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公开(公告)号：US12189112B2
公开(公告)日：2025-01-07
申请号：US17783924
申请日：2020-12-10
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan Halperin , Dan Gluck , Noam Yorav-Raphael , Yochay Shlomo Eshel , Sarah Levy , Joseph Joel Pollak
Abstract: Apparatus and methods are described for use with a blood sample. Using a microscope (24), three images of a microscopic imaging field of the blood sample are acquired, each of the images being acquired using respective, different imaging conditions, and the first one of the three images being acquired under violet-light brightfield imaging. Using at least one computer processor (28), an artificial color microscopic image of the microscopic imaging field is generated, by mapping the first one of the three images to a red channel of the artificial color microscopic image, mapping a second one of the three images to a second color channel of the artificial color microscopic image, and mapping a third one of the three images to a third color channel of the artificial color microscopic image. Other applications are also described.
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公开(公告)号：US11803964B2
公开(公告)日：2023-10-31
申请号：US17576023
申请日：2022-01-14
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
CPC classification number: G06T7/0012 , G02B7/38 , G02B21/16 , G02B21/244 , G02B21/361 , G02B21/367 , G06T7/507 , G06T2207/10056 , G06T2207/30024
Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells disposed in a monolayer. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level relative to the image contrast of images acquired at depth levels within a given range of distances from the identified depth level. The cell sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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公开(公告)号：US11199690B2
公开(公告)日：2021-12-14
申请号：US16851410
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
Abstract: Apparatus and methods are described including acquiring microscopic images of a blood sample, and identifying deformed red blood cells within the microscopic images. A degree of red blood cell deformity within the sample is determined, at least partially based upon the identified deformed red blood cells. A sample-informative parameter that is indicative of a characteristic of the blood sample as a whole is determined, at least partially based upon the degree of red blood cell deformity within the sample. Other applications are also described.
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公开(公告)号：US11100634B2
公开(公告)日：2021-08-24
申请号：US16232124
申请日：2018-12-26
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.
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公开(公告)号：US10176565B2
公开(公告)日：2019-01-08
申请号：US14285672
申请日：2014-05-23
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: The present disclosure provides a method of determining a reference depth level within a cell sample. The method comprises obtaining data representative of a series of images captured by performing a depth scan of the cell sample using a digital microscope, the series of images being associated with a series of depth levels of the cell sample; processing said data for detecting at least one depth level corresponding to a drop in image contrast; and identifying the detected depth level as the reference depth level.
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Patent Agency Ranking
公开(公告)号：US12196664B2
公开(公告)日：2025-01-14
申请号：US18203109
申请日：2023-05-30
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Arnon Houri Yafin , Joseph Joel Pollak , Neta Bachar , Annael Marciano , Sarah Levy Schreier
Abstract: Apparatus and methods are described for use with an output device, and a blood sample that was drawn from a subject. A microscope system acquires first and second images of the blood sample at respective times. A computer processor determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US12005443B2
公开(公告)日：2024-06-11
申请号：US17064193
申请日：2020-10-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Ido Bachelet , Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Noam Yorav-Raphael
CPC classification number: B01L3/502715 , G01N15/1433 , G01N21/23 , G01N21/5907 , G01N21/6458 , B01L2300/0816 , B01L2300/0864 , G01N2015/016 , G01N2015/1006 , G01N2021/5957 , G01N2021/6419 , G01N2021/6421 , G06V2201/03 , G06V2201/04
Abstract: Apparatus and methods are described including successively acquiring a plurality of microscopic images of a portion of a blood sample, and tracking motion of pixels within the successively acquired microscopic images. Trypomastigote parasite candidates within the blood sample are identified, by identifying pixel motion that is typical of trypomastigote parasites. It is determined that the blood sample is infected with trypomastigote parasites, at least partially in response thereto. An output is generated indicating that that the blood sample is infected with trypomastigote parasites. Other applications are also described.
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公开(公告)号：US11914133B2
公开(公告)日：2024-02-27
申请号：US17568858
申请日：2022-01-05
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo Eshel , Natalie Lezmy , Dan Gluck , Arnon Houri Yafin , Joseph Joel Pollak
CPC classification number: G02B21/367 , G01N21/8851 , G02B21/365 , G06T7/0012 , G06V20/693 , G06V20/698 , G01N2021/8887 , G06T2207/10056 , G06T2207/30024 , G06T2207/30101
Abstract: Apparatus and methods are described for analyzing a bodily sample. A microscope system acquires one or more microscope images of the bodily sample. A computer processor identifies elements as being candidates of a given entity, in the one or more images. At least one sample-informative feature, relating to a characteristic of the candidates of the given entity in the sample as a whole, is extracted from the one or more images. A characteristic of the sample is determined at least partially based upon the sample-informative feature, and an output is generated in response thereto. Other applications are also described.
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公开(公告)号：US11614609B2
公开(公告)日：2023-03-28
申请号：US17083659
申请日：2020-10-29
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam Yorav-Raphael , Joseph Joel Pollak , Sarah Levy Schreier , Yochay Shlomo Eshel
Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.
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公开(公告)号：US11609413B2
公开(公告)日：2023-03-21
申请号：US17083775
申请日：2020-10-29
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam Yorav-Raphael , Joseph Joel Pollak , Sarah Levy Schreier , Yochay Shlomo Eshel
Abstract: Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.
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