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    New 2,4-dinitro- or 2-amino-4-nitro- or 2-nitro-4-amino-6-hydroxyalkylanilines, the process for preparation thereof and their use in dyeing keratinous fibres, and especially human hair
    92.
    发明授权
    New 2,4-dinitro- or 2-amino-4-nitro- or 2-nitro-4-amino-6-hydroxyalkylanilines, the process for preparation thereof and their use in dyeing keratinous fibres, and especially human hair 失效
    新的2,4-二硝基或2-氨基-4-硝基 - 或2-硝基-4-氨基-6-羟基烷基苯胺，其制备方法及其在染色角质纤维，特别是人类头发中的用途

    公开(公告)号：US4888445A

    公开(公告)日：1989-12-19

    申请号：US119083

    申请日：1987-11-10

    Applicant: Alex Junino ,  Gerard Lang ,  Nicole Jehanno

    Inventor： Alex Junino ,  Gerard Lang ,  Nicole Jehanno

    IPC: A61K8/41 ,  A61Q5/06 ,  A61Q5/10 ,  C07C215/68 ,  C09B51/00

    CPC classification number: A61K8/418 ,  A61Q5/065 ,  A61Q5/10

    Abstract: The invention relates to a compound of formula ##STR1## in which: X denotes a branched or unbranched alkylene radical containing 2 to 6 carbon atoms, optionally being able to be substituted with one or more hydroxyl radicals;R denotes a hydrogen atom, an alkyl or a mono- or polyhydroxyalkyl radical or an aminoalkyl radical in which the amine group can be mono- or disubstituted with an alkyl radical or with a mono- or polyhydroxyalkyl radical, the nitrogen atom also being able to form part of a heterocyclic system and the alkyl radicals containing 1 to 4 carbon atoms;R' denotes a hydrogen atom or a C.sub.1 to C.sub.4 alkyl radical;Y and Z denote a nitro and/or --NHR.sub.1 radical, R.sub.1 and R, which may be identical or different, having the meanings given above for R, with the proviso that when Y and Z are identical, they necessarily denote nitro radicals,and the cosmetically acceptable salts of the compounds containing a salifiable amine group, and also the process for preparing it and its use in dyeing keratinous fibres, and especially human hair.

    Abstract translation: 本发明涉及式（I）的化合物，其中：X表示含有2至6个碳原子的支链或非支链亚烷基，任选地可被一个或多个羟基取代; R表示氢原子，烷基或单羟基或多羟基烷基或氨基烷基，其中胺基可以被烷基或与单羟基或多羟基烷基单体或二取代，氮原子也可以 形成杂环体系的一部分和含有1至4个碳原子的烷基; R'表示氢原子或C1〜C4烷基; Y和Z表示硝基和/或-NHR 1基团，R 1和R可以相同或不同，具有上面对R给出的含义，条件是当Y和Z相同时，它们必须表示硝基，并且 含有可成胺基团的化合物的化妆品可接受的盐，以及其制备方法及其在染色角质纤维，特别是人类头发中的用途。

    New chloro-meta-phenylenediamines, their use as couplers in the oxidation dyeing of keratinous fibres, dyeing compositions for hair containing these compounds and dyeing process using the said
    95.
    发明授权
    New chloro-meta-phenylenediamines, their use as couplers in the oxidation dyeing of keratinous fibres, dyeing compositions for hair containing these compounds and dyeing process using the said 失效
    新的氯代间苯二胺，它们用作角质纤维的氧化染色中的成色剂，含有这些化合物的头发的染色组合物和使用所述

    公开(公告)号：US4865618A

    公开(公告)日：1989-09-12

    申请号：US200399

    申请日：1988-05-31

    Applicant: Alex Junino ,  Jean J. Vandenbossche ,  Herve Borowiak ,  Gerard Lang

    Inventor： Alex Junino ,  Jean J. Vandenbossche ,  Herve Borowiak ,  Gerard Lang

    IPC: A61K8/00 ,  A61K20060101 ,  A61K8/41 ,  A61Q5/10 ,  C07C20060101 ,  C07C215/20 ,  C07C217/84 ,  C09B53/02 ,  D06P1/32 ,  D06P3/04 ,  D06P3/14

