公开(公告)号：US08865458B2

公开(公告)日：2014-10-21

申请号：US13776172

申请日：2013-02-25

申请人： Alere Switzerland GmbH

发明人： James T. Ramsey ,  Larry Hartselle

IPC分类号： C12M1/34 ,  G01N33/558 ,  A61B10/00

CPC分类号： B01L3/508 ,  A61B10/007 ,  A61B10/0096 ,  G01N33/558 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/81

摘要： The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows through the specimen passage slot into the reservoir. Flow into the reservoir may be limited by the reservoir seal. The test device positioned within the reservoir detects the presence or concentration of an analyte within the sample or specimen.

摘要翻译： 本发明包括但不限于包括能够收集试样的室，样品通道槽，储存器，储存器密封件和测试装置的样本收集装置。 添加到室中的样品或样品流过样品通道槽进入储存器。 流入储存器的流量可能受到储存器密封的限制。 位于储存器内的测试装置检测样品或样品中分析物的存在或浓度。

公开(公告)号：US08857282B2

公开(公告)日：2014-10-14

申请号：US13254465

申请日：2010-03-29

申请人： Roger Lee-Smith

发明人： Roger Lee-Smith

IPC分类号： B01L3/00 ,  G01N1/40

CPC分类号： B01L3/508 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2200/0678 ,  G01N2001/4027

摘要： A method and sample holding assembly are described for use in the preparation of samples for analysis. The method comprises the steps of collecting a sample in a concentration tube which is open at one end and closed at the other, the closed end being selectively openable. A vial is coupled to the open end, the tube is inverted, the closed end is opened, and then solvent is evaporated from the sample via the opened end until the concentrated sample is confined to the vial. A sample holding assembly for use in the present method is also described. It comprises a concentration tube, and an adaptor arrangement for coupling a vial to the open end of the tube and defining a fluid path between the tube and the vial.

摘要翻译： 描述了用于制备用于分析的样品的方法和样品保持组件。 该方法包括以下步骤：在一端开放并在另一端闭合的浓缩管中收集样品，封闭端可选择性地打开。 将小瓶联接到开口端，将管倒置，封闭端打开，然后通过开口端从样品中蒸发溶剂，直到浓缩的样品被限制在小瓶中。 还描述了用于本方法的样品保持组件。 它包括浓缩管和用于将小瓶连接到管的开口端并在管和小瓶之间限定流体路径的适配器装置。

公开(公告)号：US08852122B2

公开(公告)日：2014-10-07

申请号：US14254325

申请日：2014-04-16

申请人： Porex Corporation

发明人： Guoqiang Mao ,  James P. Wingo

IPC分类号： A61B5/00

CPC分类号： G01N1/10 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/151 ,  A61B5/15101 ,  A61B10/0045 ,  A61B10/0096 ,  B01L3/50 ,  B01L3/5023 ,  B01L3/5029 ,  B01L3/508 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2400/0406 ,  G01N1/02 ,  G01N33/521 ,  G01N2001/028 ,  H01J49/0031 ,  H01J49/0436 ,  Y10T29/49826 ,  Y10T436/25

摘要： The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand.

摘要翻译： 本发明提供了一种液体采样，存储，传送和传送装置，其包括容纳多孔笔尖的壳体。 设备中的多孔笔尖接触样品，收集样品，储存样品，将样品运送到其多孔基质内，并根据需要从多孔基质中释放样品。

公开(公告)号：US08844385B2

公开(公告)日：2014-09-30

申请号：US13857646

申请日：2013-04-05

申请人： GE Healthcare Bio-Sciences AB

发明人： Nils Norrman ,  Ronnie Palmgren

IPC分类号： B01L3/02 ,  G01N30/84 ,  G01N1/22 ,  G01N30/06 ,  B01L3/00 ,  G01N30/00 ,  G01N30/60

CPC分类号： G01N30/84 ,  B01L3/0275 ,  B01L3/508 ,  B01L2200/026 ,  B01L2300/0681 ,  B01L2400/0605 ,  G01N30/6065 ,  G01N2030/009 ,  G01N2030/062

摘要： The present invention relates to a device and method for separation of proteins and other biomolecules. A preferred use is for sample preparation of crude as well as pre-fractionated samples. In a preferred embodiment, the device of the present invention is a pipette tip having dual channels, one for inlet of sample and one for outlet. The outlet, but not the inlet, channel is provided with sample separation media for separation of a desired biomolecule from a sample. The flow through the sample separation media is unidirectional.

