公开(公告)号：US10899497B2

公开(公告)日：2021-01-26

申请号：US15846288

申请日：2017-12-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Holger Burkardt ,  Norbert Frisch

IPC: B65D19/38 ,  B65D5/46 ,  B65D5/60 ,  B65D5/62 ,  B65D71/00 ,  B65D77/00 ,  B65B5/06 ,  B65B7/02 ,  B65G65/00

Abstract: A process for safeguarding a product during transportation includes forming a package by surrounding a product with packaging material and accommodating the package in an external packaging that includes a carrier element and a bag element. The carrier element includes an upper side including a border and a lower side opposite the upper side, wherein the lower side includes a base. Further, the bag element includes a base and a bag opening with a border opposite the base of the bag element. The package is accommodated in the external packaging by loading the package onto the carrier element such that the package is carried by the carrier element and loading the carrier element via the bag opening into the bag element such that the bag element surrounds the carrier element and the bag element extends on the upper side of the carrier element beyond the border of the carrier element.

公开(公告)号：US10895580B2

公开(公告)日：2021-01-19

申请号：US15986210

申请日：2018-05-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marco Maetzler ,  Christopher Schofield ,  Ole Lambaek ,  Moritz von Hopffgarten

IPC: G01N35/00 ,  G01N35/10 ,  B01L3/02 ,  G16H10/40

Abstract: A method for operating a laboratory system comprising instruments for processing samples and a control unit connected by a communication network is presented. The method comprises receiving and identifying a biological sample and retrieving an order list from a database. The list comprises a plurality of targets defining one or more processing steps to be carried out on the biological sample by one or more of the laboratory instruments. The method also comprises selecting a workflow strategy and retrieving workflow acceptance criterion corresponding to the workflow strategy. The control unit determines a sample workflow for processing the sample based on the workflow strategy and determines whether the sample workflow satisfies the workflow acceptance criterion. If the sample workflow does not satisfy the workflow acceptance criterion, workflow strategy and the workflow acceptance criterion is refined and the sample workflow is determined again until it satisfies the workflow acceptance criterion.

公开(公告)号：US10895414B2

公开(公告)日：2021-01-19

申请号：US15947929

申请日：2018-04-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Meyer

IPC: F25D25/02 ,  F25D31/00 ,  G01N35/04 ,  G01N35/00 ,  C12M1/00 ,  B01L7/02 ,  G01N1/31 ,  G01N1/30 ,  G01N1/00 ,  A61B10/00 ,  G01N1/28 ,  G02B21/34

Abstract: A drawer assembly for a laboratory instrument comprises a drawer loaded with a magazine. The drawer assembly comprises a frame comprising a portion adjacent the drawer that extends in a longitudinal direction. The drawer moves relative to the frame between a retracted position and an extended position. The frame comprises a path having a first portion and a second portion below the first portion. The drawer assembly comprises a rolling element moveable in the path and a lifting mechanism to lift the rolling element from a second portion to a first portion when the drawer is in the retracted position. The path is configured such that the rolling element is located in the first portion and contacts the drawer when the drawer is moved from the retracted position to the extended position and that the rolling element enters the second portion exclusively when the drawer is in the extended position.

公开(公告)号：US20210009660A1

公开(公告)日：2021-01-14

申请号：US15934055

申请日：2018-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Alfred Engel ,  Pavel Kubalec ,  Alfons Nichtl ,  Tobias Oelschlaegel ,  Rainer Schlecht

IPC: C07K16/00

Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.

公开(公告)号：US20200378981A1

公开(公告)日：2020-12-03

申请号：US16998444

申请日：2020-08-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Hund ,  Thomas Dieterle ,  Olav Lapaire

IPC: G01N33/68

Abstract: The present invention is directed to a method for predicting the risk of a female subject to develop postpartum HELLP syndrome, postpartum preeclampsia, or postpartum eclampsia. The method is based on the determination of the levels of i) sFlt-1 and PlGF, or ii) Endoglin and PlGF in a first sample obtained from said subject before delivery of baby, and a second sample of from said subject obtained after delivery of baby. Moreover, encompassed by the invention are devices and kits for carrying out the method of the present invention.