    CPC classification number: A61K8/411 ,  A61Q5/10

    Abstract: New chloro-meta-phenylenediamines, their use as couplers in the oxidation dyeing of keratinous fibres, dyeing compositions for hair containing these compounds and dyeing process using the said compositions.The invention relates to the compounds of formula: ##STR1## in which Z and Z' denote, independently of one another, an alkyl radical having from 1 to 4 carbon atoms or a hydroxyalkyl radical having from 2 to 4 carbon atoms, andR.sub.1 and R.sub.2 denote, independently of one another, a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms or a mono- or polyhydroxyalkyl radical having 2 or 3 carbon atoms, to their addition salts with an acid, and to their use by way of couplers for the oxidation dyeing of keratinous fibres, especially human hair.These compounds, when they are combined with paraphenylenediamines, surprisingly give beige to light brown hues or purple hues of greater or lesser redness, depending on the substitution of the 5-amino group of the chlorobenzene.

    Abstract translation: 新的氯代间苯二胺，它们用作角质纤维的氧化染色中的成色剂，含有这些化合物的头发的染色组合物和使用所述组合物的染色方法。 本发明涉及下式的化合物：其中Z和Z'彼此独立地表示具有1至4个碳原子的烷基或具有2至4个碳原子的羟烷基， 并且R 1和R 2彼此独立地表示氢原子，具有1至4个碳原子的烷基或具有2或3个碳原子的单羟基或多羟基烷基，与它们与酸的加成盐，以及它们 通过成色剂用于角质纤维，特别是人类头发的氧化染色。 这些化合物当与对苯二胺结合时，令人惊讶的是，由于取代氯苯的5-氨基，令人惊讶的是，它使浅棕色色调或更多或更少发红的紫色色调发亮。

    Benzofuran derivatives and medicinal and cosmetic compositions containing them
    97.
    发明授权
    Benzofuran derivatives and medicinal and cosmetic compositions containing them 失效
    苯并呋喃衍生物和含有它们的药物和化妆品组合物

    公开(公告)号：US4775663A

    公开(公告)日：1988-10-04

    申请号：US19941

    申请日：1987-02-27

    Applicant: Serge Forestier ,  Alain Lagrange ,  Gerard Lang ,  Braham Shroot

    Inventor： Serge Forestier ,  Alain Lagrange ,  Gerard Lang ,  Braham Shroot

    IPC: C07D307/93 ,  A61K8/04 ,  A61K8/25 ,  A61K8/31 ,  A61K8/36 ,  A61K8/49 ,  A61K8/65 ,  A61K8/73 ,  A61K8/86 ,  A61K31/34 ,  A61K31/343 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61Q5/00 ,  A61Q5/02 ,  C07D307/94 ,  C07D307/77

    CPC classification number: A61K8/4973 ,  A61K8/671 ,  A61Q19/00 ,  C07D307/94 ,  A61Q17/04

    Abstract: A benzofuran derivative which is a compound of formula (I): ##STR1## wherein a to d each are 0 to 1, with a+b+c+d.gtoreq.2; R.sub.1 to R.sub.6 are each H or C.sub.1 -C.sub.6 alkyl; R.sub.7 is --CH.sub.2 OR.sub.8 (R.sub.8 =H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 mono- or polyhydroxyalkyl), --COR.sub.9 (R.sub.9 =H, C.sub.1 -C.sub.6 alkyl, ##STR2## which is an amino acid or amino sugar residue or where R' and R" are H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 mono- or polyhydroxyalkyl, C.sub.3 -C.sub.6 alkenyl or form a heterocycle) or OR.sub.10 (where R.sub.10 is H, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.6 mono- or polyhydroxyalkyl or --OR.sub.10 is derived from a sugar) has retinoid type action and can be used in cosmetics (body and hair hygiene) and in medicine (treatment of dermatological conditions; atopy; degenerative diseases of connective tissue; or corneopathies).

