公开(公告)号：US09121551B2

公开(公告)日：2015-09-01

申请号：US13738670

申请日：2013-01-10

Applicant: PANASONIC CORPORATION

Inventor： Yoshitsugu Uriu ,  Akio Hirata

IPC: G01N35/10 ,  F17D1/08 ,  G01N1/00 ,  G01N1/40 ,  B01L3/02

CPC classification number: F17D1/08 ,  B01L3/0244 ,  B01L2400/02 ,  G01N1/00 ,  G01N1/4005 ,  G01N35/1079 ,  G01N2035/1034 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: In order to provide a method for collecting a droplet attached on an external surface of a needle into a capillary tube, the present invention is a method for collecting a droplet attached on an external surface of a needle into a capillary tube, the method comprising steps of: (a) preparing a substrate comprising a capillary tube; a flexible thin film; a liquid-repellent film; and a hole; (b) moving the needle in the Z-direction to move the droplet from the external surface of the needle to the surface of the liquid-repellent film; (c) allowing the droplet to arrive at an inlet of the capillary tube by moving the needle more in the Z-direction, so as to suck the droplet into the capillary tube by a capillary phenomenon.

Abstract translation: 为了提供将附着在针的外表面上的微滴收集到毛细管中的方法，本发明是一种将附着在针的外表面上的微滴收集到毛细管中的方法，该方法包括步骤 （a）制备包括毛细管的基材; 柔性薄膜; 防液膜; 和一个洞; （b）沿Z方向移动针头以将液滴从针的外表面移动到防液膜的表面; （c）通过在Z方向上移动针头使液滴通过毛细管现象将液滴吸入毛细管中，从而使液滴到达毛细管入口。

公开(公告)号：US20150129427A1

公开(公告)日：2015-05-14

申请号：US14394895

申请日：2013-04-19

Applicant: UNIVERSITEIT LEIDEN

Inventor： Robert-Jan Raterink ,  Peter Lindenburg ,  Thomas Hankemeier

IPC: B03C5/02

CPC classification number: B03C5/02 ,  B01D11/0419 ,  B01D57/02 ,  B01D61/246 ,  B01D61/38 ,  B01D61/42 ,  G01N1/4005 ,  G01N27/44756 ,  G01N2001/4011 ,  G01N2001/4038 ,  G01N2030/009 ,  G01N2030/062 ,  G01N2035/1053

Abstract: The present invention relates to a process for the extraction of analyte compounds from a sample comprising one or more analytes in a donor phase into an acceptor phase, comprising the steps of: a) providing an electrically conductive donor phase comprising the compounds in a first electrically conductive solvent or solvent blend, and an electrode arranged in electrically conductive contact with the donor phase, b) providing an electrically conductive acceptor phase in electrically conductive contact with a second electrode; and c) providing an insulator phase in fluid communication with at least one of the donor phase and the acceptor phase, wherein the insulator phase is immiscible with the donor phase and/or the acceptor phase, and d) (d) applying an electrical field between the first and the second electrode.

Abstract translation: 本发明涉及一种从包含供体相中的一种或多种分析物的样品中提取分析物质到受体相中的方法，所述方法包括以下步骤：a）提供包含所述化合物的导电供体相， 导电溶剂或溶剂共混物，以及布置成与供体相导电接触的电极，b）提供与第二电极导电接触的导电受体相; 以及c）提供与供体相和受体相中的至少一个流体连通的绝缘体相，其中绝缘体相与施主相和/或受体相不混溶，以及d）（d）施加电场 在第一和第二电极之间。

公开(公告)号：US20150086970A1

公开(公告)日：2015-03-26

申请号：US14398409

申请日：2012-05-03

Applicant: Michael Poirier

Inventor： Michael Poirier

IPC: G01N33/49 ,  G01N1/40

CPC classification number: G01N1/4005 ,  B01D69/02 ,  B01D2319/06 ,  B01D2325/36 ,  B01D2325/38 ,  G01N33/491

Abstract: Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.

