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公开(公告)号：US20050182138A1
公开(公告)日：2005-08-18
申请号：US11075232
申请日：2005-03-08
申请人： Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye Mamo
发明人： Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye Mamo
IPC分类号： C07K5/02 , C07K5/103 , A61K31/165 , C07C237/40
CPC分类号： C07K5/101 , C07K5/0205
摘要： Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.
摘要翻译： 提供了二肽衍生的β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Abeta肽沉积为特征的其它疾病。 本发明的化合物提供了通过施用这些抑制剂以减少Aβ肽形成和药物组合物治疗的有用方法。
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公开(公告)号：US06992081B2
公开(公告)日：2006-01-31
申请号：US09960634
申请日：2001-09-21
申请人： Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
发明人： Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
IPC分类号： A01N43/46 , A01N43/58 , A61K31/55 , A61K31/54 , A61K31/535
CPC分类号： C07D295/185 , A61K38/00 , C07B2200/07 , C07C237/22 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D307/14 , C07D307/33 , C07D307/52 , C07D403/02 , C07D413/02 , C07D417/02 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
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公开(公告)号：US20060287306A1
公开(公告)日：2006-12-21
申请号：US11345660
申请日：2006-01-31
申请人： Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
发明人： Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/496 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D295/185 , A61K38/00 , C07B2200/07 , C07C237/22 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D307/14 , C07D307/33 , C07D307/52 , C07D403/02 , C07D413/02 , C07D417/02 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及用于治疗阿尔茨海默病和其他类似疾病的式（XII）（XIII）和（XIV）的取代的羟基亚乙基化合物。
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公开(公告)号：US20060276642A1
公开(公告)日：2006-12-07
申请号：US11405705
申请日：2006-04-17
申请人： Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
发明人： Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
IPC分类号： C07D471/02 , C07D279/12 , C07D211/26 , C07D237/28
CPC分类号： C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
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公开(公告)号：US07276484B2
公开(公告)日：2007-10-02
申请号：US11075232
申请日：2005-03-08
申请人： Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
发明人： Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
IPC分类号： C07K5/06
CPC分类号： C07K5/101 , C07K5/0205
摘要： Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.
摘要翻译： 提供了二肽衍生的β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Abeta肽沉积为特征的其它疾病。 本发明的化合物提供了通过施用这些抑制剂以减少Aβ肽形成和药物组合物治疗的有用方法。
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公开(公告)号：US06864240B1
公开(公告)日：2005-03-08
申请号：US09594978
申请日：2000-06-15
申请人： Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
发明人： Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
CPC分类号： C07K5/101 , C07K5/0205
摘要： Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.
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公开(公告)号：US06737420B2
公开(公告)日：2004-05-18
申请号：US09815960
申请日：2001-03-23
申请人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号： A01N5502
CPC分类号： C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII): useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及式（XII）的取代羟基亚乙基化合物：可用于治疗阿尔茨海默氏病和其它类似疾病。
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公开(公告)号：US07119085B2
公开(公告)日：2006-10-10
申请号：US09816876
申请日：2001-03-23
申请人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号： A61K31/55 , A61K31/535 , A61K31/35 , A61K31/34
CPC分类号： C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
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公开(公告)号：US07030239B2
公开(公告)日：2006-04-18
申请号：US10847819
申请日：2004-05-18
申请人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号： C07D237/00 , C07D237/02 , C07D237/26 , C07D237/28 , C07D487/00
CPC分类号： C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及可用于治疗阿尔茨海默氏病和其他类似疾病的式（XII）的取代的羟基亚乙基化合物。
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公开(公告)号：US20070213316A1
公开(公告)日：2007-09-13
申请号：US11636903
申请日：2006-12-11
申请人： Varghese John , Michel Maillard , Barbara Jagodzinska , James Beck , Andrea Gailunas , John Freskos , John Mickelson , Lakshman Samala , Jennifer Sealy , Ruth TenBrink , Lawrence Fang , Roy Hom
发明人： Varghese John , Michel Maillard , Barbara Jagodzinska , James Beck , Andrea Gailunas , John Freskos , John Mickelson , Lakshman Samala , Jennifer Sealy , Ruth TenBrink , Lawrence Fang , Roy Hom
IPC分类号： A61K31/553 , A61K31/554 , A61K31/55 , A61K31/54 , A61K31/5377 , A61K31/275 , A61K31/4965
CPC分类号： C07D263/32 , C07C233/36 , C07C233/40 , C07C233/58 , C07C233/78 , C07C235/20 , C07C235/50 , C07C235/74 , C07C237/04 , C07C237/06 , C07C237/08 , C07C237/22 , C07C237/42 , C07C251/38 , C07C255/58 , C07C271/28 , C07C271/44 , C07C311/08 , C07C311/16 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/37 , C07C317/46 , C07C317/50 , C07C323/60 , C07C323/62 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/267 , C07D207/27 , C07D209/42 , C07D211/58 , C07D211/60 , C07D211/96 , C07D213/71 , C07D213/80 , C07D213/82 , C07D213/85 , C07D215/36 , C07D215/42 , C07D215/48 , C07D215/56 , C07D217/22 , C07D231/14 , C07D231/38 , C07D233/84 , C07D233/90 , C07D237/14 , C07D239/28 , C07D239/42 , C07D239/48 , C07D241/20 , C07D241/24 , C07D241/44 , C07D243/08 , C07D249/06 , C07D249/10 , C07D251/46 , C07D251/54 , C07D257/04 , C07D257/06 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D263/48 , C07D263/54 , C07D263/58 , C07D265/36 , C07D271/08 , C07D271/12 , C07D275/06 , C07D277/30 , C07D277/36 , C07D277/56 , C07D277/68 , C07D277/82 , C07D279/16 , C07D285/06 , C07D285/10 , C07D285/135 , C07D295/155 , C07D295/185 , C07D295/192 , C07D295/26 , C07D307/20 , C07D307/46 , C07D307/68 , C07D307/84 , C07D307/86 , C07D307/91 , C07D311/04 , C07D333/22 , C07D333/32 , C07D333/34 , C07D333/38 , C07D333/62 , C07D333/68 , C07D335/06 , C07D401/04 , C07D405/12 , C07D409/04 , C07D411/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D473/06 , C07D473/08 , C07D473/16 , C07D487/04 , C07D495/04
摘要： Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
摘要翻译： 公开了下式的化合物，其中R 1，R 2，R 1，R 2，R 2，R 2， ＆lt; 2＆gt;和＆lt; 3＆gt;如本文所定义。 这些化合物具有作为β-分泌酶抑制剂的活性，因此可用于治疗诸如阿尔茨海默氏病之类的各种紊乱。
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