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公开(公告)号：US07144903B2
公开(公告)日：2006-12-05
申请号：US10155605
申请日：2002-05-22
申请人： Tassie Collins , Hossen Mahmud , Jonathan Houze , Alan Xi Huang , Julio C. Medina , Xuemei Wang , Feng Xu , Qingge Xu , Liusheng Zhu
发明人： Tassie Collins , Hossen Mahmud , Jonathan Houze , Alan Xi Huang , Julio C. Medina , Xuemei Wang , Feng Xu , Qingge Xu , Liusheng Zhu
IPC分类号： C07D417/12 , C07D419/12 , C07D401/00 , A61K31/425
CPC分类号： C07D417/12 , A61K31/265 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4245 , A61K31/426 , C07D277/42 , C07D277/82 , C07D513/04
摘要： Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.
摘要翻译： 提供了可用于治疗趋化因子受体介导的病症和疾病的化合物，组合物和方法。 特别地，本发明提供调节CCR4功能或CCR4介导的应答的化合物。 主题化合物和组合物可用于治疗或预防炎性疾病和疾病。
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公开(公告)号：US07262204B2
公开(公告)日：2007-08-28
申请号：US10654112
申请日：2003-09-02
申请人： Tassie Collins , Daniel J. Dairaghi , Hossen Mahmud , Brian E. McMaster , Julio C. Medina , Thomas J. Schall , Feng Xu , Xuemei Wang
发明人： Tassie Collins , Daniel J. Dairaghi , Hossen Mahmud , Brian E. McMaster , Julio C. Medina , Thomas J. Schall , Feng Xu , Xuemei Wang
IPC分类号： A61K31/47 , A61K31/425 , A61K31/385
CPC分类号： C07D417/12 , A61K31/00 , A61K31/265 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4245 , A61K31/426 , C07D277/42 , C07D277/82 , C07D513/04
摘要： Compounds and compositions are provided that bind to the CCR4 chemokine receptor and which are useful for treating diseases associated with CCR4 activity, such as contact hypersensitivity.
摘要翻译： 提供了结合CCR4趋化因子受体的化合物和组合物，其可用于治疗与CCR4活性相关的疾病，例如接触性超敏反应。
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公开(公告)号：US20050101540A1
公开(公告)日：2005-05-12
申请号：US11014344
申请日：2004-12-14
申请人： Alan Huang , Jiwen Liu , Julio Medina , Xuemei Wang , Feng Xu , Liusheng Zhu
发明人： Alan Huang , Jiwen Liu , Julio Medina , Xuemei Wang , Feng Xu , Liusheng Zhu
IPC分类号： A61K38/00 , A61K45/06 , C07D307/85 , C07D405/12 , C07K5/02 , C07K5/06 , C07K5/062 , A61K38/04 , C07D487/02 , G01N33/53
CPC分类号： C07D307/85 , A61K38/00 , A61K45/06 , C07D405/12 , C07K5/06034 , C07K5/0606
摘要： The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.
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公开(公告)号：US06884782B2
公开(公告)日：2005-04-26
申请号：US10008244
申请日：2001-11-07
申请人： Alan Huang , Jiwen Liu , Julio Medina , Xuemei Wang , Feng Xu , Liusheng Zhu
发明人： Alan Huang , Jiwen Liu , Julio Medina , Xuemei Wang , Feng Xu , Liusheng Zhu
IPC分类号： A61K38/00 , A61K45/06 , C07D307/85 , C07D405/12 , C07K5/02 , C07K5/06 , C07K5/062
CPC分类号： C07D307/85 , A61K38/00 , A61K45/06 , C07D405/12 , C07K5/06034 , C07K5/0606
摘要： The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.
