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公开(公告)号：US20120309738A1
公开(公告)日：2012-12-06
申请号：US13314565
申请日：2011-12-08
申请人： Henning Priepke , Raimund Kuelzer , Juergen Mack , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
发明人： Henning Priepke , Raimund Kuelzer , Juergen Mack , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
IPC分类号： A61K31/497 , A61K31/454 , C07D403/10 , A61K31/4184 , C07D413/10 , A61K31/5377 , A61K31/496 , A61K31/4709 , C07D409/14 , C07D405/14 , C07D417/14 , A61K31/427 , C07D403/14 , C07D235/30 , C07D401/14 , A61K31/4439 , A61K31/422 , C07D413/14 , A61K31/4545 , A61P29/00 , C07D401/10
CPC分类号： C07D403/04 , C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合成酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为治疗和/或预防炎性疾病和相关病症的药物的用途 。 A，M，W，R 1，R 2，R 3，R 4，R 6，R 2，R 7，R 8，R 9，R a，R b具有在说明书中给出的含义。
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公开(公告)号：US08921405B2
公开(公告)日：2014-12-30
申请号：US13942077
申请日：2013-07-15
申请人： Roland Pfau , Kirsten Arndt , Henri Doods , Klaus Klinder , Raimund Kuelzer , Dimitrijs Lubriks , Juergen Mack , Benjamin Pelcman , Henning Priepke , Robert Roenn , Dirk Stenkamp , Edgars Suna
发明人： Roland Pfau , Kirsten Arndt , Henri Doods , Klaus Klinder , Raimund Kuelzer , Dimitrijs Lubriks , Juergen Mack , Benjamin Pelcman , Henning Priepke , Robert Roenn , Dirk Stenkamp , Edgars Suna
IPC分类号： A61K31/4168 , C07D235/30 , C07D403/12 , C07D401/12 , C07D409/12 , C07D405/12
CPC分类号： C07D235/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds of general formula I in which A, L, M, Q2, Q3, Q4, R1, R5, Ra, Rb, Rc, W, X, Y, Z1, Z2, Z3 are defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.
摘要翻译： 本发明涉及其中A，L，M，Q2，Q3，Q4，R 1，R 5，R a，R b，R c，W，X，Y，Z 1，Z 2，Z 3在说明书中定义的通式I化合物 ，其盐，特别是其生理上可接受的盐。 该化合物在治疗和/或预防炎性疾病和相关病症，特别是治疗和/或预防疼痛中具有潜在的用途。 本发明还涉及这些化合物作为药物，含有它们的药物组合物及其制备的用途。
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公开(公告)号：US08466186B2
公开(公告)日：2013-06-18
申请号：US13314565
申请日：2011-12-08
申请人： Henning Priepke , Raimund Kuelzer , Juergen Mack , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
发明人： Henning Priepke , Raimund Kuelzer , Juergen Mack , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
IPC分类号： A01N43/52 , A01N33/02 , A01N33/18 , A61K31/135 , A61K31/04
CPC分类号： C07D403/04 , C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合成酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为治疗和/或预防炎性疾病和相关病症的药物的用途 。 A，M，W，R 1，R 2，R 3，R 4，R 6，R 2，R 7，R 8，R 9，R a，R b具有在说明书中给出的含义。
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公开(公告)号：US08916599B2
公开(公告)日：2014-12-23
申请号：US13119834
申请日：2009-09-25
申请人： Roland Pfau , Kirsten Arndt , Henri Doods , Norbert Hauel , Klaus Klinder , Raimund Kuelzer , Juergen Mack , Henning Priepke , Dirk Stenkamp
发明人： Roland Pfau , Kirsten Arndt , Henri Doods , Norbert Hauel , Klaus Klinder , Raimund Kuelzer , Juergen Mack , Henning Priepke , Dirk Stenkamp
IPC分类号： A61K31/4184 , C07D235/30 , C07D417/12 , C07D401/14 , C07D263/58 , C07D401/12 , C07D405/12 , C07D413/12 , C07D403/12 , C07D471/04 , C07D277/82
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.
摘要翻译： 提供式（I）化合物，其中R1，R6，R8，Q2，Q3，Q3a，Q4，L和A具有说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗 需要和/或需要MAPEG家族成员的活性抑制，特别是治疗炎症和/或癌症的疾病。
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公开(公告)号：US20110312935A1
公开(公告)日：2011-12-22
申请号：US13119834
申请日：2009-09-25
申请人： Roland Pfau , Kirsten Arndt , Henri Doods , Norbert Hauel , Klaus Klinder , Raimund Kuelzer , Juergen Mack , Henning Priepke , Dirk Stenkamp
发明人： Roland Pfau , Kirsten Arndt , Henri Doods , Norbert Hauel , Klaus Klinder , Raimund Kuelzer , Juergen Mack , Henning Priepke , Dirk Stenkamp
IPC分类号： A61K31/5377 , C07D401/12 , C07D417/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D413/14 , A61K31/4184 , A61K31/4439 , A61K31/427 , A61K31/428 , A61K31/4725 , A61K31/437 , A61P11/06 , A61P11/00 , A61P29/00 , A61P25/06 , A61P31/12 , A61P31/04 , A61P31/10 , A61P35/00 , A61P9/10 , A61P19/06 , A61P19/02 , A61P19/08 , A61P17/06 , A61P9/00 , A61P19/10 , A61P25/00 , A61P3/10 , A61P37/08 , A61P43/00 , C07D235/30
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.
