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333 条记录 (耗时 0.02 秒)

    Novel thermo-responsive water-soluble polymers for viscosity switch
    91.
    发明申请
    Novel thermo-responsive water-soluble polymers for viscosity switch 有权
    用于粘度开关的新型热响应性水溶性聚合物

    公开(公告)号：US20060235176A1

    公开(公告)日：2006-10-19

    申请号：US11283805

    申请日：2005-11-22

    申请人： Hsun-Yu Lee ,  Chih-Hsiang Lin ,  In-Mau Chen

    发明人： Hsun-Yu Lee ,  Chih-Hsiang Lin ,  In-Mau Chen

    IPC分类号： C08F26/10

    CPC分类号： C08F220/56 ,  C08F220/06 ,  C08F220/54 ,  C08F226/10

    摘要： A thermal responsive, water soluble copolymer is disclosed, which comprises the co-polymerization product of: (a) 0.5˜20 wt % of N-isopropyl acrylamide (NIPAAm); (b) 0.5˜20 wt % of 1-vinyl-2- pyrrolidinone (VPD); (c) 0.01˜10 wt % of acrylic acid (AA); and (d) 80˜90 wt % of acrylamide. The viscosity of.the co-polymerization product is adjustable by temperature. Moreover, phase-separating does not occur in the copolymer while temperature is changing and the structure as well as the fluidity are maintained, therefore, the copolymer of the present invention is suitable for the application of a micro-fluidic chip.

    摘要翻译： 公开了一种热响应性水溶性共聚物，其包含：（a）0.5〜20重量％的N-异丙基丙烯酰胺（NIPAAm）的共聚产物; （b）0.5〜20重量％的1-乙烯基-2-吡咯烷酮（VPD）; （c）0.01〜10重量％的丙烯酸（AA）; 和（d）80〜90重量％的丙烯酰胺。 共聚产物的粘度可通过温度调节。 此外，在温度变化的同时，在共聚物中不发生相分离，结构和流动性得以保持，因此本发明的共聚物适用于微流体芯片的应用。

    Zwitterionic materials
    96.
    发明授权
    Zwitterionic materials 失效
    两性离子材料

    公开(公告)号：US5645883A

    公开(公告)日：1997-07-08

    申请号：US464677

    申请日：1995-06-07

    申请人： Jeremy Colin Russell ,  Richard Neil Templar Freeman ,  Stephen Alexander Charles

    发明人： Jeremy Colin Russell ,  Richard Neil Templar Freeman ,  Stephen Alexander Charles

    IPC分类号： A61L27/00 ,  A61L27/34 ,  A61L33/00 ,  A61L33/06 ,  C07F9/09 ,  C07F9/10 ,  C08F20/10 ,  C08F20/18 ,  C08F20/26 ,  C08F20/34 ,  C08F20/52 ,  C08F20/56 ,  C08F26/10 ,  C08G18/08 ,  C08G18/30 ,  C08G63/692 ,  B05D3/02

    CPC分类号： C08G63/6926 ,  A61L27/34 ,  A61L33/00 ,  A61L33/0082 ,  A61L33/066 ,  C07F9/091 ,  C07F9/10 ,  C08G18/0833

    摘要： The present invention provides materials which comprise a surface having pendant zwitterionic groups Z comprising, as anion, a phosphate, sulphonate, carboxylate or phosphate-ester group or a phosphate ester group in which one or more of the ester oxygen atoms is replaced by --S--, --NH-- or by a valence bond and, as cation, an ammonium, phosphonium or sulphonium moiety, provided that where the anion is a phosphate-ester group or derivative thereof or sulphonate and the cation is a trialkyl quaternary ammonium group (the alkyl groups each containing from 1 to 4 carbon atoms) and the group linking the anion and cation moieties is an alkylene group, the alkylene group, contains at least 5, preferably at least 6, and more preferably at least 7, carbon atoms. The materials have improved biocompatibility for instance as evidenced by reduced protein deposition and reduced platelet activation.

    摘要翻译： PCT No.PCT / GB94 / 00178 Sec。 371日期：1995年6月7日 102（e）1995年6月7日PCT PCT 1994年1月28日PCT公布。 第WO94 / 16749号公报 日期1994年8月4日本发明提供了包含具有侧向两性离子基团Z的表面的材料，其包含作为阴离子的磷酸盐，磺酸盐，羧酸盐或磷酸酯基团或磷酸酯基团，其中一个或多个酯氧原子 由-S-，-NH-或价键取代，并且作为阳离子，铵，鏻或锍部分，其中阴离子是磷酸酯基团或其衍生物或磺酸盐并且阳离子是三烷基 季铵基（各自含有1至4个碳原子的烷基）和连接阴离子和阳离子部分的基团是亚烷基，亚烷基含有至少5个，优选至少6个，更优选至少7个 ，碳原子。 这些材料具有改善的生物相容性，例如通过减少的蛋白质沉积和减少的血小板活化来证明。

    Polymers for separation of biomolecules by capillary electrophoresis
    99.
    发明授权
    Polymers for separation of biomolecules by capillary electrophoresis 失效

    公开(公告)号：US5567292A

    公开(公告)日：1996-10-22

    申请号：US350852

    申请日：1994-12-06

    申请人： Ramakrishna S. Madabhushi ,  Steven M. Menchen ,  J. William Efcavitch ,  Paul D. Grossman

    发明人： Ramakrishna S. Madabhushi ,  Steven M. Menchen ,  J. William Efcavitch ,  Paul D. Grossman

    IPC分类号： C08F20/52 ,  C08F26/10 ,  C08F122/38 ,  C08F126/10 ,  C08G63/06 ,  C08G63/08 ,  G01N27/447 ,  C07K1/26 ,  C25B7/00 ,  C25B15/00

    CPC分类号： G01N27/44752 ,  G01N27/44747

    摘要： The invention provides uncharged water-soluble silica-adsorbing polymers for suppressing electroendoosmotic flow and to reduce analyte-wall interactions in capillary electrophoresis. In one aspect of the invention, one or more of such polymers are employed as components of a separation medium for the separation of biomolecules, such as polynucleotides, polysaccharides, proteins, and the like, by capillary electrophoresis. Generally, such polymers are characterized by (i) water solubility over the temperature range between about 20.degree. C. to about 50.degree. C., (ii) concentration in a separation medium in the range between about 0.001% to about 10% (weight/volume), (iii) molecular weight in the range of about 5.times.10.sup.3 to about 1.times.10.sup.6 daltons, and (iv) absence of charged groups in an aqueous medium having pH in the range of about 6 to about 9. In one embodiment, polymers of the invention are selected from the group consisting of polylactams, such as polyvinylpyrrolidone; N,N-disubstituted polyacrylamides; and N-substituted polyacrylamides. In accordance with the method of the invention, a sufficient amount of polymer adsorbs to the capillary surface to establish a zone of high viscosity that shields the analyte from the wall and impedes the movement of an electrical double layer under an electric field.