Abstract translation: 提出了具有第一和第二部分的血浆分离装置分离含血液的装置和方法。 最优选地，第一部分产生细胞部分和血浆部分，第二部分捕获血浆部分。 然后，第一致动器然后流体地隔离第二部分内的等离子体部分的一部分，并且第二致动器从第二部分移动血浆部分的隔离部分。

公开(公告)号：US08940146B2

公开(公告)日：2015-01-27

申请号：US13312377

申请日：2011-12-06

Applicant: Roger Trones ,  Trond Lovli

Inventor： Roger Trones ,  Trond Lovli

IPC: G01N1/40 ,  B01D61/38

CPC classification number: G01N1/4005 ,  B01D61/38 ,  G01N2001/4011 ,  G01N2001/4016

Abstract: A device for electro membrane extraction has a syringe holder adapted to hold a syringe having an acceptor solution, and a sample vial holder adapted to hold a sample vial having a vial cap, where the vial cap includes an inside funnel to be equipped with a prewetted hollow fiber membrane having a tube like shape sealed at the end opposite the funnel and forming a lumen, and steering guides for at least two electrodes, a first electrode to be immersed in a donor solution placed in the sample vial, a second electrode to be immersed, through the funnel in the vial cap, into the lumen of the hollow fiber membrane, and a positioning device for sliding the first electrode in and out of the donor solution in the sample vial and for sliding the second electrode in and out of the lumen of the hollow fiber membrane.

Abstract translation: 用于电膜提取的装置具有适于保持具有受体溶液的注射器的注射器保持器和适于保持具有小瓶盖的样品瓶的样品瓶保持架，其中小瓶盖包括内漏斗以配备预润湿 中空纤维膜，其具有在与漏斗相对的端部密封并形成内腔的管状形状，以及用于至少两个电极的转向引导件，浸没在放置在样品瓶中的供体溶液中的第一电极，第二电极 通过小瓶盖中的漏斗浸入中空纤维膜的内腔中;以及定位装置，用于将第一电极滑入和取出样品瓶中的供体溶液，并将第二电极滑入和移出 中空纤维膜的内腔。

公开(公告)号：US20150004687A1

公开(公告)日：2015-01-01

申请号：US14370566

申请日：2012-12-28

Applicant: Hitachi Chemical Company, Ltd. ,  Tokyo University of Agriculture and Technology

Inventor： Yoshihito Kikuhara ,  Hisashige Kanbara ,  Takahiro Suzuki ,  Tadashi Matsunaga ,  Tomoko Yoshino ,  Masahito Hosokawa

IPC: G01N1/40

CPC classification number: G01N1/4005 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0874 ,  C12M47/02 ,  G01N15/0272 ,  G01N15/06 ,  G01N2001/4088 ,  G01N2015/0065

Abstract: A cell trapping device includes a housing that includes an inlet opening connected to an inlet line through which a cell dispersion liquid is introduced and an outlet opening connected to an outlet line through which the cell dispersion liquid is discharged; and a filter which is positioned within the housing and includes a trapping region for trapping cancer cells contained in the cell dispersion liquid. The filter is bonded to the housing, at least a part of the trapping region is formed of an observation region for observing the trapping region from the outside, the inlet line and the inlet opening are arranged at outer positions than the observation region when viewed from a normal line direction of the filter, and the inlet line is extended along an in-plane direction of the filter.

Abstract translation: 细胞捕获装置包括壳体，其包括连接到入口线的入口开口，细胞分散液通过该入口引入，并且出口开口连接到排出细胞分散液体的出口线; 以及位于壳体内并且包括用于捕获包含在细胞分散液中的癌细胞的捕获区域的过滤器。 过滤器结合到壳体，捕集区域的至少一部分由用于从外部观察捕获区域的观察区域形成，入口管线和入口开口布置在比观察区域更靠外部的位置，当从 过滤器的法线方向，并且入口管线沿着过滤器的面内方向延伸。

公开(公告)号：US08889071B2

公开(公告)日：2014-11-18

申请号：US13262057

申请日：2009-12-07

Applicant: Arata Aota ,  Takehiko Kitamori

Inventor： Arata Aota ,  Takehiko Kitamori

IPC: G01N30/96 ,  G01N33/00 ,  B01D21/00 ,  B01D61/00 ,  B01D63/00 ,  G01N1/40 ,  G01N33/49

CPC classification number: G01N33/491 ,  G01N1/4005

Abstract: An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.

