公开(公告)号：US20100273988A1

公开(公告)日：2010-10-28

申请号：US12311950

申请日：2007-10-19

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： C07K16/46 ,  C07K16/22 ,  C07K16/00

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30

摘要： A monoclonal antibody having a neutralizing activity on HB-EGF is disclosed. The monoclonal antibody of the present invention is preferably an antibody that does not bind to the HB-EGF protein on the cell surface of HB-EGF-expressing cells. Also provided are an anti-cancer agent and a cell proliferation inhibitor, which comprise the monoclonal antibody of the present invention as an active ingredient, and a method of treating cancer, the method comprising administering the monoclonal antibody of the present invention. Cancers that can be treated by the anti-cancer agent of the present invention include pancreatic cancer, liver cancer, esophageal cancer, melanoma, colorectal cancer, gastric cancer, ovarian cancer, bladder cancer, and brain tumors.

摘要翻译： 公开了具有HB-EGF中和活性的单克隆抗体。 本发明的单克隆抗体优选为在HB-EGF表达细胞的细胞表面不结合HB-EGF蛋白的抗体。 还提供了包含本发明的单克隆抗体作为活性成分的抗癌剂和细胞增殖抑制剂以及治疗癌症的方法，所述方法包括施用本发明的单克隆抗体。 可以通过本发明的抗癌剂治疗的癌症包括胰腺癌，肝癌，食管癌，黑素瘤，结肠直肠癌，胃癌，卵巢癌，膀胱癌和脑肿瘤。

公开(公告)号：US20090245050A1

公开(公告)日：2009-10-01

申请号：US12415608

申请日：2009-03-31

申请人： Manabu Murakami ,  Shigeru Fukinuki ,  Naoki Kimura

发明人： Manabu Murakami ,  Shigeru Fukinuki ,  Naoki Kimura

IPC分类号： G11B7/12

CPC分类号： G11B7/126 ,  G11B7/1275 ,  G11B2007/0006

摘要： According to one embodiment, an optical disk device includes types of semiconductor laser diodes configured to emit laser light of different wavelengths, an output control circuit configured to control light output of each semiconductor laser diode, and a composite power source configured to generate voltages required for driving the types of semiconductor laser diodes and operating the output control circuit from a single power source voltage and to selectively output the generated voltages. The composite power source includes an input port to input an external control signal at a time of voltage selection and is configured to change the output voltage stepwise in response to the control signal.

摘要翻译： 根据一个实施例，光盘装置包括配置为发射不同波长的激光的半导体激光二极管的类型，被配置为控制每个半导体激光二极管的光输出的输出控制电路和被配置为产生 驱动类型的半导体激光二极管，并从单个电源电压操作输出控制电路并选择性地输出所产生的电压。 复合电源包括在电压选择时输入外部控制信号的输入端口，并且被配置为响应于控制信号逐步改变输出电压。

公开(公告)号：US07572039B2

公开(公告)日：2009-08-11

申请号：US11950904

申请日：2007-12-05

申请人： Naoki Kimura ,  Masakazu Ohashi ,  Shunichirou Hirafune

发明人： Naoki Kimura ,  Masakazu Ohashi ,  Shunichirou Hirafune

IPC分类号： F21S8/08

CPC分类号： H01L33/641 ,  G02F1/133603 ,  G02F1/133608 ,  H01L33/60 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2924/181 ,  H05K1/053 ,  H05K1/183 ,  Y10S362/80 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

摘要： A porcelain enamel substrate mounts a light emitting device in which a porcelain enamel layer is coated onto a surface of a core metal, and a reflective cup portion that has a flat bottom surface and a sloping portion that surrounds this bottom surface is provided on a light emitting device mounting surface, and an electrode for energizing a light emitting device is provided on the light emitting device mounting surface, and the thickness of the electrode within the reflective cup portion is within a range of 5 μm to 100 μm.

