公开(公告)号：US20240359009A1

公开(公告)日：2024-10-31

申请号：US18646450

申请日：2024-04-25

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Eduardo Jose Chichilnisky ,  Praful K. Vasireddy ,  Nishal Pradeepkumar Shah

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： Systems and methods for calibration of retinal prosthetics in accordance with embodiments of the invention are illustrated. A closed loop calibration process is described whereby a multi-electrode stimulation regime can be calibrated to a given user's retina. Multi-electrode stimulation can provide increased stimulation selectivity, but significantly increases complexity. Systems and methods described herein provide computational steps that significantly reduce the amount of trials and computation required in order to achieve clinically viable selectivity, making closed-loop calibration of retinal prosthetics possible in significantly less time than open-loop calibration.

公开(公告)号：US20240359006A1

公开(公告)日：2024-10-31

申请号：US18648764

申请日：2024-04-29

申请人： Northwestern University

发明人： Timothy L. Sita

IPC分类号： A61N1/36 ,  A61N1/04 ,  A61N1/20

CPC分类号： A61N1/36002 ,  A61N1/0408 ,  A61N1/205 ,  A61N1/36034

摘要： Electrical modulation provides treatment of brain tumors, such as glioblastoma. An electrical stimulus may be applied to the brain of a patient with a brain tumor (e.g., primary or metastatic brain tumor in upfront, adjuvant, or recurrent treatment setting) via bitemporal and/or unitemporal electrodes. The electrical modulation acts on brain tumor networks to slow tumor growth and increase survivability of the patient. The electrical modulation also transiently permits passage of therapeutics across the blood-brain barrier. The electrical modulation also sensitizes brain tumors to radiation therapy, immunotherapy, and chemotherapy.

公开(公告)号：US20240358492A1

公开(公告)日：2024-10-31

申请号：US18765429

申请日：2024-07-08

申请人： Peter Mats Forsell

发明人： Peter Mats Forsell

IPC分类号： A61F2/04 ,  A61B1/04 ,  A61B1/06 ,  A61B1/273 ,  A61B1/313 ,  A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/08 ,  A61B17/30 ,  A61B17/32 ,  A61B17/34 ,  A61F5/00 ,  A61N1/36

CPC分类号： A61F2/04 ,  A61B17/00234 ,  A61B17/0469 ,  A61B17/064 ,  A61F5/003 ,  A61F5/0083 ,  A61B1/04 ,  A61B1/06 ,  A61B1/2736 ,  A61B1/3132 ,  A61B17/00 ,  A61B2017/00278 ,  A61B2017/00561 ,  A61B2017/00818 ,  A61B2017/00827 ,  A61B17/068 ,  A61B17/0682 ,  A61B17/08 ,  A61B2017/081 ,  A61B17/30 ,  A61B2017/306 ,  A61B2017/308 ,  A61B17/320016 ,  A61B17/3423 ,  A61B17/3474 ,  A61F2002/044 ,  A61F2002/045 ,  A61F5/0003 ,  A61F5/0013 ,  A61F2005/0016 ,  A61F2005/002 ,  A61F2005/0023 ,  A61F5/0026 ,  A61F5/0033 ,  A61F5/0036 ,  A61F5/004 ,  A61F5/0043 ,  A61F5/0046 ,  A61F5/005 ,  A61F5/0063 ,  A61F5/0069 ,  A61F5/0073 ,  A61F5/0076 ,  A61F5/0079 ,  A61F5/0086 ,  A61F5/0089 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61N1/36007

摘要： A volume filling device for treatment of obesity is placed outside the stomach wall of the patient to reduce the inner volume of the stomach, thereby affecting the patient's appetite. By providing the volume filling device outside the stomach wall, contact with stomach acids is avoided, thereby increasing the life of the device.

公开(公告)号：US12128245B2

公开(公告)日：2024-10-29

申请号：US17045785

申请日：2019-04-12

申请人： KWANGWOON UNIVERSITY INDUSTRY-ACADEMIC COLLABORATION FOUNDATION

发明人： Nam Young Kim ,  Eun Seong Kim

IPC分类号： A61N1/40 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61N1/36 ,  A61N5/04

CPC分类号： A61N1/40 ,  A61N1/36002 ,  A61B2018/00333 ,  A61B2018/00446 ,  A61B2018/00452 ,  A61B2018/00494 ,  A61B2018/00511 ,  A61B2018/00517 ,  A61B2018/00529 ,  A61B2018/00541 ,  A61B2018/00547 ,  A61B2018/00559 ,  A61B18/12 ,  A61B18/1815 ,  A61N5/045

摘要： A device for inducing migration of cancer cells for cancer treatment includes an RF absorber including an antenna for irradiating a living tissue including cancer cells with an RF frequency of a specific band for cancer treatment.

公开(公告)号：US12128241B2

公开(公告)日：2024-10-29

申请号：US17643817

申请日：2021-12-10

申请人： Medtronic, Inc.

发明人： Todd D. Zenisek

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/37247 ,  A61N1/36135 ,  A61N1/36167

摘要： A medical system includes techniques for adjusting the cycling of electrical stimulation therapy delivered by a medical device based on user input. The disclosure describes techniques to iteratively adjust the duration that stimulation is delivered and not delivered based on user input indicative of patient's symptoms.