Abstract translation: 公开了一种用于分离等离子体的装置，通过该装置可以将血浆与少量的全血细胞样品分离而不进行离心。 该装置包括血流通过的血液通道; 以及等离子体通道，血浆从血液中分离出来。 等离子体通道至少部分地与所述血液通道平行布置，并且血液通道和等离子体通道沿着通道的纵向方向至少部分地彼此接触。 使血液以流过血液通道的血液中的血细胞成分轴向积聚并且不发生溶血的流速流动。 在分离成血细胞层和等离子体层之后，等离子体移动到等离子体通道。

公开(公告)号：US08875559B2

公开(公告)日：2014-11-04

申请号：US13314175

申请日：2011-12-07

Applicant: Peter R. Bossard

Inventor： Peter R. Bossard

IPC: G01N7/10 ,  G01N33/00

CPC classification number: G01N7/10 ,  C01B3/501 ,  G01N1/4005 ,  G01N33/0014

Abstract: A system and method for taking a sample of hydrogen gas and conditioning that sample so that extremely low levels of contamination can be more accurately detected. Initially a sample of hydrogen gas is captured and isolated in a collection chamber. A hydrogen permeable membrane is provided having a first side and a second side. The first side of the hydrogen permeable membrane is exposed to the gas sample held within the collection chamber. The hydrogen gas contained within the gas sample begins to permeate through the hydrogen permeable membrane and exit the collection chamber. This causes the pressure of the gas sample within the collection chamber to decrease. Since contaminants remain in the collection chamber, the concentration of contaminants within the remaining sample increases exponentially. The residual pressure within the collection chamber is measured and converted into a contaminant level reading.

Abstract translation: 一种采集氢气样品和调节样品的系统和方法，以便能够更精确地检测到极低水平的污染物。 最初，在收集室中捕获和分离氢气样品。 提供具有第一侧和第二侧的氢可渗透膜。 氢可渗透膜的第一侧暴露于收集室内保持的气体样品。 包含在气体样品中的氢气开始渗透通过氢可渗透膜并离开收集室。 这导致收集室内的气体样品的压力降低。 由于污染物残留在收集室中，所以剩余样品中的污染物浓度呈指数增加。 测量收集室内的剩余压力并将其转换为污染物水平读数。

公开(公告)号：US20140283626A1

公开(公告)日：2014-09-25

申请号：US13999653

申请日：2014-03-14

Applicant: Gary Michael McMurtry ,  Daniel N. Kokubun

Inventor： Gary Michael McMurtry ,  Daniel N. Kokubun

IPC: G01N1/10 ,  H05B3/00 ,  G01K7/22

CPC classification number: G01N1/10 ,  B01D63/02 ,  B01D63/063 ,  B01D69/10 ,  G01N1/22 ,  G01N1/4005 ,  G01N2001/2267 ,  H01J49/0427

Abstract: A high-transmittance sampler of dissolved gases and volatile organic compounds (VOC) is described that is based upon a thin polymer membrane with tubular geometry. Very high hydrostatic pressures are maintained by surrounding the polymer tube or coating with sintered material. The sintered material can be surrounded by additional metal support, with holes for passage of molecules into the vacuum chamber of a sensor system such as a mass spectrometer. A method is described that uses the plastic behavior of the polymer to seal the ends of the sampler against leakage. Other features of the sampler are compact size, varied vacuum housing geometry, and provision for heat with regulation to the vacuum assembly of the sampler. The hydrodynamic design of fluid flow through the sampler and the compact and variable vacuum geometry allow greater response and sensitivity than previous samplers, and allow its operation to very high hydrostatic pressures.