摘要翻译： 本发明提供用于抑制或治疗由STAT转录因子特别是STAT4和STAT6调节的病症或病症的化合物，组合物和方法。 另外，这些化合物可用于诊断依赖于STAT信号的病症。
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5.发明申请公开(公告)号：US20080312270A1
公开(公告)日：2008-12-18
申请号：US12113121
申请日：2008-04-30
申请人： Matthew Brown , Michael G. Johnson , An-Rong Li , Jiwen Liu , Sarah E. Lively , Julio C. Medina , Wang Shen , Xuemei Wang , Yingcai Wang
发明人： Matthew Brown , Michael G. Johnson , An-Rong Li , Jiwen Liu , Sarah E. Lively , Julio C. Medina , Wang Shen , Xuemei Wang , Yingcai Wang
IPC分类号： A61K31/437 , C07D209/04 , A61K31/404 , C07D277/62 , A61K31/428 , C07D235/04 , A61K31/4184 , C07K14/00 , A61P17/00 , A61P35/00 , A61P1/00 , A61P19/02 , A61P3/00 , A61P11/00 , C12N5/00 , C07D231/54 , A61K31/416 , A61K31/47 , C07D215/00 , C07D471/02
CPC分类号： C07D209/08 , C07D209/10 , C07D209/34 , C07D209/42 , C07D209/48 , C07D213/68 , C07D213/76 , C07D215/38 , C07D231/56 , C07D235/08 , C07D235/22 , C07D277/82 , C07D405/12 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译： 本文提供了可用于治疗炎症和免疫相关疾病和病症的化合物，组合物和方法。 特别地，本发明提供调节参与特应性疾病，炎性病症和癌症的蛋白质的功能和/或表达的化合物。 主题化合物是羧酸衍生物。
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6.发明授权公开(公告)号：US07960567B2
公开(公告)日：2011-06-14
申请号：US12113121
申请日：2008-04-30
申请人： Matthew Brown , Michael G. Johnson , An-Rong Li , Jiwen Liu , Sarah E. Lively , Julio C. Medina , Wang Shen , Xuemei Wang , Yingcai Wang
发明人： Matthew Brown , Michael G. Johnson , An-Rong Li , Jiwen Liu , Sarah E. Lively , Julio C. Medina , Wang Shen , Xuemei Wang , Yingcai Wang
IPC分类号： C07D209/08 , C07D209/12 , C07D209/30 , C07D209/42 , C07D209/48 , A61K31/404 , A61K31/4035
CPC分类号： C07D209/08 , C07D209/10 , C07D209/34 , C07D209/42 , C07D209/48 , C07D213/68 , C07D213/76 , C07D215/38 , C07D231/56 , C07D235/08 , C07D235/22 , C07D277/82 , C07D405/12 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译： 本文提供了可用于治疗炎症和免疫相关疾病和病症的化合物，组合物和方法。 特别地，本发明提供调节参与特应性疾病，炎性病症和癌症的蛋白质的功能和/或表达的化合物。 主题化合物是羧酸衍生物。
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公开(公告)号：US07105427B1
公开(公告)日：2006-09-12
申请号：US10929939
申请日：2004-08-30
申请人： Wei-Kan Chu , Lin Shao , Xinming Lu , Jiarui Liu , Xuemei Wang
发明人： Wei-Kan Chu , Lin Shao , Xinming Lu , Jiarui Liu , Xuemei Wang
IPC分类号： H01L21/425
CPC分类号： H01L21/2254 , H01L21/2257 , H01L21/26506 , H01L21/26513 , H01L29/34
摘要： Vacancies and dopant ions are introduced near the surface of a semiconductor wafer. The dopant ions which diffuse by an interstitialcy mechanism have diffusivity greatly reduced, which leads to a very low resistivity doped region and a very shallow junction.
摘要翻译： 在半导体晶片的表面附近引入空位和掺杂离子。 通过间隙机制扩散的掺杂离子具有大大降低的扩散率，这导致非常低的电阻率掺杂区域和非常浅的结。
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公开(公告)号：USD963926S1
公开(公告)日：2022-09-13
申请号：US29732008
申请日：2020-04-20
申请人： Xuemei Wang
设计人： Xuemei Wang
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公开(公告)号：US09273400B2
公开(公告)日：2016-03-01
申请号：US13071010
申请日：2011-03-24
CPC分类号： C23C28/36 , C23C4/02 , C23C4/06 , C23C4/10 , C23C4/18 , C23C24/04 , C23C28/044 , C23C28/048 , C23C28/44 , Y10T428/2495 , Y10T428/24983
摘要： An erosion resistant coating for a substrate includes two or more coating layers affixed to the substrate having an increasing modulus of elasticity and hardness from an innermost layer of the coating adjacent to the substrate to an outermost layer of the coating furthest from the substrate. A method of applying a coating system to a substrate includes applying a first layer of a high hardness and high modulus of elasticity material combined with an added metal to the substrate. A second layer of the high hardness and high modulus of elasticity material combined with the added metal is applied to the first layer, resulting in a coating system wherein the second layer has a modulus of elasticity and hardness greater than the modulus of elasticity and hardness of the first layer.
摘要翻译： 用于基材的抗侵蚀涂层包括固定到基材上的两层或更多层涂层，其具有从邻近基材的涂层的最内层到离基材最远的涂层的最外层的增加的弹性模量和硬度。 将涂布系统施加到基材的方法包括将与添加的金属组合的高硬度和高弹性模量材料的第一层施加到基材上。 将高硬度和高弹性模量材料与添加的金属组合的第二层施加到第一层，得到涂层体系，其中第二层的弹性模量和硬度大于弹性模量和硬度 第一层。
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公开(公告)号：US20090130774A1
公开(公告)日：2009-05-21
申请号：US11795163
申请日：2006-01-13
申请人： David Peretz , Melissa Michelitsch , Celine Hu , Xuemei Wang , Man Gao , Michael Connolly , Thomas Horn , Ronald Zuckermann , David Chien
发明人： David Peretz , Melissa Michelitsch , Celine Hu , Xuemei Wang , Man Gao , Michael Connolly , Thomas Horn , Ronald Zuckermann , David Chien
IPC分类号： G01N33/566
CPC分类号： B82Y30/00 , G01N33/6896 , G01N2800/2828
摘要： Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described for use in detecting PrPsc in biological samples. In particular, ELISA assays are described.
摘要翻译： 描述了与PrPsc形式的朊病毒蛋白优先相互作用的肽试剂用于检测生物样品中的PrPsc。 特别地，描述了ELISA测定。
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