公开(公告)号：US20250121246A1

公开(公告)日：2025-04-17

申请号：US18379664

申请日：2023-10-13

Applicant: Bin Liu

Inventor： Bin Liu

IPC: A63B21/00 ,  A63B21/062

Abstract: The present invention discloses a fitness equipment comprising frame assembly, drive assembly, slide trolley and a smith system. Two base frames set opposite to each other are connected by connecting rod, and the first column and the second column are set in the vertical direction of the connecting rod which are connected by gantry frame, and the first cross beam and the second cross beam are set vertically on the connecting rod and the gantry frame, respectively, and the third column is set between them, thus forming the structure of fitness equipment, and pulley assembly is cooperated with the first wire rope, the second wire rope, and the third wire rope so that it can drive the slide car moves, realizing the alignment from the middle, which can reduce friction and increase the service life of the multifunctional fitness equipment when in use.

公开(公告)号：US20160376296A1

公开(公告)日：2016-12-29

申请号：US14934665

申请日：2015-11-06

Applicant: Yi Pang ,  Bin Liu

Inventor： Yi Pang ,  Bin Liu

IPC: C07F9/6533 ,  G01N33/58 ,  C12Q1/02

CPC classification number: A61B5/0071 ,  A61K31/713 ,  A61K49/0021 ,  C07D311/30 ,  C07F9/6533 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2310/3515 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2320/35 ,  C12N2320/53 ,  C12Q1/02 ,  G01N33/582 ,  H05K999/99 ,  C12N2310/3533 ,  C12N2310/3531 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Flavonoid compounds may be prepared that are selective for certain cell organelles, and may be used as biological imaging agents. Organelles that may be imaged with flavonoid compounds include mitochondria and lysosomes. Advantageously, the flavonoids show specificity to certain organelles and may exhibit a florescence “turn-on” mechanism, where the flavonoids that have target an organelle exhibit a florescence response when excited.

Abstract translation: 可以制备对某些细胞器具有选择性的类黄酮化合物，并且可以用作生物成像剂。 可能用黄酮类化合物成像的细胞器包括线粒体和溶酶体。 有利地，类黄酮对某些细胞器显示特异性并且可能表现出荧光“开启”机制，其中靶向细胞器的类黄酮在激发时表现出荧光反应。

公开(公告)号：US09145462B2

公开(公告)日：2015-09-29

申请号：US13172759

申请日：2011-06-29

Applicant: Bin Liu ,  James D. Marks ,  Xiaodong Zhu ,  Scott Bidlingmaier

Inventor： Bin Liu ,  James D. Marks ,  Xiaodong Zhu ,  Scott Bidlingmaier

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C12N5/095 ,  G01N33/574

CPC classification number: C07K16/18 ,  A61K47/6843 ,  A61K51/1045 ,  C07K16/2896 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C12N5/0695 ,  G01N33/57407

Abstract: The present disclosure is generally related to antibodies that bind specifically to glioblastoma multiforme (GBM) cells. In particular, the present disclosure provides compositions comprising human single chain or full-length antibodies that bind tumor cells. Additionally the present disclosure provides methods of using the anti-GBM antibodies.

Abstract translation: 本公开通常涉及特异性结合多形性胶质母细胞瘤（GBM）细胞的抗体。 特别地，本公开提供了包含结合肿瘤细胞的人单链或全长抗体的组合物。 另外，本公开提供了使用抗GBM抗体的方法。

公开(公告)号：US20140328764A1

公开(公告)日：2014-11-06

申请号：US14342074

申请日：2012-09-03

Applicant: Benzhong Tang ,  Wei Qin ,  Jianzhao Liu ,  Sijie Chen ,  Tsz Kin Kwok ,  Bin Liu ,  Kai Li ,  Dan Ding ,  Haibin Shi ,  Jun Long Geng ,  Jingzhi Sun ,  Anjun Qin ,  Qiuli Zhao

Inventor： Benzhong Tang ,  Wei Qin ,  Jianzhao Liu ,  Sijie Chen ,  Tsz Kin Kwok ,  Bin Liu ,  Kai Li ,  Dan Ding ,  Haibin Shi ,  Jun Long Geng ,  Jingzhi Sun ,  Anjun Qin ,  Qiuli Zhao