Abstract translation: 描述了溶解气体和挥发性有机化合物（VOC）的高透光率取样器，其基于具有管状几何形状的薄聚合物膜。 通过围绕聚合物管或用烧结材料涂覆来维持非常高的静水压力。 烧结材料可以由额外的金属支撑体包围，其中有分子进入传感器系统例如质谱仪的真空室的孔。 描述了使用聚合物的塑性行为来密封取样器的端部以防止泄漏的方法。 采样器的其他特征是紧凑的尺寸，不同的真空壳体几何形状，以及对采样器的真空组件进行调节的热量。 通过采样器的流体流动动力学设计和紧凑且可变的真空几何形状允许比以前的采样器更大的响应和灵敏度，并允许其操作达到非常高的静水压力。

公开(公告)号：US20140273070A1

公开(公告)日：2014-09-18

申请号：US14215645

申请日：2014-03-17

Applicant: Matthew Hale

Inventor： Matthew Hale

IPC: G01N1/40

CPC classification number: B01L3/50255 ,  B01D61/18 ,  B01D63/16 ,  B01D2315/02 ,  B01J8/006 ,  B01L2200/028 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2400/0409 ,  G01N1/34 ,  G01N1/40 ,  G01N1/4005 ,  G01N1/4077 ,  G01N2001/4088 ,  G01N2035/00495 ,  Y10T436/255

Abstract: A well plate includes a including a top portion, a bottom portion and a membrane disposed between the top portion and the bottom portion. The top portion defines a sample well in fluid communication with an opening defined by the membrane and in fluid communication with a reservoir defined by the bottom portion. The well plate is configured to be used in a centrifugation process of a test sample including a sample material and a wash liquid. The test sample configured to be received within the sample well and the reservoir. The membrane configured to filter the wash liquid from the test sample during the centrifugation process such that the wash liquid can pass from the reservoir, through the membrane and can be captured within a collection chamber while the sample material remains within the reservoir.

Abstract translation: 井板包括：顶部，底部和设置在顶部和底部之间的膜。 顶部限定与由膜限定的开口流体连通并与由底部限定的储存器流体连通的样本井。 孔板构造成用于包括样品材料和洗涤液体的测试样品的离心过程。 测试样品被配置为接收在样品阱和储存器中。 所述膜构造成在离心过程期间从测试样品中过滤洗涤液体，使得洗涤液体可以从储存器通过膜并且可以在样品材料保留在储存器内时在收集室内捕获。

公开(公告)号：US08808541B2

公开(公告)日：2014-08-19

申请号：US12074479

申请日：2008-03-03

Applicant: Marwan Nasralla

Inventor： Marwan Nasralla

IPC: B01D61/26 ,  B01D63/00 ,  B01D35/30 ,  G01N1/40 ,  B01D61/28 ,  B01L3/00

CPC classification number: G01N1/4005 ,  B01D61/28 ,  B01L3/502 ,  G01N2001/4016 ,  Y10S436/809

Abstract: A dialysis cell is provided for the measurement of free thyroxine. The dialysis cell preferably includes a polyhedral housing including a top, a bottom and four sides. The dialysis cell is made up of a buffer portion and serum portion. The buffer portion includes a cavity and the serum portion includes a cavity which, when the buffer portion and serum portion are assembled together, form a central chamber. The central chamber is divided by a vertically aligned dialysis membrane held in place by two O-rings. Buffer is introduced into the dialysis cell's buffer portion through a buffer inlet extending from the dialysis cell's top side to the buffer portion's cavity. Similarly, serum is introduced into the serum portion through an inlet which extends from an opening formed on the dialysis cell's top to the serum portion's cavity.

Abstract translation: 提供了一种用于测量游离甲状腺素的透析池。 透析池优选地包括多面体壳体，其包括顶部，底部和四个侧面。 透析池由缓冲部分和血清部分组成。 缓冲部分包括空腔，血清部分包括空腔，当缓冲部分和血清部分组装在一起时，形成中心室。 中央室由两个O形环保持在适当位置的垂直排列的透析膜分隔开。 将缓冲液通过从透析池顶部延伸到缓冲部分腔的缓冲入口引入透析池的缓冲部分。 类似地，血清通过从透析池顶部上形成的开口延伸到血清部分腔的入口引入血清部分。