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137 条记录 (耗时 0.037 秒)

    Agent apparatus
    91.
    发明授权
    Agent apparatus 失效
    代理设备

    公开(公告)号：US06437689B2

    公开(公告)日：2002-08-20

    申请号：US09814169

    申请日：2001-03-22

    申请人： Makoto Kawai ,  Kazuya Tamura

    发明人： Makoto Kawai ,  Kazuya Tamura

    IPC分类号： B60Q100

    CPC分类号： B60R25/25 ,  B60R25/2081 ,  B60R25/252 ,  B60R25/257

    摘要： An agent apparatus increases security, and can make responses suited to individuals, thereby increasing convenience. The agent apparatus comprises an individual recognition unit which recognizes individuals who use a vehicle; a memory unit which stores agent data corresponding to each individual recognized by the individual recognition unit; a selection unit which selects agent data corresponding to a specific individuals recognized by the individual recognition unit from the agent data stored in the memory unit; and a response unit which responds to the individual based on the agent data selected by the selection unit.

    摘要翻译： 代理机构增加安全性，并且可以使响应适合于个人，从而增加方便性。 代理装置包括识别使用车辆的个人的个人识别单元; 存储单元，其存储与由各个识别单元识别的每个个体对应的代理数据; 选择单元，从存储在存储单元中的代理数据中选择与由个人识别单元识别的特定个人对应的代理数据; 以及响应单元，其基于由所述选择单元选择的代理数据对所述个人进行响应。

    Antibodies, production method of the antibodies, hybridomas which produce the antibodies, production method of the hybridomas and antigen proteins recognized by the antibodies
    92.
    发明授权
    Antibodies, production method of the antibodies, hybridomas which produce the antibodies, production method of the hybridomas and antigen proteins recognized by the antibodies 有权
    抗体的制备方法，产生抗体的杂交瘤，抗体识别的杂交瘤的生产方法和抗原蛋白

    公开(公告)号：US06255107B1

    公开(公告)日：2001-07-03

    申请号：US09229932

    申请日：1999-01-13

    申请人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi

    发明人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi

    IPC分类号： C12N512

    CPC分类号： C07K14/705 ,  C07K16/28

    摘要： The invention is related to antibodies which specifically react with connective tissue type-human mast cells, a production method of the antibodies, hybridomas which produce the antibodies, a production method of the hybridomas and antigen proteins recognized by the antibodies. After cord blood cells were cultured in the presence of SCF and IL-6, they were further cocultured with primary culture of human skin fibroblasts, and connective tissue type-human mast cells were thus obtained. A rat was immunized using the cells, hybridomas were prepared and selected by an ordinary method, and novel monoclonal antibodies were harvested from the culture supernatant of the selected hybridomas. The monoclonal antibodies specifically reacted with connective tissue type-human mast cells.

    摘要翻译： 本发明涉及与结缔组织型 - 人肥大细胞特异性反应的抗体，抗体的制备方法，产生抗体的杂交瘤，由抗体识别的杂交瘤和抗原蛋白的制备方法。 在SCF和IL-6存在下培养脐带血细胞后，与人皮肤成纤维细胞的原代培养物进一步共培养，得到结缔组织型人类肥大细胞。 使用细胞免疫大鼠，通过常规方法制备杂交瘤并选择，并从所选择的杂交瘤的培养上清液中收获新的单克隆抗体。 单克隆抗体与结缔组织型 - 人类肥大细胞特异性反应。

    Liquid level indication device
    93.
    发明授权
    Liquid level indication device 失效
    液位指示装置

    公开(公告)号：US4845986A

    公开(公告)日：1989-07-11

    申请号：US894919

    申请日：1986-08-08

    申请人： Chikahisa Hayashi ,  Makoto Kawai ,  Yoshikazu Hirose

    发明人： Chikahisa Hayashi ,  Makoto Kawai ,  Yoshikazu Hirose

    IPC分类号： G01F23/72

    CPC分类号： G01F23/72

    摘要： A liquid level indicator for detecting a liquid level by utilizing the variation inductance of a coil having a core made of an electrical insulating magnetic material and provided inside a winding of the coil. The core may be made by piling a plurality of thin, plate-shaped conductive materials one on another in the cross-sectional direction of the coil so that they are insulated from each other or by winding a conductive magnetic material at least one turn in the form of a roll so that a closed loop current is not formed in the cross-sectional direction of the coil. An eddy current loss of the core so arranged is so small that it can be disregarded. Furthermore, the winding component of the core itself is substantially released in the equivalent circuit of the coil.

