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公开(公告)号：US10775355B2
公开(公告)日：2020-09-15
申请号：US16009434
申请日：2018-06-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Tobias Franz , Uwe Kobold , Peter Kupser , Roland Thiele
IPC: G01N30/88 , G01N30/06 , G01N30/08 , G01N30/24 , G01N30/46 , G01N30/72 , G01N35/00 , B01D15/18 , G01N30/60 , G01N1/40 , G01N30/02
Abstract: A clinical diagnostic system is presented and comprises a sample preparation station for automatically preparing samples comprising analytes of interest, a liquid chromatography (LC) separation station comprising a plurality of LC channels and a sample preparation/LC interface for inputting prepared samples into the LC channels. The system further comprises a controller to assign samples to pre-defined sample preparation workflows each comprising a pre-defined sequence of sample preparation steps and requiring a pre-defined time for completion depending on the analytes. The controller further assigns an LC channel for each prepared sample depending on the analytes and plans an LC channel input sequence for inputting the prepared samples that allows analytes from different LC channels to elute in a non-overlapping LC eluate output sequence based on expected elution times. The controller further sets and initiates a start sequence that generates a prepared sample output sequence that matches the LC channel input sequence.
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公开(公告)号：US10330693B2
公开(公告)日：2019-06-25
申请号：US15132915
申请日：2016-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
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公开(公告)号：US20180292368A1
公开(公告)日：2018-10-11
申请号：US16009434
申请日：2018-06-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Tobias Franz , Uwe Kobold , Peter Kupser , Roland Thiele
Abstract: A clinical diagnostic system is presented and comprises a sample preparation station for automatically preparing samples comprising analytes of interest, a liquid chromatography (LC) separation station comprising a plurality of LC channels and a sample preparation/LC interface for inputting prepared samples into the LC channels. The system further comprises a controller to assign samples to pre-defined sample preparation workflows each comprising a pre-defined sequence of sample preparation steps and requiring a pre-defined time for completion depending on the analytes. The controller further assigns an LC channel for each prepared sample depending on the analytes and plans an LC channel input sequence for inputting the prepared samples that allows analytes from different LC channels to elute in a non-overlapping LC eluate output sequence based on expected elution times. The controller further sets and initiates a start sequence that generates a prepared sample output sequence that matches the LC channel input sequence.
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Patent Agency Ranking
公开(公告)号：US20160231344A1
公开(公告)日：2016-08-11
申请号：US15132915
申请日：2016-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
CPC classification number: G01N35/1002 , A61M5/14216 , A61M5/16809 , B01L3/0217 , B01L3/0224 , B01L3/502 , B01L2200/025 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01F11/021 , G01N35/00871 , G01N35/1016 , G01N35/1097 , G01N2035/1025 , Y10T436/119163 , Y10T436/2575
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
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公开(公告)号：US20150140669A1
公开(公告)日：2015-05-21
申请号：US14530862
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thursten Brueckner , Timo Klein
CPC classification number: G01N35/1002 , A61M5/14216 , A61M5/16809 , B01L3/0217 , B01L3/0224 , B01L3/502 , B01L2200/025 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01F11/021 , G01N35/00871 , G01N35/1016 , G01N35/1097 , G01N2035/1025 , Y10T436/119163 , Y10T436/2575
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
Abstract translation: 提出了用于分配流体的盒。 墨盒包括阀。 阀包括用于泵送流体的泵送室。 阀门定位泵送管道。 泵送室导管连接到泵送室。 墨盒还包括用于改变泵送室的容积的柱塞。 墨盒还包括用于将储存器与阀连接的储存器导管。 阀将泵室导管定位成与储存器导管连接。 墨盒还包括用于分配流体的出口导管。 阀进一步旋转泵送室导管以与出口导管连接。
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公开(公告)号：US20230384269A1
公开(公告)日：2023-11-30
申请号：US18447604
申请日：2023-08-10
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Peter Kupser , Andreas Leinenbach
CPC classification number: G01N30/16 , G01N30/6078 , G01N30/6047 , G01N35/00732 , G01N2030/167 , G01N2030/027
Abstract: A column device for an automatic analyser. The automatic analyzer comprises a high performance liquid chromatography (HPLC) module. The HPLC module comprises a fixation device configured to automatically fix and release a chromatographic column. The column device comprises a column jacket and a capillary. The capillary comprises predetermined dimensions and is disposed within the column jacket. The column device is configured to be installed at the HPLC module using the fixation device. Further, an automatic analyzer is disclosed.
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公开(公告)号：US20230333069A1
公开(公告)日：2023-10-19
申请号：US18337020
申请日：2023-06-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thomas Hoffmann , Peter Kupser , Andreas Leinenbach , Indranil Mitra , Jatin Nandania , Cornelia Werner
CPC classification number: G01N30/12 , G01N30/7233 , G01N2030/027
Abstract: The present invention relates to a method for detecting and/or quantifying an analyte in a sample using mass spectrometry. The method of the invention comprises: extracting the analyte from the sample using solid phase extraction (SPE) so as to obtain an SPE extract comprising the analyte, concentrating the analyte, said concentrating comprising evaporating solvent from the SPE-extract; and detecting and/or quantifying the analyte in the sample using mass spectrometry.
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公开(公告)号：US09341641B2
公开(公告)日：2016-05-17
申请号：US14530862
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
CPC classification number: G01N35/1002 , A61M5/14216 , A61M5/16809 , B01L3/0217 , B01L3/0224 , B01L3/502 , B01L2200/025 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01F11/021 , G01N35/00871 , G01N35/1016 , G01N35/1097 , G01N2035/1025 , Y10T436/119163 , Y10T436/2575
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
Abstract translation: 提出了用于分配流体的盒。 墨盒包括阀。 阀包括用于泵送流体的泵送室。 阀门定位泵送管道。 泵送室导管连接到泵送室。 墨盒还包括用于改变泵送室的容积的柱塞。 墨盒还包括用于将储存器与阀连接的储存器导管。 阀将泵室导管定位成与储存器导管连接。 墨盒还包括用于分配流体的出口导管。 阀进一步旋转泵送室导管以与出口导管连接。
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