公开(公告)号：US20110151473A1

公开(公告)日：2011-06-23

申请号：US12952967

申请日：2010-11-23

申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07K14/705

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C12N9/6421 ,  C12N9/6475 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.

摘要翻译： 公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。

公开(公告)号：US20110081360A1

公开(公告)日：2011-04-07

申请号：US12943722

申请日：2010-11-10

申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  A61P37/04 ,  A61P9/00 ,  A61P17/06 ,  A61P17/00 ,  A61P11/00

CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/2866 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.

摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US07906634B2

公开(公告)日：2011-03-15

申请号：US12324825

申请日：2008-11-26

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

IPC分类号： C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K16/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20110002888A1

公开(公告)日：2011-01-06

申请号：US12793658

申请日：2010-06-03

申请人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David Lafleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

发明人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David Lafleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

IPC分类号： A61K38/21 ,  C07K14/76 ,  A61K38/38 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  A61K38/46 ,  A61K38/18 ,  A61K38/22 ,  A61K39/395 ,  A61K38/43 ,  C12N9/96 ,  A61K39/12 ,  A61K38/30 ,  A61P35/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P37/02 ,  A61P9/08 ,  A61P9/00 ,  A61P9/04 ,  A61P1/16 ,  A61P25/30 ,  A61P31/12 ,  A61P9/12

CPC分类号： C07K14/58 ,  C07K14/765 ,  C07K2319/01

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US07838636B1

公开(公告)日：2010-11-23

申请号：US11760578

申请日：2007-06-08

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

IPC分类号： C07K16/40 ,  C12P21/08 ,  C12P21/06 ,  C12N15/09

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20100144058A1

公开(公告)日：2010-06-10

申请号：US12701301

申请日：2010-02-05

申请人： James P. Beltzer ,  M. Daniel Potter ,  Tony J. Fleming ,  Craig A. Rosen

发明人： James P. Beltzer ,  M. Daniel Potter ,  Tony J. Fleming ,  Craig A. Rosen

IPC分类号： G01N33/53 ,  C07K7/08 ,  C07K14/00 ,  C07K16/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00

摘要： Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate function of B lymphocyte stimulator or B lymphocyte stimulator receptor, comprising B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate B lymphocyte stimulator function or B lymphocyte stimulator receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator.

摘要翻译： 特异性结合B淋巴细胞刺激物蛋白或B淋巴细胞刺激物样多肽的结合多肽可用于本发明的用于检测，诊断或预测与异常B淋巴细胞刺激物或B淋巴细胞刺激受体表达或不适当功能相关的疾病或病症的方法 B淋巴细胞刺激剂或B淋巴细胞刺激物受体，其包含特异性结合B淋巴细胞刺激物的B淋巴细胞刺激物结合多肽或其片段或变体。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激剂或B淋巴细胞刺激剂受体表达或不适当的B淋巴细胞刺激物功能或B淋巴细胞刺激因子受体功能相关的疾病或病症的方法和组合物，其包括向动物， 优选人，有效量的一种或多种B淋巴细胞刺激剂结合多肽或其片段或变体，其特异性结合B淋巴细胞刺激物。

公开(公告)号：US20100093627A1

公开(公告)日：2010-04-15

申请号：US12534585

申请日：2009-08-03

申请人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben

发明人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben

IPC分类号： A61K38/38 ,  C12N15/63 ,  C12N5/00 ,  C12N1/19 ,  C12N5/07 ,  C12P21/00 ,  C07K14/76 ,  A61P3/00 ,  A61P37/06

CPC分类号： C07K14/765 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/35 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20090192088A1

公开(公告)日：2009-07-30

申请号：US12396033

申请日：2009-03-02

申请人： Jing-Shan Hu ,  Craig A. Rosen ,  Liang Cao

发明人： Jing-Shan Hu ,  Craig A. Rosen ,  Liang Cao

IPC分类号： A61K38/18 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12N15/09 ,  C07K14/475 ,  C07K16/22 ,  A61P9/00

CPC分类号： C07K14/52 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00

摘要： Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided are methods of using the antibodies and antagonists to inhibit the action of VEGF2 for therapeutic purposes.

摘要翻译： 公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以与合适的药物载体或稀释剂组合以提供针对各种疾病的诊断，治疗和/或预防效果。 还提供了使用抗体和拮抗剂抑制VEGF2作用于治疗目的的作用的方法。

公开(公告)号：US20090169565A1

公开(公告)日：2009-07-02

申请号：US12393693

申请日：2009-02-26

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53 ,  A61P37/00

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.

摘要翻译： 本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。 本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。 还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

公开(公告)号：US07514081B2

公开(公告)日：2009-04-07

申请号：US11427956

申请日：2006-06-30

申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

IPC分类号： A61K39/395

CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K14/5255 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S514/885

摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

摘要翻译： 本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。 特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。 还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了关于TNF家族相关疾病的诊断和治疗方法。