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公开(公告)号：US4578383A
公开(公告)日：1986-03-25
申请号：US627367
申请日：1984-07-02
申请人： Suresh S. Stampwala , James C. French , Josefino B. Tunac , Timothy R. Hurley , Richard H. Bunge
发明人： Suresh S. Stampwala , James C. French , Josefino B. Tunac , Timothy R. Hurley , Richard H. Bunge
IPC分类号： C12P17/06 , A61K31/665 , A61K31/685
摘要： Novel phosphorus containing antibiotic compounds that are antitumor agents designated CL 1565-A, CL 1565-B, CL 1565-T and their salts, a process for the production and the method of using said compounds, and pharmaceutical compositions containing various salts of the compounds of the invention alone or in combination with other antitumor agents in the treatment of microbial infections and neoplastic diseases, are provided.
摘要翻译： 含有抗氧化剂的新型抗生素化合物是CL 1565-A，CL 1565-B，CL 1565-T及其盐的抗肿瘤剂，生产方法和使用所述化合物的方法，以及含有各种化合物的盐的药物组合物 的本发明单独或与其它抗肿瘤剂组合用于治疗微生物感染和肿瘤疾病。
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公开(公告)号：US4530835A
公开(公告)日：1985-07-23
申请号：US512088
申请日：1983-07-08
CPC分类号： C12P1/06
摘要： A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors.Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds.The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.
摘要翻译： 确定为ATCC 39363的放线菌的纯化分离物能够产生具有针对移植肿瘤的活性的含硫抗生素化合物的复合物。 抗生素化合物CL-1577A和CL-1577B及其密切相关的同系物通过在需氧条件下培养分离物ATCC 39363，在含有可同化碳源和氮的来源的培养基中培养，直到产生大量的CL-1577复合物，随后 分离复合物或一种或多种化合物。 还公开了抗生素化合物CL-1577A，CL-1577B，它们的同系物和包含这些物质的药物组合物和合适的载体。
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公开(公告)号：US4725621A
公开(公告)日：1988-02-16
申请号：US835825
申请日：1986-03-03
IPC分类号： C07D309/30 , A61K31/365
CPC分类号： C07D309/30
摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957E which also exhibits antitumor properties.The antimicrobial compound CL-1957E is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantially quantity of the CL-1957E compound is produced, and subsequently isolating the CL-1957E compound.The antibiotic compound CL-1957E and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.
摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够生产也具有抗肿瘤性质的抗微生物化合物CL-1957E。 抗微生物化合物CL-1957E是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957E化合物，然后分离出CL-1957E化合物。 还公开了抗生素化合物CL-1957E和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。
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公开(公告)号：US4696794A
公开(公告)日：1987-09-29
申请号：US928443
申请日：1986-11-07
CPC分类号： C12P1/06
摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957D.The antimicrobial compound CL-1957D is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957D compound is produced, and subsequently isolating the CL-1957D compound.The antibiotic compound CL-1957D and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections in mammals, employing these pharmaceutical compositions.
摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够产生抗微生物化合物CL-1957D。 抗微生物化合物CL-1957D是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957D化合物，然后分离出CL-1957D化合物。 还公开了抗生素化合物CL-1957D和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物微生物感染的方法。
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公开(公告)号：US4680416A
公开(公告)日：1987-07-14
申请号：US755389
申请日：1985-07-16
CPC分类号： C12R1/465 , C07C59/42 , C07D309/32 , C07F9/113 , C07F9/6552 , C12P17/06 , C12P9/00
摘要： Novel pyranone compounds and related compounds, methods of preparing the compounds, and their use as cytotoxic and/or antileukemic agents or precursors, are provided.
摘要翻译： 提供新型的吡喃酮类化合物和相关化合物，制备化合物的方法及其作为细胞毒性和/或抗白血病剂或前体的用途。
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6.发明授权CL-1577D And CL-1577E antibiotic/antitumor compounds, their production and use 失效CL-1577D和CL-1577E抗生素/抗肿瘤化合物，其生产和使用
公开(公告)号：US4539203A
公开(公告)日：1985-09-03
申请号：US670240
申请日：1984-11-13
申请人： Alex J. Brankiewicz , Richard H. Bunge , James C. French , Gerard C. Hokanson , Timothy R. Hurley , John P. Schaumberg
发明人： Alex J. Brankiewicz , Richard H. Bunge , James C. French , Gerard C. Hokanson , Timothy R. Hurley , John P. Schaumberg
CPC分类号： C12P1/06
摘要： Compounds CL-1577D and CL-1577E are prepared by cultivation of a purified isolate of Actinomycete designated ATCC 39363 in a culture medium having assimilable sources of carbon and nitrogen. The compounds are effective antimicrobial agents and possess cytotoxic activity against L1210 murine leukemia cells and P388 murine leukemia cells.
