公开(公告)号：US20240360405A1

公开(公告)日：2024-10-31

申请号：US18696177

申请日：2022-09-30

申请人： LG CHEM, LTD.

发明人： Jungyeon LEE ,  Min Kyung SUNG ,  Jae Hyung KIM

IPC分类号： C12N1/20 ,  C12N9/02 ,  C12N9/10 ,  C12N9/22 ,  C12N9/88 ,  C12P7/52 ,  C12R1/19

CPC分类号： C12N1/205 ,  C12N9/0008 ,  C12N9/1085 ,  C12N9/22 ,  C12N9/88 ,  C12P7/52 ,  C12N2310/20 ,  C12R2001/19 ,  C12Y102/01003 ,  C12Y205/01006 ,  C12Y402/0103

摘要： The present specification pertains to a microorganism and/or Escherichia coli and a use thereof, wherein the microorganism and/or Escherichia coli has 3-hydroxypropionic acid or 3-hydroxypropionate (3-HP) production ability, with a foreign 3-HP production gene inserted into the genomic DNA thereof, and has a use of measuring the production ability of the inserted 3-HP production gene.

公开(公告)号：US12104160B2

公开(公告)日：2024-10-01

申请号：US17307850

申请日：2021-05-04

申请人： ZYMOCHEM, INC.

发明人： Harshal Chokhawala

IPC分类号： C12P7/42 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/24 ,  C12N9/88 ,  C12N15/52 ,  C12P7/04 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/44 ,  C12P7/6409 ,  C12P13/00 ,  C12P17/08 ,  C12P17/10

CPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0016 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/88 ,  C12N9/93 ,  C12P7/04 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/6409 ,  C12P13/001 ,  C12P13/005 ,  C12P17/08 ,  C12P17/10 ,  C12Y101/01001 ,  C12Y101/01002 ,  C12Y101/01035 ,  C12Y101/01078 ,  C12Y101/01268 ,  C12Y101/01269 ,  C12Y102/01003 ,  C12Y102/01005 ,  C12Y102/01022 ,  C12Y102/01024 ,  C12Y102/01026 ,  C12Y102/01048 ,  C12Y102/01063 ,  C12Y102/07005 ,  C12Y102/99006 ,  C12Y103/01044 ,  C12Y103/01045 ,  C12Y103/01086 ,  C12Y104/01 ,  C12Y203/01001 ,  C12Y203/01032 ,  C12Y203/01035 ,  C12Y203/01057 ,  C12Y206/01008 ,  C12Y206/01009 ,  C12Y206/01036 ,  C12Y206/01043 ,  C12Y206/01048 ,  C12Y206/01076 ,  C12Y206/01082 ,  C12Y207/01031 ,  C12Y207/01165 ,  C12Y208/03 ,  C12Y301/03 ,  C12Y301/03002 ,  C12Y301/03008 ,  C12Y301/03019 ,  C12Y301/0302 ,  C12Y302/01 ,  C12Y401/01001 ,  C12Y401/02 ,  C12Y401/02014 ,  C12Y401/0202 ,  C12Y401/02021 ,  C12Y401/03016 ,  C12Y401/03017 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y402/01028 ,  C12Y402/0103 ,  C12Y402/01079 ,  C12Y402/0112 ,  C12Y602/01 ,  Y02E50/30

摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3 β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.

公开(公告)号：US20240316123A1

公开(公告)日：2024-09-26

申请号：US18616811

申请日：2024-03-26

申请人： ZBiotics Company

发明人： Zachary Abbott

IPC分类号： A61K35/742 ,  A61K9/00 ,  A61K35/00 ,  A61K35/741 ,  A61K38/00 ,  A61P39/02 ,  C07K14/32 ,  C12N9/02 ,  C12N15/63

CPC分类号： A61K35/742 ,  A61K9/0053 ,  A61P39/02 ,  C07K14/32 ,  C12N9/0008 ,  C12N15/63 ,  C12Y102/01003 ,  A61K9/0095 ,  A61K2035/115 ,  A61K35/741 ,  A61K38/00

摘要： Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

公开(公告)号：US20240191164A1

公开(公告)日：2024-06-13

申请号：US18532529

申请日：2023-12-07

申请人： Voodoo Scientific USA, Inc.

发明人： Joana Montenegro ,  Martin Duncan Enriquez

IPC分类号： C12G3/08 ,  C12G3/021 ,  C12G3/07 ,  C12N9/02

CPC分类号： C12G3/08 ,  C12G3/021 ,  C12G3/07 ,  C12N9/0008 ,  C12Y102/01003 ,  C12Y102/01004

摘要： Methods of producing a consumable alcoholic product involve utilizing one or more enzymes to reduce or remove an oral pain response otherwise experienced upon consumption of the product. Methods involve admixing at least one oxidase with a fermentate and optionally distilling the fermentate to produce a consumable alcoholic product, such as a distilled alcohol. Methods involve admixing at least one oxidase comprising an aldehyde dehydrogenase.