摘要翻译： 本发明涉及分离蛋白质和其他生物分子的装置和方法。 优选的用途是用于样品制备粗品以及预先分馏的样品。 在优选实施例中，本发明的装置是具有双通道的移液管尖端，一个用于样品入口，一个用于出口。 出口但不是入口通道设置有样品分离介质，用于将期望的生物分子与样品分离。 通过样品分离介质的流动是单向的。

公开(公告)号：US20140179566A1

公开(公告)日：2014-06-26

申请号：US14195358

申请日：2014-03-03

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： John LINTON ,  Arrin Katz ,  Colin Brenan ,  Karl Yoder ,  Robert Hess ,  Leila Hasan ,  Robert Ellis ,  Tanya Kanigan ,  Kristine Friesen ,  Thomas Morrison ,  Javier Garcia

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6858 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/508 ,  B01L3/50853 ,  B01L3/50857 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/16 ,  B01L2300/1822 ,  B01L2300/1838 ,  G01N21/03 ,  G01N21/15 ,  G01N21/253 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2021/158 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

摘要翻译： 用于容纳至少一个样品和试剂用于分析的系统。 该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。 框架设置在盖之间，以相对于盖限定内部空间。 框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。 微流体阵列设置在内部体积中。 阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

公开(公告)号：US20140133702A1

公开(公告)日：2014-05-15

申请号：US14072652

申请日：2013-11-05

申请人： California Institute of Technology

发明人： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Shuo Pang ,  Changhuei Yang ,  Benjamin Judkewitz ,  Ying Min Wang

IPC分类号： G06K9/00

CPC分类号： G06K9/00624 ,  B01L3/502792 ,  B01L3/508 ,  B01L2300/0654 ,  C12M41/36 ,  G01N21/03 ,  G01N21/25 ,  G01N21/272 ,  G01N2201/10

摘要： Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.

摘要翻译： 快速区分生长细胞和碎片的方法，其确定标本图像的延时电影，跟踪每个实体的特征，并将每个实体分类为生长细胞或碎片。

公开(公告)号：US08697436B2

公开(公告)日：2014-04-15

申请号：US13143303

申请日：2009-12-02

申请人： Karl Pflanz ,  Andreas Graus

发明人： Karl Pflanz ,  Andreas Graus

IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/22 ,  B01L3/00

CPC分类号： C12M23/10 ,  B01L3/508 ,  B01L3/5635 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/0681 ,  C12M25/04

摘要： The invention relates to a transfer unit for receiving in particular a porous disc-shaped medium from a first treatment device, having an upper part, wherein the upper part comprises a fixing edge that can be connected to an edge of the medium for removing the medium from the first treatment device, wherein the upper part comprises an opening closed by a removable cover, by means of which successive treatments in a further treatment device can be performed. The invention further relates to a method wherein an upper part of a transfer unit is placed on a disc-shaped medium disposed in a first lower part of a first treatment device and exposed to the liquid sample and is connected to an edge of the medium, wherein the upper part is lifted off from the first lower part with the disc-shaped medium connected thereto, and is placed on a further lower part of a corresponding treatment device, and is further processed through an opening in the upper part.

摘要翻译： 本发明涉及一种用于从具有上部部分的第一处理装置接收特别是多孔盘状介质的转移单元，其中上部包括固定边缘，该固定边缘可连接到介质的边缘以移除介质 从第一处理装置，其中上部包括由可移除盖封闭的开口，通过该开口能够执行另外的处理装置中的连续处理。 本发明还涉及一种方法，其中将转印单元的上部放置在设置在第一处理装置的第一下部的盘形介质上并暴露于液体样品并连接到介质的边缘， 其中，所述上部部分与所述第一下部部分相连，其中所述盘形介质连接到所述第一下部部分，并且被放置在相应的处理装置的另一下部，并且通过所述上部的开口被进一步加工。