摘要翻译： 瓷搪瓷基板安装有将瓷釉层涂覆在芯金属的表面上的发光装置，并且具有平坦的底面和围绕该底面的倾斜部的反射杯部设置在光 发光装置安装面以及用于赋能发光装置的电极设置在发光装置安装面上，反射杯部内的电极的厚度在5μm〜100μm的范围内。

公开(公告)号：US07508522B2

公开(公告)日：2009-03-24

申请号：US11047970

申请日：2005-01-31

申请人： Yutaka Kadowaki ,  Shu Morikawa ,  Jun Matsumoto ,  Naoki Kimura ,  Shinji Yamamoto

发明人： Yutaka Kadowaki ,  Shu Morikawa ,  Jun Matsumoto ,  Naoki Kimura ,  Shinji Yamamoto

IPC分类号： G01N21/55

CPC分类号： G01N21/55

摘要： A reflected light measuring apparatus including an illumination system and a light receiving system which receives reflected light from a measuring area of an object illuminated with measuring light projected from the illumination system. The illumination system projects the measuring light with a prescribed angular width onto each point in the measuring area. The illumination system and the light receiving system project the measuring light onto the measuring area and receive the reflected light via a telecentric optical system.

摘要翻译： 一种反射光测量装置，包括照明系统和光接收系统，其接收来自从照明系统投射的测量光照射的物体的测量区域的反射光。 照明系统将测量光以规定的角度宽度投射到测量区域的每个点上。 照明系统和光接收系统将测量光投射到测量区域上，并通过远心光学系统接收反射光。

公开(公告)号：US07253446B2

公开(公告)日：2007-08-07

申请号：US11344126

申请日：2006-02-01

申请人： Ken Sakuma ,  Naoki Kimura ,  Koichiro Masuko ,  Naoto Hirosaki

发明人： Ken Sakuma ,  Naoki Kimura ,  Koichiro Masuko ,  Naoto Hirosaki

IPC分类号： H01L21/22 ,  H01L31/0256 ,  H01L31/0296 ,  H01L33/00

CPC分类号： C04B35/597 ,  C04B2235/3224 ,  C04B2235/3865 ,  C04B2235/3873 ,  C04B2235/766 ,  C04B2235/767 ,  C09K11/0883 ,  C09K11/7734 ,  H01L33/504 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/8592 ,  H01L2924/181 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

摘要： A light-emitting device and illumination apparatus using the same are provided. The light-emitting device includes a semiconductor light-emitting element that emits blue-violet or blue light and a fluorescent material that absorbs the light emitted by the semiconductor light-emitting element and emits fluorescence of wavelengths different from the light, wherein the fluorescent material includes a mixture of a first fluorescent material, a second fluorescent material that has a longer emission wavelength than that of the first fluorescent material, and a third fluorescent material that has a longer emission wavelength than the second fluorescent material, and the first fluorescent material is a europium-activated β-SiAlON fluorescent material, the second fluorescent material is a europium-activated α-SiAlON fluorescent material, and the third fluorescent material is a nitride crystalline red fluorescent material of a general formula of (Ca,Eu)AlSiN3. The illumination apparatus includes a light source including a light emitting device as described above.

摘要翻译： 提供了一种使用其的发光装置和照明装置。 发光装置包括发射蓝紫色或蓝色光的半导体发光元件和吸收由半导体发光元件发射的光并发射与光不同的波长的荧光的荧光材料，其中荧光材料 包括第一荧光材料，具有比第一荧光材料的发光波长长的发光波长的第二荧光材料和具有比第二荧光材料更长的发射波长的第三荧光材料的混合物，并且第一荧光材料是 铕活化的β-SiAlON荧光材料，第二荧光材料是铕活化的α-SiAlON荧光材料，第三荧光材料是通式为（Ca，Eu）AlSiN 3的氮化物结晶红色荧光材料。 照明装置包括如上所述的包括发光装置的光源。

公开(公告)号：US07238518B2

公开(公告)日：2007-07-03

申请号：US10677853

申请日：2003-10-02

申请人： Nagahide Matsubara ,  Takeshi Nagasaka ,  Naoki Kimura ,  Osamu Suzuki

发明人： Nagahide Matsubara ,  Takeshi Nagasaka ,  Naoki Kimura ,  Osamu Suzuki

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6827 ,  C12Q2600/156 ,  C12Q2531/113 ,  C12Q2523/125 ,  C12Q2565/501

摘要： The presence or absence of methylation of C's in CpG dinucleotide in a sample DNA that contains a target sequence including the CpG dinucleotide is detected as follows. Multiple kinds of capture oligonucleotides immobilized on a base material and including: an oligonucleotide having a nucleotide sequence complimentary to or identical to a nucleotide sequence corresponding to the target sequence in which all of C's other than C's in the all of CpG dinucleotide are replaced with T's; and an oligonucleotide having a nucleotide sequence complimentary to or identical to a nucleotide sequence corresponding to the target sequence in which all of C's are replaced with T's are hybridized with the sample DNA in which non-methylated C's have been converted into U's by deamination or an amplification product thereof, and the presence or absence of methylation is detected based on the result of the hybridization.

