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    IMPLANTABLE ANALYTE SENSOR
    95.
    发明申请
    IMPLANTABLE ANALYTE SENSOR 审中-公开
    可分析分析仪

    公开(公告)号：US20090030294A1

    公开(公告)日：2009-01-29

    申请号：US12247137

    申请日：2008-10-07

    申请人： James R. Petisce ,  Mark Brister ,  Mark Shults ,  James H. Brauker ,  Paul V. Neale

    发明人： James R. Petisce ,  Mark Brister ,  Mark Shults ,  James H. Brauker ,  Paul V. Neale

    IPC分类号： A61B5/07 ,  B28B11/04

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532

    摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.

    摘要翻译： 一种可植入分析物传感器，包括用于测量分析物的感测区域和用于将传感器主体固定在主机中的非感测区域。 将传感器植入精确尺寸的袋中以在体内稳定分析物传感器，并且能够在形成传感器周围的异物胶囊之前和之后测量主体中分析物的浓度。 传感器还提供用于通过传感器主体，电子电路和为在小型化传感器主体中长期使用而优化的电源的RF传输的发射器。

    Biointerface membrane with macro-and micro-architecture
    99.
    发明授权
    Biointerface membrane with macro-and micro-architecture 有权
    具有宏观和微观结构的生物界面膜

    公开(公告)号：US07364592B2

    公开(公告)日：2008-04-29

    申请号：US11055779

    申请日：2005-02-09

    申请人： Victoria Carr-Brendel ,  Peter C. Simpson ,  James H. Brauker

    发明人： Victoria Carr-Brendel ,  Peter C. Simpson ,  James H. Brauker

    IPC分类号： A61F2/02

    CPC分类号： A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/10 ,  B33Y80/00

    摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.

    摘要翻译： 本文公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并连接到宏结构和/或位于宏观架构的至少一部分内的微架构。 宏观和微观结构共同协调管理和操纵体内异物反应的高级别组织结构和低水平细胞组织，从而增加接近装置 - 组织界面的新生血管形成，干扰屏障细胞层 形成并提供良好的组织锚定，同时减少运动神经的影响，并破坏FBC的组织和/或挛缩。 优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传送或测量装置中的分析物浓度的装置， 和/或其组合。