公开(公告)号：US10792088B2

公开(公告)日：2020-10-06

申请号：US15789727

申请日：2017-10-20

Applicant: Old Dominion University Research Foundation

Inventor： Claudia Muratori ,  Andrei G. Pakhomov ,  Olga N. Pakhomova

IPC: A61B18/14 ,  A61B18/00 ,  A61B18/02 ,  A61B18/12

Abstract: The methods disclosed herein are directed towards improving ablation efficiency associated with applying nanosecond electric pulses (nsEP) to tissue. In particular, applying nsEP to tissue can open pores in the cellular membranes of the tissue. These pores can be kept open longer by cooling the tissue. The combined application of nsEP and the cooling of tissue may have synergistic effects on triggering apoptosis of cells in the tissue. This allows for numerous practical benefits associated with nsEP-based tissue ablation to be realized. For instance, nsEP of lower pulse strength or lower numbers of pulses to be used, which can be provided by smaller pulse generators operating on less power.

公开(公告)号：US10668278B2

公开(公告)日：2020-06-02

申请号：US15311130

申请日：2015-03-24

Applicant: Old Dominion University Research Foundation

Inventor： Richard Heller ,  Chen Yeong-Jer

IPC: A61B1/00 ,  A61N1/32 ,  A61B18/14 ,  A61N1/36 ,  A61N1/05 ,  A61B1/005 ,  A61B1/018 ,  A61B1/04 ,  A61B1/06 ,  A61M5/158 ,  A61B18/00 ,  A61B18/12

Abstract: Catheter devices can include an elongate housing extending along a major axis, the elongate housing comprising a first end an opening. The catheter devices can also include an electrode assembly disposed in the elongate housing and including deformable electrodes with respective electrode distal ends, where the electrode distal ends each consist of respective member portions and respective tip portions. The electrode assembly is slidably movable within the housing along the major axis to allow the electrode distal end portions to transition between a first retracted position and a second extended position. The catheter device is configured such that an average distance between the tip portions in the second position is configured to be greater than an average distance between the tip portions in the first position the tip portions are positioned substantially in a same plane when the electrode assembly is in the second position.

公开(公告)号：US10328259B2

公开(公告)日：2019-06-25

申请号：US16014822

申请日：2018-06-21

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Shu Xiao ,  Andrei Pakhomov ,  Karl H. Schoenbach

IPC: A61N1/36 ,  A61N2/00 ,  A61N5/02 ,  A61N1/40

Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.

公开(公告)号：US10070914B2

公开(公告)日：2018-09-11

申请号：US14366909

申请日：2012-12-20

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Richard Heller ,  James Camp ,  Stephen P. Beebe ,  Shu Xiao ,  Amy Donate

IPC: A61N1/30 ,  A61B18/12 ,  A61N1/40 ,  A61N1/32 ,  A61N5/00 ,  A61N5/02 ,  A61N5/06 ,  A61B18/18 ,  A61B18/20 ,  A61B18/24 ,  A61B18/00 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

公开(公告)号：US09724011B2

公开(公告)日：2017-08-08

申请号：US14885023

申请日：2015-10-16

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. Schoenbach ,  Shu Xiao

IPC: A61B5/05 ,  A61B6/03

CPC classification number: A61B5/0507 ,  A61B5/05 ,  A61B6/03 ,  A61B2576/00

Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.

公开(公告)号：US08697134B2

公开(公告)日：2014-04-15

申请号：US13165103

申请日：2011-06-21

Applicant: Ramjee Balasubramanian ,  Zaharoula M. Kalaitzis ,  Srujana Prayakarao

Inventor： Ramjee Balasubramanian ,  Zaharoula M. Kalaitzis ,  Srujana Prayakarao

IPC: A61K9/51 ,  C08F136/22 ,  C08F8/02 ,  C08F8/14 ,  C08F2/46 ,  C08F8/34

CPC classification number: A61K9/5138 ,  A61K47/32 ,  B82Y5/00 ,  B82Y40/00 ,  C08G75/045

Abstract: Described is a direct method for the fabrication of resorcinarene nanocapsules by photopolymerization of compounds of formula (I), such as resorcinarene tetraalkene tetrathiol (RTATT), in the absence of any template or preorganization. Further, by varying the polymerization media, a variety of other polymeric architectures like lattices, fibrous networks, and nanoparticles were obtained. The morphology and structure were characterized by transmission electron microscopy, energy dispersive spectroscopy, scanning electron microscopy, dynamic light scattering, infrared and nuclear magnetic resonance spectroscopy. These morphologically distinct resorcinarene polymeric architectures contain residual thiol and ene functional groups offering potential functionalization opportunities.