公开(公告)号：US20240189400A1

公开(公告)日：2024-06-13

申请号：US18519569

申请日：2023-11-27

申请人： PICOENTECH Co., LTD.

发明人： Hung Taeck KWON

IPC分类号： A61K38/44 ,  A61K9/00 ,  A61K36/064

CPC分类号： A61K38/44 ,  A61K9/0056 ,  A61K36/064 ,  C12Y102/01003

摘要： A food and drug composition for suppressing tremor or movement disorder, containing novel aldehyde dehydrogenase encoded by a gene having more than 98% homology to the gene of SEQ ID NO: 1. In addition, the embodiments relate to a food composition and pharmaceutical composition for suppressing tremor or movement disorder, containing a lysate of any one or a mixture thereof selected from KCTC13925BP, KCTC 14122BP, KCTC14123BP, KCTC14983BP, KCTC14984BP, and KCTC14985BP.

公开(公告)号：US20240182915A1

公开(公告)日：2024-06-06

申请号：US18519500

申请日：2023-11-27

申请人： PICOENTECH Co., LTD.

发明人： Hung Taeck KWON

IPC分类号： C12N15/81 ,  A61P3/00 ,  A61P25/00 ,  A61P39/06 ,  C12N1/18 ,  C12N9/02 ,  C12R1/865

CPC分类号： C12N15/81 ,  A61P3/00 ,  A61P25/00 ,  A61P39/06 ,  C12N1/185 ,  C12N9/0008 ,  C12R2001/865 ,  C12Y102/01003

摘要： Food and pharmaceutical compositions for promoting decomposition of the endogenous aldehyde produced by oxidation of an alcohol or an endogenous amine compound, including the aldehyde dehydrogenase contained in any one or a mixture thereof selected from Saccharomyces cerevisiae KCTC13925BP, KCTC14122BP, KCTC14123BP, KCTC14983BP, KCTC14984BP, and KCTC14985BP. The food and pharmaceutical composition suppress oxidative stress and auto-brewery symptom.

公开(公告)号：US20230416752A1

公开(公告)日：2023-12-28

申请号：US18036801

申请日：2021-11-12

申请人： Dicerna Pharmaceuticals, Inc.

发明人： Bob Dale BROWN ,  Henryk T. DUDEK ,  Utsav SAXENA

IPC分类号： C12N15/113 ,  A61K31/145 ,  A61K31/713

CPC分类号： C12N15/1137 ,  C12Y102/01003 ,  A61K31/145 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/315 ,  C12N2310/3125 ,  C12N2320/32 ,  C12N2320/53

摘要： This disclosure relates to chemically modified oligonucleotides, compositions, and methods useful for reducing ALDH2 expression, to treat alcoholism. Disclosed oligonucleotide for the reduction of ALDH2 expression is modified for enhanced pharmacological properties.

公开(公告)号：US20170204420A1

公开(公告)日：2017-07-20

申请号：US15405514

申请日：2017-01-13

申请人： INVISTA North American S.á r.I.

发明人： Adriana Leonora Botes ,  Alex Van Eck Conradie ,  Changlin Chen ,  Paul S. Pearlman

IPC分类号： C12N15/52 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12P7/24 ,  C12N9/02 ,  C12N9/00 ,  C12N9/80 ,  C12P7/44 ,  C12P13/00 ,  C12N9/04 ,  C12N9/16

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1288 ,  C12N9/16 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12P7/18 ,  C12P7/24 ,  C12P7/42 ,  C12P7/44 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01 ,  C12Y101/01085 ,  C12Y101/01087 ,  C12Y101/01258 ,  C12Y101/01286 ,  C12Y102/01 ,  C12Y102/01003 ,  C12Y102/0101 ,  C12Y102/99006 ,  C12Y203/01032 ,  C12Y203/03013 ,  C12Y203/03014 ,  C12Y206/01 ,  C12Y207/08 ,  C12Y208/03012 ,  C12Y301/02 ,  C12Y305/01062 ,  C12Y401/01043 ,  C12Y402/01033 ,  C12Y402/01036 ,  C12Y402/01114 ,  C12Y602/01005

摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.

公开(公告)号：US20170044551A1

公开(公告)日：2017-02-16

申请号：US15072140

申请日：2016-03-16

申请人： ZYMOCHEM INC.

