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    TIMING-AWARE DATA PREFETCHING FOR MICROPROCESSORS
    93.
    发明申请
    TIMING-AWARE DATA PREFETCHING FOR MICROPROCESSORS 有权
    用于微处理器的时序数据预取

    公开(公告)号：US20120311270A1

    公开(公告)日：2012-12-06

    申请号：US13149425

    申请日：2011-05-31

    申请人： Xian-He Sun ,  Yong Chen ,  Huaiyu Zhu

    发明人： Xian-He Sun ,  Yong Chen ,  Huaiyu Zhu

    IPC分类号： G06F12/02

    CPC分类号： G06F12/0862 ,  G06F2212/6026

    摘要： A method and apparatus for prefetching data from memory for a multicore data processor. A prefetcher issues a plurality of requests to prefetch data from a memory device to a memory cache. Consecutive cache misses are recorded in response to at least two of the plurality of requests. A time between the cache misses is determined and a timing of a further request to prefetch data from the memory device to the memory cache is altered as a function of the determined time between the two cache misses.

    摘要翻译： 一种用于从多内存数据处理器的存储器预取数据的方法和装置。 预取器发出多个请求以将数据从存储器设备预取到存储器高速缓存。 响应于多个请求中的至少两个来记录连续的高速缓存未命中。 确定高速缓存未命中之间的时间，并且根据确定的两个高速缓存未命中的时间来改变从存储器设备向存储器高速缓存预取数据的进一步请求的定时。

    Electronic Commerce Transaction Method and Electronic Commerce Transaction System for Enterprise Network Marketing and Purchase Outsourcing
    96.
    发明申请
    Electronic Commerce Transaction Method and Electronic Commerce Transaction System for Enterprise Network Marketing and Purchase Outsourcing 审中-公开
    电子商务交易方式和企业网络营销外包电子商务交易系统

    公开(公告)号：US20100299216A1

    公开(公告)日：2010-11-25

    申请号：US12746478

    申请日：2008-05-16

    申请人： Yong Chen

    发明人： Yong Chen

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/00 ,  G06Q30/0277 ,  G06Q30/08

    摘要： The invention discloses an electronic business method and system for enterprise cyber marketing and procurement outsourcing. The electronic business system includes: an enterprise information publishing system; a professional information publishing system; an authorizing, sending, receiving and managing system for email, network telephone, network fax and instant messaging tool; a bidding system; a B2B information flow subdivision charging system; a mutual evaluation system; and a complaint management system. In particular, the invention can be applied to a B2B electronic business method to overcome limitations of the existing B2B method. The invention is a people-oriented electronic business method and system, a multi-lingual professional online support method that is based on demands and with a low cost. The invention allows an enterprise to outsource its cyber marketing and procurement to multi-lingual professionals anywhere in the world, so that the enterprise can obtain the cyber marketing and procurement service by sharing the services offered by those multi-lingual professionals from anywhere in the world at low labor cost.

    摘要翻译： 本发明公开了一种用于企业网络营销和采购外包的电子商务方法和系统。 电子商务系统包括：企业信息发布系统; 专业的信息发布系统; 电子邮件，网络电话，网络传真和即时通讯工具的授权，发送，接收和管理系统; 招标制度; B2B信息流细分收费系统; 相互评估系统; 和投诉管理系统。 特别地，本发明可以应用于B2B电子商务方法以克服现有B2B方法的限制。 本发明是以人为本的电子商务方法和系统，是一种基于需求和低成本的多语言专业在线支持方式。 本发明允许企业将其网络营销和采购外包给世界各地的多语言专业人员，使企业能够通过分享来自世界各地的多语言专业人员提供的服务来获取网络营销和采购服务 劳动力成本低。

    ONE POT SYNTHESIS OF TETRAZOLE DERIVATIVES OF RAPAMYCIN
    97.
    发明申请
    ONE POT SYNTHESIS OF TETRAZOLE DERIVATIVES OF RAPAMYCIN 有权
    一种合成RAPAMYCIN的四唑衍生物的方法

