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    Micelles for delivery of nitric oxide
    92.
    发明申请
    Micelles for delivery of nitric oxide 有权
    胶束用于输送一氧化氮

    公开(公告)号：US20100003338A1

    公开(公告)日：2010-01-07

    申请号：US12217507

    申请日：2008-07-03

    申请人： Jeffrey A. Hubbell ,  Yun Suk Jo ,  Andre J. Van der Vlies

    发明人： Jeffrey A. Hubbell ,  Yun Suk Jo ,  Andre J. Van der Vlies

    IPC分类号： A61K9/14 ,  A61K31/80 ,  A61K31/787 ,  A61K31/77

    CPC分类号： A61K31/77 ,  A61K9/1075 ,  A61K9/1273 ,  A61K31/787 ,  A61K31/80 ,  A61K47/48176 ,  A61K47/488 ,  A61K47/58 ,  A61K47/6907 ,  Y10S977/906

    摘要： Embodiments include a vehicle for delivery of nitric oxide comprising: a collection of micelles having an internal micelle core that comprises a polymer with N-diazeniumdiolate comprising NO complexed with secondary amines of the polymer. Embodiments include a method of making a nitric oxide vehicle comprising dissolving a polymer that comprises secondary amines in an aqueous solution and combining the polymer with nitric oxide in the solution to form a N-diazeniumdiolate comprising the nitric oxide complexed with the secondary amines, with the formation of the N-diazeniumdiolate causing the polymer to be at least partially insoluble in the solution and to form a collection of micelles that have an internal core that comprises N-diazeniumdiolate.

    摘要翻译： 实施方案包括用于递送一氧化氮的载体，其包含：具有内部胶束芯的胶束的集合，所述胶束芯包含与包含与所述聚合物的仲胺络合的NO的具有N二氮烯鎓二醇的聚合物。 实施方案包括制备一氧化氮载体的方法，其包括将包含仲胺的聚合物溶解在水溶液中，并将该聚合物与一氧化氮混合在溶液中以形成包含与仲胺络合的一氧化氮的N-二氮烯鎓二醇， 形成N-二氮烯鎓二硫酸盐，导致聚合物至少部分不溶于溶液中，并形成具有内核的包含N-二氮茚鎓二醇的胶束的集合。

    Controlled release of non heparin-binding growth factors from heparin-containing matrices
    99.
    发明授权
    Controlled release of non heparin-binding growth factors from heparin-containing matrices 失效
    从含肝素的基质中控制非肝素结合生长因子的释放

    公开(公告)号：US06723344B2

    公开(公告)日：2004-04-20

    申请号：US09848664

    申请日：2001-05-03

    申请人： Shelly E. Sakiyama-Elbert ,  Jeffrey A. Hubbell

    发明人： Shelly E. Sakiyama-Elbert ,  Jeffrey A. Hubbell

    IPC分类号： A61K914

    CPC分类号： A61L27/20 ,  A61K47/62 ,  A61K47/6903 ,  A61L27/227 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/602

    摘要： Matrices that support cell adhesion and growth are disclosed that deliver low heparin-binding affinity growth factor protein peptides in a controlled manner. These matrices comprise covalently or non-covalently bound heparin or heparin-like polymers, which serve to sequester the low heparin-binding affinity growth factor protein peptides within the matrix. The controlled release of some low heparin-binding affinity growth factor or peptides thereof occurs by degradation of some matrix component or dissociation of the low heparin-binding affinity growth factor protein peptides from the bound heparin. This differs from many controlled delivery devices in that release is not controlled solely by diffusion, and the rate of release may therefore be regulated by altering the rate of degradation of the matrix component or the amount of heparin bound within the matrix. The controlled release of such low heparin-binding affinity growth factor proteins such as NGF-&bgr;, NT-3 and BDNF, is demonstrated. The invention also identifies basic domains that can be utilized to identify other low heparin-binding affinity growth factor protein peptides useful in delivery as part of the matrices described herein.

    摘要翻译： 公开了以受控方式递送低肝素结合亲和力生长因子蛋白质肽的支持细胞粘附和生长的基质。 这些基质包括共价或非共价结合的肝素或肝素样聚合物，其用于螯合基质内的低肝素结合亲和力生长因子蛋白质肽。 一些低肝素结合亲和力生长因子或其肽的受控释放通过某些基质成分的降解或从结合肝素解离低肝素结合亲和力生长因子蛋白质肽而发生。 这与许多控制递送装置不同，因为释放不仅仅通过扩散控制，因此可以通过改变基质组分的降解速率或在基质内结合的肝素的量来调节释放速率。 证明了这种低肝素结合亲和力生长因子蛋白如NGF-β，NT-3和BDNF的受控释放。 本发明还鉴定了可用于鉴定作为本文所述的基质的一部分用于递送的其它低水平肝素结合亲和力生长因子蛋白质肽的基本结构域。