公开(公告)号：US4959351A

公开(公告)日：1990-09-25

申请号：US635257

申请日：1984-07-27

申请人： Ulrich Grau

发明人： Ulrich Grau

IPC分类号： A61K38/28 ,  A61K38/00 ,  C07K14/575 ,  C07K14/62

CPC分类号： C07K14/622 ,  C07K14/62 ,  C30B7/00 ,  A61K38/00

摘要： The invention relates to a process for the preparation of crystal suspensions of one or more insulin derivatives of the formula I ##STR1## R.sup.1 denotes H or H-Phe, R.sup.30 represents the radical of a neutral L-aminoacid which can be genetically coded andR.sup.31 represents a physiologically acceptable organic group of basic character with up to 50 carbon atoms, in the build-up of which 0 to 3 .alpha.-aminoacids participate and in which any terminal carboxyl function present can be free, as the ester function, as the amide function, as the lactone or reduced to CH.sub.2 OH, with an isoelectric point between 5.8 and 8.5,which comprises carrying out the crystallization in an aqueous medium close to the isoelectric point of the derivative or derivatives in the presence of an aromatic hydroxy compound, to crystals and crystal suspensions obtained by the process and to the use thereof.

摘要翻译： 本发明涉及一种制备一种或多种式I的胰岛素衍生物的晶体悬浮液的方法，其中R 1表示H或H-Phe，R 30表示可以在遗传上的中性L-氨基酸的基团 编码，R31代表具有多达50个碳原子的基本特征的生理上可接受的有机基团，其中0至3个α-氨基酸参与并且其中存在的任何末端羧基官能团可以作为酯官能团， 作为酰胺官能团，作为内酯或还原成CH2OH，等电点为5.8〜8.5，其包括在芳族羟基化合物存在下在接近衍生物或衍生物的等电点的水性介质中进行结晶 ，通过该方法获得的晶体和晶体悬浮液及其用途。

公开(公告)号：US08690174B2

公开(公告)日：2014-04-08

申请号：US12694621

申请日：2010-01-27

申请人： Ulrich Grau ,  Ralf Mayer

发明人： Ulrich Grau ,  Ralf Mayer

IPC分类号： B60G21/055 ,  F16D3/10

CPC分类号： B60G21/0555 ,  B60G2202/22 ,  B60G2204/4191

摘要： A slewing motor for an active roll stabilizer, which can be connected by its drive to one stabilizer half, and which can be connected on the stator side to another stabilizer half of a divided stabilizer. A torsion element, whose rotational rigidity is lower than the rotational rigidity of the stabilizer, is effectively arranged between the drive and the one stabilizer half.

摘要翻译： 一种用于主动式滚动稳定器的回转马达，其可以通过其驱动器连接到一个稳定器一侧，并且其可以在定子侧连接到分立的稳定器的另一个稳定器一半。 旋转刚度低于稳定器的旋转刚度的扭转元件被有效地布置在驱动器和一个稳定器半体之间。

公开(公告)号：US06684831B2

公开(公告)日：2004-02-03

申请号：US10128900

申请日：2002-04-24

申请人： Ulrich Grau

发明人： Ulrich Grau

IPC分类号： F01L134

CPC分类号： F01L13/0015 ,  F01L13/0026 ,  F01L2013/0073 ,  F01L2103/01 ,  F01L2201/00 ,  F01L2800/13

摘要： The invention concerns an electrically rotatable shaft, and more particularly, an adjusting shaft (1) of a fully variable mechanical valve train of an internal combustion engine, said shaft comprising an adjusting cam (2). The low-friction and lash-free configuration of a drive required for a rapid and exact functioning of the fully variable mechanical valve train is achieved by the fact that the adjusting shaft (1) is rotated by an actuator (3) that comprises an adjusting lever (4) connected rotationally fast to the adjusting shaft (1), while the free end of the adjusting lever is articulated preferably on the screw nut (10) of a screw-and-nut drive (5) that is driven by an electromotor (6).

摘要翻译： 本发明涉及一种电动旋转的轴，更具体地说，涉及一种内燃机的全可变的机械气门机构的调节轴（1），所述轴包括调节凸轮（2）。 完全可变的机械气门机构的快速和精确地运行所需的驱动器的低摩擦和无间隙构造通过以下事实实现：调节轴（1）由包括调节器（3）的致动器（3）旋转， 杠杆（4）旋转地快速地连接到调节轴（1），而调节杆的自由端优选地铰接在由电动机驱动的螺母和螺母驱动器（5）的螺母（10）上 （6）。

