公开(公告)号：US20150369962A1

公开(公告)日：2015-12-24

申请号：US14840169

申请日：2015-08-31

Applicant: Novartis AG

Inventor： Frank Chang ,  Venkat Shankar

IPC: G02B1/04 ,  G02C7/04 ,  B29C39/02 ,  B29C35/08 ,  B29C39/00

CPC classification number: G02B1/043 ,  B29C35/08 ,  B29C39/006 ,  B29C39/026 ,  B29K2083/00 ,  B29L2011/0041 ,  C08G18/61 ,  C08G18/755 ,  C08G73/0233 ,  C08G73/0246 ,  C08G77/452 ,  G02C7/049 ,  C08L83/04 ,  C08L101/14 ,  C08G18/10 ,  C08G18/6453 ,  C08G18/6415 ,  C08G18/2825 ,  C08G18/4833

Abstract: The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention.

Abstract translation: 本发明提供一类包含至少一个聚硅氧烷链段，至少一个聚恶唑啉链段和两个末端烯基的可光化交联的两亲性预聚物。 本发明还涉及包含由包含本发明的预聚物的可聚合材料的步进生长聚合获得的硅酮水凝胶材料和由本发明的预聚物制备隐形眼镜的方法的医疗装置。

公开(公告)号：US20150309213A1

公开(公告)日：2015-10-29

申请号：US14793767

申请日：2015-07-08

Applicant: Novartis AG

Inventor： Frank Chang

IPC: G02B1/04

CPC classification number: G02B1/043 ,  B29D11/00038 ,  C07F7/0838 ,  C07F7/089 ,  C08F30/08 ,  C08L83/04 ,  C08L33/26 ,  C08L101/14

Abstract: The invention provides an amphiphilic siloxane-containing vinylic monomer which comprises one sole ethylenically unsaturated group and a siloxane-containing group covalently linked to the ethylenically-unsaturated group through a hydrophilic linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing vinylic monomer of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing vinylic monomer of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.

Abstract translation: 本发明提供了一种含两个含硅氧烷的乙烯基单体，其包括一个唯一的烯键式不饱和基团和通过亲水接头与烯键式不饱和基团共价连接的含硅氧烷基团。 本发明还涉及包含衍生自本发明的两亲性硅氧烷的乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。 此外，本发明提供了一种使用包含本发明的两亲性含硅氧烷的乙烯基单体和/或本发明的可光化交联的含硅氧烷预聚物的水性透镜形成剂制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20150309210A1

公开(公告)日：2015-10-29

申请号：US14694150

申请日：2015-04-23

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang

IPC: G02B1/04 ,  C07F7/18 ,  C07F9/09 ,  C08F230/08

CPC classification number: G02B1/043 ,  C07F7/1804 ,  C07F9/09 ,  C07F9/092 ,  C08F230/08 ,  C08F283/124 ,  C08G77/20 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08G77/50 ,  C08L101/14 ,  C08L83/04 ,  C08L83/14 ,  C08L33/10

Abstract: The invention provides a hydrophilized carbosiloxane vinylic monomer which comprises (1) a poly(carbosiloxane) segment, (2) one sole ethylenically unsaturated group, and (3) at least one terminal or pendant group which is a hydrophilic group or hydrophilic polymer chain. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a hydrophilized carbosiloxane vinylic monomer of the invention.

Abstract translation: 本发明提供亲水化的碳硅氧烷乙烯基单体，其包含（1）聚（碳硅氧烷）链段，（2）一个唯一烯属不饱和基团，和（3）至少一个亲水基团或亲水性聚合物链的末端或侧基。 本发明还涉及包含衍生自本发明的亲水化的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。

公开(公告)号：US09103965B2

公开(公告)日：2015-08-11

申请号：US14105275

申请日：2013-12-13

Applicant: Novartis AG

Inventor： Frank Chang

IPC: G02B1/04 ,  B29D11/00 ,  C08F30/08 ,  C07F7/08

CPC classification number: G02B1/043 ,  B29D11/00038 ,  C07F7/0838 ,  C07F7/089 ,  C08F30/08 ,  C08L83/04 ,  C08L33/26 ,  C08L101/14

Abstract: The invention provides an amphiphilic siloxane-containing vinylic monomer which comprises one sole ethylenically unsaturated group and a siloxane-containing group covalently linked to the ethylenically-unsaturated group through a hydrophilic linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing vinylic monomer of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing vinylic monomer of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.