公开(公告)号：US12128236B2

公开(公告)日：2024-10-29

申请号：US18179845

申请日：2023-03-07

申请人： Boston Scientific Neuromodulation Corporation

发明人： Bradley L. Hershey ,  Changfang Zhu

IPC分类号： A61N1/36 ,  A61B5/24 ,  A61N1/00 ,  A61B5/00

CPC分类号： A61N1/36139 ,  A61B5/24 ,  A61N1/00 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36128 ,  A61B5/40 ,  A61N1/36125

摘要： An Implantable Pulse Generator (IPG) is disclosed that is capable of sensing a degree to which recruited neurons in a patient's tissue are firing synchronously, and of modifying a stimulation program to promote desynchronicity and to reduce paresthesia. An evoked compound action potential (ECAP) of the recruited neurons is sensed as a measure of synchronicity by at least one non-active electrode. An ECAP algorithm operable in the IPG assesses the shape of the ECAP and determines one or more ECAP shape parameters that indicate whether the recruited neurons are firing synchronously or desynchronously. If the shape parameters indicate significant synchronicity, the ECAP algorithm can adjust the stimulation program to promote desynchronous firing.

公开(公告)号：US20240350808A1

公开(公告)日：2024-10-24

申请号：US18685989

申请日：2022-08-26

申请人： GALVANI BIOELECTRONICS LIMITED

发明人： David Karl Lee PETERSON ,  Kevin KWONG ,  Gerald Edwin HUNSBERGER ,  Jason MIRANDA ,  Isha GUPTA ,  Paul MATTEUCCI ,  Daniel CHEW

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/08 ,  A61N1/375

CPC分类号： A61N1/3614 ,  A61N1/0556 ,  A61N1/36139 ,  A61N1/36142 ,  A61N1/36146 ,  A61N1/375 ,  A61N2001/083

摘要： Systems for applying electrical stimulation to a nerve and determining a change in measured impedance or sensed electrical fields that is indicative of an electrical event, are disclosed herein. The system comprises an implantable housing comprising a signal generator, an implantable neural interface, an impedance measuring circuit or an electrical field sensing circuit, and processing circuitry. Methods for determining the presence of an electrical event in a system for applying electrical stimulation to a nerve, are also disclosed herein. The method comprises periodically sensing an impedance in an electrical pathway and determining an electrical event in the electrical pathway by identifying a change in the sensed impedance.

公开(公告)号：US20240350806A1

公开(公告)日：2024-10-24

申请号：US18642248

申请日：2024-04-22

申请人： Regents of the University of Minnesota

发明人： Oscar Miranda Dominguez ,  Cristian Andres Morales Carrasco, III ,  Damien Fair

IPC分类号： A61N1/36 ,  A61N2/00 ,  G16H15/00 ,  G16H40/63

CPC分类号： A61N1/36128 ,  G16H15/00 ,  G16H40/63 ,  A61N2/006

摘要： Subject-specific energy distribution mapping of functional networks is used to inform the planning, guidance, and/or monitoring of neuromodulation, including non-invasive brain stimulation, deep brain stimulation, prefrontal cortical stimulation, intracranial electrical stimulation, focused ultrasound-based neuromodulation, pharmacological-based neuromodulation, or the like.

公开(公告)号：US12122058B2

公开(公告)日：2024-10-22

申请号：US17796191

申请日：2020-11-19

申请人： Panasonic Intellectual Property Management Co., Ltd.

发明人： Yoshiaki Kanamori ,  Kenji Narita

IPC分类号： B26B19/48 ,  A61N1/04 ,  A61N1/32 ,  A61N1/36

CPC分类号： B26B19/48 ,  A61N1/0428 ,  A61N1/0476 ,  A61N1/328 ,  A61N1/3603

摘要： A beauty instrument according to the present disclosure comprises a skin electrode disposed in a head, a grip electrode disposed in a grip, a voltage application circuit for applying a voltage between the skin electrode and the grip electrode to cause a current to flow between the skin electrode and the grip electrode through a human body, and a controller that controls the voltage application circuit. The controller comprises a touch detector that detects touch of a skin surface of the human body with the skin electrode. Before the touch detector detects the touch, the voltage application circuit is controlled to apply a first voltage having a relatively high frequency, and after the touch detector detects the touch, the voltage application circuit is controlled to apply a second voltage having a relatively low frequency.

公开(公告)号：US12121729B2

公开(公告)日：2024-10-22

申请号：US16335970

申请日：2017-09-25

申请人： Neural Integrative Solutions LLC

发明人： Steven M. Falowski

IPC分类号： A61N1/36 ,  A61B5/395 ,  A61N1/05 ,  A61N1/375

CPC分类号： A61N1/36135 ,  A61B5/395 ,  A61N1/0551 ,  A61N1/36 ,  A61N1/36128 ,  A61N1/36175 ,  A61N1/3752

摘要： Disclosed and described here are an adapter for a neuromonitoring system for placement of an electrode in a subject and a method for confirming placement of an electrode on an appropriate nerve fiber of a dorsal root ganglion during a dorsal root ganglion stimulation procedure.