公开(公告)号：US20180140648A1

公开(公告)日：2018-05-24

申请号：US15575827

申请日：2016-05-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: A61K35/747 ,  A61K35/745 ,  A61P3/08

CPC classification number: A61K35/747 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K2300/00 ,  A61P3/08 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475

Abstract: A method of improving the glucose response in glucose tolerant and intolerant subjects is provided. The method comprises providing to the subject probiotic compositions, or agents which specifically reduce bacterial species.

公开(公告)号：US20180134808A1

公开(公告)日：2018-05-17

申请号：US15865479

申请日：2018-01-09

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Tamar DANON ,  Netta SELA ,  Abraham SHANZER ,  Rina ARAD-YELLIN ,  Raghavendra KIKKERI

IPC: C07K16/44 ,  C07F3/06 ,  C07D233/61 ,  C07K16/40

CPC classification number: C07K16/44 ,  C07D233/61 ,  C07F3/06 ,  C07K16/40 ,  C07K2317/565 ,  C07K2317/76

Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

公开(公告)号：US09966458B2

公开(公告)日：2018-05-08

申请号：US15178951

申请日：2016-06-10

Applicant: Westfälische Wilhelms Universität Münster ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

Inventor： Benjamin Göhler ,  Volker Hamelbeck ,  G. Friedrich Hanne ,  Helmut Zacharias ,  Ron Naaman ,  Tal Zvi Markus

IPC: H01L29/66 ,  B82Y10/00 ,  H01L51/00 ,  H01L51/05

CPC classification number: H01L29/66984 ,  B82Y10/00 ,  H01L51/0093 ,  H01L51/0595

Abstract: The present invention relates to a method and a device for providing a current of spin-polarized electrons. More particularly, the present invention is suited for use in spin electronics or detection of spin-polarized electrons.

公开(公告)号：US20180119227A1

公开(公告)日：2018-05-03

申请号：US15724309

申请日：2017-10-04

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Zvi LIVNEH ,  Tamar PAZ-ELIZUR

IPC: C12Q1/6886 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  G01N33/57423

Abstract: Methods and kits for determining a risk of a subject, or subjects for developing lung cancer is disclosed. The method comprises determining a level of catalytic activity of N-methylpurine DNA glycosylase (MPG), or apurinic/apyrimidinic endonuclease 1 (APE1), or both, or MPG and 8-oxoguanine DNA glycosylase (OGG1), or MPG and APE1 and OGG1 in peripheral blood cells of a subject, wherein levels of MPG above a predetermined reference value, or APE1 or OGG1, or a integrated DNA repair score below a predetermined reference value is indicative of an increased risk of developing lung cancer.

公开(公告)号：US20180117173A1

公开(公告)日：2018-05-03

申请号：US15573550

申请日：2016-05-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Valery KRIZHANOVSKY ,  Yossi OVADYA

IPC: A61K47/68 ,  C12N15/113 ,  C07K16/18 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K47/6843 ,  A61K45/06 ,  A61K47/6807 ,  A61K47/6849 ,  A61P35/00 ,  C07K16/18 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/3513

Abstract: A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.

公开(公告)号：US20180071369A1

公开(公告)日：2018-03-15

申请号：US15561053

申请日：2016-03-31

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David MIRELMAN ,  Aharon RABINKOV ,  Angela RUBAN ,  Ghil JONA ,  Eli HAZUM ,  Vladas BUMELIS ,  Nerijus MAKAUSKAS ,  Saule SUDZIUVIENE ,  Elena NARMONTAITE

IPC: A61K38/45 ,  C12N9/10

CPC classification number: A61K38/45 ,  C12N9/1096 ,  C12Y206/01001

Abstract: A protein preparation comprising Glutamate Oxaloacetate Transaminase 1 (GOT1) polypeptide molecules is disclosed, the GOT1 being identical in its sequence to that present in human serum. 100% of the GOT1 polypeptide molecules of the preparation have an alanine at position 1 of the GOT1 polypeptide. The GOT1 polypeptide molecules constitute at least 95% of the proteins in the preparation. Methods of generating same and uses thereof are also disclosed.

公开(公告)号：US20180064682A1

公开(公告)日：2018-03-08

申请号：US15798530

申请日：2017-10-31

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Menachem RUBINSTEIN ,  Efrat DVASH-RIESENFELD

IPC: A61K31/366 ,  A61K31/381 ,  A61K31/41

Abstract: The present invention relates to the alleviation of adverse side effects resulting from statin therapy. The present invention further relates to the use of an inhibitor of leukotriene C4 (LTC4) mediated activity for alleviating at least one side effects of statin therapy.

公开(公告)号：US09901660B2

公开(公告)日：2018-02-27

申请号：US14902574

申请日：2014-07-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Noa Iuster ,  Raya Sorkin

IPC: A61K9/127 ,  A61L27/52 ,  A61L27/34 ,  A61K9/00 ,  C09D133/06 ,  A61L27/44 ,  C08F2/10 ,  C08F2/44

CPC classification number: A61L27/52 ,  A61K9/0019 ,  A61K9/0024 ,  A61L27/34 ,  A61L27/44 ,  A61L2300/626 ,  A61L2400/10 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/24 ,  A61L2430/38 ,  C08F2/10 ,  C08F2/44 ,  C09D133/066

Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

公开(公告)号：US20180045754A1

公开(公告)日：2018-02-15

申请号：US15557104

申请日：2016-03-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eli ZELDOV ,  Lior EMBON ,  Dorri HALBERTAL ,  Yonathan ANAHORY ,  Yuri MYASOEDOV ,  Jo CUPPENS

IPC: G01Q60/58

CPC classification number: G01Q60/58 ,  G01K7/006 ,  G01K2203/00 ,  G01N27/041

Abstract: A device and methods for use thereof in low-temperature thermal scanning microscopy, providing non-contact, non-invasive localized temperature and thermal conductivity measurements in nanometer scale ranges with a temperature resolution in the micro-Kelvin order. A superconductive cap mounted on the tip of an elongated support probe is electrically-connected to superconductive leads for carrying electrical current through the cap. The critical superconducting current of the leads is configured to be greater than the critical current supported by the cap, and the cap's critical current is configured to be a function of its temperature. Thus, the temperature of the cap is measured by measuring its critical superconducting current. In a related embodiment, driving a current greater than the critical current of the cap quenches the cap's superconductivity, and permits the cap to dissipate resistive heat into the sample being scanned. Scanning of the sample in this mode thus images its thermal conductivity patterns.

公开(公告)号：US20180042994A1

公开(公告)日：2018-02-15

申请号：US15525618

申请日：2015-11-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Atan GROSS ,  Yehudit ZALTSMAN ,  Liat PINKAS ,  Maria MARYANOVICH ,  Liat BUZAGLO ,  Antonella RUGGIERO ,  Amir BAHAT ,  Andres GOLDMAN ,  Michael MULLOKANDOV

IPC: A61K38/17 ,  C12N5/00

CPC classification number: A61K38/1761 ,  C12N5/0018

Abstract: Uses of agent which downregulate an activity or expression of a component participating in the mitochondrial apoptotic pathway are disclosed.