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    VORTIOXETINE MANUFACTURING PROCESS
    93.
    发明申请
    VORTIOXETINE MANUFACTURING PROCESS 有权
    VORTIOXETINE制造工艺

    公开(公告)号：US20160009670A1

    公开(公告)日：2016-01-14

    申请号：US14767350

    申请日：2014-02-20

    申请人： H. LUNDBECK A/S

    发明人： Thomas Ruhland ,  Kim Lasse Christensen

    IPC分类号： C07D295/096 ,  C07F15/02

    CPC分类号： C07D295/096 ,  C07F15/02

    摘要： A process for the manufacture of vortioxetine is provided in which a compound of formula I, formula I is reacted with optionally substituted piperazine and 2,4-dimethylthiophenol(ate) followed by de-complexation.

    摘要翻译： 提供了一种制备伏妥托汀的方法，其中式I式I化合物与任选取代的哌嗪和2,4-二甲基苯硫酚（ate）反应，随后脱络合。

    ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
    95.
    发明申请
    ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES 有权
    有机电致发光材料和器件

    公开(公告)号：US20150236279A1

    公开(公告)日：2015-08-20

    申请号：US14616438

    申请日：2015-02-06

    申请人： Universal Display Corporation ,  University of Southern California

    发明人： Geza SZIGETHY ,  Jason Brooks ,  Mark E. Thompson ,  Patrick Saris ,  Peter I. Djurovich

    IPC分类号： H01L51/00 ,  C07F17/02

    CPC分类号： H01L51/0085 ,  C07F15/0033 ,  C07F15/02 ,  H01L51/5016

    摘要： A compound having a structure of Formula M(LA)x(LB)y(LC)z, where ligand LA is ligand LB is and ligand LC is is disclosed. In Formula M(LA)x(LB)y(LC)z, M is a metal having an atomic number greater than 40; x is 1, 2, or 3; y and z are 0, 1, or 2; x+y+z is the oxidation state of metal M; Z1-Z6 are each C or N; ZD is N or a carbene carbon; rings C and D are independently a 5 or 6-membered carbocyclic or heterocyclic ring; R4 is substituted, while each of R1, R2, R3, RC, RD, R11, R12, and R13 are selected from hydrogen and a variety of moieties; and any adjacent substituents of R1, R2, R3, R4, RC, RD, R11, R12, and R13 are optionally joined to form a ring. Formulations and devices, such as an OLEDs, that include the compound of formula M(LA)x(LB)y(LC)z are also described.

    摘要翻译： 公开了具有式M（LA）x（LB）y（LC）z的结构的化合物，其中配位体LA是配位体LB，并且配体LC是公开的。 在式M（LA）x（LB）y（LC）z中，M是原子序数大于40的金属; x为1,2或3; y和z分别为0,1或2; x + y + z是金属M的氧化态; Z1-Z6各自为C或N; ZD为N或碳烯碳; 环C和D独立地为5或6元碳环或杂环; R 4是取代的，而R 1，R 2，R 3，RC，RD，R 11，R 12和R 13各自选自氢和各种部分; 并且R 1，R 2，R 3，R 4，RC，RD，R 11，R 12和R 13的任何相邻的取代基任选地连接形成环。 还描述了包括式M（LA）x（LB）y（LC）z的化合物的制剂和装置，例如OLED。

    FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME
    96.
    发明申请
    FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME 有权
    有机有机化合物，其用途及其制备方法

    公开(公告)号：US20150232495A1

    公开(公告)日：2015-08-20

    申请号：US14502774

    申请日：2014-09-30

    申请人： Panion & BF Biotech, Inc.

    发明人： David W.K. KWOK ,  Nikolay Mintchev Stoynov

    IPC分类号： C07F15/02

    CPC分类号： C07F15/025 ,  A61K31/295 ,  C07C51/41 ,  C07C51/412 ,  C07C51/418 ,  C07C59/265 ,  C07F15/02 ,  C07C55/10 ,  C07C59/255 ,  C07C53/08 ,  C07C59/245 ,  C07C57/15

    摘要： The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. The ferric organic compounds of the present invention can be delivered effectively by oral route with better delivery to treat patients suffering from hyperphosphatemia, metabolic acidosis and other disorders responsive to ferric organic compound therapy.

    摘要翻译： 本发明公开了一种新型的三价铁有机化合物，其包括柠檬酸铁的形式，其可在较宽的pH范围内溶解并具有大的活性表面积。 本发明的铁有机化合物可以通过口服途径有效地递送，具有更好的输送以治疗患有高磷酸盐血症，代谢性酸中毒和对三价铁有机化合物治疗有反应的其它病症的患者。

    Supported ligands having a high local density of coordinating atoms
    99.
    发明授权
    Supported ligands having a high local density of coordinating atoms 有权
    具有高的配位原子的局部密度的配体

    公开(公告)号：US09045511B2

    公开(公告)日：2015-06-02

    申请号：US13807645

    申请日：2011-06-24

    申请人： Jean-Cyrille Hierso ,  Matthieu Beauperin ,  Philippe Meunier

    发明人： Jean-Cyrille Hierso ,  Matthieu Beauperin ,  Philippe Meunier

    IPC分类号： C07F17/02 ,  C07F15/02 ,  C07D319/06

    CPC分类号： C07F15/02 ,  B01J31/1625 ,  B01J31/1658 ,  B01J31/2409 ,  B01J2231/4205 ,  B01J2531/16 ,  B01J2531/824 ,  C07D319/06 ,  C07F17/02 ,  Y02P20/588

    摘要： The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis.

    摘要翻译： 本发明涉及化合物，特别是金属络合物的次膦酸配体，以及包括所述配体的金属络合物和包括所述金属络合物或所述化合物的载体催化剂。 本发明还涉及用于合成所述化合物，络合物和载体催化剂以及用于所述合成方法的中间产物的方法。 本发明还涉及所述化合物的用途。 本发明的化合物是已被官能化以能够异源化的二茂铁化合物。 本发明特别可用于多相催化领域。