公开(公告)号：US5015728A

公开(公告)日：1991-05-14

申请号：US172236

申请日：1988-03-23

申请人： Rainer Obermeier ,  Rolf Geiger ,  Ulrich Grau

发明人： Rainer Obermeier ,  Rolf Geiger ,  Ulrich Grau

IPC分类号： C07K14/575 ,  A61K38/00 ,  A61K38/28 ,  A61P5/00 ,  C07K14/62 ,  C12P21/02

CPC分类号： C07K14/62 ,  A61K38/00 ,  Y02P20/55

摘要： The invention relates to a process for the preparation of an insulin derivative of the formula I ##STR1## in which R.sup.1 denotes H or H-Phe, R.sup.30 represents the radical of a naturally occurring L-aminoacid and R.sup.31 represents a physiologically acceptable organic group of neutral or basic character consisting of 1 to 3 .alpha.-aminoacids in which the terminal carboxyl function is present in the free form and which insulin derivative has an isoelectric point above 5.8, which comprises reacting an insulin of the formula I in which R.sup.30 denotes the radical of a genetically codable L-aminoacid and R.sup.31 represents OH or a protective group of the carboxyl function, with a peptide or aminoacid derivatives of the formula R-R.sup.30 -R.sup.31 consisting of 2 to 4 .alpha.-aminocacids, in which the terminal carboxyl function is in free form, in the presence of a trypsin-like endopeptidase at a pH value below the isoelectric point of the starting insulin.

摘要翻译： 本发明涉及一种制备式I（I）的胰岛素衍生物的方法，其中R1表示H或H-Phe，R30表示天然存在的L-氨基酸的基团，R31表示生理上可接受的 由1〜3个α-氨基酸组成的中性或碱性有机基团，其中末端羧基官能团以游离形式存在，哪种胰岛素衍生物具有高于5.8的等电点，其包括使式I的胰岛素与R30 表示可遗传编码的L-氨基酸的基团，R31表示OH或羧基官能团的保护基团，具有由2至4个α-氨基酸组成的式R-R30-R31的肽或氨基酸衍生物，其中末端 在胰蛋白酶样内肽酶的存在下，羧基功能是游离形式，其pH值低于起始胰岛素的等电点。

公开(公告)号：US4850966A

公开(公告)日：1989-07-25

申请号：US17617

申请日：1987-02-24

申请人： Ulrich Grau ,  Wolfgang Pohler

发明人： Ulrich Grau ,  Wolfgang Pohler

IPC分类号： A61J1/05 ,  A61J1/06 ,  A61M5/24 ,  A61M5/31

CPC分类号： A61M5/2448 ,  A61J1/062 ,  B01F13/0052 ,  B01F15/00512 ,  Y10S604/903

摘要： A medicament container, such as an injection ampule, for multiple administration of medicament suspensions the containers is filled with medicament so as to be free of gas bubbles, and includes at least one inert mixing element of suitable size whose density is different from that of the suspension. The mixing element acts to homogenize the medicament suspension as the container is shaken.

摘要翻译： 用于多次施用药物悬浮液的药剂容器，例如注射安瓿，容器被填充有药物以便不含气泡，并且包括至少一种适合尺寸的惰性混合元件，其密度不同于 悬挂。 当容器摇动时，混合元件用于使药物悬浮液均匀化。

公开(公告)号：US20110140378A1

公开(公告)日：2011-06-16

申请号：US13054225

申请日：2009-06-22

申请人： Ulrich Grau ,  Thorsten Meyerhoefer ,  Ralf Mayer

发明人： Ulrich Grau ,  Thorsten Meyerhoefer ,  Ralf Mayer

IPC分类号： B60G17/015 ,  F16H1/28 ,  B60G21/055 ,  H02K7/108

CPC分类号： B60G21/0555 ,  B60G2202/42 ,  B60G2204/419 ,  F16D7/08

摘要： An electromechanical actuator, especially for an anti-roll bar of a motor vehicle, that has two actuator elements, which can be rotated relative to each other about a common rotational axis, for which purpose an electric motor and a gearbox coupled therewith are provided. The electric motor is arranged in an actuator element for transmitting a torque, and an output shaft of the gearbox is coupled to the other actuator element. A mechanical overload coupling is provided in the torque-transmitting load path from the electric motor to the gearbox output shaft.

