-
公开(公告)号：US20240307524A1
公开(公告)日：2024-09-19
申请号：US18576969
申请日：2022-07-07
IPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00
CPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00 , C12N2770/00022 , C12N2770/00034
摘要： The present invention provides multimeric protein complex comprising three polypeptides each comprising N- to C-terminally: (i) a receptor-binding domain (RBD) of an S1 subunit of an S protein of a coronavirus, (ii) optionally a S2 subunit of an S protein of a coronavirus; and (iii) a multimerization domain comprising a collagen-like region (CLR) of ficolin-2, wherein the multimerization domain enables the assembly of the polypeptides into a multimeric protein complex. The present invention further provides polynucleotides encoding the polypeptides of the multimeric protein complex, expression vectors, pharmaceutical compositions and uses of the multimeric protein complexes, such as a vaccine.
-
公开(公告)号：US20240285792A1
公开(公告)日：2024-08-29
申请号：US18426706
申请日：2024-01-30
CPC分类号： A61K47/6901 , A61K9/0019 , A61K9/5184 , A61K31/555 , A61K39/12 , A61P35/00 , A61K2039/585 , C12N2750/12022 , C12N2750/12023 , C12N2770/00034 , C12N2770/00042 , C12N2770/32022 , C12N2770/32023
摘要： Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
-
公开(公告)号：US20240271147A1
公开(公告)日：2024-08-15
申请号：US18568456
申请日：2022-06-10
IPC分类号： C12N15/82 , C07K14/005
CPC分类号： C12N15/8201 , C07K14/005 , C12N2770/00022 , C12N2770/00023 , C12N2770/00034 , C12N2770/00042
摘要： Provided herein is a method for stabilising a single stranded RNA (ssRNA) by encapsidation of the ssRNA with a tobamovirus coat protein to obtain a pseudovirion (PsV), the method comprising expressing a tobamovirus coat protein and the ssRNA comprising a tobamovirus encapsidation origin (OriA), wherein the expressed tobamovirus coat protein interacts with the OriA sequence on the ssRNA to initiate encapsidation of the ssRNA by the tobamovirus coat protein, thereby forming a pseudovirion. The PsVs produced according to the method can be used as a diagnostic control composition, where the ssRNA is a sequence detected by a molecular diagnostic assay. The pseudovirions may also be used as a vaccine to elicit an immune response in a subject, and in pharmaceutical compositions to be administered to a subject.
-
公开(公告)号：US10052377B2
公开(公告)日：2018-08-21
申请号：US15397214
申请日：2017-01-03
发明人： Eric James Gowans
IPC分类号： A61K35/12 , A61K39/29 , A61K31/711 , A61K39/12 , A61K39/21 , C12N7/00 , A61K35/15 , A61K39/00
CPC分类号： A61K39/29 , A61K31/711 , A61K35/12 , A61K35/15 , A61K39/12 , A61K39/21 , A61K2039/515 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/6037 , A61K2039/605 , A61K2039/6068 , C07K2319/00 , C07K2319/40 , C07K2319/50 , C07K2319/55 , C12N7/00 , C12N2740/16234 , C12N2770/00034 , C12N2770/24234 , A61K2300/00
摘要： The present invention relates to methods of inducing or enhancing an immune response against an immunogen in a subject. The invention further includes isolated nucleic acid vaccines, cellular vaccines, fusion proteins, expression vectors, vaccines, and immunogenic compositions for use therein.
-
公开(公告)号：US20170106081A1
公开(公告)日：2017-04-20
申请号：US15397214
申请日：2017-01-03
发明人： Eric James Gowans
CPC分类号： A61K39/29 , A61K31/711 , A61K35/12 , A61K35/15 , A61K39/12 , A61K39/21 , A61K2039/515 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/6037 , A61K2039/605 , A61K2039/6068 , C07K2319/00 , C07K2319/40 , C07K2319/50 , C07K2319/55 , C12N7/00 , C12N2740/16234 , C12N2770/00034 , C12N2770/24234 , A61K2300/00
摘要： The present invention relates to methods of inducing or enhancing an immune response against an immunogen in a subject. The invention further includes isolated nucleic acid vaccines, cellular vaccines, fusion proteins, expression vectors, vaccines, and immunogenic compositions for use therein.