摘要翻译： 提供式（I）化合物，其中R1，R6，R8，Q2，Q3，Q3a，Q4，L和A具有说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗 需要和/或需要MAPEG家族成员的活性抑制，特别是治疗炎症和/或癌症的疾病。
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公开(公告)号：US09040565B2
公开(公告)日：2015-05-26
申请号：US13119835
申请日：2009-09-25
申请人： Roland Pfau , Kirsten Arndt , Henri Doods , Norbert Hauel , Klaus Klinder , Raimund Kuelzer , Juergen Mack , Dirk Stenkamp
发明人： Roland Pfau , Kirsten Arndt , Henri Doods , Norbert Hauel , Klaus Klinder , Raimund Kuelzer , Juergen Mack , Dirk Stenkamp
IPC分类号： A61K31/44 , C07D401/00 , C07D221/02 , C07D471/02 , C07D235/30 , C07D263/58 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.
摘要翻译： 提供式（I）化合物，其中R1，R6，R8，Q2，Q3，Q3a，Q4，L和A具有说明书中给出的含义及其药学上可接受的盐，该化合物可用于治疗 需要和/或需要MAPEG家族成员的活性抑制，特别是治疗炎症和/或癌症的疾病。
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公开(公告)号：US08372838B2
公开(公告)日：2013-02-12
申请号：US13031895
申请日：2011-02-22
申请人： Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
发明人： Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D405/12 , C07C237/24 , C07C2601/02 , C07D207/277 , C07D211/62 , C07D213/81 , C07D233/90 , C07D239/28 , C07D239/557 , C07D261/18 , C07D271/10 , C07D401/12
摘要： Compounds of the formula I wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are defined as described in the specification, which are bradykinin B1 antagonists, and their use as medicaments.
摘要翻译： 其中n，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11和X如说明书中所描述的缓激肽B1拮抗剂及其作为药物的用途的式I化合物 。
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公开(公告)号：US08916589B2
公开(公告)日：2014-12-23
申请号：US12675224
申请日：2008-08-28
申请人： Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
发明人： Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
IPC分类号： A61K31/44 , A61K31/41 , C07D239/28 , C07C237/24 , C07C317/44 , C07D209/42 , C07D213/64 , C07D213/82 , C07D233/90 , C07D237/24 , C07D239/34 , C07D239/36 , C07D239/42 , C07D261/18 , C07D263/34 , C07D277/56 , C07D307/68 , C07K5/062 , C07K5/078
CPC分类号： C07D239/28 , C07C237/24 , C07C317/44 , C07C2601/02 , C07D209/42 , C07D213/64 , C07D213/82 , C07D233/90 , C07D237/24 , C07D239/34 , C07D239/36 , C07D239/42 , C07D261/18 , C07D263/34 , C07D277/56 , C07D307/68 , C07K5/06026 , C07K5/06139
摘要： The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as stated hereinafter, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译： 本发明涉及通式I的化合物，其中n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如下文所定义，对映异构体，非对映体，其混合物及其盐， 其有机或无机酸或碱的生理上可接受的盐，其具有有价值的性质，其制备，含有药理学有效化合物的药物组合物，其制备及其用途。
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公开(公告)号：US20110263626A1
公开(公告)日：2011-10-27
申请号：US12675224
申请日：2008-08-28
申请人： Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-metz , Rainer Walter
发明人： Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-metz , Rainer Walter
IPC分类号： A61K31/505 , C07C235/40 , C07D213/82 , C07C255/44 , C07D261/18 , C07C229/48 , C07D263/34 , C07D213/81 , C07D239/38 , C07D307/68 , C07D233/90 , C07D231/14 , C07D209/42 , C07D277/56 , A61K31/165 , A61K31/44 , A61K31/42 , A61K31/24 , A61K31/197 , A61K31/421 , A61K31/341 , A61K31/415 , A61K31/50 , A61K31/404 , A61K31/426 , A61P25/00 , C07D239/28
CPC分类号： C07D239/28 , C07C237/24 , C07C317/44 , C07C2601/02 , C07D209/42 , C07D213/64 , C07D213/82 , C07D233/90 , C07D237/24 , C07D239/34 , C07D239/36 , C07D239/42 , C07D261/18 , C07D263/34 , C07D277/56 , C07D307/68 , C07K5/06026 , C07K5/06139
摘要： The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as stated hereinafter, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译： 本发明涉及通式I的化合物，其中n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如下文所定义，对映异构体，非对映体，其混合物及其盐， 其有机或无机酸或碱的生理上可接受的盐，其具有有价值的性质，其制备，含有药理学有效化合物的药物组合物，其制备及其用途。
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公开(公告)号：US10170238B2
公开(公告)日：2019-01-01
申请号：US13609878
申请日：2012-09-11
申请人： Marcin Rejman , Guenter Lohr , Juergen Mack , Friederike Dietzel , Volker Amann
发明人： Marcin Rejman , Guenter Lohr , Juergen Mack , Friederike Dietzel , Volker Amann
IPC分类号： H01F27/30 , H01F27/26 , H02J7/02 , H01F38/14 , H02J50/10 , H02J50/40 , H01F27/245 , H02J5/00
摘要： A hand tool device having at least one charging coil, which includes at least one coil core which is at least partially made of a ceramic material and which is provided for transmitting energy. The coil core may be configured as a composite component.
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