公开(公告)号：US06908926B1

公开(公告)日：2005-06-21

申请号：US09548081

申请日：2000-04-12

申请人： Florencio Zaragoza Dörwald ,  Knud Erik Andersen ,  Tine Krogh Jørgensen ,  Bernd Peschke ,  Birgitte Schjellerup Wulff ,  Ingrid Pettersson ,  Klaus Rudolf ,  Dirk Stenkamp ,  Rudolf Hurnaus ,  Stephan Georg Müller ,  Bernd Krist

发明人： Florencio Zaragoza Dörwald ,  Knud Erik Andersen ,  Tine Krogh Jørgensen ,  Bernd Peschke ,  Birgitte Schjellerup Wulff ,  Ingrid Pettersson ,  Klaus Rudolf ,  Dirk Stenkamp ,  Rudolf Hurnaus ,  Stephan Georg Müller ,  Bernd Krist

IPC分类号： A61K31/437 ,  C07D235/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

CPC分类号： C07D235/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

摘要： Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula I wherein R1, R2, R3, R4, R5, R6, A, X, Y and Z are as defined in the specification.

摘要翻译： 公开了一类新颖的取代的咪唑化合物，含有它们的药物组合物和这些化合物在治疗和/或预防与组胺H3受体相关的疾病和病症中的用途。 更具体地说，这些化合物可用于治疗和/或预防与组胺H3受体相互作用有益的疾病和病症。 这些咪唑化合物具有式I，其中R 1，R 2，R 3，R 4，R 4， SUP> 5，R 6，A，X，Y和Z如说明书中所定义。

公开(公告)号：US06437147B1

公开(公告)日：2002-08-20

申请号：US09810237

申请日：2001-03-16

申请人： Knud Erik Andersen ,  Florencio Zaragoza Dorwald ,  Bernd Peschke ,  Ulla Grove Sidelmann ,  Klaus Rudolf ,  Dirk Stenkamp ,  Rudolf Hurnaus ,  Stephan Georg Muller ,  Bernd Krist ,  Birgitte Eriksen

发明人： Knud Erik Andersen ,  Florencio Zaragoza Dorwald ,  Bernd Peschke ,  Ulla Grove Sidelmann ,  Klaus Rudolf ,  Dirk Stenkamp ,  Rudolf Hurnaus ,  Stephan Georg Muller ,  Bernd Krist ,  Birgitte Eriksen

IPC分类号： A61K3142

CPC分类号： C07D235/04

摘要： A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

摘要翻译： 一类新颖的咪唑并杂环化合物，包含它们的药物组合物及其用于治疗和/或预防与组胺H3受体有关的疾病和病症的用途。 更具体地，这些化合物可用于治疗和/或预防与组胺H3受体的相互作用有益的疾病和病症。

公开(公告)号：US20090221589A1

公开(公告)日：2009-09-03

申请号：US12097931

申请日：2006-12-18

申请人： Thomas Trieselmann ,  Bradford S. Hamilton ,  Stephan G. Mueller ,  Dirk Stenkamp

发明人： Thomas Trieselmann ,  Bradford S. Hamilton ,  Stephan G. Mueller ,  Dirk Stenkamp

IPC分类号： A61K31/4164 ,  A61K31/502 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61P13/10

CPC分类号： A61K31/135

摘要： The present invention relates to the use of new beta-agonists of general formula (Ia) or (Ib) wherein the groups R1 to R12 and R1 to R7, respectively, have the meanings given in the claims and specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, for preparing a medicament for the treatment of overactive bladder.

