公开(公告)号：US09234840B2

公开(公告)日：2016-01-12

申请号：US14006463

申请日：2012-03-22

申请人： Mark Brezinski

发明人： Mark Brezinski

IPC分类号： G01N21/43 ,  G01N21/45 ,  G01N21/49 ,  G01N21/84

CPC分类号： G01N21/45 ,  G01N21/49 ,  G01N21/84

摘要： An optical system and method for characterizing an object is provided. The system includes at least one light source configured to direct photons toward an object and an interferometer configured to receive photons from the object. The system also includes at least one detector system adapted to detect an optical signal at an output of the interferometer and to remove, from the detected optical signal, a signal portion representing first order photon correlations, when present. The system also includes a processor configured to receive data relating to second-order correlated photons from said at least one detector system, each photon or photon pair subject to at least two indistinguishable paths to a photon or photon pair, but differing in at least one of time and length. The processor is configured to characterize the object based on a self interference of the second-order correlated photons from a common location within the object.

摘要翻译： 提供了一种用于表征物体的光学系统和方法。 该系统包括被配置为将光子引向物体的至少一个光源和被配置为从物体接收光子的干涉仪。 该系统还包括至少一个检测器系统，其适于在干涉仪的输出处检测光学信号，并且在存在时从检测到的光信号中去除表示一阶光子相关的信号部分。 该系统还包括处理器，其被配置为从所述至少一个检测器系统接收与二阶相关光子有关的数据，每个光子或光子对经受至少两个不可分辨的光子或光子对路径，但在至少一个 的时间和长度。 处理器被配置为基于来自对象内的公共位置的二阶相关光子的自身干扰来表征对象。

公开(公告)号：US20140139847A1

公开(公告)日：2014-05-22

申请号：US14006463

申请日：2012-03-22

申请人： Mark Brezinski

发明人： Mark Brezinski

IPC分类号： G01N21/45 ,  G01N21/84

CPC分类号： G01N21/45 ,  G01N21/49 ,  G01N21/84

摘要： An optical system and method for characterizing an object is provided. The system includes at least one light source configured to direct photons toward an object and an interferometer configured to receive photons from the object. The system also includes at least one detector system adapted to detect an optical signal at an output of the interferometer and to remove, from the detected optical signal, a signal portion representing first order photon correlations, when present. The system also includes a processor configured to receive data relating to second-order correlated photons from said at least one detector system, each photon or photon pair subject to at least two indistinguishable paths to a photon or photon pair, but differing in at least one of time and length. The processor is configured to characterize the object based on a self interference of the second-order correlated photons from a common location within the object.

摘要翻译： 提供了一种用于表征物体的光学系统和方法。 该系统包括被配置为将光子引向物体的至少一个光源和被配置为从物体接收光子的干涉仪。 该系统还包括至少一个检测器系统，其适于在干涉仪的输出处检测光学信号，并且在存在时从检测到的光信号中去除表示一阶光子相关的信号部分。 该系统还包括处理器，其被配置为从所述至少一个检测器系统接收与二阶相关光子相关的数据，每个光子或光子对经受至少两个不可区分的光子或光子对路径，但在至少一个 的时间和长度。 处理器被配置为基于来自对象内的公共位置的二阶相关光子的自身干扰来表征对象。

公开(公告)号：US6134003A

公开(公告)日：2000-10-17

申请号：US607787

申请日：1996-02-27

申请人： Guillermo Tearney ,  Stephen A. Boppart ,  Brett E. Bouma ,  Mark Brezinski ,  Eric A. Swanson ,  James G. Fujimoto

发明人： Guillermo Tearney ,  Stephen A. Boppart ,  Brett E. Bouma ,  Mark Brezinski ,  Eric A. Swanson ,  James G. Fujimoto

IPC分类号： G01B11/00 ,  A61B1/00 ,  A61B3/10 ,  A61B3/12 ,  A61B5/00 ,  A61B5/103 ,  A61B8/12 ,  A61B10/00 ,  A61M25/00 ,  G01B9/02 ,  G01B11/02 ,  G01B11/12 ,  G01B11/24 ,  G01J1/00 ,  G01N21/17 ,  G01N21/35 ,  G01N21/47 ,  G02B5/18 ,  G02B27/44 ,  G11B7/00 ,  G11B7/005 ,  G11B7/125 ,  G11B7/24 ,  H01S5/14

CPC分类号： B82Y15/00 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B3/102 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/445 ,  A61B5/6852 ,  G01B11/00 ,  G01B11/026 ,  G01B11/12 ,  G01B11/2441 ,  G01B9/02002 ,  G01B9/02004 ,  G01B9/02007 ,  G01B9/0201 ,  G01B9/0205 ,  G01B9/02091 ,  G01J1/00 ,  G01N21/4795 ,  G02B5/1828 ,  G11B7/005 ,  G11B7/127 ,  A61B2562/0242 ,  A61B3/1005 ,  G01B2290/65 ,  G01B2290/70 ,  G11B2007/0013 ,  G11B7/24 ,  H01S5/141

摘要： An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating a image of the structure in response to the signal from the detector. The system provides both rotational and longitudinal scanning of an image.