摘要翻译： 在包含CpG二核苷酸的靶序列的样品DNA中CpG二核苷酸中C的甲基化的存在或不存在如下。 固定在基材上的多种捕获寡核苷酸，包括：与对应于靶序列的核苷酸序列互补或相同的核苷酸序列的寡核苷酸，其中所有CpG二核苷酸中除C以外的全部C被T ; 并且具有与对应于其中全部C被T替换的靶序列的核苷酸序列互补或相同的核苷酸序列的寡核苷酸与其中非甲基化C已经通过脱氨酸转化成U的样品DNA杂交或 其扩增产物，并且基于杂交的结果检测甲基化的存在或不存在。

公开(公告)号：US20060229838A1

公开(公告)日：2006-10-12

申请号：US11398792

申请日：2006-04-06

申请人： Naoki Kimura ,  Toru Kobayashi ,  Norio Ishikawa

发明人： Naoki Kimura ,  Toru Kobayashi ,  Norio Ishikawa

IPC分类号： G01D1/00

CPC分类号： G01J3/50 ,  G01J3/02 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0289 ,  G01N21/25

摘要： A support apparatus for optical characteristic measurement includes a measurement data inputter configured to input measurement data obtained by an optical characteristic measuring instrument, an image inputter configured to input an image of a measurement object, a measurement table in which the measurement data and the image of the measurement object corresponding to the measurement data are recorded, and a measurement data manager configured to record the measurement data inputted by the measurement data inputter in the measurement table so as to be associated with the image of the measurement object every time an optical characteristic of the measurement object is measured.

摘要翻译： 用于光学特性测量的支持装置包括测量数据输入器，其被配置为输入由光学特性测量仪器获得的测量数据，被配置为输入测量对象的图像的图像输入器，测量数据和测量数据的图像 记录与测量数据相对应的测量对象，并且测量数据管理器被配置为将测量数据输入器输入的测量数据记录在测量表中，以便每当测量对象的光学特性 测量对象。

公开(公告)号：US20060068392A1

公开(公告)日：2006-03-30

申请号：US10535582

申请日：2003-11-25

申请人： Naoki Kimura ,  Ryuichi Oda

发明人： Naoki Kimura ,  Ryuichi Oda

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12N11/16 ,  G01N1/28 ,  B05D3/00

CPC分类号： G01N33/553 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00387 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B82Y30/00 ,  C12Q1/6834

摘要： A solution of a nucleic acid is spotted on a metal carrier consisting of a metal selected from Groups I, II, III, IV, V, VI, and VII of second to seventh periods and transition elements in a periodic table, or of an alloy containing the metal, and the solution is dried. Then, the nucleic acid is immobilized on the carrier spotted with the solution by irradiating the carrier with an ultraviolet ray containing a component having a wavelength of 280 nm, of which irradiation dose is 100 mJ/cm2 or more.

摘要翻译： 将核酸溶液点在由选自第二至第七个周期的第I，II，III，IV，V，VI和VII族的金属组成的金属载体上，周期表中的过渡元素，或合金 含有金属，溶液干燥。 然后，通过用包含波长280nm的成分的紫外线照射载体，照射剂量为100mJ / cm 2以上，将核酸固定在载体上， 更多。

公开(公告)号：US20060061263A1

公开(公告)日：2006-03-23

申请号：US11178363

申请日：2005-07-12

申请人： Ken Sakuma ,  Koji Omichi ,  Naoki Kimura ,  Masakazu Ohashi ,  Daiichiro Tanaka ,  Naoto Hirosaki

发明人： Ken Sakuma ,  Koji Omichi ,  Naoki Kimura ,  Masakazu Ohashi ,  Daiichiro Tanaka ,  Naoto Hirosaki