摘要翻译： 本发明涉及通式（Ia）或（Ib）的新的β-激动剂的用途，其中R1至R12和R1至R7分别具有权利要求和说明书中给出的含义，互变异构体，对映异构体 ，非对映异构体，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，用于制备治疗膀胱过动症的药物。

公开(公告)号：US06903337B2

公开(公告)日：2005-06-07

申请号：US10185729

申请日：2002-07-01

申请人： Oliver Kienzle ,  Dirk Stenkamp ,  Michael Steigerwald ,  Rainer Knippelmeyer ,  Max Haider ,  Heiko Müller ,  Stephan Uhlemann

发明人： Oliver Kienzle ,  Dirk Stenkamp ,  Michael Steigerwald ,  Rainer Knippelmeyer ,  Max Haider ,  Heiko Müller ,  Stephan Uhlemann

IPC分类号： G03F7/20 ,  H01J31/00 ,  H01J37/09 ,  H01J37/12 ,  H01J37/147 ,  H01J37/244 ,  H01J37/28 ,  H01J37/285

CPC分类号： H01J37/28 ,  H01J2237/082 ,  H01J2237/2446

摘要： An examining system for imaging an object positionable in an object plane, includes an illumination device for supplying energy to a delimited field of the object such that charged particles emerge from locations of the field, the field being displaceable in the plane of the object, a first deflector for providing a variable deflection field for guiding charged particles emerging from locations of a selectable region of the object through a fixed, predetermined beam cross-section, and a position-sensitive detector disposed in the beam path such that the charged particles, after having passed through the first deflector, impinge on the position-sensitive detector, wherein particles emerging from different locations of the region are imaged on different locations of the position-sensitive detector which are allocated to the locations of emergence.

摘要翻译： 一种用于对物体平面中定位的物体进行成像的检查系统，包括用于向物体的界定场提供能量的照明装置，使得带电粒子从场的位置出现，该场可在物体的平面中移动， 第一偏转器，用于提供可变偏转场，用于引导通过固定的预定光束横截面从物体的可选择区域的位置出射的带电粒子，以及设置在光束路径中的位置敏感检测器，使得带电粒子在 已经穿过第一偏转器，撞击位置敏感检测器，其中从该区域的不同位置出现的颗粒被成像在位置敏感检测器的分配到出现位置的不同位置上。

公开(公告)号：US06678240B2

公开(公告)日：2004-01-13

申请号：US10247270

申请日：2002-09-19

申请人： Bernd Geh ,  Paul Gräupner ,  Klaus Wurmbrand ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler

发明人： Bernd Geh ,  Paul Gräupner ,  Klaus Wurmbrand ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler

IPC分类号： G03B2732

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

摘要翻译： 为了优化其中至少一个相对于至少一个固定光学元件移动的多个光学元件的图像特性，首先测量由所有光学元件的相互作用产生的整体图像缺陷。 这被表示为正交函数集的基函数的线性组合。 然后将可移动元件移动到新的测量位置，并再次测量整个图像缺陷。 在新的整体图像缺陷的线性组合表示之后，根据获得的数据计算可移动元件和静止元件的图像缺陷。 只有一个可移动光学元件可以直接计算和调整整个图像缺陷最小化的目标位置。 如果有多个可移动的光学元件可用，则给出用于有效确定各个目标位置的方法。

公开(公告)号：US06934011B2

公开(公告)日：2005-08-23

申请号：US10697811

申请日：2003-10-30

申请人： Bernd Geh ,  Paul Gräupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler ,  Klaus Wurmbrand

发明人： Bernd Geh ,  Paul Gräupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stühler ,  Klaus Wurmbrand

IPC分类号： G02B7/02 ,  G01B11/00 ,  G02B13/00 ,  G02B27/00 ,  G03F7/20 ,  G03F7/207 ,  H01L21/027 ,  G03B27/32

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

公开(公告)号：US20050254042A1

公开(公告)日：2005-11-17

申请号：US11187730

申请日：2005-07-22

申请人： Bernd Geh ,  Paul Graupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stuhler ,  Klaus Wurmbrand

发明人： Bernd Geh ,  Paul Graupner ,  Thomas Stammler ,  Dirk Stenkamp ,  Jochen Stuhler ,  Klaus Wurmbrand

IPC分类号： G02B7/02 ,  G01B11/00 ,  G02B13/00 ,  G02B27/00 ,  G03F7/20 ,  G03F7/207 ,  H01L21/027

CPC分类号： G03F7/706 ,  G01M11/0207 ,  G01M11/0242 ,  G01M11/0257 ,  G02B27/0012 ,  G03F7/70225 ,  G03F7/70258 ,  G03F7/70666

摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.

