公开(公告)号：US20180020955A1

公开(公告)日：2018-01-25

申请号：US15610413

申请日：2017-05-31

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Peyman Tavallali ,  Derek Rinderknecht ,  Morteza Gharib

IPC: A61B5/11 ,  A61B8/06 ,  A61B5/00 ,  A61B5/02 ,  A61B5/026 ,  A61B5/024 ,  A61B5/021 ,  A61B8/08 ,  A61B5/029

CPC classification number: A61B5/1128 ,  A61B5/0004 ,  A61B5/0013 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/0261 ,  A61B5/029 ,  A61B5/1102 ,  A61B5/7235 ,  A61B5/7278 ,  A61B5/7282 ,  A61B8/065 ,  A61B8/5223 ,  A61B2562/0228

Abstract: Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination.

公开(公告)号：US09744037B2

公开(公告)日：2017-08-29

申请号：US14212860

申请日：2014-03-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Arash Kheradvar ,  Gregory S. Kelley ,  Morteza Gharib

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2439 ,  A61F2/2418 ,  A61F2002/9505 ,  A61F2002/9517 ,  A61F2220/0033 ,  A61F2250/0006

Abstract: Improved catheter devices for delivery, repositioning and/or percutaneous retrieval of percutaneously implanted heart valves are described, including a medical device handle that provides an array of features helpful in conducting a percutaneous heart valve implantation procedure while variously enabling radial expansion or contraction and/or lateral positioning control over the heart valve during the medical procedure.

公开(公告)号：US09736463B2

公开(公告)日：2017-08-15

申请号：US14739565

申请日：2015-06-15

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Jian Lu ,  Emilio Graff ,  Francisco Pereira

IPC: H04N13/02 ,  G01B11/25 ,  G02B5/00 ,  G03B15/12 ,  G03B35/02 ,  G06T7/50

CPC classification number: H04N13/254 ,  G01B11/2509 ,  G02B5/005 ,  G02B2207/129 ,  G03B15/12 ,  G03B35/02 ,  G06T7/50 ,  H04N13/204 ,  H04N13/207

Abstract: A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an entire image of a target object, at least one defocusing aperture located off of the optical axis, a sensor operable for capturing electromagnetic radiation transmitted from an object through the lens and the central aperture and the at least one defocusing aperture, and a processor communicatively connected with the sensor for processing the sensor information and producing a 3-D image of the object. Different optical filters can be used for the central aperture and the defocusing apertures respectively, whereby a background image produced by the central aperture can be easily distinguished from defocused images produced by the defocusing apertures.

公开(公告)号：US09713243B2

公开(公告)日：2017-07-18

申请号：US14929192

申请日：2015-10-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Francisco Pereira ,  Sean A. Mendoza

IPC: B23K10/00 ,  H05H1/24 ,  H01T19/00

CPC classification number: H05H1/24 ,  H01T19/00 ,  H05H1/2475 ,  H05H2001/2481

Abstract: A toroidal plasma is generated without voltage input. It can be produced using a pressurized water jet directed at a non-conductive, dielectric plate. Systems and methods employing the setup are described in which energy is generated and optionally harvested in addition to corona light.

公开(公告)号：US09596452B2

公开(公告)日：2017-03-14

申请号：US14303988

申请日：2014-06-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Jian Lu ,  Scott Hsieh ,  Francisco Pereira ,  Alexei Harvard ,  David Jeon

IPC: H04N13/02 ,  G02B7/34 ,  G03B9/02 ,  G03B19/12 ,  G03B35/00 ,  H04N5/235 ,  H04N9/04 ,  G03B17/14 ,  G03B17/56

CPC classification number: H04N13/204 ,  G02B7/34 ,  G03B9/02 ,  G03B17/14 ,  G03B17/565 ,  G03B19/12 ,  G03B35/00 ,  H04N5/235 ,  H04N5/2356 ,  H04N9/045

Abstract: A lens and aperture device for determining 3D information. An SLR camera has a lens and aperture that allows the SLR camera to determine defocused information.

Abstract translation: 用于确定3D信息的透镜和光圈装置。 单反相机具有透镜和光圈，允许单反相机确定散焦信息。

公开(公告)号：US20170014039A1

公开(公告)日：2017-01-19

申请号：US15277672

申请日：2016-09-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Peyman Tavallali ,  Thomas Yizhao Hou ,  Morteza Gharib

IPC: A61B5/024 ,  A61B5/00

CPC classification number: A61B5/02416 ,  A61B5/0004 ,  A61B5/0013 ,  A61B5/0077 ,  A61B5/02028 ,  A61B5/02405 ,  A61B5/02438 ,  A61B5/0507 ,  A61B5/7235 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/746 ,  A61B8/02 ,  A61B8/06 ,  A61B8/5223 ,  A61B8/565

Abstract: Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/ measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/or is diagnosis. Exemplary uses include identifying (diagnosing) the presence of arrhythmia, heat failure, atrial fibrillation, aneurysms, vessel stenosis or aortic valve dysfunction and the necessity for valve replacement and/or monitoring congestive heart failure progression, together with identifying the acute need for hospitalization in connection with daily testing for any such condition.