摘要翻译： 化合物CL-1577D和CL-1577E通过在具有可吸收碳源和氮源的培养基中培养称为ATCC 39363的放线菌的纯化分离物来制备。 这些化合物是有效的抗微生物剂，对L1210鼠白血病细胞和P388鼠白血病细胞具有细胞毒活性。
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公开(公告)号：US4657909A
公开(公告)日：1987-04-14
申请号：US743321
申请日：1985-06-10
申请人： Christopher F. Bigge , Edward F. Elslager , James C. French , Blanche D. Graham , Gerard C. Hokanson , Stephen W. Mamber , Tim A. Smitka , Josefino B. Tunac , John H. Wilton
发明人： Christopher F. Bigge , Edward F. Elslager , James C. French , Blanche D. Graham , Gerard C. Hokanson , Stephen W. Mamber , Tim A. Smitka , Josefino B. Tunac , John H. Wilton
IPC分类号： C12N1/20 , A61K31/495 , A61P31/04 , A61P35/00 , C07D241/46 , C12P17/12 , C12R1/465 , C07D401/12 , C07D403/12
CPC分类号： C12R1/465 , C07D241/46 , C12P17/12 , Y10S435/886
摘要： Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity.A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.
摘要翻译： 衍生自6-甲酰基-4,7,9-三羟基-1-吩嗪甲酸，甲酯的酸，酯，亚胺酸，亚胺酯和亚胺酰胺，得自6-甲酰基-4,7,9-三羟基-8- 甲基-1-吩嗪羧酸甲酯显示出抗菌和抗肿瘤活性。 纯化的链霉菌链霉菌NRRL 15738的菌株能够从含有可同化碳源的发酵液中分离得到6-甲酰基-4,7,9-三羟基-8-甲基-1-吩嗪甲酸甲酯， 氮。
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公开(公告)号：US4918100A
公开(公告)日：1990-04-17
申请号：US763577
申请日：1985-08-08
IPC分类号： C07D309/22 , C07D309/32 , C12P17/06
CPC分类号： C12R1/01 , C07D309/22 , C07D309/32 , C12P17/06
摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957B which also exhibits antitumor properties.The antimicrobial compound CL-1957B is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957B compound is produced, and subsequently isolating the compound.The antibiotic compound CL-1957B, its pharmaceutically acceptable salts, the pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.
摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够生产也具有抗肿瘤性质的抗微生物化合物CL-1957B。 抗微生物化合物CL-1957B是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957B化合物，然后分离该化合物。 还公开了抗生素化合物CL-1957B及其药学上可接受的盐，包含该物质的药物组合物和药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。
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公开(公告)号：US4771070A
公开(公告)日：1988-09-13
申请号：US912684
申请日：1986-09-26
IPC分类号： C07D309/22 , C12P17/06 , A61K31/365 , C07D309/38
CPC分类号： C07D309/22 , C12P17/06
摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties.The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound.The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.
摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够产生也具有抗肿瘤性质的抗微生物化合物CL-1957A。 抗微生物化合物CL-1957A是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957A化合物，然后分离出CL-1957A化合物。 还公开了抗生素化合物CL-1957A和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。
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10.发明授权2-chloropentostatin compound having adenosine diaminase inhibitory activity 失效具有腺苷二氨基酶抑制活性的2-氯磷酸抑制素化合物
公开(公告)号：US4713372A
公开(公告)日：1987-12-15
申请号：US796139
申请日：1985-11-08
申请人： John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac , Marjorie A. Underhill
发明人： John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac , Marjorie A. Underhill
IPC分类号： C07H19/052 , C12P19/38 , A61K31/70 , C07H17/02
CPC分类号： C12R1/01 , C07H19/052 , C12P19/38
摘要： 2'-Chloropentostatin is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinosyl)adenine. A pure strain of actinomycete, designated ATCC 39365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.
摘要翻译： 2'-Chloropostostatin是腺苷脱氨酶的有效抑制剂，并且具有用作增强抗病毒剂用于治疗DNA病毒活性的药剂的用途，所述药物含有腺嘌呤部分，例如9-（β-D-阿拉伯糖基） 腺嘌呤 还公开了一种能够产生2'-氯生物素抑制素的命名为ATCC 39365的放线菌纯化菌株，通过需氧发酵生产2'-氯生物素抑制素的方法，以及包含2'-氯磷酸内酯的药物组合物。
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