Abstract translation: 本发明提供了一种含两个含硅氧烷的乙烯基单体，其包括一个唯一的烯键式不饱和基团和通过亲水接头与烯键式不饱和基团共价连接的含硅氧烷基团。 本发明还涉及包含衍生自本发明的两亲性硅氧烷的乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。 此外，本发明提供了一种使用包含本发明的两亲性含硅氧烷的乙烯基单体和/或本发明的可光化交联的含硅氧烷预聚物的水性透镜形成剂制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US09066981B2

公开(公告)日：2015-06-30

申请号：US14102741

申请日：2013-12-11

Applicant: Novartis AG

Inventor： Frank Chang ,  Jinyu Huang ,  Robert Scott ,  Guigui Wang

IPC: G02C7/04 ,  A61K47/32 ,  C08F230/08 ,  C08F290/06 ,  C08F291/04 ,  C08F293/00 ,  C08G77/14 ,  C08G77/26 ,  G02B1/04

CPC classification number: A61K47/32 ,  B29D11/00038 ,  C08F8/14 ,  C08F8/26 ,  C08F230/08 ,  C08F283/12 ,  C08F290/068 ,  C08F291/04 ,  C08F293/005 ,  C08F299/08 ,  C08F2438/01 ,  C08F2810/30 ,  C08F2810/40 ,  C08G77/14 ,  C08G77/26 ,  C08G77/385 ,  C08G77/392 ,  C08J3/075 ,  C08J2300/14 ,  C08J2383/06 ,  C08J2383/07 ,  C08J2383/08 ,  C08L53/00 ,  G02B1/043 ,  G02C7/04 ,  C08F220/56 ,  C08F226/10 ,  C08F220/28 ,  C08L101/14 ,  C08L83/04 ,  C08F220/20

Abstract: The invention provide a class of actinically-crosslinkable silicone-containing prepolymers obtained by functionalizing an intermediary copolymer to have two or more thiol or ethylenically-unsaturated groups covalently attached thereto, wherein the intermediary copolymer is an atom-transfer radical polymerization (ATRP) product of a reactive mixture comprising a polysiloxane ATRP macroinitiator and at least one hydrophilic vinylic monomer. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design.

Abstract translation: 本发明提供一类通过官能化中间共聚物获得的具有两个或更多个共价连接到其上的硫醇或烯键式不饱和基团获得的含有机硅的预聚物，其中中间共聚物是原子转移自由基聚合（ATRP） 包含聚硅氧烷ATRP大分子引发剂和至少一种亲水性乙烯基单体的反应性混合物。 本发明还涉及由本发明的预聚物制成的硅酮水凝胶隐形眼镜以及以成本有效的方式制造隐形眼镜并以与原始透镜设计的高一致性和高保真度的方法。

公开(公告)号：US09052440B2

公开(公告)日：2015-06-09

申请号：US14453021

申请日：2014-08-06

Applicant: Novartis AG

Inventor： Selma Kuyu ,  Dawn Alison Smith ,  Jinyu Huang ,  Frank Chang ,  Robert Scott ,  Arturo Norberto Medina ,  Venkat Shankar

IPC: A61K47/34 ,  C08G77/38 ,  G02B1/04 ,  C08G77/42 ,  C08G77/442 ,  C08G77/46 ,  C08L83/10 ,  C08G77/20

CPC classification number: G02B1/043 ,  A61K47/34 ,  C08G77/20 ,  C08G77/38 ,  C08G77/42 ,  C08G77/442 ,  C08G77/46 ,  C08L83/10 ,  G02B2207/109 ,  C08L83/12 ,  C08L83/14

Abstract: The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

Abstract translation: 本发明提供一类线性延伸的聚硅氧烷交联剂，其包含两个末端烯键式不饱和基团，至少两个聚硅氧烷链段和悬浮的亲水性聚合物链，每个共价连接到分隔每对相邻聚硅氧烷链段的二价有机基团。 本发明还涉及包含衍生自本发明的链延长聚硅氧烷交联剂的交联单元和包含这种聚合物的眼用透镜的聚合物。

公开(公告)号：US20150153482A1

公开(公告)日：2015-06-04

申请号：US14617310

申请日：2015-02-09

Applicant: Novartis AG

Inventor： Frank Chang ,  Robert Scott ,  Jinyu Huang ,  Arturo N. Medina ,  Dawn A. Smith ,  Laura A. Sanders ,  John Dallas Pruitt

IPC: G02B1/04 ,  C08G77/388

CPC classification number: G02B1/043 ,  C08F290/068 ,  C08G77/388 ,  C08G77/458 ,  C08G2210/00 ,  C08L2205/02 ,  C08L83/04 ,  C08L51/085 ,  C08L101/14 ,  C08F220/56 ,  C08F220/28

Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

Abstract translation: 本发明提供一种两亲性聚硅氧烷预聚物，其包含衍生自至少一种亲水乙烯基单体的亲水性单体单元，衍生自至少一种具有至少两个末端烯属不饱和基团的聚硅氧烷交联剂的聚硅氧烷交联单元，悬浮聚硅氧烷链各自被终止 具有一个烯键式不饱和基团，以及衍生自除RAFT试剂之外的链转移剂的链转移单元。 本发明的预聚物适用于制备水凝胶隐形眼镜。 本发明还涉及由本发明的两亲聚硅氧烷预聚物制成的水凝胶隐形眼镜以及制备本发明的两亲性聚硅氧烷预聚物和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20150152228A1

公开(公告)日：2015-06-04

申请号：US14618135

申请日：2015-02-10

Applicant: Novartis AG

Inventor： Frank Chang ,  Jinyu Huang ,  Laura Ann Sanders

IPC: C08G77/46 ,  G02B1/04

CPC classification number: C08G77/28 ,  C08F290/068 ,  C08G77/20 ,  C08G77/48 ,  G02B1/043 ,  C08L83/14 ,  C08L83/12

Abstract: The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polylsiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR-S— in which DR is a divalent oranic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

Abstract translation: 本发明提供一类链延长聚硅氧烷交联剂，其包含（1）至少两个聚硅氧烷链段，其中每对相邻的聚硅氧烷链段通过一个二价有机基团连接，所述二价有机基团包括至少一个侧链亲水基团（羟基和/或羧基 基团）或至少一个悬浮的亲水性聚合物链和二硫醚连接-S-DR-S-，其中DR是二价的基团; 和（2）两个末端烯属不饱和基团。 本发明还涉及包含衍生自本发明的扩链聚硅氧烷交联剂的交联单元和包含这种聚合物的眼用透镜的聚合物。

公开(公告)号：US20140171539A1

公开(公告)日：2014-06-19

申请号：US14105334

申请日：2013-12-13

Applicant: NOVARTIS AG

Inventor： Frank Chang ,  Jian S. Zhou

IPC: G02B1/04

CPC classification number: G02B1/043 ,  C07F7/0838 ,  C08F220/58 ,  C08F220/60 ,  C08F230/08 ,  C08F2220/585 ,  C08F2220/606 ,  C08L43/04 ,  C08L101/14 ,  C08L33/26 ,  C08L83/04

Abstract: The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.

Abstract translation: 本发明提供了一种两亲硅氧烷（甲基）丙烯酰胺，其包括一个底部（甲基）丙烯酰胺基，一个底部三（三甲基甲硅烷氧基）甲硅烷基和一个聚乙二醇链段，其是悬挂聚合物链或在（甲基） ）丙烯酰胺基和三（三甲基甲硅烷氧基）甲硅烷基。 本发明还涉及聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜，其包含衍生自两亲硅氧烷的（甲基）丙烯酰胺基的单体单元，一个 三（甲基甲硅烷氧基）甲硅烷基。 另外，本发明提供一种使用包含本发明的两亲性硅氧烷（甲基）丙烯酰胺基，一个三（三甲基甲硅烷氧基）甲硅烷基和/或光化学反应的水性透镜形成剂的硅酮水凝胶隐形眼镜的制备方法 - 本发明的可交联的含硅氧烷预聚物。

公开(公告)号：US20130172600A1

公开(公告)日：2013-07-04

申请号：US13778882

申请日：2013-02-27

Applicant: Novartis AG

Inventor： Frank Chang ,  Norberto Arturo Medina

IPC: C07C231/12 ,  C07C67/00

CPC classification number: C07C231/12 ,  C07C67/00 ,  C08F8/00 ,  C08F220/06 ,  C08F220/26 ,  C08F220/56 ,  C08F230/08 ,  C08F2220/286 ,  C08F2800/20 ,  C08F2810/20 ,  C08F2810/30 ,  C08G77/442 ,  C08J3/075 ,  C08J3/28 ,  C08J2433/04 ,  C08J2483/04 ,  G02B1/043 ,  C08L51/085 ,  C08F290/068 ,  C08F285/00

Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.

Abstract translation: 本发明涉及可通过（a）共聚选自N，N-二甲基丙烯酰胺（DMA），丙烯酸2-羟基乙酯（HEA），甲基丙烯酸缩水甘油酯（GMA））的至少两种不同亲水性单体的新型可交联共聚物， ，N-乙烯基吡咯烷酮（NVP），丙烯酸（AA）和重均分子量为200〜1500的C1-C4-烷氧基聚乙二醇（甲基）丙烯酸酯，以及至少一种包含两种或更多种烯键式不饱和双 在具有官能团的链转移剂的存在下进行键合; 和（b）使所得共聚物的一种或多种官能团与具有烯属不饱和基团的有机化合物反应。