摘要翻译： 为了优化其中至少一个相对于至少一个固定光学元件移动的多个光学元件的图像特性，首先测量由所有光学元件的相互作用产生的整体图像缺陷。 这被表示为正交函数集的基函数的线性组合。 然后将可移动元件移动到新的测量位置，并再次测量整个图像缺陷。 在新的整体图像缺陷的线性组合表示之后，根据获得的数据计算可移动元件和静止元件的图像缺陷。 只有一个可移动光学元件可以直接计算和调整整个图像缺陷最小化的目标位置。 如果有多个可移动的光学元件可用，则给出用于有效确定各个目标位置的方法。

公开(公告)号：US08466186B2

公开(公告)日：2013-06-18

申请号：US13314565

申请日：2011-12-08

申请人： Henning Priepke ,  Raimund Kuelzer ,  Juergen Mack ,  Roland Pfau ,  Dirk Stenkamp ,  Benjamin Pelcman ,  Robert Roenn ,  Dimitrijs Lubriks ,  Edgars Suna

发明人： Henning Priepke ,  Raimund Kuelzer ,  Juergen Mack ,  Roland Pfau ,  Dirk Stenkamp ,  Benjamin Pelcman ,  Robert Roenn ,  Dimitrijs Lubriks ,  Edgars Suna

IPC分类号： A01N43/52 ,  A01N33/02 ,  A01N33/18 ,  A61K31/135 ,  A61K31/04

CPC分类号： C07D403/04 ,  C07D235/30 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.

摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合成酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为治疗和/或预防炎性疾病和相关病症的药物的用途 。 A，M，W，R 1，R 2，R 3，R 4，R 6，R 2，R 7，R 8，R 9，R a，R b具有在说明书中给出的含义。

公开(公告)号：US07214698B2

公开(公告)日：2007-05-08

申请号：US11276649

申请日：2006-03-09

申请人： Thomas Trieselmann ,  Bradford S. Hamilton ,  Dirk Stenkamp ,  Stephan Georg Mueller

发明人： Thomas Trieselmann ,  Bradford S. Hamilton ,  Dirk Stenkamp ,  Stephan Georg Mueller

IPC分类号： A61K31/4164

CPC分类号： C07D233/64 ,  C07D233/84 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

摘要： The present invention relates to new beta-agonists of general formula 1: wherein the groups R1 to R12 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these compounds and their use as pharmaceutical compositions.

摘要翻译： 本发明涉及通式1的新β-激动剂：其中R 1至R 12基团具有权利要求书和说明书中给出的含义，其异构体， 制备这些化合物的方法及其作为药物组合物的用途。

公开(公告)号：US08933079B2

公开(公告)日：2015-01-13

申请号：US13780343

申请日：2013-02-28

申请人： Thorsten Oost ,  Ralf Lotz ,  Dirk Stenkamp

发明人： Thorsten Oost ,  Ralf Lotz ,  Dirk Stenkamp

IPC分类号： A61K31/501 ,  A61K31/4412 ,  C07D213/69 ,  C07D237/16 ,  C07D401/12 ,  C07D401/14 ,  C07D401/10 ,  C07D413/10 ,  C07D413/12 ,  C07D403/10

CPC分类号： C07D401/12 ,  C07D213/69 ,  C07D237/16 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D413/10 ,  C07D413/12

摘要： Pyridone and pyridazinone derivatives that are active against the melanin-concentrating hormone (MCH) and useful as anti-obesity pharmaceuticals.

摘要翻译： 对黑色素浓缩激素（MCH）有活性的吡啶酮和哒嗪酮衍生物，可用作抗肥胖药物。