    公开(公告)号：US20100204466A1

    公开(公告)日：2010-08-12

    申请号：US12711072

    申请日：2010-02-23

    申请人： Madhup K. Dhaon ,  Chi-nung Hsiao ,  Subhash R. Patel ,  Peter J. Bonk ,  Sanjay R. Chemburkar ,  Yong Chen

    发明人： Madhup K. Dhaon ,  Chi-nung Hsiao ,  Subhash R. Patel ,  Peter J. Bonk ,  Sanjay R. Chemburkar ,  Yong Chen

    IPC分类号： C07D498/18

    CPC分类号： C07D498/18

    摘要： A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at −30° C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane. The solids are dissolved in acetone, treated with butylated-hydroxy toluene (BHT), and the solution concentrated. The process is repeated twice with acetone to remove solvents. At least one stabilizing agent is added, such as BHT at 0.5% before drying.

    摘要翻译： 提出了大规模获得唑他莫司和其他雷帕霉素衍生物的单步一锅法，改进了现有的合成方案。 在一个实施方案中，将干燥的雷帕霉素溶于乙酸异丙酯（IPAc）中。 将溶液冷却，加入2,6-二甲基吡啶，然后在-30℃下缓慢加入三氟甲磺酸酐。然后通过过滤除去盐。 然后向该三氟甲磺酸酯溶液中加入四唑，然后加入叔丁基二异丙基乙胺（DIEA）。 在室温下孵育后，将产物浓缩并通过硅胶柱纯化，使用THF /庚烷作为洗脱剂。 收集含有产物的级分，浓缩并再次使用丙酮/庚烷柱纯化。 将含产物的级分浓缩。 将产物溶于t-BME中并用庚烷沉淀。 将固体溶解在丙酮中，用丁基化羟基甲苯（BHT）处理，浓缩溶液。 用丙酮重复该过程两次以除去溶剂。 在干燥前加入至少一种稳定剂，例如0.5％的BHT。

    One pot synthesis of tetrazole derivatives of rapamycin
    98.
    发明授权
    One pot synthesis of tetrazole derivatives of rapamycin 有权
    雷帕霉素四唑衍生物的一锅合成

    公开(公告)号：US07700614B2

    公开(公告)日：2010-04-20

    申请号：US11300671

    申请日：2005-12-14

    申请人： Madhup K. Dhaon ,  Chi-nung Hsiao ,  Subhash R. Patel ,  Peter J. Bonk ,  Sanjay R. Chemburkar ,  Yong Chen

    发明人： Madhup K. Dhaon ,  Chi-nung Hsiao ,  Subhash R. Patel ,  Peter J. Bonk ,  Sanjay R. Chemburkar ,  Yong Chen

    IPC分类号： C07D498/18

    CPC分类号： C07D498/18

    摘要： A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at −30° C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane. The solids are dissolved in acetone, treated with butylated-hydroxy toluene (BHT), and the solution concentrated. The process is repeated twice with acetone to remove solvents. At least one stabilizing agent is added, such as BHT at 0.5% before drying.

    摘要翻译： 提出了大规模获得唑他莫司和其他雷帕霉素衍生物的单步一锅法，改进了现有的合成方案。 在一个实施方案中，将干燥的雷帕霉素溶于乙酸异丙酯（IPAc）中。 将溶液冷却，加入2,6-二甲基吡啶，然后在-30℃下缓慢加入三氟甲磺酸酐。然后通过过滤除去盐。 然后向该三氟甲磺酸酯溶液中加入四唑，然后加入叔丁基二异丙基乙胺（DIEA）。 在室温下孵育后，将产物浓缩并通过硅胶柱纯化，使用THF /庚烷作为洗脱剂。 收集含有产物的级分，浓缩并再次使用丙酮/庚烷柱纯化。 将含产物的级分浓缩。 将产物溶于t-BME中并用庚烷沉淀。 将固体溶解在丙酮中，用丁基化羟基甲苯（BHT）处理，浓缩溶液。 用丙酮重复该过程两次以除去溶剂。 在干燥前加入至少一种稳定剂，例如0.5％的BHT。