Abstract translation: 描述了在没有任何模板或预组织的情况下通过式（I）化合物如间苯二酚四烯四硫醇（RTATT）的光聚合制备间苯二酚纳米胶囊的直接方法。 此外，通过改变聚合介质，获得了各种其它聚合物结构如晶格，纤维网和纳米颗粒。 通过透射电子显微镜，能量色散光谱，扫描电子显微镜，动态光散射，红外和核磁共振光谱表征形态和结构。 这些形态上不同的间苯二酚聚合体系结构包含残留的硫醇和烯官能团，提供潜在的功能化机会。

公开(公告)号：US20130061518A1

公开(公告)日：2013-03-14

申请号：US13671064

申请日：2012-11-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUN

Inventor： Gary C. SCHAFRAN ,  Juergen F. KOLB ,  Aron STUBBINS ,  Karl H. SCHOENBACH

IPC: A01G1/00 ,  A01D44/00

CPC classification number: A01G2/00 ,  C12M33/00 ,  C12N1/12 ,  C12N13/00 ,  C12P7/649 ,  Y02E50/13 ,  Y02E50/17

Abstract: A method and device for aggregating algae in an aqueous solution is disclosed. The method can include providing an algae feed comprising a liquid and algae dispersed therein. The algae feed can be aggregated by applying a nanosecond pulsed electric field to the algae feed. The nanosecond pulsed electric field can include a plurality of electric pulses having a pulse duration ranging from 1 to 1,000 nanoseconds. The method can also include separating an aggregated algae stream from the algae feed and feeding the aggregated algae stream to a lipid extraction operation.

Abstract translation: 公开了一种在水溶液中聚集藻类的方法和装置。 该方法可以包括提供包含分散在其中的液体和藻类的藻类饲料。 藻类饲料可以通过将纳秒脉冲电场施加到藻类饲料来聚集。 纳秒脉冲电场可以包括具有1至1,000纳秒的脉冲持续时间的多个电脉冲。 该方法还可以包括从藻类饲料中分离聚集的藻类物流，并将聚集的藻类物流进行脂质提取操作。

公开(公告)号：US20120323044A1

公开(公告)日：2012-12-20

申请号：US13569621

申请日：2012-08-08

Applicant: Patrick G. Hatcher ,  Zhanfei Liu ,  Elodie Salmon

Inventor： Patrick G. Hatcher ,  Zhanfei Liu ,  Elodie Salmon

IPC: C07C41/38 ,  C07C43/13 ,  C07C43/10

CPC classification number: C10L1/026 ,  C10G2300/1014 ,  C10G2300/4081 ,  C11C3/003 ,  Y02E50/13 ,  Y02P20/582 ,  Y02P30/20

Abstract: Disclosed are processes for producing glycerol-related products. One process for producing glycerol-related products comprises introducing glycerol and an alkylation reagent to a substantially oxygen free environment. Another process for producing glycerol-related products comprises introducing a glycerol and tetramethylammonium hydroxide to a substantially oxygen free environment.

Abstract translation: 公开了生产甘油相关产品的方法。 制备甘油相关产物的一个方法包括将甘油和烷基化试剂引入基本上无氧的环境中。 制备甘油相关产物的另一种方法包括将甘油和四甲基氢氧化铵引入到基本上无氧的环境中。

公开(公告)号：US20120237762A1

公开(公告)日：2012-09-20

申请号：US13423216

申请日：2012-03-17

Applicant: Charles E. Hunt ,  Helmut Baumgart ,  Diefeng Gu

Inventor： Charles E. Hunt ,  Helmut Baumgart ,  Diefeng Gu

IPC: B32B17/06 ,  B05D5/12 ,  B05D5/06

CPC classification number: C09K11/54 ,  C09K11/7787 ,  C23C16/045 ,  C23C16/407 ,  C23C16/45525 ,  H01J2329/20 ,  H01L21/02554 ,  H01L21/0262 ,  H01L2933/0041 ,  Y10T428/26

Abstract: A device construct for lighting and display applications is fabricated from a substrate, a deposited phosphor layer over the substrate, and a layer of thermal and electrically-conductive luminescent material over the deposited layer. The layer of thermal and electrically-conductive luminescent material is a thin film that conforms to the morphology of the phosphor layer. The device is fabricated by providing a substrate, depositing a thin layer of phosphor powder on the substrate by any technique, and coating the phosphor layer with a layer of thermal and electrically-conductive luminescent material by atomic layer deposition.

Abstract translation: 用于照明和显示应用的器件结构由衬底，衬底上的沉积磷光体层以及沉积层上的热和导电发光材料层制成。 热和导电发光材料层是符合荧光体层的形态的薄膜。 该器件通过提供衬底，通过任何技术在衬底上沉积薄层荧光体粉末并通过原子层沉积用一层导热和导电的发光材料涂覆荧光体层来制造。

公开(公告)号：US20120200566A1

公开(公告)日：2012-08-09

申请号：US13311289

申请日：2011-12-05

Applicant: Andrey Chernikov ,  Nikos Chrisochoides

Inventor： Andrey Chernikov ,  Nikos Chrisochoides

IPC: G06T17/00

CPC classification number: G06T17/205

Abstract: A method for generating and refining meshes for a three-dimensional domain. The method includes generating a initial Delaunay mesh; identifying selection balls whose radius-edge ratio is greater than an upper bound value; and refining the generated Delaunay mesh by inserting points within the selection balls to reduce the radius-edge ratios of all tetrahedral in the mesh below a given upper bound value. Selection balls include one-dimensional selection balls, two-dimensional selection balls, and three-dimensional selection balls. The selection balls of a lower dimension are refined before the selection balls of a higher dimension are refined.

Abstract translation: 一种用于生成和精炼三维域的网格的方法。 该方法包括生成一个初始的Delaunay网格; 识别其半径边缘比大于上限值的选择球; 并通过在选择球内插入点来精炼生成的Delaunay网格，以减少网格中所有四面体的半径边比例低于给定的上限值。 选择球包括一维选择球，二维选择球和三维选择球。 在更高维度的选择球被精炼之前，对较低维度的选择球进行精炼。