摘要翻译： 一种机电致动器，特别是用于机动车辆的防倾杆，其具有两个致动器元件，该致动器元件可围绕共同的旋转轴线相对于彼此旋转，为此，提供了与其耦合的电动马达和齿轮箱。 电动机布置在用于传递扭矩的致动器元件中，并且齿轮箱的输出轴联接到另一个致动器元件。 在从电动机到变速箱输出轴的扭矩传递负载路径中提供机械过载联轴器。

公开(公告)号：US20070080513A1

公开(公告)日：2007-04-12

申请号：US10574379

申请日：2004-08-25

申请人： Jurgen Osterlanger ,  Manfred Kraus ,  Ulrich Grau ,  Ivo Agner ,  Oswald Friedmann ,  Dirk Eifler ,  Wolfgang Hill ,  Manuel Metzinger

发明人： Jurgen Osterlanger ,  Manfred Kraus ,  Ulrich Grau ,  Ivo Agner ,  Oswald Friedmann ,  Dirk Eifler ,  Wolfgang Hill ,  Manuel Metzinger

IPC分类号： B62D17/00

CPC分类号： B60G3/26 ,  B60G7/008 ,  B60G2200/142 ,  B60G2200/46 ,  B60G2204/129 ,  B60G2204/148 ,  B60G2204/418 ,  B60G2204/4232 ,  B60G2206/50 ,  B62D17/00

摘要： A device for modifying the wheel camber of a wheel (1) on a motor vehicle is provided, in which the heel (1) is pivotally mounted to a wheel carrier (5, 51) by a pivot bearing (4, 50). A pivoting plane is defined by the pivot bearing (4, 50) which extends in an approximately transverse manner to a central plane (E) of the wheel, the position of a virtual center of rotation (D) of the pivot bearing (4, 50) lying above the wheel contact plane and on a side of the central plane (E) of the wheel that faces toward the vehicle.

摘要翻译： 提供了一种用于修改机动车辆上的车轮（1）的车轮外倾的装置，其中脚跟（1）通过枢转轴承（4,50）枢转地安装到车轮承载件（5,51）。 枢转轴承（4,50）以枢转轴承（4,50）的虚拟中心（D）的中心平面（E）的方式大致横向地延伸， 50）位于车轮接触平面上方和面向车辆的车轮的中心平面（E）的一侧。

公开(公告)号：US4801684A

公开(公告)日：1989-01-31

申请号：US924850

申请日：1986-09-02

申请人： Ulrich Grau

发明人： Ulrich Grau

IPC分类号： C07K1/30 ,  C07K1/107 ,  C07K1/113 ,  C07K14/575 ,  C07K14/62 ,  C07K14/625 ,  C07K7/40

CPC分类号： C07K14/625 ,  Y10S930/26

摘要： A process for the preparation of insulin precursors of the formula (I) ##STR1## in which R is hydrogen or the presequence P.sub.m --Q.sub.n --, in which P is a sequence of naturally occurring amino acids with m being from 0 to 50, Q are basic natural amino acids, and n is an integer from 1 to 4, Y represents --Lys.sup.B29 --Z.sup.B30 --, in which Z denotes Ala, Thr or Ser, and the bridge extending from A-1 to A-21 is an insulin A-chain, the bridge extending from B-1 to B-30 represents an insulin B-chain, and X is a bridge which is bonded to the insulin A-chain at the amino group of A-1 and is bonded to the insulin B-chain at the .epsilon.-amino group of B-29-- in which case it is bonded to the free bond of Z.sup.B30 OH-- or at the carboxyl group of B-30, from reaction mixtures which result from folding of insulin precursors from S-sulfonates of the formula (II) ##STR2## in which R, X and Y have the abovementioned meanings, which comprises the false recombinants contained in the reaction mixture being precipitated by adjustment of the reaction mixture to pH 4 to 6, the precipitate being removed in customary manner and converted by sulfitolysis into the S-sulfonate of the formula (II), and the latter then being subjected to renewed folding.

摘要翻译： PCT No.PCT / EP86 / 00008 Sec。 371日期1986年9月2日第 102（e）1986年9月2日PCT PCT 1月11日，PCT PCT。 出版物WO86 / 04335 日期：1986年7月31日。一种制备式（I）的胰岛素前体的方法，其中R是氢或前序Pm-Qn-，其中P是天然存在的氨基 具有0至50的m，Q是碱性天然氨基酸，n是1至4的整数，Y表示-LysB29-ZB30-，其中Z表示Ala，Thr或Ser，并且从A延伸的桥 -1至A-21是胰岛素A链，从B-1延伸到B-30的桥表示胰岛素B链，X是与氨基的氨基上的胰岛素A链结合的桥 A-1，并且在B-29-的ε-氨基处与胰岛素B链结合，在这种情况下，它与ZB30OH的游离键或B-30的羧基结合，由反应混合物 其中R，X和Y具有上述含义的式（II）的S-磺酸盐的胰岛素前体的折叠，其包含反应混合物中包含的假重组体 通过将反应混合物调节至pH4至6沉淀，以常规方式除去沉淀物并通过亚硫酸解转化成式（II）的S-磺酸盐，然后将其再进行折叠。

