摘要:
The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 on hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula —CO—, etc.; X indicates a single bond, an oxygen atom etc.; R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D1, D2, W1 and W2 are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.
摘要:
The invention provides an N,N-substituted cyclic amine compound represented by the following formula (VIII): wherein A represents an aryl group etc.; E represents a group represented by the formula —CO— or a group represented by the formula —CHOH—; G represents an oxygen atom etc.; J represents an aryl group which may be substituted; R1 represents a lower alkyl group etc.; Alk represents a linear or branched lower alkylene group; n, v, w, x and y are independent of each other and each represents 0 or 1; and p represents 2 or 3, or a pharmacologically acceptable salt thereof. The compound of the present invention or a salt thereof is effective to treat a disease against which calcium antagonism is effective. The disease may include acute ischemic stroke, cerebral apoplexy, cerebral infarction, head trauma, cerebral nerve cell death, Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, Huntington disease, cerebral circulatory metabolism disturbance, cerebral function disturbance, pain, spasm, schizophrenia, migraine, epilepsy, maniac-depressive psychosis, nerve degenerative diseases, cerebral ischemia, AIDS dementia complications, edema, anxiety disorder (generalized anxiety disorder) and diabetic neuropathy.
摘要:
Signals are evenly distributed and transmitted using a plurality of channels. Multicast and broadcast communications are efficiently made. Signals from each sub transmission paths are distributed onto a plurality of channels to send them via these channels. Furthermore, signals are inserted into the channels by finding empty packets from the channels, thus allowing input of signals to the channels that transfer various kinds of signals. Upon multicast or broadcast communications, an input signal is copied in correspondence with a plurality of channels.
摘要:
A sensor 42d is provided for detecting release of a state of a workpiece fixed and held with workpiece holding members during rotation of a spindle 9. When the release of the state of the wokpiece fixed and held is detected, the sliding members are driven in a direction of an axial center (in a direction as shown by an arrow D) by a reciprocating drive means 42. Even if holding force, such as the oil pressure of the workpiece holding member, is lowered, the decrease of the holding force of the workpiece can be extremely avoided by moving the sliding members in the direction of the workpiece.
摘要:
Gas shielded arc welding is performed using gas nozzle 10 which includes a straight portion 14 that permits the shielding gas flows from orifices 18 to flow parallel to the axial direction and a constricted portion 20 continuous from the straight portion 14 that constricts the gas flows from the straight portion 14 as they travel toward the distal end and the nozzle 10 satisfies the following relations (1) and (2): 1.5≦(Dp/Do)≦2.5 (1) 1.0≦(L/Dp) (2) where Dp is the inside diameter of the straight portion 14, Do is the inside diameter of the distal gas outlet of the constricted portion 20, and L is the axial length of the constricted portion 20.
摘要:
The pyrazolinone derivatives represented by the formula [I]: [wherein R1, R2, R3, R4 and R5 may be identical or different and represent independently a hydrogen atom, a halogen atom, an alkyl group, a haloalkyl group, an alkoxyl group, etc.; R6 represents an optionally substituted alkyl group, etc.; X represents an optionally substituted alkyl group, etc,; and Y represents an oxygen atom or a sulfur atom] are provided.
摘要:
In a discharge lamp apparatus for a vehicle, it is determined that a grounded condition is present when a lamp voltage is less than a predetermined voltage and a lamp current is less than a predetermined current. Electric power supply to the lamp is stopped temporarily in response to the determination of the grounded condition, and then the lighting operation is restarted again. If the grounded condition is determined again, the above operation is repeated. If this repetition continues for a predetermined period, the lighting operation is disabled continuously. In controlling the lamp, a voltage of a battery is boosted by a voltage booster transformer, which is turned on and off by a MOS transistor so that electric power supplied to the lamp is duty-controlled. An upper limit is set to the duty ratio, and the upper limit is increased as the lamp current decreases, so that the lighting characteristics of the lamp is improved. A starter transformer has a closed magnetic circuit core, and is encased within a ballast casing, which is disposed under the lamp.
摘要:
A high voltage electric-discharge lamp is used as a light source of a headlight device for use in an automobile vehicle. Light from the discharge lamp is reflected on the curved surface of a reflector disposed at a back side of the discharge lamp, and projected forward. To reduce high frequency electromagnetic noises emitted forward from the device, which interfere with radios and televisions mounted on a vehicle driven ahead, a shade to intercept light emitted directly forward from the discharge lamp is disposed in front of the discharge lamp, and the shade is grounded. To further enhance noise reduction effects, a second grounding passage is provided. The second grounding passage is formed by grounding terminals attached to the shade and a wire connecting the terminals to the ground. Other components constituting the headlight device may be also grounded to secure a higher shielding effect. The electromagnetic noises interfering with radios and televisions mounted on a vehicle driving ahead are sufficiently reduced to a harmless level.
摘要:
In a discharge lamp device, the electric power supplied to a discharge lamp is controlled in order of first to fourth control regions from the start of lighting of the discharge lamp. In the first control region, the lamp current is held constant until the lamp voltage reaches a first voltage value. In the second control region, the lamp current is reduced so as to have a correlation with a first time constant curve for a constant time after the lamp voltage reaches the first voltage value. In the third control region, the lamp current is reduced so as to have a correlation with a second time constant curve after a lapse of the constant time. The second time constant curve differs from the first time constant curve. In the fourth control region, a control value of the electric power supplied to the discharge lamp is free of a function of a lapse of time from the start of lighting of the discharge lamp, but is a function of at least the lamp voltage and the lamp current, and the electric power supplied to the discharge lamp is controlled by that control value. Through such a control, luminous flux is built up in a short time from the start of the lighting and an occurrence of overshoot or undershoot is minimized to a possible extent.
摘要:
A lamp current i.sub.L flows through a first resistor. Electric current I, which is the output current of a voltage-current converter which converts a lamp voltage V.sub.L to a lamp current I, flows through a second resistor. Feedback control is executed to make V.sub.-, which is the voltage of one terminal of the second resistor, equal a reference voltage V.sub.ref. The power applied to the lamp during start-up is controlled to be the same as the power applied to the lamp during its stable lighting for a predetermined lamp voltage range. Using the following two linear equations, the electric current I is set as I=aV.sub.L +b (where a and b are positive constants) when the lamp voltage V.sub.L is lower than a first predetermined voltage V.sub.a which is less than the lamp voltage during the normal stable lighting period of the lamp, and as I=cV.sub.L +d (where c and d are positive constants with c b), when the lamp voltage V.sub.L is greater than or equal to the first predetermined value V.sub.a.