摘要:
The present invention provides a compound having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases, inflammatory diseases, and allergic diseases.As a result of studies on a novel condensed heterocyclic derivative, the inventors have found that a compound having a cross-linked structure has an excellent JAK3 inhibition activity, and have completed the present invention.In other words, it is verified that the compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
摘要:
A semiconductor laser device includes: a laminated body including an active layer, a cladding layer provided on the active layer, and a contact layer provided on the cladding layer, the laminated body having a first and second end face forming a resonator for light emitted from the active layer; and an electrode provided on the contact layer and including an ohmic section injecting a current into the active layer and a first current adjustment section provided between one end of the ohmic section and the first end face. The ohmic section contains a metal which has a smaller work function than any metal constituting the current adjustment section.
摘要:
A stream processing section (12) analyzes input stream data and, if the stream data includes a compressed/coded graphics object, decodes the graphics object line by line and writes the decoded graphics object into a graphics object buffer (14), and, if the stream data includes control information of a graphics object, writes the control information into a control information buffer (13). A graphics control section (15) renders a graphics object stored in the graphics object buffer (14) in a graphics plane (16) based on control information stored in the control information buffer (13). When a decoding error has occurred, the stream processing section (12) restarts decoding from the next or a subsequent line.
摘要:
A reflector has a curved part covering the light source and a pair of end parts extending at the two sides of the curved part. The inside surface of each end part has a plurality of substantially parallel projections or depressions. The light-guiding plate has an incident surface and an emission surface substantially perpendicular to the incident surface, the incident surface having a plurality of projections or depressions extending substantially parallel to the emission surface. Also, the reflection surface of the light-guiding plate has projections.
摘要:
According to one embodiment, an edge detection module detects edges in a frame of a moving picture signal in accordance with an edge determination reference value. A resolution conversion module converts a resolution of the frame from a first resolution to a second resolution, thereby generating a provisional high-resolution image. A corresponding pixel point detection module detects corresponding pixels in the provisional high-resolution image, which correspond to each of the detected edges. An image quality enhancement process module executes an image quality enhancement process for sharpening for each of the detected corresponding pixels in the provisional high-resolution image. A control module varies the edge determination reference value based on the detected edge number and a maximum edge number at which an information processing apparatus is able to complete the resolution-enhancing process for one frame within a target process time.
摘要:
The invention relates to compound of the formula (I) or its salt, wherein —R1, —R2, —R3, —R4, —R5, -M-, —X— and —Y═ are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.
摘要:
Disclosed is a magnetic one-component toner for development of an electrostatic latent image used in a magnetic one-component jumping development system in which a photoconductor is an a-Si photoconductor having a thickness of 30 μm or less and Rz of a developer carrier is from 2.0 to 6.0 μm. A cleaning means for removing the toner from the surface of the photoconductor is a cleaning blade. Titanium oxide, as an external additive, is added to the toner. The titanium oxide has a liberation rate within a range from 10 to 22% and contains a low resistance titanium oxide having a volume resistivity within a range from 100 to 107Ω·cm and a high resistance titanium oxide having a volume resistivity within a range from 108 to 1013Ω·cm, a mass ratio of the low resistance titanium oxide to the high resistance titanium oxide within a range from 1.3:1 to 4:1.
摘要:
To provide a semiconductor laser device capable of reducing the power consumption and enhancing the reliability. The semiconductor laser device includes: a crystal substrate; a first clad layer of a first conductivity type formed on the crystal substrate; a first light guide layer of the first conductivity type formed on the first clad layer; an active layer of a single or multiple quantum well structure formed on the first light guide layer; an overflow preventing layer of a second conductivity type formed on the active layer; a second light guide layer of the second conductivity type formed on the overflow preventing layer; and a second clad layer of the second conductivity type formed on the second light guide layer, wherein the carrier concentration of the second light guide layer is set to the carrier concentration or more of the second clad layer.
摘要:
The viscosity of a puncture-preventing sealant (7) is set in a range of 25 to 35 dPa·s, and a thixotropy index is set in a range of 6.5 to 11.0, the sealant (7) being filled in a sealant chamber (6) defined to extend along an outer periphery of an air chamber (5) in a tire (T). When the tire (T) is being rotated by traveling of a vehicle, the viscosity of the sealant (7) is reduced by a stirring action provided by a vibration or a centrifugal force of the sealant (7), whereby the sealant (7) can be diffused uniformly in the sealant chamber (6). When the vehicle has been stopped and the stirring action has been extinguished, the viscosity of the sealant (7) is increased, whereby the sealant (7) is maintained in a state in which it has been diffused uniformly in the sealant chamber (6) without flowing downwards in the sealant chamber (6) by gravitation. Therefore, even when the vehicle is travelling at a high speed, the generation of a vibration and a noise can be prevented. In this manner, the puncture-preventing sealant is provided, which has such a nature that the sealant is easy to flow due to a low viscosity during traveling of a vehicle, and the sealant is difficult to flow due to a high viscosity when the sealant is left to stand.
摘要:
An electronic device is provided with a fuel cell which is formed to introduce air from at least two surfaces of a casing of the fuel cell and to supply a fuel from an inside of the casing for high energy efficiency. The fuel cell is structured to form an air-supply space between the fuel cell and the electronic device and mounted in a manner that the surface of the fuel cell, which is on a reverse side of the surface facing the electronic device, is exposed to the ambient air. The electronic device is provided with a fuel cell structured to supply air from at least two surfaces of the casing to achieve better energy efficiency.