IPC分类号： H01J1/62

CPC分类号： C09K11/7734 ,  C04B35/597 ,  C04B35/6261 ,  C04B35/6262 ,  C04B35/62695 ,  C04B35/645 ,  C04B2235/3208 ,  C04B2235/3224 ,  C04B2235/3865 ,  C04B2235/3878 ,  C04B2235/442 ,  C04B2235/5427 ,  C09K11/0883 ,  H01L33/502 ,  H01L2224/32245 ,  H01L2224/32257 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/73265 ,  H01L2224/8592 ,  H01L2924/181 ,  H05B33/14 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

摘要： An incandescent lamp color light emitting diode lamp comprises a semiconductor blue light emitting diode chip having a center emission wavelength in a range of from 400 nm to 480 nm and a phosphor that absorbs light emitted from the diode chip to emit light having a different wavelength than the light emitted from the diode chip. The phosphor is represented by a general formula of Mp(Si, Al)12(O, N)16:Eu2+q. The main phase is an α-SiAlON phosphor having an α SiAlON structure, wherein M is at least one element of Ca, Y, Mg, Li, Sc, Pr, Nd, Pm, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Sr and p is from 0.75 to 1.0; and q is between 0.02 and 0.09. The diode lamp emits light having an emission color produced by a mixture of the light emitted from the semiconductor blue light emitting and the light emitted from the α-SiAlON. The chromaticity range thereof falls within the range defined by chromaticity coordinates (x, y) of (0.4775, 0.4283), (0.4594, 0.3971), (0.4348, 0.4185), and (0.4214, 0.3887) on the XYZ chromaticity diagram.

摘要翻译： 白炽灯彩色发光二极管灯包括具有400nm至480nm范围内的中心发射波长的半导体蓝色发光二极管芯片和吸收从二极管芯片发射的光以发射具有不同波长的光的荧光体 从二极管芯片发出的光。 磷光体由通式（Si，Al）12（O，N）16：Eu 2+表示， + 。 主相是具有αSiAlON结构的α-SiAlON荧光体，其中M是Ca，Y，Mg，Li，Sc，Pr，Nd，Pm，Sm，Gd，Tb，Dy，Ho，Er中的至少一种元素 ，Tm，Yb，Lu和Sr，p为0.75〜1.0; q在0.02和0.09之间。 二极管灯发射具有由半导体蓝光发射的光和从α-SiAlON发射的光的混合产生的发射颜色的光。 其色度范围落在由XYZ色度图上的（0.4775,0.4283），（0.4594,0.3971），（0.4348,0.4185）和（0.4214,0.3887）的色度坐标（x，y）定义的范围内。

公开(公告)号：US20050179902A1

公开(公告)日：2005-08-18

申请号：US11047970

申请日：2005-01-31

申请人： Yutaka Kadowaki ,  Shu Morikawa ,  Jun Matsumoto ,  Naoki Kimura ,  Shinji Yamamoto

发明人： Yutaka Kadowaki ,  Shu Morikawa ,  Jun Matsumoto ,  Naoki Kimura ,  Shinji Yamamoto

IPC分类号： G01J3/50 ,  G01N21/55

CPC分类号： G01N21/55

摘要： An illumination system comprises a light source unit, a condenser lens, and a lens for constructing a telecentric optical system, and projects measuring light onto a specimen to be measured, from an angle tilted by a prescribed angle relative to the normal to the specimen. A light receiving system is an optical system comprising the lens, a light receiving lens, and a light receiving sensor and, of the reflected light produced by reflection of the measuring light, the light receiving system receives reflected light rays reflected in a direction whose angle to the normal to the measuring surface is 0°. In this way, the telecentric optical system is constructed by placing the lens in the light paths of the illumination system and the light receiving system; with this configuration, the projection angle of the measuring light to the curved specimen and the receiving angle of the reflected light from the curved specimen, respectively, can be made the same within the curved surface of the specimen.

摘要翻译： 照明系统包括光源单元，聚光透镜和用于构造远心光学系统的透镜，并且从相对于样本的法线倾斜规定角度的角度将测量光投射到待测量的样本上。 光接收系统是包括透镜，光接收透镜和光接收传感器的光学系统，并且通过测量光的反射产生的反射光，光接收系统接收在角度方向上反射的反射光线 到测量表面的法线为0°。 以这种方式，通过将透镜放置在照明系统和光接收系统的光路中来构造远心光学系统; 通过该结构，能够使测定光与弯曲试样的投影角度和来自弯曲试样的反射光的接收角度分别在试样的曲面内相同。