公开(公告)号：US20140099243A1

公开(公告)日：2014-04-10

申请号：US14119724

申请日：2012-05-16

申请人： Hidetoshi Kotera ,  Atsuhito Okonogi ,  Masataka Ohoka ,  Katsuya Maruo

发明人： Hidetoshi Kotera ,  Atsuhito Okonogi ,  Masataka Ohoka ,  Katsuya Maruo

IPC分类号： G03F7/004 ,  B01L3/00

CPC分类号： G03F7/0045 ,  B01J2219/00637 ,  B01J2219/00743 ,  B01L3/508 ,  C08G59/24 ,  C08G59/3218 ,  C08L63/00 ,  C08L2205/02 ,  G03F7/038

摘要： It is intended to obtain a photosensitive resin composition that is capable of forming a highly fine pattern with a high aspect ratio while attaining the high adhesion of the pattern to a substrate, having low autofluorescence, and being exceedingly suitable for producing a biochip that causes exceedingly low damage on cultured cells. The photosensitive resin composition for forming a biochip of the present invention contains: an epoxy compound (A1) of a particular structure having an oxycyclohexane skeleton having an epoxy group; an epoxy compound (A2) of a particular structure which is a polyvalent carboxylic acid derivative having an epoxidized cyclohexenyl group; a cationic photoinitiator (B); and a solvent (C).

摘要翻译： 旨在获得能够形成具有高纵横比的高精细图案的感光性树脂组合物，同时获得图案对基材的高粘附性，具有低自发荧光，并且非常适合于生产极其重要的生物芯片 培养细胞损伤小。 本发明的生物芯片形成用感光性树脂组合物含有具有环氧基的氧基环己烷骨架的具体结构的环氧化合物（A1） 具有环氧化环己烯基的多价羧酸衍生物的具体结构的环氧化合物（A2） 阳离子光引发剂（B）; 和溶剂（C）。

公开(公告)号：US20140093430A1

公开(公告)日：2014-04-03

申请号：US13632945

申请日：2012-10-01

申请人： Cepheid

发明人： Ronald Chang ,  Douglas Dority

IPC分类号： G01N21/75

CPC分类号： G01N21/75 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00833 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/505 ,  B01L3/508 ,  B01L7/52 ,  B01L2300/042 ,  B01L2300/0809 ,  B01L2300/0858 ,  B01L2300/168 ,  B01L2300/1805 ,  F28D2021/0077 ,  F28F3/12 ,  F28F21/04 ,  F28F2280/10 ,  G01N21/0303 ,  G01N21/0332 ,  G01N2035/00326

摘要： A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.

摘要翻译： 具有用于保持样品的反应室的反应容器通过制造具有限定室的小壁的刚性框架的壳体来制造。 壳体还限定了用于将流体引入腔室的端口。 至少一个片或薄膜连接到刚性框架以形成腔室的至少一个主壁。 在优选实施例中，两个片或膜连接到刚性框架的相对侧面以形成腔室的两个相对的主壁，主壁通过次壁彼此连接。

公开(公告)号：US08632739B2

公开(公告)日：2014-01-21

申请号：US13472777

申请日：2012-05-16

申请人： Gregory A. Testa ,  Tim Svenstrup Poulsen ,  Steen Hauge Matthiesen ,  Ole Feldballe Rasmussen ,  Lars Winther

发明人： Gregory A. Testa ,  Tim Svenstrup Poulsen ,  Steen Hauge Matthiesen ,  Ole Feldballe Rasmussen ,  Lars Winther

IPC分类号： B01L3/00

CPC分类号： C12Q1/6841 ,  B01L3/508 ,  B01L7/52 ,  B01L2200/142 ,  B01L2300/043 ,  B01L2300/069 ,  B01L2300/0822 ,  B01L2300/10 ,  B01L2300/1822 ,  B01L2300/1844 ,  C12M41/14 ,  C12M41/36 ,  G01N1/312 ,  Y10T436/143333

摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.

摘要翻译： 用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括：至少一个储存器（18），其能够容纳与所述腔室内的表面相邻和/或面对实质的流体 至少一种生物样品的一部分。 该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。 充满水的储存器为室提供湿气并阻止样品干燥。