摘要翻译： 用于执行光学相干断层摄影的成像系统包括光辐射源; 参考光学反射器; 通向参考光反射器的第一光路; 以及耦合到内窥镜单元的第二光路。 内窥镜单元优选地包括限定孔的细长壳体; 可旋转的单模光纤，其具有定位在所述细长壳体的所述孔的长度内并延伸所述细长壳体的所述孔的长度的近端和远端; 以及耦合到可旋转单模光纤的远端的光学系统，定位成将光辐射从单模光纤传输到结构，并将反射的光辐射从结构传输到单模光纤。 该系统还包括一个光束分配器，将沿着第一光路的光辐射源的光辐射分成沿着第二光路; 以及检测器，其被定位成接收来自沿着第一光路传输的反射器的反射光辐射以及沿着第二光路从结构传输的反射光辐射。 检测器响应于来自参考反射器的反射光辐射和来自结构的反射光辐射产生信号，以及响应于来自检测器的信号产生结构图像的处理器。 该系统提供图像的旋转和纵向扫描。

公开(公告)号：US06564087B1

公开(公告)日：2003-05-13

申请号：US09359574

申请日：1999-07-22

申请人： Constantinos Pitris ,  Stephen A. Boppart ,  Xingde Li ,  Mark Brezinski ,  Eric Swanson ,  Edward McNamara ,  James G. Fujimoto

发明人： Constantinos Pitris ,  Stephen A. Boppart ,  Xingde Li ,  Mark Brezinski ,  Eric Swanson ,  Edward McNamara ,  James G. Fujimoto

IPC分类号： A61B500

CPC分类号： A61B5/6852 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B3/1005 ,  A61B3/102 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/445 ,  A61B5/6848 ,  A61B2562/0242 ,  A61B2562/028 ,  B82Y15/00 ,  G01B9/0205 ,  G01B9/02091 ,  G01B11/00 ,  G01B11/026 ,  G01B11/12 ,  G01B11/2441 ,  G01B2290/65 ,  G01J1/00 ,  G01N21/4795 ,  G02B5/1828 ,  G11B7/0037 ,  G11B7/005 ,  G11B7/08564 ,  G11B7/0908 ,  G11B7/0945 ,  G11B7/126 ,  G11B7/127 ,  G11B7/128 ,  G11B7/1353 ,  G11B7/14 ,  G11B7/24 ,  G11B2007/0013 ,  H01S5/141

摘要： A fiber optic needle probe for measuring or imaging the internal structure of a specimen includes a needle defining a bore, an optical fiber substantially positioned within the bore, and a beam director in optical communication with the optical fiber. At least a portion of the wall of the needle is capable of transmitting light. The beam director directs light from the optical fiber to an internal structure being imaged and receives light from the structure through a transparent portion of the wall. An actuating device causes motion of any, or all of, the needle, optical fiber, and beam director to scan the internal structure of the specimen. The fiber optic needle probe allows imaging inside a solid tissue or organ without intraluminal insertion. When used in conjunction with an OCT imaging system, the fiber optic needle probe enables tomographic imaging of the microstructure of internal organs and tissues which were previously impossible to image in a living subject.

摘要翻译： 用于测量或成像试样的内部结构的光纤针头探针包括限定孔的针，基本上位于孔内的光纤，以及与光纤光学通信的光束指向器。 针的壁的至少一部分能够透光。 光束指示器将光从光纤引导到被成像的内部结构，并且通过壁的透明部分接收来自结构的光。 致动装置导致针，光纤和光束导向器中的任何一个或全部的运动扫描样本的内部结构。 光纤针头探针允许在没有腔内插入的情况下在固体组织或器官内进行成像。 当与OCT成像系统结合使用时，光纤针头探针能够对以前不可能在活体中形成的内部器官和组织的微结构进行层析成像。

公开(公告)号：US09506740B2

公开(公告)日：2016-11-29

申请号：US13513052

申请日：2010-12-01

申请人： Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

发明人： Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

IPC分类号： G01B11/02 ,  G01B9/02 ,  A61B5/00 ,  G01N21/47 ,  G01N21/17

CPC分类号： G01B9/02091 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02074 ,  G01N21/4795 ,  G01N2021/1787

摘要： Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration data. Moreover, systems that include logarithmic amplification of the spectral interference signal and variable band-pass filtering of the spectral interference signal are provided. Such systems increase the dynamic range and visualization capabilities relative to conventional spectral domain OCT systems.