    LASER DESORPTION IONIZATION AND PEPTIDE SEQUENCING ON LASER INDUCED SILICON MICROCOLUMN ARRAYS
    99.
    发明申请
    LASER DESORPTION IONIZATION AND PEPTIDE SEQUENCING ON LASER INDUCED SILICON MICROCOLUMN ARRAYS 有权
    在激光诱导硅微阵列上的激光解吸离子和肽序列

    公开(公告)号：US20090321626A1

    公开(公告)日：2009-12-31

    申请号：US11674671

    申请日：2007-02-14

    申请人： Akos Vertes ,  Yong Chen

    发明人： Akos Vertes ,  Yong Chen

    IPC分类号： H01J49/26 ,  B32B3/10 ,  B29C59/16

    CPC分类号： B29C59/16 ,  B29C2059/023 ,  B29C2791/009 ,  H01J49/0418 ,  Y10T428/24479

    摘要： The present invention provides a method of producing a laser-patterned silicon surface, especially silicon wafers for use in laser desorption ionization (LDI-MS) (including MALDI-MS and SELDI-MS), devices containing the same, and methods of testing samples employing the same. The surface is prepared by subjecting a silicon substrate to multiple laser shots from a high-power picosecond or femtosecond laser while in a processing environment, e.g., underwater, and generates a remarkable homogenous microcolumn array capable of providing an improved substrate for LDI-MS.

    摘要翻译： 本发明提供了一种制造激光图案化硅表面的方法，特别是用于激光解吸电离（LDI-MS）（包括MALDI-MS和SELDI-MS）的硅晶片，含有该硅表面的器件，以及测试样品的方法 用同样的 该表面是通过在处理环境（例如水下）中使硅衬底经受来自高功率皮秒或飞秒激光器的多次激光照射，并且产生能够为LDI-MS提供改进的衬底的显着均匀的微柱阵列。

    Nanoscale electric lithography
    100.
    发明授权
    Nanoscale electric lithography 有权
    纳米级电光刻技术

    公开(公告)号：US07455788B2

    公开(公告)日：2008-11-25

    申请号：US11480256

    申请日：2006-06-29

    申请人： Yong Chen

    发明人： Yong Chen

    IPC分类号： H01L21/302

    CPC分类号： B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03G13/28 ,  G03G13/283 ,  G03G13/286

    摘要： A nanoscale lithographic method in which a reusable conductive mask, having a pattern of conductive surfaces and insulating surfaces, is positioned upon a substrate whose surface contains an electrically responsive resist layer over a buried conductive layer. When an electric field is applied between the conductive mask and buried conductive layer, the resist layer is altered in portions adjacent the conductive areas of the mask. Selective processing is performed on the surface of the substrate, after mask removal, to remove portions of the resist layer according to the pattern transferred from the mask. The substrate may be a target substrate, or the substrate may be utilized for a lithographic masking step of another substrate. In one aspect of the invention the electrodes to which the charge is applied are divided, such as into a plurality of rows and columns wherein any desired pattern may be created without the need to fabricate specific masks.

    摘要翻译： 一种纳米级光刻方法，其中具有导电表面和绝缘表面图案的可重复使用的导电掩模位于其表面在掩埋导电层上包含电响应抗蚀剂层的基底上。 当在导电掩模和掩埋导电层之间施加电场时，抗蚀剂层在与掩模的导电区域相邻的部分中改变。 在掩模移除之后，在基板的表面上进行选择性处理，以根据从掩模转印的图案去除部分抗蚀剂层。 衬底可以是目标衬底，或者衬底可以用于另一衬底的光刻掩模步骤。 在本发明的一个方面，施加电荷的电极被分割成多个行和列，其中可以创建任何期望的图案，而不需要制造特定的掩模。