    摘要翻译： 一种液位指示器，用于通过利用具有由电绝缘磁性材料制成的芯并且设置在线圈的绕组内的线圈的变化电感来检测液位。 芯可以通过在线圈的横截面方向上一个接一个地堆叠多个薄的板状导电材料制成，使得它们彼此绝缘或者通过将导电磁性材料卷绕在至少一个转弯处 使得在线圈的横截面方向上不形成闭环电流。 如此排列的核心的涡流损耗非常小，可以忽略。 此外，芯本身的绕组部件基本上被释放在线圈的等效电路中。

    ELECTRODE MOUNTING STRUCTURE OF SURFACE TREATMENT APPARATUS
    94.
    发明申请
    ELECTRODE MOUNTING STRUCTURE OF SURFACE TREATMENT APPARATUS 有权
    表面处理装置的电极安装结构

    公开(公告)号：US20090321253A1

    公开(公告)日：2009-12-31

    申请号：US12490034

    申请日：2009-06-23

    申请人： Tomohiro ASOU ,  Seiya KUNIOKA ,  Hitoshi MURAMATSU ,  Nobuyuki SYZUKI ,  Akira Ishibashi ,  Makoto Kawai

    发明人： Tomohiro ASOU ,  Seiya KUNIOKA ,  Hitoshi MURAMATSU ,  Nobuyuki SYZUKI ,  Akira Ishibashi ,  Makoto Kawai

    IPC分类号： C25D17/10

    CPC分类号： C25D5/34 ,  C25D7/04 ,  C25D17/12 ,  C25F3/02 ,  C25F7/00

    摘要： An electrode mounting structure of a surface treatment apparatus in which a metal electrode is disposed so as to oppose to an inner-peripheral surface of a cylinder, the electrode and the cylinder are energized in a state where treatment liquid is interposed between the electrode and the cylinder inner-peripheral surface so as to perform pre-plating or plating to the cylinder inner-peripheral surface, and the metal electrode is detachably attached to a metal electrode holder member. The structure includes a resin coupler having a threaded portion engaged with a threaded portion formed on the electrode holder member.

    摘要翻译： 一种表面处理装置的电极安装结构，其中金属电极设置成与气缸的内周面相对设置，电极和气缸在处理液介于电极和电极之间的状态下通电 气缸内周面，以便对气缸内周面进行预镀或电镀，并且金属电极可拆卸地安装在金属电极保持构件上。 该结构包括树脂耦合器，其具有与形成在电极保持器构件上的螺纹部分接合的螺纹部分。

    Antibody against a mast cell surface antigen
    96.
    发明申请
    Antibody against a mast cell surface antigen 审中-公开
    针对肥大细胞表面抗原的抗体

    公开(公告)号：US20060276631A1

    公开(公告)日：2006-12-07

    申请号：US11415575

    申请日：2006-05-02

    申请人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi ,  Masao Shibata ,  Motoki Kuhara

    发明人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi ,  Masao Shibata ,  Motoki Kuhara

    IPC分类号： C07K14/74 ,  C07K16/28 ,  C07H21/04

    CPC分类号： C07K14/705 ,  C07K16/28

    摘要： A mast cell surface antigen, DNA thereof and an antibody against the antigen are provided. The amino acid sequence of this mast cell surface antigen is the translation of the coding region of its DNA. The base sequence of this DNA has been clarified in the following manner. Namely, mast cells obtained by incubating cord blood monocular cells are co-incubated with primary culture of fibroblasts to give connective tissue type mast cells (MC-TC). Then mRNA is extracted from this MC-TC cell extraction and a cDNA library is constructed therefrom. Immunological screening is carried out with the use of anti-MC-TC antiserum and the base sequence of the positive clone thus obtained is identified. Owing to the clarification of the amino acid sequence of this mast cell antigen, it becomes possible to reveal the role of mast cells in the pathology of allergic diseases and thus an antibody against mast cells can be easily obtained.