公开(公告)号：US06966286B2

公开(公告)日：2005-11-22

申请号：US10850240

申请日：2004-05-20

申请人： Ulrich Grau

发明人： Ulrich Grau

IPC分类号： F01L13/00 ,  F02D13/02 ,  F02D41/00 ,  F02D41/06 ,  F02D41/14 ,  F02D41/34 ,  F01L1/34

CPC分类号： F02D41/008 ,  F01L13/0015 ,  F01L13/0021 ,  F01L13/0026 ,  F01L2201/00 ,  F01L2800/00 ,  F02D13/0234 ,  F02D13/0238 ,  F02D41/0002 ,  F02D41/062 ,  F02D41/1454 ,  F02D41/1497 ,  F02D2013/0296 ,  F02D2041/001 ,  Y02T10/18 ,  Y02T10/42

摘要： A method for equalizing the filling of cylinders of a multi-cylinder internal combustion engine (14) comprising a fully variable mechanical valve train (20) having an adjusting shaft (1) that controls the valve lift of the inlet valves of a cylinder bank and can be rotated together with its rotationally fixed adjusting cam (2) by an electromechanical actuator (3) whereby an equalization of the filling of the individual cylinders is achieved by the fact that filling-dependent engine data are measured by a sensor (16) while the engine (14) is running and are processed using suitable software in a control device (15) into signals with which the actuator (3) rotates the adjusting shaft (1) selectively for each cylinder in keeping with the opening phase and thus regulates the lift and the time cross-section of the individual inlet valves and, as a consequence, also the filling of the individual cylinders to a desired set value.

摘要翻译： 一种用于均衡多气缸内燃机（14）的气缸的填充的方法，包括具有调节轴（1）的完全可变的机械气门机构（20），所述调节轴（1）控制气缸组的入口阀的气门升程， 可以通过机电致动器（3）与其旋转固定的调节凸轮（2）一起旋转，由此通过传感器（16）测量与填充相关的发动机数据的事实来实现各个气缸的填充的均衡，同时 发动机（14）运行并使用控制装置（15）中的合适的软件进行处理，使得致动器（3）根据开启阶段选择性地为每个气缸旋转调节轴（1），从而调节 提升和各个入口阀的时间横截面，结果也将各个气缸的填充达到所需的设定值。

公开(公告)号：US06550755B2

公开(公告)日：2003-04-22

申请号：US09937958

申请日：2002-03-15

申请人： Herbert Ehrhardt ,  Ulrich Grau ,  Gerhard Meyer ,  Alexander Zernickel ,  Vladimir Kobelev ,  Markus Röhling

发明人： Herbert Ehrhardt ,  Ulrich Grau ,  Gerhard Meyer ,  Alexander Zernickel ,  Vladimir Kobelev ,  Markus Röhling

IPC分类号： F16F106

CPC分类号： B60G15/068 ,  B60G15/063 ,  B60G15/07 ,  B60G2200/142 ,  B60G2200/44 ,  B60G2202/312 ,  B60G2204/1242 ,  B60G2204/418 ,  B60G2206/426

摘要： A coil spring (1) and support bearing (2) arrangement for suspension struts (3) with a shock absorber, supporting a steering knuckle of an automobile has a rolling-contact bearing (7), with an axis (x); a receiving body (6), arranged below the rolling-contact bearing (7) in which the rolling-contact bearing is inserted; and a coil spring (1). The coil spring (1) has a force application line (f), which is offset relative to the axis (x) of the rolling-contact bearing (7) at an angle (a). The coil spring (1) has a first portion (8), which, starting from the winding end (17), winds around the receiving body (6). The first portion (8) abuts the receiving body (6). The winding end (17) of the coil spring (1) is arranged in the area of the plane E1 formed by the force application line (f) and the axis (x). Thus, the axial forces acting from the coil spring (1) onto the rolling-contact bearing (7) have a maximum in the area of the force application line (f) of the transversal forces acting on the rolling-contact bearing (7).

摘要翻译： 具有支撑汽车转向节的减振器的悬挂支杆（3）的螺旋弹簧（1）和支撑轴承（2）布置具有轴线（x）的滚动接触轴承（7）。 接收体（6），布置在滚动接触轴承（7）的下方，滚动接触轴承插入其中; 和螺旋弹簧（1）。 螺旋弹簧（1）具有力作用线（f），其相对于滚动接触轴承（7）的轴线（x）以角度（a）偏移。 螺旋弹簧（1）具有从卷绕端（17）开始的第一部分（8）绕着接收体（6）缠绕。 第一部分（8）邻接接收体（6）。 螺旋弹簧（1）的卷绕端（17）布置在由施力线（f）和轴线（x）形成的平面E1的区域中。 因此，从螺旋弹簧（1）作用到滚动接触轴承（7）上的轴向力在作用在滚动接触轴承（7）上的横向力的施力线（f）的面积上具有最大值， 。