifying the performing of a licensed in-vitro diagnostic test for which license information is stored in a licenses database; and computing license compensation due to a licensor for the performing of the licensed in-vitro diagnostic test based on royalty calculation information stored in the licenses database. The recording, identifying, and computing operations are performed by one or more computers. The method may further include remitting the computed license compensation to the licensor, the remitting also being performed by one or more computers. The licensed in-vitro diagnostic test may comprise a licensed biomarker test, for example one obtained by DNA or RNA sequencing, and the method may further comprise: performing the licensed biomarker test using a genome sequencer, wherein the performing of the licensed biomarker test and the computing of license compensation are both performed at a single medical facility.
摘要翻译： 一种方法包括：记录诊断事件的电子记录，包括进行体外诊断测试; 在记录期间，识别许可证体验诊断测试的执行，许可信息被存储在许可证数据库中; 以及根据许可人根据存储在许可证数据库中的版税计算信息执行许可的体外诊断测试来计算许可证补偿。 记录，识别和计算操作由一个或多个计算机执行。 该方法还可以包括将所计算的许可证补偿递交给许可方，还由一个或多个计算机执行。 许可的体外诊断测试可以包括许可的生物标志物测试，例如通过DNA或RNA测序获得的测试，并且该方法还可以包括：使用基因组测序仪进行许可的生物标志物测试，其中执行许可的生物标志物测试和 许可证补偿的计算都在单一医疗机构进行。
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公开(公告)号：US08932540B2
公开(公告)日：2015-01-13
申请号：US13395321
申请日：2010-09-06
CPC分类号： B03C1/034 , B01L3/502761 , B01L2200/0668 , B01L2400/043 , B03C1/0335 , B03C1/24 , B03C2201/18
摘要： A device for transporting magnetic or magnetizable beads over a transport surface includes a chamber holding magnetic or magnetizable beads in a fluid, a transport element including the transport surface within the chamber, and a current wire structure including at least two sets of meandering current wires arranged on a side of the transport element opposite to the transport surface. The at least two sets are displaced with respect to each other in at least two directions. A switching unit switches currents individually applied to the sets of current wires according to a current driving scheme resulting in a transport of the beads over the transport surface.
摘要翻译： 用于在输送表面上传送磁性或可磁化珠的装置包括在流体中容纳磁性或可磁化珠粒的腔室，包括腔室内的输送表面的输送元件，以及包括至少两组曲折的电流布线的电流线结构， 在运输元件的与运输表面相对的一侧。 至少两组相对于彼此在至少两个方向上移位。 开关单元根据当前的驱动方案来切换单独施加到电流线组的电流，从而导致小珠在输送表面上的传送。
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