    摘要翻译： 提供肥大细胞表面抗原，其DNA和针对抗原的抗体。 该肥大细胞表面抗原的氨基酸序列是其DNA编码区的翻译。 该DNA的碱基序列已经以下述方式进行了说明。 即，将通过孵育脐带血单核细胞获得的肥大细胞与成纤维细胞的原代培养物共温育以产生结缔组织型肥大细胞（MC-TC）。 然后从该MC-TC细胞提取中提取mRNA，并由其构建cDNA文库。 使用抗MC-TC抗血清进行免疫筛选，鉴定得到的阳性克隆的碱基序列。 由于这种肥大细胞抗原的氨基酸序列的澄清，可以揭示肥大细胞在过敏性疾病的病理学中的作用，因此可以容易地获得抗肥大细胞的抗体。

    N-benzenesulfonyl L-proline compounds as bradykinin antagonists
    97.
    发明授权
    N-benzenesulfonyl L-proline compounds as bradykinin antagonists 失效
    N-苯磺酰基L-脯氨酸化合物作为缓激肽拮抗剂

    公开(公告)号：US06734306B2

    公开(公告)日：2004-05-11

    申请号：US10010863

    申请日：2001-12-05

    申请人： Yasuhiro Katsu ,  Makoto Kawai ,  Hiroki Koike ,  Seiji Nukui

    发明人： Yasuhiro Katsu ,  Makoto Kawai ,  Hiroki Koike ,  Seiji Nukui

    IPC分类号： C07D40114

    CPC分类号： C07D451/02 ,  C07D401/12 ,  C07D401/14 ,  C07D451/04 ,  C07D453/02 ,  C07D487/08

    摘要： This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein X1 and X2 are halo; R1 and R2 are independently hydrogen or C1-4 alkyl; R3 and R4 are each hydrogen or halo; and R5 is (a) —C3-9 diazacycloalkyl optionally substituted with C5-11 azabicycloalkyl; (b) —C3-9 azacycloalkyl-NH—(C5-11 azabicycloalkyl optionally substituted with C1-4 alkyl); (c) —NH—C1-3 alkyl-C(O)—C5-11 diazabicycloalkyl; (d) —NH—C1-3 alkyl-C(O)—NH—C5-11 azabicycloalkyl, the C5-11 azabicycloalkyl being optionally substituted with C1-4 alkyl; (e) —C3-9 azacycloalkyl optionally substituted with C3-9 azacycloalkyl; or (f) —NH—C1-5 alkyl-NH—C(O)—C4-9 cycloalkyl-NH2. These compounds are useful for the treatment of medical conditions mediated by bradykinin such as inflammation, allergic rhinitis, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.

    摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，其中X 1和X 2为卤素; R 1和R 2独立地是氢或C 1-4烷基; R 3和R 4各自为氢或卤素; （b）-C3-9氮杂环烷基-NH-（任选被C 1-4烷基取代的C 5-10氮杂双环烷基）;（c）-C（= NH-C 1-3烷基-C（O）-C 5-11二氮杂双环烷基;（d）-NH-C 1-3烷基-C（O）-NH-C 5-11氮杂双环烷基，C 5-11氮杂双环烷基任选被C 1 -4-烷基;（e）任选被C 3-9氮杂环烷基取代的-C3-9氮杂环烷基; 或（f）-NH-C 1-5烷基-NH-C（O）-C 4-9环烷基-NH 2。这些化合物可用于治疗由缓激肽介导的医学病症如炎症，过敏性鼻炎，疼痛等。 本发明还提供了包含上述化合物的药物组合物。

    1,4-dihydropyridine compounds as bradykinin antagonists
    98.
    发明授权
    1,4-dihydropyridine compounds as bradykinin antagonists 失效
    1,4-二氢吡啶化合物作为缓激肽拮抗剂

    公开(公告)号：US06653313B2

    公开(公告)日：2003-11-25

    申请号：US09903157

    申请日：2001-07-11

    申请人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    发明人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    IPC分类号： A61K31496

    CPC分类号： A61K31/46 ,  A61K31/496 ,  C07D451/04 ,  Y02A50/411

    摘要： The present invention relates to compounds of the formula wherein each A is independently halo; Y is —(CH2)m—, —C(O)— or —S(O)—; R1 and R2 are independently C1-4 alkyl; R3 is substituted azacycloalkyl etc.; R4 is phenyl substituted at the 2-position with a substituent selected from substituted C1-7 alkyl, substituted C1-7 alkoxy, amine, etc; R5 is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.

    摘要翻译： 本发明涉及各种化合物，每个A独立地是卤素; Y是 - （CH 2）m - ， - C（O） - 或-S（O） - ; R 1和R 2独立地是C 1-4烷基; R 3是取代的氮杂环烷基等; R 4是在2-位上被取代基取代的C 1-7烷基，取代的C 1-7烷氧基，胺等取代的苯基; R 5是氢或C 1-4烷基; m为0,1或2; 本发明还涉及含有这些化合物的药物组合物以及这些化合物在治疗和预防炎症，哮喘，变应性鼻炎，疼痛和其它疾病中的用途 。