-
6.发明申请POLYPEPTIDE DERIVED FROM gp41, A VACCINE COMPOSITION COMPRISING SAID POLYPEPTIDE, AND USES FOR TREATING AN INFECTION BY AN HIV VIRUS IN AN INDIVIDUAL 审中-公开从gp41衍生的多肽，包含上述多肽的疫苗组合物，以及用于治疗HIV病毒感染个体的用途公开(公告)号：US20140335119A1
公开(公告)日：2014-11-13
申请号：US14286467
申请日：2014-05-23
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Assistance Publique Hopitaux de Paris
发明人： Vincent VIEILLARD , Patrice DEBRE
CPC分类号： A61K39/21 , A61K2039/57 , A61K2039/6081 , A61K2039/64 , C07K14/005 , C07K16/1063 , C07K16/2803 , C07K2317/76 , C07K2317/92 , C12N7/00 , C12N2740/16134 , C12N2770/00034 , G01N15/1459 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2015/149
摘要： The present invention relates to the field of the in vitro diagnosis of the progression status of an infection of an individual with a virus belonging to the family of the Human Immunodeficiency Viruses (HIV) as well as with the therapeutical treatment of this infectious disease. The invention also relates to immunological compounds and vaccine compositions comprising a polypeptide derived from gp41.
摘要翻译： 本发明涉及体外诊断患有属于人类免疫缺陷病毒（HIV）家族的病毒的个体的感染进展状态的领域以及该感染性疾病的治疗方法。 本发明还涉及包含衍生自gp41的多肽的免疫化合物和疫苗组合物。
-
公开(公告)号：US20180133304A1
公开(公告)日：2018-05-17
申请号：US15589677
申请日：2017-05-08
IPC分类号： A61K39/12 , A61P35/00 , A61P35/04 , A61K31/704
CPC分类号： A61K39/12 , A61K31/704 , A61K2039/5258 , A61K2039/544 , A61K2039/585 , A61P35/00 , A61P35/04 , C12N7/00 , C12N2770/00023 , C12N2770/00034 , C12N2770/00071 , C12N2770/32022 , C12N2770/32023 , C12N2770/32034 , C12N2770/32071
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
-
公开(公告)号：US09879230B2
公开(公告)日：2018-01-30
申请号：US14344360
申请日：2012-09-12
CPC分类号： C12N7/00 , C12N15/86 , C12N2740/15022 , C12N2740/15034 , C12N2740/15043 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334 , C12N2770/00021 , C12N2770/00034
摘要： Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5′ and 3′ long terminal repeat sequences (LTRs) of the caprine lentivirus: the Caprine Arthritis Encephalitis Virus (CAEV) or of another retrovirus not integrating human cells and at least one viral gene of another retrovirus. A vector including such a nucleic acid, an immunogenic or vaccinal composition including the vector or the nucleic acid, as well as their use for treating and/or preventing an infection by a retrovirus or a disease induced by a pathogenic agent are also described.
-
公开(公告)号：US20170298370A1
公开(公告)日：2017-10-19
申请号：US15477563
申请日：2017-04-03
CPC分类号： C12N15/8203 , C12N7/00 , C12N15/86 , C12N2770/00034 , C12N2770/00043
摘要： Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes. Specifically exemplified herein are vectors for transfecting citrus trees. The vectors allow for the expression of useful proteins, such as those that can protect the tree from disease. Specifically exemplified herein are methods of transfecting woody trees that allow multiple applications of vectors while avoiding superinfection exclusion.
-
10.发明授权公开(公告)号：US09585952B2
公开(公告)日：2017-03-07
申请号：US14401182
申请日：2013-05-16
发明人： Eric James Gowans
IPC分类号： A61K47/48 , A61K39/29 , A61K31/711 , A61K39/12 , A61K35/12 , A61K39/21 , C12N7/00 , A61K39/00
CPC分类号： A61K39/29 , A61K31/711 , A61K35/12 , A61K35/15 , A61K39/12 , A61K39/21 , A61K2039/515 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/6037 , A61K2039/605 , A61K2039/6068 , C07K2319/00 , C07K2319/40 , C07K2319/50 , C07K2319/55 , C12N7/00 , C12N2740/16234 , C12N2770/00034 , C12N2770/24234 , A61K2300/00
摘要： The present invention relates to methods of inducing or enhancing an immune response against an immunogen in a subject. The invention further includes isolated nucleic acid vaccines, cellular vaccines, fusion proteins, expression vectors, vaccines, and immunogenic compositions for use therein.
摘要翻译： 本发明涉及在受试者中诱导或增强针对免疫原的免疫应答的方法。 本发明还包括分离的核酸疫苗，细胞疫苗，融合蛋白，表达载体，疫苗和用于其中的免疫原性组合物。
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.019 秒)