IPC: G01N33/58 ,  A61K49/00 ,  G01N33/574 ,  C12Q1/37

CPC classification number: G01N33/582 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/0093 ,  C09K11/06 ,  C12Q1/37 ,  G01N33/574 ,  G01N2333/96466

Abstract: The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

Abstract translation: 荧光生物探针的发展包括显示聚集诱导发射（AIE）性质的有机荧光化合物，其生产方法及其在体外和体内生物成像中的实际应用。

公开(公告)号：US08522348B2

公开(公告)日：2013-08-27

申请号：US12846541

申请日：2010-07-29

Applicant: Yan Chen ,  Zhichun Li ,  Gao Xia ,  Bin Liu

Inventor： Yan Chen ,  Zhichun Li ,  Gao Xia ,  Bin Liu

IPC: G06F11/00

CPC classification number: H04L63/1416 ,  H04L63/1433 ,  H04L69/22

Abstract: Systems, methods, and apparatus are provided for vulnerability signature based Network Intrusion Detection and/or Prevention which achieves high throughput comparable to that of the state-of-the-art regex-based systems while offering improved accuracy. A candidate selection algorithm efficiently matches thousands of vulnerability signatures simultaneously using a small amount of memory. A parsing transition state machine achieves fast protocol parsing. Certain examples provide a computer-implemented method for network intrusion detection. The method includes capturing a data message and invoking a protocol parser to parse the data message. The method also includes matching the parsed data message against a plurality of vulnerability signatures in parallel using a candidate selection algorithm and detecting an unwanted network intrusion based on an outcome of the matching.

Abstract translation: 提供了基于漏洞签名的网络入侵检测和/或预防的系统，方法和装置，其实现了与现有技术的基于正则表达式的系统相当的高吞吐量，同时提供了更高的精度。 候选者选择算法使用少量内存同时有效地匹配数千个漏洞签名。 解析过渡状态机实现快速协议解析。 某些示例提供用于网络入侵检测的计算机实现的方法。 该方法包括捕获数据消息并调用协议解析器来解析数据消息。 该方法还包括使用候选选择算法并行地解析解析的数据消息与多个脆弱性签名并且基于匹配的结果来检测不需要的网络入侵。

公开(公告)号：US08507290B2

公开(公告)日：2013-08-13

申请号：US13498985

申请日：2010-09-28

Applicant: Bin Liu ,  Kanyi Pu

Inventor： Bin Liu ,  Kanyi Pu

IPC: G01N21/64 ,  G01N33/50 ,  C07F7/21

CPC classification number: C07F7/21 ,  B82Y15/00 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1051 ,  G01N33/54386 ,  G01N33/582 ,  G01N33/588

Abstract: The present invention generally relates to water-soluble, highly fluorescent polyhedral oligomeric silsesquioxane (POSS) compounds useful for sensing and bioimaging applications.

Abstract translation: 本发明通常涉及可用于感测和生物成像应用的水溶性，高度荧光的多面体低聚倍半硅氧烷（POSS）化合物。

公开(公告)号：US20130182259A1

公开(公告)日：2013-07-18

申请号：US13513052

申请日：2010-12-01

Applicant: Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

Inventor： Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

IPC: G01B9/02

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02074 ,  G01N21/4795 ,  G01N2021/1787

Abstract: Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration data. Moreover, systems that include logarithmic amplification of the spectral interference signal and variable band-pass filtering of the spectral interference signal are provided. Such systems increase the dynamic range and visualization capabilities relative to conventional spectral domain OCT systems.

