Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
    93.
    发明申请
    Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists 有权
    使用α7受体结合胆碱能激动剂治疗胰腺炎

    公开(公告)号:US20090123456A1

    公开(公告)日:2009-05-14

    申请号:US11724605

    申请日:2007-03-15

    摘要: A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein.

    摘要翻译: 一种治疗患有胰腺炎的患者的方法,其包括以足以减少从巨噬细胞释放的促炎细胞因子的量的治疗有效量的对α7烟碱受体选择性的胆碱能激动剂治疗所述患者,其中所述病症是 急性胰腺炎。 本发明的化合物包括可卡因的四元类似物; (1-氮杂 - 双环[2.2.2]辛-3-基) - 氨基甲酸1-(2-氟苯基) - 乙酯; 式(I)化合物,式(II)化合物,式(III)化合物,式(IV)化合物和能够减弱急性胰腺炎症状的寡核苷酸或模拟物,其中寡核苷酸或模拟物 基本上由大于5个核苷酸长的序列组成,其与α7胆碱能受体的mRNA互补。 本文描述了式(I),(II),(III)和(IV)的变量。

    Isoflavone Glycosides as Peroxisome Proliferator-Activated Receptor-alpha Modulator
    94.
    发明申请
    Isoflavone Glycosides as Peroxisome Proliferator-Activated Receptor-alpha Modulator 审中-公开
    异黄酮糖苷作为过氧化物酶体增殖物激活受体-α调节剂

    公开(公告)号:US20090099099A1

    公开(公告)日:2009-04-16

    申请号:US11872771

    申请日:2007-10-16

    IPC分类号: A61K31/7048 C07H3/02 A61P3/04

    CPC分类号: C07H3/02

    摘要: A method of treating or preventing diseases related to modulation of PPAR-α in comprising administering to a human or other mammals in need of such treatment an effective amount of plant material derived from plants of the genera Puerila Lobata.

    摘要翻译: 一种治疗或预​​防与PPAR-α调节有关的疾病的方法,其包括对需要这种治疗的人或其他哺乳动物施用有效量的源自普拉里巴拉杜鹃属植物的植物材料。

    METHODS AND APPARATUS TO PROVIDE PARAMETERIZED OFFLOADING ON MULTIPROCESSOR ARCHITECTURES
    99.
    发明申请
    METHODS AND APPARATUS TO PROVIDE PARAMETERIZED OFFLOADING ON MULTIPROCESSOR ARCHITECTURES 审中-公开
    在多处理器架构上提供参数化卸载的方法和装置

    公开(公告)号:US20080163183A1

    公开(公告)日:2008-07-03

    申请号:US11618143

    申请日:2006-12-29

    IPC分类号: G06F9/45

    CPC分类号: G06F8/456 G06F2209/509

    摘要: Methods and apparatus to provide parameterized offloading in multiprocessor systems are disclosed. An example method includes partitioning source code into a first task and a second task, and compiling object code from the source code, such that the first task is compiled to execute on a first processor core and the second task is compiled to execute on a second processor core, the assignment of the first task to the first core being dependent on an input parameter.

    摘要翻译: 公开了在多处理器系统中提供参数化卸载的方法和装置。 示例性方法包括将源代码分割成第一任务和第二任务,以及从源代码编译目标代码,使得第一任务被编译为在第一处理器核上执行,并且第二任务被编译为在第二任务上执行 处理器核心,将第一个任务分配给第一个内核取决于输入参数。