公开(公告)号：US20200348294A1

公开(公告)日：2020-11-05

申请号：US16931599

申请日：2020-07-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Gaston Hubertus Maria Vondenhoff ,  Stephan Hug

IPC: G01N33/543 ,  C08F292/00 ,  C08J3/24 ,  C08K3/22 ,  C08G83/00 ,  C08K9/04 ,  C08K5/17 ,  H01F1/00

Abstract: The present disclosure relates to hypercrosslinked magnetic particle with a polymer matrix and at least one magnetic core (M), wherein the polymer matrix has at least one crosslinked polymer having at least one hypercrosslinking bond, wherein the hypercrosslinking bond is a molecule having at least two nitrogen atoms within its structure which are part of the hypercrosslinking bond; and having at least one positive charge. Further, the disclosure relates to a method of preparing the hypercrosslinked magnetic particle and also to hypercrosslinked magnetic particle obtained or obtainable from the method. Also described is the use of the hypercrosslinked magnetic particles for enrichment or purification of at least one analyte as well as to the use of the hypercrosslinked magnetic particles for purification of water.

公开(公告)号：US10809245B2

公开(公告)日：2020-10-20

申请号：US15452104

申请日：2017-03-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Kai Hebestreit ,  Sylvia Saecker ,  Klaus Thome ,  Marina Swan Backhaus

IPC: G01N33/487 ,  G01N35/00 ,  B01L3/00 ,  G01N21/77 ,  G01N27/416 ,  G06K7/10 ,  G01N21/84

Abstract: A test element analysis system for the analytical examination of a sample comprising: at least one evaluation device with at least one test element holder and at least one measuring device for measuring a change in a measuring zone of a test element; at least one barcode reader comprising at least one circuit board having a front side facing the barcode of the test element positioned in the test element holder and a reverse side facing away from the test element, wherein at least one electronic control element of the barcode reader is disposed on the circuit board and wherein the circuit board comprises at least one cavity penetrating the circuit board; at least one camera carrier element; and at least one camera electrically connected to the camera carrier element, with the camera carrier element and the camera being positioned such that the camera observes the barcode through the cavity.

公开(公告)号：US20200315508A1

公开(公告)日：2020-10-08

申请号：US16908963

申请日：2020-06-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Thome ,  Reiner Stein ,  Lars Fischheiter ,  Jerome Greenhalgh

IPC: A61B5/145 ,  G01N33/487 ,  G01N35/00

Abstract: A medical instrument and method thereof for performing a measurement on a biological sample using a test strip are disclosed. The medical instrument may comprise: an analytical unit for analyzing the test strip, wherein the analytical unit comprises a test strip mount which receives the test strip to perform the measurement; a test strip port which receives the test strip, wherein the test strip port is aligned with the test strip mount along an insertion direction; and a shutter movable between open and closed positions, the shutter comprises a test strip opening, wherein the test strip opening is aligned with the test strip port and the test strip mount when the shutter is in the open position, wherein the shutter comprises a shutter mechanism that rotates the shutter parallel to the insertion direction about a rotational axis to move the shutter between the open position and the closed position.

公开(公告)号：US20200277406A1

公开(公告)日：2020-09-03

申请号：US16821537

申请日：2020-03-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

IPC: C07K19/00 ,  C07K16/32 ,  C07K16/18 ,  C07K16/28

Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

公开(公告)号：US20200263160A1

公开(公告)日：2020-08-20

申请号：US16865487

申请日：2020-05-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Werner Hoelke ,  Michaela Fischer ,  Johann-Peter Thalhofer ,  Markus Weber

IPC: C12N9/96 ,  C12N9/52 ,  C12N9/64 ,  C12N9/54

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.