Abstract translation: 提供了增强频域光学相干断层扫描（OCT）的系统和方法，特别提供了一种使用采集的校准信号校准光谱干扰信号的系统和方法，校准信号可以对数放大，以进一步提高 校准，从校准信号中计算出一系列更准确的校准数据，采用这些校准数据对采集到的光谱干涉信号进行校准，而且包括频谱干扰信号的对数放大和可变带通滤波的系统 提供了光谱干扰信号，相对于常规光谱域OCT系统，这种系统增加了动态范围和可视化能力。

公开(公告)号：US20130109029A1

公开(公告)日：2013-05-02

申请号：US13806447

申请日：2011-06-29

Applicant: Bin Liu ,  Kanyi Pu ,  Kai Li ,  Liping Cai ,  Yanyan Wang ,  Dan Ding

Inventor： Bin Liu ,  Kanyi Pu ,  Kai Li ,  Liping Cai ,  Yanyan Wang ,  Dan Ding

IPC: C07K17/02

CPC classification number: C07K17/02 ,  B82Y15/00 ,  C07D285/10 ,  C09K11/06 ,  C09K2211/1416 ,  G01N33/582 ,  G01N33/588

Abstract: The present invention relates to conjugated polyelectrolyte (CPE) or oligoelectrolyte (COE) compounds represented by general structural formulae (I)-(IV), or a salt thereof and methods of using these compounds to detect targets in samples. In particular, the methods include: (1) exposing a sample to a compound of structural formula (I), (II) or (IV) or a salt thereof, allowing the compound to bind to a target and detecting a signal produced by the compound; (2) functionalizing a solid support with a ligand, incubating the sample with a charged CPE or COE and detecting the fluorescence of the solid support and thereby detecting the target or (3) functionalizing a surface of a solid support with a charged ligand, thereby creating a charge on the surface of the solid support; incubating the ligand-functionalized solid support with a sample, whereupon binding of the target, the charge on the surface of the solid support switches; incubating the sample with CPE or COE that has a complementary charge to the charge of the target-bound surface; and detecting the fluorescence of the solid support and thereby detecting the target. The compounds of the present invention possess high photoluminescence quantum yields in biological media, low cytotoxicity, and excellent environmental stability and photostability and can be used in biosensor and bioimaging applications.

Abstract translation: 本发明涉及由通式（I） - （IV）表示的共轭聚电解质（CPE）或低聚电解质（COE）化合物或其盐，以及使用这些化合物检测样品中靶标的方法。 特别地，所述方法包括：（1）将样品暴露于结构式（I），（II）或（IV）的化合物或其盐，使化合物与靶标结合并检测由 复合; （2）用配体官能化固体支持物，将样品与带电荷的CPE或COE孵育并检测固体支持物的荧光，从而检测靶，或（3）用带电的配体使固体支持物的表面官能化，从而 在固体支撑体的表面上产生电荷; 将配体官能化的固体支持物与样品一起孵育，随后靶标结合，固体支持开关表面上的电荷; 将样品与具有补充电荷的CPE或COE孵育到靶结合表面的电荷; 并检测固体支持物的荧光，从而检测目标物。 本发明的化合物在生物培养基中具有高的光致发光量子产率，低的细胞毒性和优异的环境稳定性和光稳定性，并可用于生物传感器和生物成像应用。

公开(公告)号：US08338532B2

公开(公告)日：2012-12-25

申请号：US13038378

申请日：2011-03-01

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C08G63/91 ,  C08G63/00 ,  C12Q1/68

CPC classification number: C08G61/02 ,  C08G61/122 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6439 ,  C12Q2563/131 ,  C12Q2537/119 ,  C12Q2525/107

Abstract: The invention further relates to multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及可以是共轭聚合物的多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US08265748B2

公开(公告)日：2012-09-11

申请号：US12350749

申请日：2009-01-08

Applicant: Bin Liu ,  Hu Luo

Inventor： Bin Liu ,  Hu Luo

IPC: A61N1/34

CPC classification number: A61N1/046 ,  A61N1/0472 ,  A61N1/0492 ,  A61N1/3925 ,  A61N1/3993

Abstract: A defibrillator includes a defibrillator mainframe and a defibrillating electrode. The defibrillator mainframe includes a main control unit and a master device electrically connected to the main control unit. The defibrillating electrode comprises a slave device supporting a bus protocol, the master device and slave device being interconnected through a bus.

Abstract translation: 除颤器包括除颤器主机和去纤颤电极。 除颤器主机包括主控制单元和与主控制单元电连接的主设备。 除颤电极包括支持总线协议的从设备，主设备和从设备通过总线互连。