摘要翻译： 提供了增强频域光学相干断层扫描（OCT）的系统和方法，特别提供了一种使用采集的校准信号校准光谱干扰信号的系统和方法，校准信号可以对数放大，以进一步提高 校准，从校准信号中计算出一系列更准确的校准数据，采用这些校准数据对采集到的光谱干涉信号进行校准，而且包括频谱干扰信号的对数放大和可变带通滤波的系统 提供了光谱干扰信号，相对于常规光谱域OCT系统，这种系统增加了动态范围和可视化能力。

公开(公告)号：US06501551B1

公开(公告)日：2002-12-31

申请号：US09414293

申请日：1999-10-05

申请人： Guillermo Tearney ,  Stephen A. Boppart ,  Brett E. Bouma ,  Mark Brezinski ,  Eric A. Swanson ,  James G. Fujimoto

发明人： Guillermo Tearney ,  Stephen A. Boppart ,  Brett E. Bouma ,  Mark Brezinski ,  Eric A. Swanson ,  James G. Fujimoto

IPC分类号： G01B902

CPC分类号： G11B7/005 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B3/1005 ,  A61B3/102 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/445 ,  A61B5/6852 ,  A61B2562/0242 ,  B82Y15/00 ,  G01B9/02002 ,  G01B9/02004 ,  G01B9/02007 ,  G01B9/0201 ,  G01B9/0205 ,  G01B9/02091 ,  G01B11/00 ,  G01B11/026 ,  G01B11/12 ,  G01B11/2441 ,  G01B2290/65 ,  G01B2290/70 ,  G01J1/00 ,  G01N21/4795 ,  G11B7/127 ,  G11B7/24 ,  G11B2007/0013 ,  H01S5/141

摘要： An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating a image of the structure in response to the signal from the detector. The system provides both rotational and longitudinal scanning of an image.

摘要翻译： 用于执行光学相干断层摄影的成像系统包括光辐射源; 参考光学反射器; 通向参考光反射器的第一光路; 以及耦合到内窥镜单元的第二光路。 内窥镜单元优选地包括限定孔的细长壳体; 可旋转的单模光纤，其具有定位在所述细长壳体的所述孔的长度内并延伸所述细长壳体的所述孔的长度的近端和远端; 以及耦合到可旋转单模光纤的远端的光学系统，定位成将光辐射从单模光纤传输到结构，并将反射的光辐射从结构传输到单模光纤。 该系统还包括一个光束分配器，将沿着第一光路的光辐射源的光辐射分成沿着第二光路; 以及检测器，其被定位成接收来自沿着第一光路传输的反射器的反射光辐射以及沿着第二光路从结构传输的反射光辐射。 检测器响应于来自参考反射器的反射光辐射和来自结构的反射光辐射产生信号，以及响应于来自检测器的信号产生结构图像的处理器。 该系统提供图像的旋转和纵向扫描。

公开(公告)号：US20130182259A1

公开(公告)日：2013-07-18

申请号：US13513052

申请日：2010-12-01

申请人： Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

发明人： Mark Brezinski ,  Bin Liu ,  Ehsan Azimi

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02074 ,  G01N21/4795 ,  G01N2021/1787

摘要： Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration data. Moreover, systems that include logarithmic amplification of the spectral interference signal and variable band-pass filtering of the spectral interference signal are provided. Such systems increase the dynamic range and visualization capabilities relative to conventional spectral domain OCT systems.

摘要翻译： 提供了增强频域光学相干断层扫描（OCT）的系统和方法，特别提供了一种使用采集的校准信号校准光谱干扰信号的系统和方法，校准信号可以对数放大，以进一步提高 校准，从校准信号中计算出一系列更准确的校准数据，采用这些校准数据对采集到的光谱干涉信号进行校准，而且包括频谱干扰信号的对数放大和可变带通滤波的系统 提供了光谱干扰信号，相对于常规光谱域OCT系统，这种系统增加了动态范围和可视化能力。