    Abstract translation: 作为式（I）的化合物的苯并呋喃衍生物：其中a至d各自为0至1，其中a + b + c + d> / = 2; R 1至R 6各自为H或C 1 -C 6烷基; R 7是-CH 2 OR 8（R 8 = H，C 1 -C 6烷基，C 2 -C 6单或多羟基烷基），-COR 9（R 9 = H，C 1 -C 6烷基，作为氨基酸或氨基糖残基或其中R '和R“是H，C 1 -C 6烷基，C 2 -C 6单或多羟基烷基，C 3 -C 6烯基或形成杂环）或OR 10（其中R 10是H，C 1 -C 20烷基，C 2 -C 6单或多羟基烷基 或-OR10衍生自糖）具有类视黄醇类作用，并且可用于化妆品（身体和头发卫生）和医学（治疗皮肤病学，特应性，结缔组织的退行性疾病或角膜炎）中。

    Cosmetic composition for protection against ultraviolet radiation and its use for this purpose
    100.
    发明授权
    Cosmetic composition for protection against ultraviolet radiation and its use for this purpose 失效
    用于防止紫外线辐射的化妆品组合物及其用于此目的

    公开(公告)号：US4726942A

    公开(公告)日：1988-02-23

    申请号：US575754

    申请日：1984-02-01

    Applicant: Gerard Lang ,  Alain Malaval ,  Madeleine Leduc

    Inventor： Gerard Lang ,  Alain Malaval ,  Madeleine Leduc

    IPC: A61K8/37 ,  A61K8/42 ,  A61K9/10 ,  A61K9/12 ,  A61Q17/04 ,  C06B23/00 ,  C06B25/24 ,  C06B25/34 ,  A61K7/42 ,  A61K7/44

    CPC classification number: A61Q17/04 ,  A61K8/37 ,  A61K8/42 ,  C06B23/007 ,  C06B25/24 ,  C06B25/34 ,  Y10S424/05 ,  Y10S514/937 ,  Y10S514/944

    Abstract: A cosmetic composition for protection against ultraviolet radiation and its use for this purpose.The present invention relates to a cosmetic composition containing, as an agent for protecting against the UV rays at least one compound of the formula ##STR1## where Ar denotes an m- or p-phenylene or biphenylene radical capable of being substituted by one or more halogen atoms, one or more C.sub.1 -C.sub.6 lower alkyl or lower alkoxy groups,R denotes a hydrogen atom, an ester group --COOR.sub.1, an amide group --CONR.sub.1 R.sub.2 or a nitrile group;R' denotes an ester group --COOR.sub.1 or amide group --CONR.sub.1 R.sub.2 ; in addition when R denotes a hydrogen atom, R' can be an acid group --COOH or its salts,R.sub.1 being capable of being a linear, branched or cyclic, saturated or unsaturated carbon chain containing up to 18 carbon atoms, unsubstituted or substituted by one or more hydroxyl, alkoxy, amino or quaternary ammonium groups,R.sub.2 being capable of being a hydrogen atom or a C.sub.1 -C.sub.6 lower alkyl group, in a cosmetically acceptable medium.

    Abstract translation: 用于防止紫外线辐射的化妆品组合物及其用于此目的。 本发明涉及一种化妆品组合物，其含有作为防止UV射线的至少一种下式化合物的作用剂，其中Ar表示可被一个或多个取代基取代的间 - 或对亚苯基或亚联苯基 卤素原子，一个或多个C 1 -C 6低级烷基或低级烷氧基，R表示氢原子，酯基-COOR 1，酰胺基-CONR1R2或腈基; R'表示酯基-COOR1或酰胺基-CONR1R2; 另外当R表示氢原子时，R'可以是酸基-COOH或其盐，R1可以是含有至多18个碳原子的直链，支链或环状，饱和或不饱和的碳链，未被取代或被 一种或多种羟基，烷氧基，氨基或季铵基团，R 2可以是化学上可接受的介质中的氢原子或C 1 -C 6低级烷基。

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