Abstract translation: 描述了用于心脏健康测量的硬件和软件方法。 分析针对受试者各种获得的血流动力学波形，以计算或近似跨越Dicrotic Notch的两个域中的两个域中的固有频率。 固有频率提供与受试者的心脏健康相关的度量/措施。 该系统可用于监测病症和/或诊断。 示例性用途包括识别（诊断）心律不齐，热衰竭，心房颤动，动脉瘤，血管狭窄或主动脉瓣功能障碍的存在以及瓣膜置换和/或监测充血性心力衰竭进展的必要性，以及确定急性住院需要 与任何此类状况的日常测试连接。

公开(公告)号：US20160144100A1

公开(公告)日：2016-05-26

申请号：US14947767

申请日：2015-11-20

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Julia Cosse ,  Stephanie Rider ,  Cong Wang

IPC: A61M5/148 ,  A61M37/00

CPC classification number: A61M5/148 ,  A61M5/1483 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: Generally, devices, systems and methods of using one or more needle(s) or micro-needle arrays are described in which a shift of fluid volume from a first expansion member position to a second expansion member position drives delivery of the fluid, which can be a drug or drug solution, through the needle(s) or micro-needle arrays.

Abstract translation: 通常，描述了使用一个或多个针或微针阵列的装置，系统和方法，其中流体体积从第一膨胀构件位置向第二膨胀构件位置的移动驱动流体的输送， 成为药物或药物溶液，通过针或微针阵列。

公开(公告)号：US20160135697A1

公开(公告)日：2016-05-19

申请号：US15006926

申请日：2016-01-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Derek Rinderknecht ,  Niema Pahlevan ,  Peyman Tavallali ,  Morteza Gharib

IPC: A61B5/024 ,  A61B7/02 ,  A61B5/02 ,  A61B5/00 ,  A61B5/0408

CPC classification number: A61B5/02427 ,  A61B5/0002 ,  A61B5/0059 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0261 ,  A61B5/0285 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/6822 ,  A61B5/6898 ,  A61B5/725 ,  A61B5/7275 ,  A61B5/742 ,  A61B7/02 ,  A61B7/04 ,  A61B2560/0431

Abstract: Systems and methods are provided for extracting hemodynamic information, optionally employing portable electronic devices with optional User Interface (UI) features for system implementation. The systems and methods may be employed for acquiring hemodynamic signals and associated electrophysiological data and/or analyzing the former or both in combination to yield useful physiological indicia or results. Such hardware and software is advantageously used for non-invasively monitoring cardiac health.

公开(公告)号：US20160015879A1

公开(公告)日：2016-01-21

申请号：US14814225

申请日：2015-07-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Niema Pahlevan

IPC: A61M1/12

CPC classification number: A61M1/122 ,  A61B5/02 ,  A61B17/12013 ,  A61B2017/00022 ,  A61B2090/064 ,  A61M1/1005 ,  A61M1/1056 ,  A61M1/1058 ,  A61M1/1067 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/125 ,  A61M2205/0283 ,  A61N1/362

Abstract: The present invention provides methods and modalities that can modify wave reflection in the vascular system in order to create constructive interactions between existing wave dynamics and new reflective waves for the purpose of lowering the workload on the heart and increasing cardiac output, providing a viable option for the prevention and treatment of many heart conditions and diseases.

Abstract translation: 本发明提供了可以修改血管系统中的波反射以便在现有波动态和新反射波之间产生建设性的相互作用的方法和方式，目的是降低心脏的工作量和增加心输出量，为 预防和治疗许多心脏病和疾病。

公开(公告)号：US20150297105A1

公开(公告)日：2015-10-22

申请号：US14601170

申请日：2015-01-20

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Derek Rinderknecht ,  Peyman Tavallali ,  Morteza Gharib

IPC: A61B5/0402 ,  A61B7/04 ,  A61B5/024 ,  A61B5/00 ,  A61B5/02

CPC classification number: A61B5/02427 ,  A61B5/0002 ,  A61B5/0059 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0261 ,  A61B5/0285 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/6822 ,  A61B5/6898 ,  A61B5/725 ,  A61B5/7275 ,  A61B5/742 ,  A61B7/02 ,  A61B7/04 ,  A61B2560/0431

Abstract: Systems and methods are provided for extracting hemodynamic information, optionally employing portable electronic devices with optional User Interface (UI) features for system implementation. The systems and methods may be employed for acquiring hemodynamic signals and associated electrophysiological data and/or analyzing the former or both in combination to yield useful physiological indicia or results. Such hardware and software is advantageously used for non-invasively monitoring cardiac health.

Abstract translation: 提供用于提取血液动力学信息的系统和方法，可选地使用具有用于系统实现的可选用户界面（UI）特征的便携式电子设备。 系统和方法可用于获得血液动力学信号和相关的电生理数据和/或组合前者或两者以产生有用的生理标记或结果。 这种硬件和软件有利地用于非侵入性地监测心脏健康。