发明人： Harshal Chokhawala

IPC分类号： C12N15/52 ,  C12N9/16 ,  C12N9/12 ,  C12N9/88 ,  C12P7/24 ,  C12N9/02 ,  C12P7/40 ,  C12P7/44 ,  C12P13/00 ,  C12P17/10 ,  C12P7/18 ,  C12P7/04 ,  C12P7/64 ,  C12N9/04 ,  C12N9/10 ,  C12N9/00 ,  C12N9/24 ,  C12N9/06 ,  C12P7/42

CPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0016 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/88 ,  C12N9/93 ,  C12P7/04 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/6409 ,  C12P13/001 ,  C12P13/005 ,  C12P17/08 ,  C12P17/10 ,  C12Y101/01001 ,  C12Y101/01002 ,  C12Y101/01035 ,  C12Y101/01078 ,  C12Y101/01268 ,  C12Y101/01269 ,  C12Y102/01003 ,  C12Y102/01005 ,  C12Y102/01022 ,  C12Y102/01024 ,  C12Y102/01026 ,  C12Y102/01048 ,  C12Y102/01063 ,  C12Y102/07005 ,  C12Y102/99006 ,  C12Y103/01044 ,  C12Y103/01045 ,  C12Y103/01086 ,  C12Y104/01 ,  C12Y203/01001 ,  C12Y203/01032 ,  C12Y203/01035 ,  C12Y203/01057 ,  C12Y206/01008 ,  C12Y206/01009 ,  C12Y206/01036 ,  C12Y206/01043 ,  C12Y206/01048 ,  C12Y206/01076 ,  C12Y206/01082 ,  C12Y207/01031 ,  C12Y207/01165 ,  C12Y208/03 ,  C12Y301/03 ,  C12Y301/03002 ,  C12Y301/03008 ,  C12Y301/03019 ,  C12Y301/0302 ,  C12Y302/01 ,  C12Y401/01001 ,  C12Y401/02 ,  C12Y401/02014 ,  C12Y401/0202 ,  C12Y401/02021 ,  C12Y401/03016 ,  C12Y401/03017 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y402/01028 ,  C12Y402/0103 ,  C12Y402/01079 ,  C12Y402/0112 ,  C12Y602/01 ,  Y02E50/343

摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.

摘要翻译： 本文提供了用于制备化合物如1-丁醇，丁酸，琥珀酸，1,4-丁二醇，1-戊醇，戊酸，戊二酸，1,5-戊二醇的方法，组合物和非天然存在的微生物生物 ，1-己醇，己酸，己二酸，1,6-己二醇，6-羟基己酸，ε-己内酯，6-氨基 - 己酸，ε-己内酰胺，六亚甲基二胺，线性脂肪酸和线性脂肪醇， 7-25碳原子长度为6-24个碳原子的直链烷烃和直链α-烯烃，癸二酸和十二烷二酸包括：a）通过醛醇加成将CN醛和丙酮酸盐转化为CN +3β-羟基酮中间体 ; 和b）通过酶促步骤或酶和化学步骤的组合将CN +3β-羟基酮中间体转化为化合物。

公开(公告)号：US20160230196A1

公开(公告)日：2016-08-11

申请号：US15015936

申请日：2016-02-04

申请人： GS CALTEX CORPORATION

发明人： Sang-Hyun LEE

IPC分类号： C12P7/16 ,  C12N9/10 ,  C12N9/04 ,  C12R1/145 ,  C12N9/02

CPC分类号： C12P7/16 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/13 ,  C12N15/52 ,  C12R1/145 ,  C12Y101/01001 ,  C12Y102/01003 ,  C12Y208/03009 ,  Y02E50/10

摘要： Embodiments of the invention provide a microorganism capable of simultaneous co-fermentation of two or more sugars in a lignocellulosic hydrolysate and having tolerance against microorganism growth inhibitory substances in the lignocellulosic hydrolysate and further having butanol productivity. In addition, embodiments of the invention provide a recombinant microorganism in which a pathway converting butyryl-CoA into butanol or a pathway converting butyrate into butyryl-CoA is promoted, and butanol productivity is increased. Further, a method for producing butanol using the microorganisms is provided.

摘要翻译： 本发明的实施方案提供了能够在木质纤维素水解产物中同时共发酵两种或更多种糖并且对木质纤维素水解产物中的微生物生长抑制物质具有耐受性并进一步具有丁醇生产力的微生物。 此外，本发明的实施方案提供了一种重组微生物，其中促进将丁酰辅酶A转化成丁醇或将丁酸转化成丁酰辅酶A的途径，并提高丁醇生产率。 此外，提供了使用微生物生产丁醇的方法。